Christopher M. Dobson Centre for Misfolding Diseases, Department of Chemistry University of Cambridge Biography Publications Institution JoVE Articles Christopher M. Dobson has not added a biography. If you are Christopher M. Dobson and would like to personalize this page please email our Author Liaison for assistance. Publications Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale Nano Letters. Nov, 2018 | Pubmed ID: 30380895 Quantifying Co-Oligomer Formation by α-Synuclein ACS Nano. Nov, 2018 | Pubmed ID: 30371053 Statistical Mechanics of Globular Oligomer Formation by Protein Molecules The Journal of Physical Chemistry. B. Oct, 2018 | Pubmed ID: 30336667 SAR by Kinetics for Drug Discovery in Protein Misfolding Diseases Proceedings of the National Academy of Sciences of the United States of America. 10, 2018 | Pubmed ID: 30257937 Microfluidic Deposition for Resolving Single-molecule Protein Architecture and Heterogeneity Nature Communications. Sep, 2018 | Pubmed ID: 30250131 Proteasome-targeted Nanobodies Alleviate Pathology and Functional Decline in an α-synuclein-based Parkinson's Disease Model NPJ Parkinson's Disease. Month, 2018 | Pubmed ID: 30155513 Obituary: Nico Van Nuland 1961-2017 European Biophysics Journal : EBJ. Sep, 2018 | Pubmed ID: 30116857 C-terminal Truncation of α-synuclein Promotes Amyloid Fibril Amplification at Physiological PH Chemical Science. Jul, 2018 | Pubmed ID: 30061982 Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells Chembiochem : a European Journal of Chemical Biology. Oct, 2018 | Pubmed ID: 30051958 Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation Biochemistry. Aug, 2018 | Pubmed ID: 30024736 Structural Differences Between Toxic and Nontoxic HypF-N Oligomers Chemical Communications (Cambridge, England). Aug, 2018 | Pubmed ID: 30020284 Stabilization and Characterization of Cytotoxic Aβ Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions ACS Chemical Neuroscience. Aug, 2018 | Pubmed ID: 29986583 Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine ACS Chemical Biology. Aug, 2018 | Pubmed ID: 29953201 Kinetic Barriers to α-synuclein Protofilament Formation and Conversion into Mature Fibrils Chemical Communications (Cambridge, England). Jul, 2018 | Pubmed ID: 29951679 Single-Molecule Characterization of the Interactions Between Extracellular Chaperones and Toxic α-Synuclein Oligomers Cell Reports. Jun, 2018 | Pubmed ID: 29924993 On-chip Measurements of Protein Unfolding from Direct Observations of Micron-scale Diffusion Chemical Science. Apr, 2018 | Pubmed ID: 29780480 Cooperative Assembly of Hsp70 Subdomain Clusters Biochemistry. Jul, 2018 | Pubmed ID: 29763298 Cholesterol Catalyses Aβ42 Aggregation Through a Heterogeneous Nucleation Pathway in the Presence of Lipid Membranes Nature Chemistry. Jun, 2018 | Pubmed ID: 29736006 Exploring the Role of Post-translational Modifications in Regulating α-synuclein Interactions by Studying the Effects of Phosphorylation on Nanobody Binding Protein Science : a Publication of the Protein Society. Jul, 2018 | Pubmed ID: 29603451 Molecular Determinants of the Interaction of EGCG with Ordered and Disordered Proteins Biopolymers. Aug, 2018 | Pubmed ID: 29603125 Distinct Thermodynamic Signatures of Oligomer Generation in the Aggregation of the Amyloid-β Peptide Nature Chemistry. May, 2018 | Pubmed ID: 29581486 Microfluidic Approaches for Probing Amyloid Assembly and Behaviour Lab on a Chip. 03, 2018 | Pubmed ID: 29527600 Bifunctional Fluorescent Probes for Detection of Amyloid Aggregates and Reactive Oxygen Species Royal Society Open Science. Feb, 2018 | Pubmed ID: 29515860 Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation Annual Review of Physical Chemistry. 04, 2018 | Pubmed ID: 29490200 Massively Parallel C. Elegans Tracking Provides Multi-dimensional Fingerprints for Phenotypic Discovery Journal of Neuroscience Methods. Aug, 2018 | Pubmed ID: 29452179 The Small Heat Shock Protein Hsp27 Binds α-synuclein Fibrils, Preventing Elongation and Cytotoxicity The Journal of Biological Chemistry. Mar, 2018 | Pubmed ID: 29382725 Biophotonics of Native Silk Fibrils Macromolecular Bioscience. Apr, 2018 | Pubmed ID: 29377575 Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2 Journal of the American Chemical Society. 02, 2018 | Pubmed ID: 29357227 Optical Structural Analysis of Individual α-Synuclein Oligomers Angewandte Chemie (International Ed. in English). Apr, 2018 | Pubmed ID: 29342318 Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions Analytical Chemistry. Mar, 2018 | Pubmed ID: 29313342 Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity ACS Chemical Biology. Mar, 2018 | Pubmed ID: 29300447 Immunization with α-synuclein/Grp94 Reshapes Peripheral Immunity and Suppresses Microgliosis in a Chronic Parkinsonism Model Glia. 01, 2018 | Pubmed ID: 29024008 The Contribution of Biophysical and Structural Studies of Protein Self-assembly to the Design of Therapeutic Strategies for Amyloid Diseases Neurobiology of Disease. Jan, 2018 | Pubmed ID: 28709995 Structural Basis of Membrane Disruption and Cellular Toxicity by α-synuclein Oligomers Science (New York, N.Y.). 