Articles by Arion J. Kennedy in JoVE
Isolatie van Vetweefsel immuuncellen Jeb S. Orr1, Arion J. Kennedy1, Alyssa H. Hasty1 1Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine Vetweefsel (AT) is een site van intense immuun cel activatie en interactie. Vrijwel alle cellen van het immuunsysteem aanwezig zijn in AT en hun verhoudingen worden veranderd door obesitas. Goede isolatie, kwantificering en karakterisering van AT immuuncelpopulaties zijn van cruciaal belang voor het begrijpen van hun rol in immunometabolic ziekte.
Other articles by Arion J. Kennedy on PubMed
Mouse Models of the Metabolic Syndrome Disease Models & Mechanisms. Mar-Apr, 2010 | Pubmed ID: 20212084 The metabolic syndrome (MetS) is characterized by obesity concomitant with other metabolic abnormalities such as hypertriglyceridemia, reduced high-density lipoprotein levels, elevated blood pressure and raised fasting glucose levels. The precise definition of MetS, the relationships of its metabolic features, and what initiates it, are debated. However, obesity is on the rise worldwide, and its association with these metabolic symptoms increases the risk for diabetes and cardiovascular disease (among many other diseases). Research needs to determine the mechanisms by which obesity and MetS increase the risk of disease. In light of this growing epidemic, it is imperative to develop animal models of MetS. These models will help determine the pathophysiological basis for MetS and how MetS increases the risk for other diseases. Among the various animal models available to study MetS, mice are the most commonly used for several reasons. First, there are several spontaneously occurring obese mouse strains that have been used for decades and that are very well characterized. Second, high-fat feeding studies require only months to induce MetS. Third, it is relatively easy to study the effects of single genes by developing transgenic or gene knockouts to determine the influence of a gene on MetS. For these reasons, this review will focus on the benefits and caveats of the most common mouse models of MetS. It is our hope that the reader will be able to use this review as a guide for the selection of mouse models for their own studies.