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JoVE Journal Cancer Research
Etablering og karakterisering af tre Afatinib-resistente lunge adenokarcinom PC-9 cellelinjer udviklet med stigende doser Afatinib
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Etablering og karakterisering af tre Afatinib-resistente lunge adenokarcinom PC-9 cellelinjer udviklet med stigende doser Afatinib

Article DOI: 10.3791/59473-v • 09:38 min • June 26th, 2019
June 26th, 2019 •
1, 1, 2, 1, 3
1Advanced Cancer Translational Research Institute, Showa University, 2Division of Breast Surgical Oncology, Department of Surgery, Showa University School of Medicine, 3Division of Allergology and Respiratory Medicine, Department of Medicine, Showa University School of Medicine

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En metode til at etablere afatinib-resistens cellelinjer fra lunge adenokarcinom PC-9 celler blev udviklet, og resistente celler blev karakteriseret. De resistente celler kan bruges til at undersøge epidermal vækstfaktor receptor tyrosinkinase hæmmer-resistensmekanismer, der gælder for patienter med ikke-småcellet lungekræft.

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Kræftforskning trinvis dosisoptrapning lægemiddelresistens EGFR-aktiverende mutationer EGFR-TKI afatinib lungekræft
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