12, 2017 | Pubmed ID: 29242346 Inhibiting the Ca Influx Induced by Human CSF Cell Reports. Dec, 2017 | Pubmed ID: 29241555 Scaling Behaviour and Rate-determining Steps in Filamentous Self-assembly Chemical Science. Oct, 2017 | Pubmed ID: 29147538 Delivery of Native Proteins into C. Elegans Using a Transduction Protocol Based on Lipid Vesicles Scientific Reports. Nov, 2017 | Pubmed ID: 29118344 Clusterin Protects Neurons Against Intracellular Proteotoxicity Acta Neuropathologica Communications. Nov, 2017 | Pubmed ID: 29115989 Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation Scientific Reports. Nov, 2017 | Pubmed ID: 29101328 Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit Journal of the American Chemical Society. 11, 2017 | Pubmed ID: 28994295 Modulation of Electrostatic Interactions to Reveal a Reaction Network Unifying the Aggregation Behaviour of the Aβ42 Peptide and Its Variants Chemical Science. Jun, 2017 | Pubmed ID: 28979758 Absolute Quantification of Amyloid Propagons by Digital Microfluidics Analytical Chemistry. Nov, 2017 | Pubmed ID: 28972786 Gradient-free Determination of Isoelectric Points of Proteins on Chip Physical Chemistry Chemical Physics : PCCP. Aug, 2017 | Pubmed ID: 28817152 Sequential Release of Proteins from Structured Multishell Microcapsules Biomacromolecules. Oct, 2017 | Pubmed ID: 28792742 Silk Micrococoons for Protein Stabilisation and Molecular Encapsulation Nature Communications. 07, 2017 | Pubmed ID: 28722016 The Relevance of Contact-independent Cell-to-cell Transfer of TDP-43 and SOD1 in Amyotrophic Lateral Sclerosis Biochimica Et Biophysica Acta. Molecular Basis of Disease. 11, 2017 | Pubmed ID: 28711596 Monomeric and Fibrillar α-synuclein Exert Opposite Effects on the Catalytic Cycle That Promotes the Proliferation of Aβ42 Aggregates Proceedings of the National Academy of Sciences of the United States of America. 07, 2017 | Pubmed ID: 28698377 Selective Targeting of Primary and Secondary Nucleation Pathways in Aβ42 Aggregation Using a Rational Antibody Scanning Method Science Advances. Jun, 2017 | Pubmed ID: 28691099 Nanobodies Raised Against Monomeric ɑ-synuclein Inhibit Fibril Formation and Destabilize Toxic Oligomeric Species BMC Biology. 07, 2017 | Pubmed ID: 28673288 Protein Homeostasis of a Metastable Subproteome Associated with Alzheimer's Disease Proceedings of the National Academy of Sciences of the United States of America. 07, 2017 | Pubmed ID: 28652376 Phage Display and Kinetic Selection of Antibodies That Specifically Inhibit Amyloid Self-replication Proceedings of the National Academy of Sciences of the United States of America. 06, 2017 | Pubmed ID: 28584111 Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade Annual Review of Biochemistry. 06, 2017 | Pubmed ID: 28498720 Amyloid-like Fibrils from an α-Helical Transmembrane Protein Biochemistry. 06, 2017 | Pubmed ID: 28493669 Ultrasensitive Measurement of Ca Influx into Lipid Vesicles Induced by Protein Aggregates Angewandte Chemie (International Ed. in English). Jun, 2017 | Pubmed ID: 28474754 Spinal Motor Neuron Protein Supersaturation Patterns Are Associated with Inclusion Body Formation in ALS Proceedings of the National Academy of Sciences of the United States of America. 05, 2017 | Pubmed ID: 28396410 Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition Between α-Synuclein Species Biochemistry. 03, 2017 | Pubmed ID: 28230968 A Natural Product Inhibits the Initiation of α-synuclein Aggregation and Suppresses Its Toxicity Proceedings of the National Academy of Sciences of the United States of America. 02, 2017 | Pubmed ID: 28096355 The Amyloid Phenomenon and Its Links with Human Disease Cold Spring Harbor Perspectives in Biology. Jun, 2017 | Pubmed ID: 28062560 Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Aβ42 Aggregation in Alzheimer's Disease Proceedings of the National Academy of Sciences of the United States of America. 01, 2017 | Pubmed ID: 28011763 Multi-dimensional Super-resolution Imaging Enables Surface Hydrophobicity Mapping Nature Communications. 12, 2016 | Pubmed ID: 27929085 The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme Biophysical Journal. Dec, 2016 | Pubmed ID: 27926837 Bifunctional Anti-Non-Amyloid Component α-Synuclein Nanobodies Are Protective In Situ PloS One. Month, 2016 | Pubmed ID: 27824888 β-Synuclein Suppresses Both the Initiation and Amplification Steps of α-synuclein Aggregation Via Competitive Binding to Surfaces Scientific Reports. 11, 2016 | Pubmed ID: 27808107 Structural Basis of Synaptic Vesicle Assembly Promoted by α-synuclein Nature Communications. 09, 2016 | Pubmed ID: 27640673 Binding Affinity of Amyloid Oligomers to Cellular Membranes is a Generic Indicator of Cellular Dysfunction in Protein Misfolding Diseases Scientific Reports. 09, 2016 | Pubmed ID: 27619987 Mutations Associated with Familial Parkinson's Disease Alter the Initiation and Amplification Steps of α-synuclein Aggregation Proceedings of the National Academy of Sciences of the United States of America. 09, 2016 | Pubmed ID: 27573854 A Protein Homeostasis Signature in Healthy Brains Recapitulates Tissue Vulnerability to Alzheimer's Disease Science Advances. 08, 2016 | Pubmed ID: 27532054 Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation Chembiochem : a European Journal of Chemical Biology. 10, 2016 | Pubmed ID: 27472818 The Chaperone HSPB8 Reduces the Accumulation of Truncated TDP-43 Species in Cells and Protects Against TDP-43-mediated Toxicity Human Molecular Genetics. 