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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

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05:15 min

February 06, 2019

DOI:

05:15 min
February 06, 2019

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Summary

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Here we present a protocol to demonstrate an efficient method for the synthesis of spirocyclic heterocycles. The five-step process utilizes solid-phase synthesis and regenerating Michael linker strategies. Generally difficult to synthesize, we present a customizable method for the synthesis of spirocyclic molecules otherwise inaccessible to other modern approaches.

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