Catrin Pritchard

Publications

• Digoxin Treatment Reactivates in Vivo Radioactive Iodide Uptake and Correlates with Favorable Clinical Outcome in Non-medullary Thyroid Cancer
  Cellular Oncology (Dordrecht). Feb, 2021  |   Pubmed ID: 33534128
• Ras/MAPK Dysregulation in Development Causes a Skeletal Myopathy in an Activating Braf Mouse Model for Cardio-facio-cutaneous Syndrome
  Developmental Dynamics : an Official Publication of the American Association of Anatomists. Feb, 2021  |   Pubmed ID: 33522658
• Development of a Patient-derived Explant Model for Prediction of Drug Responses in Endometrial Cancer
  Gynecologic Oncology. Feb, 2021  |   Pubmed ID: 33309417
• Evaluating and Comparing Immunostaining and Computational Methods for Spatial Profiling of Drug Response in Patient-derived Explants
  Laboratory Investigation; a Journal of Technical Methods and Pathology. Dec, 2020  |   Pubmed ID: 33318618
• Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development
  Cell Reports. 06, 2020  |   Pubmed ID: 32579928
• Exploration of Matrix Effects in Laser Ablation Inductively Coupled Plasma Mass Spectrometry Imaging of Cisplatin-Treated Tumors
  Analytical Chemistry. 07, 2020  |   Pubmed ID: 32545955
• Reduced Protumorigenic Tumor-Associated Macrophages With Statin Use in Premalignant Human Lung Adenocarcinoma
  JNCI Cancer Spectrum. Apr, 2020  |   Pubmed ID: 32190817
• DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation
  IScience. Feb, 2020  |   Pubmed ID: 32058953
• Patient-derived Explants (PDEs) As a Powerful Preclinical Platform for Anti-cancer Drug and Biomarker Discovery
  British Journal of Cancer. 03, 2020  |   Pubmed ID: 31894140
• Patient-derived Explants, Xenografts and Organoids: 3-dimensional Patient-relevant Pre-clinical Models in Endometrial Cancer
  Gynecologic Oncology. 01, 2020  |   Pubmed ID: 31767187
• Early Detection of Pre-malignant Lesions in a KRAS-driven Mouse Lung Cancer Model by Monitoring Circulating Free DNA
  Disease Models & Mechanisms. 02, 2019  |   Pubmed ID: 30760495
• Over-expressed, N-terminally Truncated BRAF is Detected in the Nucleus of Cells with Nuclear Phosphorylated MEK and ERK
  Heliyon. Dec, 2018  |   Pubmed ID: 30603699
• Profiling Tumour Heterogeneity Through Circulating Tumour DNA in Patients with Pancreatic Cancer
  Oncotarget. Oct, 2017  |   Pubmed ID: 29152076
• KRAS Expression in Lung-resident Myeloid Cells Promotes Pulmonary LCH-like Neoplasm Sensitive to Statin Treatment
  Blood. 07, 2017  |   Pubmed ID: 28550040
• Attenuation Limits Progression of -Induced Papillary Thyroid Cancer Cells and Sensitizes Them to BRAF Inhibitor PLX4720
  Cancer Research. 04, 2017  |   Pubmed ID: 28242615
• Explant Cultures of Non-Small Cell Lung Carcinoma Enable Evaluation of Primary Tumor Responses to Anticancer Therapy
  Cancer Research. 04, 2017  |   Pubmed ID: 28202521
• Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development
  The Journal of Biological Chemistry. 02, 2017  |   Pubmed ID: 28073913
• Inactivation of TGFβ Receptors in Stem Cells Drives Cutaneous Squamous Cell Carcinoma
  Nature Communications. Aug, 2016  |   Pubmed ID: 27558455
• Phosphorylations of Serines 21/9 in Glycogen Synthase Kinase 3α/β Are Not Required for Cell Lineage Commitment or WNT Signaling in the Normal Mouse Intestine
  PloS One. 2016  |   Pubmed ID: 27284979
• Regulation of BRAF Protein Stability by a Negative Feedback Loop Involving the MEK-ERK Pathway but Not the FBXW7 Tumour Suppressor
  Cellular Signalling. Jun, 2016  |   Pubmed ID: 26898828
• The Cholesterol-binding Protein NPC2 Restrains Recruitment of Stromal Macrophage-lineage Cells to Early-stage Lung Tumours
  EMBO Molecular Medicine. Sep, 2015  |   Pubmed ID: 26183450
• MGL Ligand Expression is Correlated to BRAF Mutation and Associated with Poor Survival of Stage III Colon Cancer Patients
  Oncotarget. Sep, 2015  |   Pubmed ID: 26172302
• KRAS(G12D)-mediated Oncogenic Transformation of Thyroid Follicular Cells Requires Long-term TSH Stimulation and is Regulated by SPRY1
  Laboratory Investigation; a Journal of Technical Methods and Pathology. Jul, 2015  |   Pubmed ID: 26146959
• Tracking Genomic Cancer Evolution for Precision Medicine: the Lung TRACERx Study
  PLoS Biology. Jul, 2014  |   Pubmed ID: 25003521
• Long-term Channel Block is Required to Inhibit Cellular Transformation by Human Ether-à-go-go-related Gene (hERG1) Potassium Channels
  Molecular Pharmacology. Aug, 2014  |   Pubmed ID: 24830940
• Hematopoietic Expression of Oncogenic BRAF Promotes Aberrant Growth of Monocyte-lineage Cells Resistant to PLX4720
