Journal
/
/
Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
JoVE Journal
Chemistry
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Chemistry
Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
DOI:

06:52 min

October 30, 2018

, ,

Chapters

  • 00:04Title
  • 00:51Carbodiimide Coupling Reaction for Primary Alcohols and Extraction Workup
  • 02:17Washing Procedure
  • 03:28Carbodiimide Coupling Reaction for Secondary and Electron-deficient Alcohols
  • 04:12Carbodiimide Coupling Reaction for Long-Chain or Hydrophobic Carboxylic Acids
  • 04:54Results: Characterization of Esters Formed from the Greener Steglich Esterification
  • 06:32Conclusion

Summary

Automatic Translation

A modified Steglich esterification reaction was used to synthesize a small library of ester derivatives with primary and secondary alcohols. The methodology uses a non-halogenated and greener solvent, acetonitrile, and enables product isolation in high yields without the need for chromatographic purification.

Related Videos

Read Article