09, 2016 | Pubmed ID: 27466192 Towards a Structural Biology of the Hydrophobic Effect in Protein Folding Scientific Reports. 07, 2016 | Pubmed ID: 27461719 Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies The Journal of Biological Chemistry. 09, 2016 | Pubmed ID: 27445339 Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform Journal of the American Chemical Society. 08, 2016 | Pubmed ID: 27387359 Quantitative Analysis of Co-oligomer Formation by Amyloid-beta Peptide Isoforms Scientific Reports. 06, 2016 | Pubmed ID: 27346247 Chemical Properties of Lipids Strongly Affect the Kinetics of the Membrane-induced Aggregation of α-synuclein Proceedings of the National Academy of Sciences of the United States of America. 06, 2016 | Pubmed ID: 27298346 Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity Scientific Reports. 06, 2016 | Pubmed ID: 27273030 The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model Molecular Cell. Apr, 2016 | Pubmed ID: 27151442 Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein Biochemistry. 06, 2016 | Pubmed ID: 27096466 Structural Characterization of the Interaction of α-synuclein Nascent Chains with the Ribosomal Surface and Trigger Factor Proceedings of the National Academy of Sciences of the United States of America. May, 2016 | Pubmed ID: 27092002 A Transcriptional Signature of Alzheimer's Disease is Associated with a Metastable Subproteome at Risk for Aggregation Proceedings of the National Academy of Sciences of the United States of America. Apr, 2016 | Pubmed ID: 27071083 Kinetic Analysis Reveals the Diversity of Microscopic Mechanisms Through Which Molecular Chaperones Suppress Amyloid Formation Nature Communications. Mar, 2016 | Pubmed ID: 27009901 Nanoscopic Insights into Seeding Mechanisms and Toxicity of α-synuclein Species in Neurons Proceedings of the National Academy of Sciences of the United States of America. Mar, 2016 | Pubmed ID: 26993805 Ca2+ is a Key Factor in α-synuclein-induced Neurotoxicity Journal of Cell Science. 05, 2016 | Pubmed ID: 26989132 Quantitative Thermophoretic Study of Disease-related Protein Aggregates Scientific Reports. Mar, 2016 | Pubmed ID: 26984748 Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing Journal of the American Chemical Society. Mar, 2016 | Pubmed ID: 26967463 An Anticancer Drug Suppresses the Primary Nucleation Reaction That Initiates the Production of the Toxic Aβ42 Aggregates Linked with Alzheimer's Disease Science Advances. Feb, 2016 | Pubmed ID: 26933687 A Structural Ensemble of a Ribosome-nascent Chain Complex During Cotranslational Protein Folding Nature Structural & Molecular Biology. Apr, 2016 | Pubmed ID: 26926436 A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins ACS Combinatorial Science. Mar, 2016 | Pubmed ID: 26923286 Kinetic Model of the Aggregation of Alpha-synuclein Provides Insights into Prion-like Spreading Proceedings of the National Academy of Sciences of the United States of America. Mar, 2016 | Pubmed ID: 26884195 An Environmentally Sensitive Fluorescent Dye As a Multidimensional Probe of Amyloid Formation The Journal of Physical Chemistry. B. Mar, 2016 | Pubmed ID: 26865546 Hamiltonian Dynamics of Protein Filament Formation Physical Review Letters. Jan, 2016 | Pubmed ID: 26849615 Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform Biophysical Journal. Feb, 2016 | Pubmed ID: 26840721 Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids ACS Chemical Neuroscience. Mar, 2016 | Pubmed ID: 26800462 Molecular Mechanisms of Protein Aggregation from Global Fitting of Kinetic Models Nature Protocols. Feb, 2016 | Pubmed ID: 26741409 Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins Under Native Solution Conditions ACS Nano. Jan, 2016 | Pubmed ID: 26678709 Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease Antioxidants & Redox Signaling. Mar, 2016 | Pubmed ID: 26564470 Chaperome Screening Leads to Identification of Grp94/Gp96 and FKBP4/52 As Modulators of the α-synuclein-elicited Immune Response FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2016 | Pubmed ID: 26443817 Single-molecule FRET Studies on Alpha-synuclein Oligomerization of Parkinson's Disease Genetically Related Mutants Scientific Reports. Nov, 2015 | Pubmed ID: 26582456 Solvent Exposure of Tyr10 As a Probe of Structural Differences Between Monomeric and Aggregated Forms of the Amyloid-β Peptide Biochemical and Biophysical Research Communications. Dec, 2015 | Pubmed ID: 26551456 The Length Distribution of Frangible Biofilaments The Journal of Chemical Physics. Oct, 2015 | Pubmed ID: 26520548 SOD1 Protein Aggregates Stimulate Macropinocytosis in Neurons to Facilitate Their Propagation Molecular Neurodegeneration. Oct, 2015 | Pubmed ID: 26520394 Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies Current Alzheimer Research. Month, 2015 | Pubmed ID: 26510979 Structure-Free Validation of Residual Dipolar Coupling and Paramagnetic Relaxation Enhancement Measurements of Disordered Proteins Biochemistry. Nov, 2015 | Pubmed ID: 26479087 Conformational Effects of the A21G Flemish Mutation on the Aggregation of Amyloid β Peptide Biological & Pharmaceutical Bulletin. Month, 2015 | Pubmed ID: 26424029 Latent Analysis of