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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
 

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Article doi: 10.3791/58508
February 6th, 2019

Summary February 6th, 2019

Here we present a protocol to demonstrate an efficient method for the synthesis of spirocyclic heterocycles. The five-step process utilizes solid-phase synthesis and regenerating Michael linker strategies. Generally difficult to synthesize, we present a customizable method for the synthesis of spirocyclic molecules otherwise inaccessible to other modern approaches.

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