Caryl E. Sortwell Biography Publications JoVE Articles Caryl E. Sortwell has not added a biography. If you are Caryl E. Sortwell and would like to personalize this page please email our Author Liaison for assistance. Publications Beta2-adrenoreceptor Agonist Clenbuterol Produces Transient Decreases in Alpha-synuclein MRNA but No Long-term Reduction in Protein NPJ Parkinson's Disease. May, 2022 | Pubmed ID: 35610264 Dopaminergic Positron Emission Tomography Imaging in the Alpha-Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease Movement Disorders : Official Journal of the Movement Disorder Society. May, 2022 | Pubmed ID: 35524682 Behavioral Phenotyping of a Rat Model of the BDNF Val66Met Polymorphism Reveals Selective Impairment of Fear Memory Translational Psychiatry. 03, 2022 | Pubmed ID: 35256586 BDNF Rs6265 Genotype Influences Outcomes of Pharmacotherapy and Subthalamic Nucleus Deep Brain Stimulation in Early-Stage Parkinson's Disease Neuromodulation : Journal of the International Neuromodulation Society. Jul, 2021 | Pubmed ID: 34288271 Preformed Fibrils Generated from Mouse Alpha-synuclein Produce More Inclusion Pathology in Rats Than Fibrils Generated from Rat Alpha-synuclein Parkinsonism & Related Disorders. 08, 2021 | Pubmed ID: 34218047 Synucleinopathy-associated Pathogenesis in Parkinson's Disease and the Potential for Brain-derived Neurotrophic Factor NPJ Parkinson's Disease. Apr, 2021 | Pubmed ID: 33846345 α-Synuclein Antisense Oligonucleotides As a Disease-modifying Therapy for Parkinson's Disease JCI Insight. 03, 2021 | Pubmed ID: 33682798 Next-Generation Diamond Electrodes for Neurochemical Sensing: Challenges and Opportunities Micromachines. Jan, 2021 | Pubmed ID: 33530395 Striatal Afferent BDNF is Disrupted by Synucleinopathy and Partially Restored by STN DBS The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2021 | Pubmed ID: 33472823 The BDNF Val66Met Polymorphism (rs6265) Enhances Dopamine Neuron Graft Efficacy and Side-effect Liability in Rs6265 Knock-in Rats Neurobiology of Disease. Jan, 2021 | Pubmed ID: 33188920 BDNF Rs6265 Variant Alters Outcomes with Levodopa in Early-Stage Parkinson's Disease Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Oct, 2020 | Pubmed ID: 33215284 Developmental Exposure to the Organochlorine Pesticide Dieldrin Causes Male-specific Exacerbation of α-synuclein-preformed Fibril-induced Toxicity and Motor Deficits Neurobiology of Disease. 07, 2020 | Pubmed ID: 32422283 Striatal Nurr1, but Not FosB Expression Links a Levodopa-induced Dyskinesia Phenotype to Genotype in Fisher 344 Vs. Lewis Hemiparkinsonian Rats Experimental Neurology. 08, 2020 | Pubmed ID: 32387398 Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 04, 2020 | Pubmed ID: 32238479 Time Course and Magnitude of Alpha-synuclein Inclusion Formation and Nigrostriatal Degeneration in the Rat Model of Synucleinopathy Triggered by Intrastriatal α-synuclein Preformed Fibrils Neurobiology of Disease. 10, 2019 | Pubmed ID: 31276792 Cell Therapy for Parkinson's Disease: Why It Doesn't Work Every Time Movement Disorders : Official Journal of the Movement Disorder Society. 08, 2019 | Pubmed ID: 31234239 Genetic Silencing of Striatal CaV1.3 Prevents and Ameliorates Levodopa Dyskinesia Movement Disorders : Official Journal of the Movement Disorder Society. 05, 2019 | Pubmed ID: 31002755 BDNF Provides Many Routes Toward STN DBS-mediated Disease Modification Movement Disorders : Official Journal of the Movement Disorder Society. 01, 2019 | Pubmed ID: 30440081 Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson's Disease Frontiers in Neuroscience. 2018 | Pubmed ID: 30233303 Glycomic and Proteomic Changes in Aging Brain Nigrostriatal Pathway Molecular & Cellular Proteomics : MCP. 09, 2018 | Pubmed ID: 29915149 Correction To: Lewy Body-like Alpha-synuclein Inclusions Trigger Reactive Microgliosis Prior to Nigral Degeneration Journal of Neuroinflammation. May, 2018 | Pubmed ID: 29843738 Bdnf Variant is Associated with Milder Motor Symptom Severity in Early-stage Parkinson's Disease Parkinsonism & Related Disorders. 08, 2018 | Pubmed ID: 29759928 Lewy Body-like Alpha-synuclein Inclusions Trigger Reactive Microgliosis Prior to Nigral Degeneration Journal of Neuroinflammation. May, 2018 | Pubmed ID: 29716614 Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity Frontiers in Molecular Neuroscience. 2018 | Pubmed ID: 29497361 Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson's Disease in Rodents Journal of Parkinson's Disease. 2018 | Pubmed ID: 29400668 Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression Scientific Reports. Nov, 2017 | Pubmed ID: 29180681 Can STN DBS Protect Both Nigral Somata and Innervation of the Striatum? Annals of Neurology. 