Unmodified Biomolecules and Their Complexes in Solution with Attomole Detection Sensitivity Nature Chemistry. Oct, 2015 | Pubmed ID: 26391079 Biophysical Approaches for the Study of Interactions Between Molecular Chaperones and Protein Aggregates Chemical Communications (Cambridge, England). Oct, 2015 | Pubmed ID: 26328629 Fast Flow Microfluidics and Single-molecule Fluorescence for the Rapid Characterization of α-synuclein Oligomers Analytical Chemistry. Sep, 2015 | Pubmed ID: 26258431 Force Generation by the Growth of Amyloid Aggregates Proceedings of the National Academy of Sciences of the United States of America. Aug, 2015 | Pubmed ID: 26195762 Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies PloS One. Month, 2015 | Pubmed ID: 26103636 Neuronal Cx3cr1 Deficiency Protects Against Amyloid β-Induced Neurotoxicity PloS One. Month, 2015 | Pubmed ID: 26038823 Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry ACS Nano. Jun, 2015 | Pubmed ID: 26030507 The Influence of Novel Gemini Surfactants Containing Cycloalkyl Side-chains on the Structural Phases of DNA in Solution Colloids and Surfaces. B, Biointerfaces. Jul, 2015 | Pubmed ID: 25969417 Widespread Proteome Remodeling and Aggregation in Aging C. Elegans Cell. May, 2015 | Pubmed ID: 25957690 Structure of a Single-chain Fv Bound to the 17 N-terminal Residues of Huntingtin Provides Insights into Pathogenic Amyloid Formation and Suppression Journal of Molecular Biology. Jun, 2015 | Pubmed ID: 25861763 Structural Characterization of Toxic Oligomers That Are Kinetically Trapped During α-synuclein Fibril Formation Proceedings of the National Academy of Sciences of the United States of America. Apr, 2015 | Pubmed ID: 25855634 Investigating the Mechanisms of Amylolysis of Starch Granules by Solution-state NMR Biomacromolecules. May, 2015 | Pubmed ID: 25815624 A Molecular Chaperone Breaks the Catalytic Cycle That Generates Toxic Aβ Oligomers Nature Structural & Molecular Biology. Mar, 2015 | Pubmed ID: 25686087 Lipid Vesicles Trigger α-synuclein Aggregation by Stimulating Primary Nucleation Nature Chemical Biology. Mar, 2015 | Pubmed ID: 25643172 Supersaturation is a Major Driving Force for Protein Aggregation in Neurodegenerative Diseases Trends in Pharmacological Sciences. Feb, 2015 | Pubmed ID: 25636813 Structure of a Low-population Intermediate State in the Release of an Enzyme Product ELife. Jan, 2015 | Pubmed ID: 25575179 Protein Microgels from Amyloid Fibril Networks ACS Nano. Jan, 2015 | Pubmed ID: 25469621 Chaperoned Amyloid Proteins for Immune Manipulation: α-Synuclein/Hsp70 Shifts Immunity Toward a Modulatory Phenotype Immunity, Inflammation and Disease. Dec, 2014 | Pubmed ID: 25866630 Ostwald's Rule of Stages Governs Structural Transitions and Morphology of Dipeptide Supramolecular Polymers Nature Communications. Nov, 2014 | Pubmed ID: 25391268 A Relationship Between the Transient Structure in the Monomeric State and the Aggregation Propensities of α-synuclein and β-synuclein Biochemistry. Nov, 2014 | Pubmed ID: 25389903 Single-molecule Imaging Reveals That Small Amyloid-β1-42 Oligomers Interact with the Cellular Prion Protein (PrP(C)) Chembiochem : a European Journal of Chemical Biology. Nov, 2014 | Pubmed ID: 25294384 Interaction of the Molecular Chaperone DNAJB6 with Growing Amyloid-beta 42 (Aβ42) Aggregates Leads to Sub-stoichiometric Inhibition of Amyloid Formation The Journal of Biological Chemistry. Nov, 2014 | Pubmed ID: 25217638 Antibodies and Protein Misfolding: From Structural Research Tools to Therapeutic Strategies Biochimica Et Biophysica Acta. Nov, 2014 | Pubmed ID: 25194824 The Physical Chemistry of the Amyloid Phenomenon: Thermodynamics and Kinetics of Filamentous Protein Aggregation Essays in Biochemistry. Month, 2014 | Pubmed ID: 25131584 Differences in Nucleation Behavior Underlie the Contrasting Aggregation Kinetics of the Aβ40 and Aβ42 Peptides Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 24938782 Direct Observation of the Three Regions in α-synuclein That Determine Its Membrane-bound Behaviour Nature Communications. May, 2014 | Pubmed ID: 24871041 Direct Observations of Amyloid β Self-assembly in Live Cells Provide Insights into Differences in the Kinetics of Aβ(1-40) and Aβ(1-42) Aggregation Chemistry & Biology. Jun, 2014 | Pubmed ID: 24856820 The Amyloid State and Its Association with Protein Misfolding Diseases Nature Reviews. Molecular Cell Biology. Jun, 2014 | Pubmed ID: 24854788 Solution Conditions Determine the Relative Importance of Nucleation and Growth Processes in α-synuclein Aggregation Proceedings of the National Academy of Sciences of the United States of America. May, 2014 | Pubmed ID: 24817693 Hypochlorite-induced Structural Modifications Enhance the Chaperone Activity of Human α2-macroglobulin Proceedings of the National Academy of Sciences of the United States of America. May, 2014 | Pubmed ID: 24799681 Understanding the Influence of Codon Translation Rates on Cotranslational Protein Folding Accounts of Chemical Research. May, 2014 | Pubmed ID: 24784899 Nucleation-conversion-polymerization Reactions of Biological Macromolecules with Prenucleation Clusters Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Mar, 2014 | Pubmed ID: 24730879 Oligomer-targeting with a Conformational Antibody Fragment