  Molecular Cancer Research : MCR. Dec, 2013  |   Pubmed ID: 24152792
• A Complex Secretory Program Orchestrated by the Inflammasome Controls Paracrine Senescence
  Nature Cell Biology. Aug, 2013  |   Pubmed ID: 23770676
• A New Mode of RAF Autoregulation: a Further Complication in the Inhibitor Paradox
  Cancer Cell. May, 2013  |   Pubmed ID: 23680140
• Mice Carrying a Complete Deletion of the Talin2 Coding Sequence Are Viable and Fertile
  Biochemical and Biophysical Research Communications. Sep, 2012  |   Pubmed ID: 22925892
• The Intermediate-activity (L597V)BRAF Mutant Acts As an Epistatic Modifier of Oncogenic RAS by Enhancing Signaling Through the RAF/MEK/ERK Pathway
  Genes & Development. Sep, 2012  |   Pubmed ID: 22892241
• Regulation of MEK/ERK Pathway Output by Subcellular Localization of B-Raf
  Biochemical Society Transactions. Feb, 2012  |   Pubmed ID: 22260667
• Cdx2 Determines the Fate of Postnatal Intestinal Endoderm
  Development (Cambridge, England). Feb, 2012  |   Pubmed ID: 22190642
• Mechanisms of Aneuploidy Induction by RAS and RAF Oncogenes
  American Journal of Cancer Research. 2011  |   Pubmed ID: 22016838
• Thyrotrophin Receptor Signaling Dependence of Braf-induced Thyroid Tumor Initiation in Mice
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011  |   Pubmed ID: 21220306
• Endothelial Cell Talin1 is Essential for Embryonic Angiogenesis
  Developmental Biology. Jan, 2011  |   Pubmed ID: 21081121
• BRAF Inactivation Drives Aneuploidy by Deregulating CRAF
  Cancer Research. Nov, 2010  |   Pubmed ID: 20978199
• V600EBraf Induces Gastrointestinal Crypt Senescence and Promotes Tumour Progression Through Enhanced CpG Methylation of P16INK4a
  EMBO Molecular Medicine. Nov, 2010  |   Pubmed ID: 20941790
• Studies on the Morphology and Spreading of Human Endothelial Cells Define Key Inter- and Intramolecular Interactions for Talin1
  European Journal of Cell Biology. Sep, 2010  |   Pubmed ID: 20605055
• Kinase-dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression Through CRAF
  Cell. Jan, 2010  |   Pubmed ID: 20141835
• Talin 2 is a Large and Complex Gene Encoding Multiple Transcripts and Protein Isoforms
  The FEBS Journal. Mar, 2009  |   Pubmed ID: 19220457
• CRAF Autophosphorylation of Serine 621 is Required to Prevent Its Proteasome-mediated Degradation
  Molecular Cell. Sep, 2008  |   Pubmed ID: 18922468
• Cdx2 Initiates Histodifferentiation of the Midgut Endoderm
  FEBS Letters. Jul, 2008  |   Pubmed ID: 18577384
• Lineage Tracing of Cardiac Explant Derived Cells
  PloS One. Apr, 2008  |   Pubmed ID: 18414652
• Mouse Models for BRAF-induced Cancers
  Biochemical Society Transactions. Nov, 2007  |   Pubmed ID: 17956344
• Expression of Endogenous Oncogenic V600EB-raf Induces Proliferation and Developmental Defects in Mice and Transformation of Primary Fibroblasts
  Cancer Research. Dec, 2005  |   Pubmed ID: 16357158
• A-Raf and Raf-1 Work Together to Influence Transient ERK Phosphorylation and Gl/S Cell Cycle Progression
  Oncogene. Aug, 2005  |   Pubmed ID: 15856007
• A Critical Function for B-Raf at Multiple Stages of Myelopoiesis
  Blood. Aug, 2005  |   Pubmed ID: 15784729
• B-Raf Acts Via the ROCKII/LIMK/cofilin Pathway to Maintain Actin Stress Fibers in Fibroblasts
  Molecular and Cellular Biology. Jul, 2004  |   Pubmed ID: 15199148
• Raf Proteins and Cancer: B-Raf is Identified As a Mutational Target
  Biochimica Et Biophysica Acta. Jun, 2003  |   Pubmed ID: 12781369
• Analysis of the Role of the SA Gene in Blood Pressure Regulation by Gene Targeting
  Hypertension (Dallas, Tex. : 1979). Jun, 2003  |   Pubmed ID: 12707288
• CAMP-dependent Protein Kinase and Ca2+ Influx Through L-type Voltage-gated Calcium Channels Mediate Raf-independent Activation of Extracellular Regulated Kinase in Response to Glucagon-like Peptide-1 in Pancreatic Beta-cells
  The Journal of Biological Chemistry. Dec, 2002  |   Pubmed ID: 12364324
• Expression of Kinase Suppressor of Ras in the Normal Adult and Embryonic Mouse
  Cell Growth & Differentiation : the Molecular Biology Journal of the American Association for Cancer Research. Jul, 2002  |   Pubmed ID: 12133899
• MEKK1 Plays a Critical Role in Activating the Transcription Factor C/EBP-beta-dependent Gene Expression in Response to IFN-gamma
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2002  |   Pubmed ID: 12048245
• ERK Signalling and Oncogene Transformation Are Not Impaired in Cells Lacking A-Raf
  Oncogene. Jan, 2002  |   Pubmed ID: 11821947
• MEK Kinase Activity is Not Necessary for Raf-1 Function
  The EMBO Journal. Apr, 2001  |   Pubmed ID: 11296227