![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](https://cloudfront.jove.com/CDNSource/teasers/58508.jpg)
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February 06, 2019
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Here we present a protocol to demonstrate an efficient method for the synthesis of spirocyclic heterocycles. The five-step process utilizes solid-phase synthesis and regenerating Michael linker strategies. Generally difficult to synthesize, we present a customizable method for the synthesis of spirocyclic molecules otherwise inaccessible to other modern approaches.
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Cite this Article
Drisko, C. R., Griffin, S. A., Huang, K. S. Solid-phase Synthesis of [4.4] Spirocyclic Oximes. J. Vis. Exp. (144), e58508, doi:10.3791/58508 (2019).
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