Promotes Toxicity in Aβ-expressing Flies Acta Neuropathologica Communications. Apr, 2014 | Pubmed ID: 24725347 Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage Biochemistry. Apr, 2014 | Pubmed ID: 24717093 Dynamics and Timekeeping in Biological Systems Annual Review of Biochemistry. Month, 2014 | Pubmed ID: 24606145 Chemical Kinetics for Drug Discovery to Combat Protein Aggregation Diseases Trends in Pharmacological Sciences. Mar, 2014 | Pubmed ID: 24560688 Targeting the Intrinsically Disordered Structural Ensemble of α-synuclein by Small Molecules As a Potential Therapeutic Strategy for Parkinson's Disease PloS One. Month, 2014 | Pubmed ID: 24551051 A Simple Lattice Model That Captures Protein Folding, Aggregation and Amyloid Formation PloS One. Month, 2014 | Pubmed ID: 24454816 Kinetic Modelling Indicates That Fast-translating Codons Can Coordinate Cotranslational Protein Folding by Avoiding Misfolded Intermediates Nature Communications. Month, 2014 | Pubmed ID: 24394622 Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics Via Two-color Super-resolution Microscopy Nano Letters. Jan, 2014 | Pubmed ID: 24303845 Single Point Mutations Induce a Switch in the Molecular Mechanism of the Aggregation of the Alzheimer's Disease Associated Aβ42 Peptide ACS Chemical Biology. Feb, 2014 | Pubmed ID: 24199868 A Clear View of Polymorphism, Twist, and Chirality in Amyloid Fibril Formation ACS Nano. Dec, 2013 | Pubmed ID: 24359171 Higher Order Amyloid Fibril Structure by MAS NMR and DNP Spectroscopy Journal of the American Chemical Society. Dec, 2013 | Pubmed ID: 24304221 Preconditioning of Microglia by α-synuclein Strongly Affects the Response Induced by Toll-like Receptor (TLR) Stimulation PloS One. Month, 2013 | Pubmed ID: 24236103 Widespread Aggregation and Neurodegenerative Diseases Are Associated with Supersaturated Proteins Cell Reports. Nov, 2013 | Pubmed ID: 24183671 In-cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-synuclein Within E. Coli Cells PloS One. Month, 2013 | Pubmed ID: 23991082 Characterization of the Interdomain Motions in Hen Lysozyme Using Residual Dipolar Couplings As Replica-averaged Structural Restraints in Molecular Dynamics Simulations Biochemistry. Sep, 2013 | Pubmed ID: 23941501 A Nanobody Binding to Non-amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation The Journal of Physical Chemistry. B. Oct, 2013 | Pubmed ID: 23919586 Identification of Small-molecule Binding Pockets in the Soluble Monomeric Form of the Aβ42 Peptide The Journal of Chemical Physics. Jul, 2013 | Pubmed ID: 23883055 Hsp70 Oligomerization is Mediated by an Interaction Between the Interdomain Linker and the Substrate-binding Domain PloS One. Month, 2013 | Pubmed ID: 23840795 α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling The Journal of Biological Chemistry. Jul, 2013 | Pubmed ID: 23740253 Proliferation of Amyloid-β42 Aggregates Occurs Through a Secondary Nucleation Mechanism Proceedings of the National Academy of Sciences of the United States of America. Jun, 2013 | Pubmed ID: 23703910 A Label-free, Quantitative Assay of Amyloid Fibril Growth Based on Intrinsic Fluorescence Chembiochem : a European Journal of Chemical Biology. May, 2013 | Pubmed ID: 23592254 Nanobodies Raised Against Monomeric α-synuclein Distinguish Between Fibrils at Different Maturation Stages Journal of Molecular Biology. Jul, 2013 | Pubmed ID: 23557833 Influence of Specific HSP70 Domains on Fibril Formation of the Yeast Prion Protein Ure2 Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. May, 2013 | Pubmed ID: 23530260 Atomic Structure and Hierarchical Assembly of a Cross-β Amyloid Fibril Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23513222 Electrostatic Effects in Filamentous Protein Aggregation Biophysical Journal. Mar, 2013 | Pubmed ID: 23473495 Protein Amyloids Develop an Intrinsic Fluorescence Signature During Aggregation The Analyst. Apr, 2013 | Pubmed ID: 23420088 Protease-activated Alpha-2-macroglobulin Can Inhibit Amyloid Formation Via Two Distinct Mechanisms FEBS Letters. Mar, 2013 | Pubmed ID: 23353684 Single Molecule Characterization of the Interactions Between Amyloid-β Peptides and the Membranes of Hippocampal Cells Journal of the American Chemical Society. Jan, 2013 | Pubmed ID: 23339742 In Vivo Translation Rates Can Substantially Delay the Cotranslational Folding of the Escherichia Coli Cytosolic Proteome Proceedings of the National Academy of Sciences of the United States of America. Jan, 2013 | Pubmed ID: 23256155 Analysis of the Native Structure, Stability and Aggregation of Biotinylated Human Lysozyme PloS One. Month, 2012 | Pubmed ID: 23166837 Amyloid-β Oligomers Are Sequestered by Both Intracellular and Extracellular Chaperones Biochemistry. Nov, 2012 | Pubmed ID: 23106396 Twisting Transition Between Crystalline and Fibrillar Phases of Aggregated Peptides Physical Review Letters. Oct, 2012 | Pubmed ID: 23102370 Nanobodies As Structural Probes of Protein Misfolding and Fibril Formation Methods in Molecular Biology (Clifton, N.J.). Month, 2012 | Pubmed ID: 22886275 Role of Elongation and Secondary Pathways in S6 Amyloid Fibril Growth Biophysical Journal. May, 2012 | Pubmed ID: 22824281 Molecular Mechanisms Used by Chaperones to Reduce the Toxicity of Aberrant Protein Oligomers Proceedings