11, 2017 | Pubmed ID: 28985650 Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS Molecular Therapy. Nucleic Acids. Sep, 2017 | Pubmed ID: 28918020 Nortriptyline Inhibits Aggregation and Neurotoxicity of Alpha-synuclein by Enhancing Reconfiguration of the Monomeric Form Neurobiology of Disease. Oct, 2017 | Pubmed ID: 28711409 Subthalamic Nucleus Deep Brain Stimulation Employs TrkB Signaling for Neuroprotection and Functional Restoration The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 07, 2017 | Pubmed ID: 28607168 Alpha-Synuclein MRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models Molecular Therapy : the Journal of the American Society of Gene Therapy. 10, 2017 | Pubmed ID: 28522034 Impact of Age and Vector Construct on Striatal and Nigral Transgene Expression Molecular Therapy. Methods & Clinical Development. 2016 | Pubmed ID: 27933309 Viral Vector-Based Modeling of Neurodegenerative Disorders: Parkinson's Disease Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26611600 Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and L-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2015 | Pubmed ID: 26558771 High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine PloS One. 2015 | Pubmed ID: 26222442 Intrastriatal Injection of Pre-formed Mouse α-synuclein Fibrils into Rats Triggers α-synuclein Pathology and Bilateral Nigrostriatal Degeneration Neurobiology of Disease. Oct, 2015 | Pubmed ID: 26093169 The Longitudinal Transcriptomic Response of the Substantia Nigra to Intrastriatal 6-hydroxydopamine Reveals Significant Upregulation of Regeneration-associated Genes PloS One. 2015 | Pubmed ID: 25992874 Interrogating the Aged Striatum: Robust Survival of Grafted Dopamine Neurons in Aging Rats Produces Inferior Behavioral Recovery and Evidence of Impaired Integration Neurobiology of Disease. May, 2015 | Pubmed ID: 25771169 Tricyclic Antidepressant Treatment Evokes Regional Changes in Neurotrophic Factors over Time Within the Intact and Degenerating Nigrostriatal System Experimental Neurology. Apr, 2015 | Pubmed ID: 25681575 Recombinant Adenoassociated Virus 2/5-mediated Gene Transfer is Reduced in the Aged Rat Midbrain Neurobiology of Aging. Feb, 2015 | Pubmed ID: 25457558 Chronic Amitriptyline Treatment Attenuates Nigrostriatal Degeneration and Significantly Alters Trophic Support in a Rat Model of Parkinsonism Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Mar, 2015 | Pubmed ID: 25267343 Morphological and Behavioral Impact of AAV2/5-mediated Overexpression of Human Wildtype Alpha-synuclein in the Rat Nigrostriatal System PloS One. 2013 | Pubmed ID: 24312298 Endogenous Neural Precursors Influence Grafted Neural Stem Cells and Contribute to Neuroprotection in the Parkinsonian Rat The European Journal of Neuroscience. Mar, 2012 | Pubmed ID: 22417168 視床下核刺激脳派生神経栄養因子線条システムと一次運動野で増加します。 Journal of Parkinson's Disease. May, 2011 | Pubmed ID: 22328911 線条体 Pleiotrophin 過剰発現 6-ヒドロキシドーパミン モデルにおける機能および形態の神経保護を提供します。 Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2011 | Pubmed ID: 22008908 Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling JoVE 64008 Genetics Stereotaxic Intracranial Delivery of Chemicals, Proteins or Viral Vectors to Study Parkinson's Disease JoVE 62128 Neuroscience モノマーからのαシヌクレイン予備型フィブリルの生成と生体内での使用 Joseph R. Patterson1, Nicole K. Polinski2, Megan F. Duffy1,3, Christopher J. Kemp1, Kelvin C. Luk4, Laura A. Volpicelli-Daley5, Nicholas M. Kanaan1, Caryl E. Sortwell1,3,6 1Department of Translational Science and Molecular Medicine, Michigan State University, 2The Michael J. Fox Foundation for Parkinson's Research, 3Neuroscience Program, Michigan State University, 4Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, 5Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 6Mercy Health Hauenstein Neuroscience Medical Center JoVE 59758 Neuroscience
Stereotaxic Intracranial Delivery of Chemicals, Proteins or Viral Vectors to Study Parkinson's Disease JoVE 62128 Neuroscience
モノマーからのαシヌクレイン予備型フィブリルの生成と生体内での使用 Joseph R. Patterson1, Nicole K. Polinski2, Megan F. Duffy1,3, Christopher J. Kemp1, Kelvin C. Luk4, Laura A. Volpicelli-Daley5, Nicholas M. Kanaan1, Caryl E. Sortwell1,3,6 1Department of Translational Science and Molecular Medicine, Michigan State University, 2The Michael J. Fox Foundation for Parkinson's Research, 3Neuroscience Program, Michigan State University, 4Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, 5Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 6Mercy Health Hauenstein Neuroscience Medical Center JoVE 59758 Neuroscience
