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Chapters
- 00:04Title
- 00:51Carbodiimide Coupling Reaction for Primary Alcohols and Extraction Workup
- 02:17Washing Procedure
- 03:28Carbodiimide Coupling Reaction for Secondary and Electron-deficient Alcohols
- 04:12Carbodiimide Coupling Reaction for Long-Chain or Hydrophobic Carboxylic Acids
- 04:54Results: Characterization of Esters Formed from the Greener Steglich Esterification
- 06:32Conclusion
A modified Steglich esterification reaction was used to synthesize a small library of ester derivatives with primary and secondary alcohols. The methodology uses a non-halogenated and greener solvent, acetonitrile, and enables product isolation in high yields without the need for chromatographic purification.