of the National Academy of Sciences of the United States of America. Jul, 2012 | Pubmed ID: 22802614 Characterizing Intermolecular Interactions That Initiate Native-like Protein Aggregation Biophysical Journal. Jun, 2012 | Pubmed ID: 22713575 Trigger Factor Slows Co-translational Folding Through Kinetic Trapping While Sterically Protecting the Nascent Chain from Aberrant Cytosolic Interactions Journal of the American Chemical Society. Jul, 2012 | Pubmed ID: 22680285 Prediction of Variable Translation Rate Effects on Cotranslational Protein Folding Nature Communications. May, 2012 | Pubmed ID: 22643895 Direct Observation of the Interconversion of Normal and Toxic Forms of α-synuclein Cell. May, 2012 | Pubmed ID: 22632969 Measuring the Kinetics of Amyloid Fibril Elongation Using Quartz Crystal Microbalances Methods in Molecular Biology (Clifton, N.J.). Month, 2012 | Pubmed ID: 22528086 Intrinsic Disorder Modulates Protein Self-assembly and Aggregation Proceedings of the National Academy of Sciences of the United States of America. May, 2012 | Pubmed ID: 22509003 Detailed Analysis of the Energy Barriers for Amyloid Fibril Growth Angewandte Chemie (International Ed. in English). May, 2012 | Pubmed ID: 22489083 Expression in Drosophila of Tandem Amyloid β Peptides Provides Insights into Links Between Aggregation and Neurotoxicity The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22461632 From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation Journal of Molecular Biology. Aug, 2012 | Pubmed ID: 22406275 The Aggregation and Neurotoxicity of TDP-43 and Its ALS-associated 25 KDa Fragment Are Differentially Affected by Molecular Chaperones in Drosophila PloS One. Month, 2012 | Pubmed ID: 22384095 Disease-related Amyloidogenic Variants of Human Lysozyme Trigger the Unfolded Protein Response and Disturb Eye Development in Drosophila Melanogaster FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2012 | Pubmed ID: 21965601 ¹H, ¹³C and ¹⁵N Resonance Assignments of Human Muscle Acylphosphatase Biomolecular NMR Assignments. Apr, 2012 | Pubmed ID: 21643968 The Extracellular Chaperone Clusterin Sequesters Oligomeric Forms of the Amyloid-β(1-40) Peptide Nature Structural & Molecular Biology. Dec, 2011 | Pubmed ID: 22179788 Experimental Free Energy Surfaces Reveal the Mechanisms of Maintenance of Protein Solubility Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22160682 Inversion of the Balance Between Hydrophobic and Hydrogen Bonding Interactions in Protein Folding and Aggregation PLoS Computational Biology. Oct, 2011 | Pubmed ID: 22022239 Nucleated Polymerisation in the Presence of Pre-formed Seed Filaments International Journal of Molecular Sciences. Month, 2011 | Pubmed ID: 22016630 Probing Small Molecule Binding to Amyloid Fibrils Physical Chemistry Chemical Physics : PCCP. Dec, 2011 | Pubmed ID: 22006124 Binding of the Molecular Chaperone αB-crystallin to Aβ Amyloid Fibrils Inhibits Fibril Elongation Biophysical Journal. Oct, 2011 | Pubmed ID: 21961594 Observation of Spatial Propagation of Amyloid Assembly from Single Nuclei Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011 | Pubmed ID: 21876182 Nucleated Polymerization with Secondary Pathways. III. Equilibrium Behavior and Oligomer Populations The Journal of Chemical Physics. Aug, 2011 | Pubmed ID: 21842956 Nucleated Polymerization with Secondary Pathways. II. Determination of Self-consistent Solutions to Growth Processes Described by Non-linear Master Equations The Journal of Chemical Physics. Aug, 2011 | Pubmed ID: 21842955 Nucleated Polymerization with Secondary Pathways. I. Time Evolution of the Principal Moments The Journal of Chemical Physics. Aug, 2011 | Pubmed ID: 21842954 Protein Solubility and Protein Homeostasis: a Generic View of Protein Misfolding Disorders Cold Spring Harbor Perspectives in Biology. Dec, 2011 | Pubmed ID: 21825020 Native-state Stability Determines the Extent of Degradation Relative to Secretion of Protein Variants from Pichia Pastoris PloS One. Month, 2011 | Pubmed ID: 21818368 In Situ Measurements of the Formation and Morphology of Intracellular β-amyloid Fibrils by Super-resolution Fluorescence Imaging Journal of the American Chemical Society. Aug, 2011 | Pubmed ID: 21793568 Intermolecular Structure Determination of Amyloid Fibrils with Magic-angle Spinning and Dynamic Nuclear Polarization NMR Journal of the American Chemical Society. Sep, 2011 | Pubmed ID: 21774549 Probing Protein Aggregation with Quartz Crystal Microbalances Methods in Molecular Biology (Clifton, N.J.). Month, 2011 | Pubmed ID: 21713635 The IFly Tracking System for an Automated Locomotor and Behavioural Analysis of Drosophila Melanogaster Integrative Biology : Quantitative Biosciences from Nano to Macro. Jul, 2011 | Pubmed ID: 21698336 Conserved C-terminal Charge Exerts a Profound Influence on the Aggregation Rate of α-synuclein Journal of Molecular Biology. Aug, 2011 | Pubmed ID: 21689664 Disulfide Bonds Reduce the Toxicity of the Amyloid Fibrils Formed by an Extracellular Protein Angewandte Chemie (International Ed. in English). Jul, 2011 | Pubmed ID: 21671315 Metastability of Native Proteins and the Phenomenon of Amyloid Formation Journal of the American Chemical Society. Sep, 2011 | Pubmed ID: 21650202 Perturbation of the Stability of