Betty Tyler Department of Neurosurgery Johns Hopkins University School of Medicine Biography Publications Institution JoVE Articles Betty Tyler has not added a biography. If you are Betty Tyler and would like to personalize this page please email our Author Liaison for assistance. Publications Dendrimer Technology in Glioma: Functional Design and Potential Applications Cancers. Feb, 2023 | Pubmed ID: 36831418 A Highly Translatable Dual-arm Local Delivery Strategy To Achieve Widespread Therapeutic Coverage in Healthy and Tumor-bearing Brain Tissues Small (Weinheim an Der Bergstrasse, Germany). Jan, 2023 | Pubmed ID: 36651002 Towards Standardization of the Parameters for Opening the Blood-brain Barrier with Focused Ultrasound to Treat Glioblastoma Multiforme: A Systematic Review of the Devices, Animal Models, and Therapeutic Compounds Used in Rodent Tumor Models Frontiers in Oncology. 2022 | Pubmed ID: 36873300 Applications of Focused Ultrasound for the Treatment of Glioblastoma: A New Frontier Cancers. Oct, 2022 | Pubmed ID: 36230843 Molecular Pathways and Genomic Landscape of Glioblastoma Stem Cells: Opportunities for Targeted Therapy Cancers. Jul, 2022 | Pubmed ID: 35954407 Polymeric Nanoparticles in Brain Cancer Therapy: A Review of Current Approaches Polymers. Jul, 2022 | Pubmed ID: 35890738 Metformin and Cancer, an Ambiguanidous Relationship Pharmaceuticals (Basel, Switzerland). May, 2022 | Pubmed ID: 35631452 Crossing the Blood-Brain Barrier: Advances in Nanoparticle Technology for Drug Delivery in Neuro-Oncology International Journal of Molecular Sciences. Apr, 2022 | Pubmed ID: 35456971 Translational Regulation by HnRNP H/F Is Essential for the Proliferation and Survival of Glioblastoma Cancers. Mar, 2022 | Pubmed ID: 35267591 Combined Intracranial Acriflavine, Temozolomide and Radiation Extends Survival in a Rat Glioma Model European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Jan, 2022 | Pubmed ID: 34968646 Synergy Between Glutamate Modulation and Anti-programmed Cell Death Protein 1 Immunotherapy for Glioblastoma Journal of Neurosurgery. Feb, 2022 | Pubmed ID: 34388730 Automatic Detection of Cotton Balls During Brain Surgery: Where Deep Learning Meets Ultrasound Imaging to Tackle Foreign Objects Proceedings of SPIE--the International Society for Optical Engineering. Feb, 2021 | Pubmed ID: 35233128 Disulfiram and Copper Combination Therapy Targets NPL4, Cancer Stem Cells and Extends Survival in a Medulloblastoma Model PloS One. 2021 | Pubmed ID: 34731160 High-Intensity Focused Ultrasound: A Review of Mechanisms and Clinical Applications Annals of Biomedical Engineering. Sep, 2021 | Pubmed ID: 34374945 Captopril Inhibits Matrix Metalloproteinase-2 and Extends Survival As a Temozolomide Adjuvant in an Intracranial Gliosarcoma Model Clinical Neurology and Neurosurgery. 08, 2021 | Pubmed ID: 34198223 Repurposing the FDA-Approved Antiviral Drug Ribavirin As Targeted Therapy for Nasopharyngeal Carcinoma Molecular Cancer Therapeutics. 09, 2020 | Pubmed ID: 32606016 Evaluating the Effects of Cerebrospinal Fluid Protein Content on the Performance of Differential Pressure Valves and Antisiphon Devices Using a Novel Benchtop Shunting Model Neurosurgery. 10, 2020 | Pubmed ID: 32521017 Dendrimer Size Effects on the Selective Brain Tumor Targeting in Orthotopic Tumor Models Upon Systemic Administration Bioengineering & Translational Medicine. May, 2020 | Pubmed ID: 32440565 Intraoperative Laser Speckle Contrast Imaging For Real-Time Visualization of Cerebral Blood Flow in Cerebrovascular Surgery: Results From Pre-Clinical Studies Scientific Reports. 05, 2020 | Pubmed ID: 32376983 Nonviral Polymeric Nanoparticles for Gene Therapy in Pediatric CNS Malignancies Nanomedicine : Nanotechnology, Biology, and Medicine. 