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En In Vivo metode til evaluering af Gut-blod barriere og lever metabolisme af mikrobiota produkter
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En In Vivo metode til evaluering af Gut-blod barriere og lever metabolisme af mikrobiota produkter

Article DOI: 10.3791/58456-v • 14:54 min • October 20th, 2018
October 20th, 2018 •
1, 1, 1, 1, 2, 1
1Department of Experimental Physiology and Pathophysiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, 2Mass Spectrometry Laboratory, Institute of Biochemistry and Biophysics, Polish Academy of Sciences

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Næringsstoffer, mikrobiota metabolitter og lægemidler til cirkulation adgang styres af gut-blod barriere (GBB). Vi beskriver en direkte metode til måling af GBB permeabilitet i vivo, der i modsætning til almindeligt anvendte indirekte metoder, er stort set ikke berørt af lever og nyre funktioner.

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Medicin spørgsmål 140 Gut-blod barriere intestinal permeabilitet leveren clearance portal blodprøvetagning tarm bakterier TMA kortkædede fedtsyrer
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