Amyloid Fibrils Through Alteration of Electrostatic Interactions Biophysical Journal. Jun, 2011 | Pubmed ID: 21641324 Population of Nonnative States of Lysozyme Variants Drives Amyloid Fibril Formation Journal of the American Chemical Society. May, 2011 | Pubmed ID: 21528861 Detection of Early Locomotor Abnormalities in a Drosophila Model of Alzheimer's Disease Journal of Neuroscience Methods. Apr, 2011 | Pubmed ID: 21315762 A FRET Sensor for Non-invasive Imaging of Amyloid Formation in Vivo Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. Feb, 2011 | Pubmed ID: 21308945 Protein Dynamics: Moore's Law in Molecular Biology Current Biology : CB. Jan, 2011 | Pubmed ID: 21256436 Relationship Between Prion Propensity and the Rates of Individual Molecular Steps of Fibril Assembly The Journal of Biological Chemistry. Apr, 2011 | Pubmed ID: 21233211 New Scenarios of Protein Folding Can Occur on the Ribosome Journal of the American Chemical Society. Jan, 2011 | Pubmed ID: 21204555 Interactions Between Amyloidophilic Dyes and Their Relevance to Studies of Amyloid Inhibitors Biophysical Journal. Nov, 2010 | Pubmed ID: 21081099 Transient Tertiary Structure Formation Within the Ribosome Exit Port Journal of the American Chemical Society. Dec, 2010 | Pubmed ID: 21062068 Glial Innate Immunity Generated by Non-aggregated Alpha-synuclein in Mouse: Differences Between Wild-type and Parkinson's Disease-linked Mutants PloS One. Oct, 2010 | Pubmed ID: 21048992 Local Cooperativity in an Amyloidogenic State of Human Lysozyme Observed at Atomic Resolution Journal of the American Chemical Society. Nov, 2010 | Pubmed ID: 20958028 Frequency Factors in a Landscape Model of Filamentous Protein Aggregation Physical Review Letters. Jun, 2010 | Pubmed ID: 20873942 Stabilization of Neurotoxic Alzheimer Amyloid-beta Oligomers by Protein Engineering Proceedings of the National Academy of Sciences of the United States of America. Aug, 2010 | Pubmed ID: 20713699 High-resolution MAS NMR Analysis of PI3-SH3 Amyloid Fibrils: Backbone Conformation and Implications for Protofilament Assembly and Structure Biochemistry. Sep, 2010 | Pubmed ID: 20707313 Surface Attachment of Protein Fibrils Via Covalent Modification Strategies The Journal of Physical Chemistry. B. Sep, 2010 | Pubmed ID: 20695458 The Non-core Regions of Human Lysozyme Amyloid Fibrils Influence Cytotoxicity Journal of Molecular Biology. Oct, 2010 | Pubmed ID: 20624399 Structure and Properties of a Complex of α-synuclein and a Single-domain Camelid Antibody Journal of Molecular Biology. Sep, 2010 | Pubmed ID: 20620148 Physicochemical Determinants of Chaperone Requirements Journal of Molecular Biology. Jul, 2010 | Pubmed ID: 20416322 Intrinsic Determinants of Neurotoxic Aggregate Formation by the Amyloid Beta Peptide Biophysical Journal. Apr, 2010 | Pubmed ID: 20409489 A Non-natural Variant of Human Lysozyme (I59T) Mimics the in Vitro Behaviour of the I56T Variant That is Responsible for a Form of Familial Amyloidosis Protein Engineering, Design & Selection : PEDS. Jul, 2010 | Pubmed ID: 20382744 Sequestration of the Abeta Peptide Prevents Toxicity and Promotes Degradation in Vivo PLoS Biology. Mar, 2010 | Pubmed ID: 20305716 The Interaction of AlphaB-crystallin with Mature Alpha-synuclein Amyloid Fibrils Inhibits Their Elongation Biophysical Journal. Mar, 2010 | Pubmed ID: 20197038 Differential Phospholipid Binding of Alpha-synuclein Variants Implicated in Parkinson's Disease Revealed by Solution NMR Spectroscopy Biochemistry. Feb, 2010 | Pubmed ID: 20041693 Folding Study of Venus Reveals a Strong Ion Dependence of Its Yellow Fluorescence Under Mildly Acidic Conditions The Journal of Biological Chemistry. Feb, 2010 | Pubmed ID: 19901033 Probing Ribosome-nascent Chain Complexes Produced in Vivo by NMR Spectroscopy Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 20018739 Analysis of Sub-tauc and Supra-tauc Motions in Protein Gbeta1 Using Molecular Dynamics Simulations Biophysical Journal. Nov, 2009 | Pubmed ID: 19883594 Chaperone Proteostasis in Parkinson's Disease: Stabilization of the Hsp70/alpha-synuclein Complex by Hip The EMBO Journal. Dec, 2009 | Pubmed ID: 19875982 Long-range Correlations Between Aliphatic 13C Nuclei in Protein MAS NMR Spectroscopy Angewandte Chemie (International Ed. in English). Month, 2009 | Pubmed ID: 19562810 Multiple Tight Phospholipid-binding Modes of Alpha-synuclein Revealed by Solution NMR Spectroscopy Journal of Molecular Biology. Jul, 2009 | Pubmed ID: 19481095 Amyloid Formation by the Pro-inflammatory S100A8/A9 Proteins in the Ageing Prostate PloS One. Month, 2009 | Pubmed ID: 19440546 Experimental Characterization of Disordered and Ordered Aggregates Populated During the Process of Amyloid Fibril Formation Proceedings of the National Academy of Sciences of the United States of America. May, 2009 | Pubmed ID: 19416886 A Generic Mechanism of Emergence of Amyloid Protofilaments from Disordered Oligomeric Aggregates PLoS Computational Biology. Nov, 2008 | Pubmed ID: 19008938 Recombinant Amyloid Beta-peptide Production by Coexpression with an Affibody Ligand BMC Biotechnology. Oct, 2008 | Pubmed ID: 18973685 Direct Characterization of Amyloidogenic Oligomers by Single-molecule Fluorescence Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008 | Pubmed