01, 2020 | Pubmed ID: 31655205 Multi-layered Core-sheath Fiber Membranes for Controlled Drug Release in the Local Treatment of Brain Tumor Scientific Reports. 11, 2019 | Pubmed ID: 31784666 The Use of Ribavirin As an Anticancer Therapeutic: Will It Go Viral? Molecular Cancer Therapeutics. 07, 2019 | Pubmed ID: 31263027 Evaluation of Select Biocompatible Markers for Labelling Peripheral Nerves on 11.7 T MRI Journal of Neuroscience Methods. 03, 2019 | Pubmed ID: 30630001 A Miniature Multi-contrast Microscope for Functional Imaging in Freely Behaving Animals Nature Communications. 01, 2019 | Pubmed ID: 30626878 Biodegradable Wafers Releasing Temozolomide and Carmustine for the Treatment of Brain Cancer Journal of Controlled Release : Official Journal of the Controlled Release Society. 02, 2019 | Pubmed ID: 30605703 Evaluation of an in Vivo Model for Ventricular Shunt Infection: a Pilot Study Using a Novel Antimicrobial-loaded Polymer Journal of Neurosurgery. 08, 2018 | Pubmed ID: 30074457 Dendritic Cell Activation Enhances Anti-PD-1 Mediated Immunotherapy Against Glioblastoma Oncotarget. Apr, 2018 | Pubmed ID: 29755681 HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy Scientific Reports. 11, 2017 | Pubmed ID: 29097800 The Efficacy of Lapatinib and Nilotinib in Combination with Radiation Therapy in a Model of NF2 Associated Peripheral Schwannoma Journal of Neuro-oncology. Oct, 2017 | Pubmed ID: 28735458 Effects of Primary and Recurrent Sacral Chordoma on the Motor and Nociceptive Function of Hindlimbs in Rats: an Orthotopic Spine Model Journal of Neurosurgery. Spine. Aug, 2017 | Pubmed ID: 28598292 Convection Enhanced Delivery of Cisplatin-loaded Brain Penetrating Nanoparticles Cures Malignant Glioma in Rats Journal of Controlled Release : Official Journal of the Controlled Release Society. Oct, 2017 | Pubmed ID: 28279797 Anti-PD-1 Antitumor Immunity is Enhanced by Local and Abrogated by Systemic Chemotherapy in GBM Science Translational Medicine. 12, 2016 | Pubmed ID: 28003545 Erratum To: Agonist Anti-GITR Monoclonal Antibody and Stereotactic Radiation Induce Immune-mediated Survival Advantage in Murine Intracranial Glioma Journal for Immunotherapy of Cancer. 2016 | Pubmed ID: 27822377 Polylactic Acid (PLA) Controlled Delivery Carriers for Biomedical Applications Advanced Drug Delivery Reviews. 12, 2016 | Pubmed ID: 27426411 Synthesis, Characterization, and Self-assembly with Plasmid DNA of a Quaternary Ammonium Derivative of Pectic Galactan and Its Fluorescent Labeling for Bioimaging Applications Carbohydrate Polymers. Oct, 2016 | Pubmed ID: 27312642 Non-virally Engineered Human Adipose Mesenchymal Stem Cells Produce BMP4, Target Brain Tumors, and Extend Survival Biomaterials. 09, 2016 | Pubmed ID: 27240162 Agonist Anti-GITR Monoclonal Antibody and Stereotactic Radiation Induce Immune-mediated Survival Advantage in Murine Intracranial Glioma Journal for Immunotherapy of Cancer. 2016 | Pubmed ID: 27190629 Nanobiotechnology-based Delivery Strategies: New Frontiers in Brain Tumor Targeted Therapies Journal of Controlled Release : Official Journal of the Controlled Release Society. 10, 2016 | Pubmed ID: 27016141 The Johns Hopkins Hunterian Laboratory Philosophy: Mentoring Students in a Scientific Neurosurgical Research Laboratory Academic Medicine : Journal of the Association of American Medical Colleges. 06, 2016 | Pubmed ID: 26934692 Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis Journal of Ophthalmology. 2015 | Pubmed ID: 26491546 MGMT Inactivation and Clinical Response in Newly Diagnosed GBM Patients Treated with Gliadel Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. Dec, 2015 | Pubmed ID: 26249244 Clostridium Novyi-NT Can Cause Regression of Orthotopically Implanted Glioblastomas in Rats Oncotarget. Mar, 2015 | Pubmed ID: 25849940 Uniform Brain Tumor Distribution and Tumor Associated Macrophage Targeting of Systemically Administered Dendrimers Biomaterials. Jun, 2015 | Pubmed ID: 25818456 Miniaturized Optical Neuroimaging in Unrestrained Animals NeuroImage. Jun, 2015 | Pubmed ID: 25791782 Interstitial Chemotherapy for Malignant Glioma: Future Prospects in the Era of Multimodal Therapy Surgical Neurology International. 