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Substantia Nigra: The black substance in the ventral midbrain or the nucleus of cells containing the black substance. These cells produce Dopamine, an important neurotransmitter in regulation of the sensorimotor system and mood. The dark colored Melanin is a by-product of dopamine synthesis.

Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector

1Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, 2Division of Nuclear Medicine, Leuven University Hospital - KU Leuven, 3Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 4Leuven Viral Vector Core, KU Leuven

JoVE 53670


 Medicine

Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake

1Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2Laboratory of Neuropsychiatry, Psychiatric Center Copenhagen and Department of Neuroscience and Pharmacology, University of Copenhagen

JoVE 56093


 Neuroscience

Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS)

1Elemental Bio-imaging Facility, University of Technology Sydney, 2Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 3Department of Pathology, The University of Melbourne, 4School of Earth Sciences, The University of Melbourne, 5Research School, Ruhr University, 6Department of Physiology, Monash University, 7ESI Ltd., Bozeman, 8Agilent Technologies, Mulgrave

JoVE 55042


 Medicine

Examination of Rapid Dopamine Dynamics with Fast Scan Cyclic Voltammetry During Intra-oral Tastant Administration in Awake Rats

1Interdepartmental Neuroscience Program, Yale University, 2Department of Biotechnical and Clinical Laboratory Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, 3Department of Psychiatry, Yale School of Medicine, 4Department of Cellular and Molecular Physiology, Yale School of Medicine

JoVE 52468


 Behavior

Analysis of Retinoic Acid-induced Neural Differentiation of Mouse Embryonic Stem Cells in Two and Three-dimensional Embryoid Bodies

1Department of Medicine, Cardeza Vascular Research Center, Sidney Kimmel Medical College, Thomas Jefferson University, 2Department of Molecular Cardiology, Cleveland Clinic Foundation, 3Department of Cancer Biology, Cardeza Vascular Research Center, Sidney Kimmel Medical College, Thomas Jefferson University

JoVE 55621


 Developmental Biology

Within-subjects Repeated-measures Design

JoVE 10034

Source: Laboratories of Gary Lewandowski, Dave Strohmetz, and Natalie Ciarocco—Monmouth University

A within-subjects, or repeated-measures, design is an experimental design where all the participants receive every level of the treatment, i.e., every independent variable. For example, in a candy taste test, the researcher would want every participant to taste and rate each type of candy. This video demonstrates a within-subjects experiment (i.e., one where there is an independent variable with several variations or levels) that examines how different motivational messages (e.g., hard work, self-affirmation, outcomes, and positive affect) influence willingness to exert physical effort. As a within-subjects design, the participant will read each of the four types of motivational messages and then lift weights to measure physical effort. By providing an overview of how a researcher conducts a repeated-measures experiment, this video allows viewers to see how to address order effects through counterbalancing, which involves a systematic approach to making sure all possible orders of the conditions occur in the study. Psychological studies often use higher


 Experimental Psychology

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