2015 | Pubmed ID: 25722936 Polymeric Nanoparticles for Nonviral Gene Therapy Extend Brain Tumor Survival in Vivo ACS Nano. Feb, 2015 | Pubmed ID: 25643235 Local Delivery of Cancer-cell Glycolytic Inhibitors in High-grade Glioma Neuro-oncology. Jan, 2015 | Pubmed ID: 25053853 Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-term Survival and a Protective Antigen-specific Memory Response in a Murine Glioma Model PloS One. 2014 | Pubmed ID: 25013914 Extravascular Optical Coherence Tomography: Evaluation of Carotid Atherosclerosis and Pravastatin Therapy Stroke. Apr, 2014 | Pubmed ID: 24627118 Radiosensitization of Malignant Gliomas Following Intracranial Delivery of Paclitaxel Biodegradable Polymer Microspheres Journal of Neurosurgery. May, 2014 | Pubmed ID: 24605841 Efficacy of Local Polymer-based and Systemic Delivery of the Anti-glutamatergic Agents Riluzole and Memantine in Rat Glioma Models Journal of Neurosurgery. Apr, 2014 | Pubmed ID: 24484234 Combination of Anti-VEGF Therapy and Temozolomide in Two Experimental Human Glioma Models Journal of Neuro-oncology. Jan, 2014 | Pubmed ID: 24185441 Increased Expression of Glutamate Transporter GLT-1 in Peritumoral Tissue Associated with Prolonged Survival and Decreases in Tumor Growth in a Rat Model of Experimental Malignant Glioma Journal of Neurosurgery. Oct, 2013 | Pubmed ID: 23909244 Microdialysis Measurement of Intratumoral Temozolomide Concentration After Cediranib, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, in a U87 Glioma Model Cancer Chemotherapy and Pharmacology. Jul, 2013 | Pubmed ID: 23649683 Combination of Paclitaxel Thermal Gel Depot with Temozolomide and Radiotherapy Significantly Prolongs Survival in an Experimental Rodent Glioma Model Journal of Neuro-oncology. Feb, 2013 | Pubmed ID: 23224713 Growth Properties of SF188/V+ Human Glioma in Rats in Vivo Observed by Magnetic Resonance Imaging Journal of Neuro-oncology. Dec, 2012 | Pubmed ID: 23011120 Suppression of Human Glioma Xenografts with Second-generation IL13R-specific Chimeric Antigen Receptor-modified T Cells Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2012 | Pubmed ID: 22966020 The Impact of Bevacizumab on Temozolomide Concentrations in Intracranial U87 Gliomas Cancer Chemotherapy and Pharmacology. Jul, 2012 | Pubmed ID: 22644796 Intracranial MEMS Based Temozolomide Delivery in a 9L Rat Gliosarcoma Model Biomaterials. Aug, 2012 | Pubmed ID: 22591609 Delayed Onset of Paresis in Rats with Experimental Intramedullary Spinal Cord Gliosarcoma Following Intratumoral Administration of the Paclitaxel Delivery System OncoGel Journal of Neurosurgery. Spine. Jan, 2012 | Pubmed ID: 22208429 Local Delivery of Rapamycin: a Toxicity and Efficacy Study in an Experimental Malignant Glioma Model in Rats Neuro-oncology. Jul, 2011 | Pubmed ID: 21727209 Differentiation Between Glioma and Radiation Necrosis Using Molecular Magnetic Resonance Imaging of Endogenous Proteins and Peptides Nature Medicine. Jan, 2011 | Pubmed ID: 21170048 Evaluation of Retinoic Acid Therapy for OTX2-positive Medulloblastomas Neuro-oncology. Jul, 2010 | Pubmed ID: 20511190 FasL Gene Knock-down Therapy Enhances the Antiglioma Immune Response Neuro-oncology. May, 2010 | Pubmed ID: 20406899 Combination of Intracranial Temozolomide with Intracranial Carmustine Improves Survival when Compared with Either Treatment Alone in a Rodent Glioma Model Neurosurgery. Mar, 2010 | Pubmed ID: 20173548 A Thermal Gel Depot for Local Delivery of Paclitaxel to Treat Experimental Brain Tumors in Rats Journal of Neurosurgery. Aug, 2010 | Pubmed ID: 20001591 Epirubicin Exhibits Potent Anti-tumor Activity in an Animal Model of Malignant Glioma when Administered Via Controlled-release Polymers Journal of Neuro-oncology. Mar, 2010 | Pubmed ID: 19693439 Inhibition of Akt Inhibits Growth of Glioblastoma and Glioblastoma Stem-like Cells Molecular Cancer Therapeutics. Feb, 2009 | Pubmed ID: 19208828 Coexpression of Neuronatin Splice Forms Promotes Medulloblastoma Growth Neuro-oncology. Oct, 2008 | Pubmed ID: 18701710 Clostridium Perfringens Enterotoxin As a Novel-targeted Therapeutic for Brain Metastasis Cancer Research. Sep, 2007 | Pubmed ID: 17804705 A Novel Intramedullary Spinal Cord Tumor Model: Functional, Radiological, and Histopathological Characterization Journal of Neurosurgery. Spine. Aug, 2005 | Pubmed ID: 16370303 Local Delivery of Doxorubicin for the Treatment of Malignant Brain Tumors in Rats Anticancer Research. Nov-Dec, 2005 | Pubmed ID: 16312042 Local Delivery of Interleukin-2 and Adriamycin is Synergistic in the Treatment of Experimental Malignant Glioma Journal of Neuro-oncology. Sep, 2005 | Pubmed ID: 16193383 A Novel Rat Model for the Study of Intraosseous Metastatic Spine Cancer Journal of Neurosurgery. Spine. Mar, 2005 | Pubmed ID: 15796355 Section on Tumors: Young Investigator Award: Local Release of Carboplatin Via an Alzet Mini-osmotic Pump Prolongs Survival in a Rat Brainstem Tumor Model Clinical Neurosurgery. 2004 | Pubmed ID: 15571163 Astroglia Induce Cytotoxic Effects on Brain Tumors Via a Nitric Oxide-dependent Pathway Both in Vitro and in Vivo Neurosurgery. May, 2004 | Pubmed ID: 15113479 Local Delivery of Minocycline and Systemic BCNU Have Synergistic Activity in the Treatment of Intracranial Glioma Journal of Neuro-oncology. Sep, 2003 | Pubmed ID: 14558595 Polilactofate Microspheres for Paclitaxel Delivery to Central Nervous System Malignancies Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2003 | Pubmed ID: 12960135 Prevention of Experimental Cerebral Vasospasm by Intracranial Delivery of a Nitric Oxide Donor from a Controlled-release Polymer: Toxicity and Efficacy Studies in Rabbits and Rats Stroke; a Journal of Cerebral Circulation. Nov, 2002 | Pubmed ID: 12411661 Hypertonic Saline Ameliorates Cerebral Edema Associated with Experimental Brain Tumor Journal of Neurosurgical Anesthesiology. Jul, 2002 | Pubmed ID: 12172290 Polymer Delivery of Camptothecin Against 9L Gliosarcoma: Release, Distribution, and Efficacy Journal of Neuro-oncology. Feb, 2002 | Pubmed ID: 12061726 The Intracerebral Administration of Phenytoin Using Controlled-release Polymers Reduces Experimental Seizures in Rats Epilepsy Research. Feb, 2002 | Pubmed ID: 11904233 चूहे के मॉडल में कम तीव्रता केंद्रित अल्ट्रासाउंड का उपयोग करके रक्त-रीढ़ की हड्डी की बाधा का विघटन Meghana Bhimreddy1, Denis Routkevitch1,2,3, Andrew M. Hersh1, Ali Mohammadabadi1,3, Arjun K. Menta1, Kelly Jiang1, Carly Weber-Levine1, A. Daniel Davidar1, Joshua Punnoose1,2,3, Kelley M. Kempski Leadingham1,3, Joshua C. Doloff2, Betty Tyler1, Nicholas Theodore1,3, Amir Manbachi1,2,3,4,5,6 1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Biomedical Engineering, Johns Hopkins University, 3HEPIUS Innovation Laboratory, Johns Hopkins University School of Medicine, 4Department of Electrical Engineering and Computer Science, Johns Hopkins University, 5Department of Mechanical Engineering, Johns Hopkins University, 6Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University JoVE 65113 Bioengineering पोर्टेबल बेंचटॉप केंद्रित अल्ट्रासाउंड सिस्टम का उपयोग करके माउस मॉडल में ग्लियोब्लास्टोमा मल्टीफॉर्म के उपचार के लिए सोनोडायनामिक थेरेपी Griffin Mess1,2, Taylor Anderson1,2, Shivani Kapoor3, Rasika Thombre1,2, Ruixing Liang4, Emre Derin1, Kelley M. Kempski-Leadingham1, Santosh K. Yadav5, Betty Tyler1, Amir Manbachi1,2,4,6,7 1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Biomedical Engineering, Johns Hopkins University, 3Krieger School of Arts and Sciences, Johns Hopkins University, 4Department of Electrical Engineering and Computer Science, Johns Hopkins University, 5Department of Radiology, Cancer Imaging Division, Johns Hopkins University School of Medicine, 6Department of Mechanical Engineering, Johns Hopkins University, 7Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine JoVE 65114 Bioengineering उच्च व्यवहार्यता ऊतक संग्रह के लिए कृन्तकों में न्यूनतम इनवेसिव ब्रेन ट्यूमर लकीर का कार्यान्वयन Safwan Alomari1, Jayanidhi Kedda1, Adarsha P. Malla2,3, Victor Pacis1, Pavlos Anastasiadis2,3, Su Xu4, Emylee McFarland2,3, Lilia Sukhon1, Bruno Gallo5, Jordina Rincon-Torroella1, Netanel Ben-Shalom1, Heather M. Ames3,6, Henry Brem1,7, Graeme F. Woodworth2,3, Betty Tyler1 1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Neurosurgery, University of Maryland School of Medicine, 3Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, 4Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 5Pontifical Catholic University of Parana, 6Department of Pathology, University of Maryland School of Medicine, 7Departments of Ophthalmology, Oncology and Biomedical Engineering, Johns Hopkins University School of Medicine JoVE 64048 Cancer Research
चूहे के मॉडल में कम तीव्रता केंद्रित अल्ट्रासाउंड का उपयोग करके रक्त-रीढ़ की हड्डी की बाधा का विघटन Meghana Bhimreddy1, Denis Routkevitch1,2,3, Andrew M. Hersh1, Ali Mohammadabadi1,3, Arjun K. Menta1, Kelly Jiang1, Carly Weber-Levine1, A. Daniel Davidar1, Joshua Punnoose1,2,3, Kelley M. Kempski Leadingham1,3, Joshua C. Doloff2, Betty Tyler1, Nicholas Theodore1,3, Amir Manbachi1,2,3,4,5,6 1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Biomedical Engineering, Johns Hopkins University, 3HEPIUS Innovation Laboratory, Johns Hopkins University School of Medicine, 4Department of Electrical Engineering and Computer Science, Johns Hopkins University, 5Department of Mechanical Engineering, Johns Hopkins University, 6Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University JoVE 65113 Bioengineering
पोर्टेबल बेंचटॉप केंद्रित अल्ट्रासाउंड सिस्टम का उपयोग करके माउस मॉडल में ग्लियोब्लास्टोमा मल्टीफॉर्म के उपचार के लिए सोनोडायनामिक थेरेपी Griffin Mess1,2, Taylor Anderson1,2, Shivani Kapoor3, Rasika Thombre1,2, Ruixing Liang4, Emre Derin1, Kelley M. Kempski-Leadingham1, Santosh K. Yadav5, Betty Tyler1, Amir Manbachi1,2,4,6,7 1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Biomedical Engineering, Johns Hopkins University, 3Krieger School of Arts and Sciences, Johns Hopkins University, 4Department of Electrical Engineering and Computer Science, Johns Hopkins University, 5Department of Radiology, Cancer Imaging Division, Johns Hopkins University School of Medicine, 6Department of Mechanical Engineering, Johns Hopkins University, 7Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine JoVE 65114 Bioengineering
उच्च व्यवहार्यता ऊतक संग्रह के लिए कृन्तकों में न्यूनतम इनवेसिव ब्रेन ट्यूमर लकीर का कार्यान्वयन Safwan Alomari1, Jayanidhi Kedda1, Adarsha P. Malla2,3, Victor Pacis1, Pavlos Anastasiadis2,3, Su Xu4, Emylee McFarland2,3, Lilia Sukhon1, Bruno Gallo5, Jordina Rincon-Torroella1, Netanel Ben-Shalom1, Heather M. Ames3,6, Henry Brem1,7, Graeme F. Woodworth2,3, Betty Tyler1 1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Neurosurgery, University of Maryland School of Medicine, 3Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, 4Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 5Pontifical Catholic University of Parana, 6Department of Pathology, University of Maryland School of Medicine, 7Departments of Ophthalmology, Oncology and Biomedical Engineering, Johns Hopkins University School of Medicine JoVE 64048 Cancer Research