ID: 18796612 Immunological Features of Alpha-synuclein in Parkinson's Disease Journal of Cellular and Molecular Medicine. Oct, 2008 | Pubmed ID: 18671754 A Coupled Equilibrium Shift Mechanism in Calmodulin-mediated Signal Transduction Structure (London, England : 1993). May, 2008 | Pubmed ID: 18462678 Molecular Determinants of the Aggregation Behavior of Alpha- and Beta-synuclein Protein Science : a Publication of the Protein Society. May, 2008 | Pubmed ID: 18436957 Systematic in Vivo Analysis of the Intrinsic Determinants of Amyloid Beta Pathogenicity PLoS Biology. Oct, 2007 | Pubmed ID: 17973577 Structural Reorganisation and Potential Toxicity of Oligomeric Species Formed During the Assembly of Amyloid Fibrils PLoS Computational Biology. Sep, 2007 | Pubmed ID: 17941703 Structure and Dynamics of a Ribosome-bound Nascent Chain by NMR Spectroscopy Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007 | Pubmed ID: 17940046 Kinetics and Thermodynamics of Amyloid Formation from Direct Measurements of Fluctuations in Fibril Mass Proceedings of the National Academy of Sciences of the United States of America. Jun, 2007 | Pubmed ID: 17540728 Similarities in the Thermodynamics and Kinetics of Aggregation of Disease-related Abeta(1-40) Peptides Protein Science : a Publication of the Protein Society. Jun, 2007 | Pubmed ID: 17525469 Characterization of the Nanoscale Properties of Individual Amyloid Fibrils Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006 | Pubmed ID: 17038504 Amyloid Fibril Formation Can Proceed from Different Conformations of a Partially Unfolded Protein Biophysical Journal. Dec, 2005 | Pubmed ID: 16169975 Determination of the Folding Transition States of Barnase by Using PhiI-value-restrained Simulations Validated by Double Mutant PhiIJ-values Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005 | Pubmed ID: 16116084 Rational Design of Aggregation-resistant Bioactive Peptides: Reengineering Human Calcitonin Proceedings of the National Academy of Sciences of the United States of America. Jul, 2005 | Pubmed ID: 16006528 Multiple Subsets of Side-chain Packing in Partially Folded States of Alpha-lactalbumins Proceedings of the National Academy of Sciences of the United States of America. Jun, 2005 | Pubmed ID: 15956205 A Glimpse at the Organization of the Protein Universe Proceedings of the National Academy of Sciences of the United States of America. Apr, 2005 | Pubmed ID: 15827120 The Formation of Spherulites by Amyloid Fibrils of Bovine Insulin Proceedings of the National Academy of Sciences of the United States of America. Oct, 2004 | Pubmed ID: 15381766 Heteronuclear NMR Investigations of Dynamic Regions of Intact Escherichia Coli Ribosomes Proceedings of the National Academy of Sciences of the United States of America. Jul, 2004 | Pubmed ID: 15263071 Short Amino Acid Stretches Can Mediate Amyloid Formation in Globular Proteins: the Src Homology 3 (SH3) Case Proceedings of the National Academy of Sciences of the United States of America. May, 2004 | Pubmed ID: 15123800 Exploring Amyloid Formation by a De Novo Design Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004 | Pubmed ID: 15070736 High-resolution Molecular Structure of a Peptide in an Amyloid Fibril Determined by Magic Angle Spinning NMR Spectroscopy Proceedings of the National Academy of Sciences of the United States of America. Jan, 2004 | Pubmed ID: 14715898 Structures and Relative Free Energies of Partially Folded States of Proteins Proceedings of the National Academy of Sciences of the United States of America. Dec, 2003 | Pubmed ID: 14657374 The Circularization of Amyloid Fibrils Formed by Apolipoprotein C-II Biophysical Journal. Dec, 2003 | Pubmed ID: 14645087 Chemical Modification of Insulin in Amyloid Fibrils Protein Science : a Publication of the Protein Society. Nov, 2003 | Pubmed ID: 14573875 Calculation of Mutational Free Energy Changes in Transition States for Protein Folding Biophysical Journal. Aug, 2003 | Pubmed ID: 12885664 Molecular Conformation of a Peptide Fragment of Transthyretin in an Amyloid Fibril Proceedings of the National Academy of Sciences of the United States of America. Dec, 2002 | Pubmed ID: 12481032 De Novo Designed Peptide-based Amyloid Fibrils Proceedings of the National Academy of Sciences of the United States of America. Dec, 2002 | Pubmed ID: 12456886 Altered Aggregation Properties of Mutant Gamma-crystallins Cause Inherited Cataract The EMBO Journal. Nov, 2002 | Pubmed ID: 12426373 The Behaviour of Polyamino Acids Reveals an Inverse Side Chain Effect in Amyloid Structure Formation The EMBO Journal. Nov, 2002 | Pubmed ID: 12411486 Studies of the Aggregation of Mutant Proteins in Vitro Provide Insights into the Genetics of Amyloid Diseases Proceedings of the National Academy of Sciences of the United States of America. Dec, 2002 | Pubmed ID: 12374855 Solution Conditions Can Promote Formation of Either Amyloid Protofilaments or Mature Fibrils from the HypF N-terminal Domain Protein Science : a Publication of the Protein Society. Dec, 2001 | Pubmed ID: 11714922 एक व्यापक क्षेत्र के दृश्य ट्रैकिंग मंच का उपयोग कर बड़ी सी एलिगेंस आबादी का स्वचालित व्यवहार विश्लेषण Michele Perni1, Sam Casford1, Francesco A. Aprile1, Ellen A. Nollen2, Tuomas P.J. Knowles1, Michele Vendruscolo1, Christopher M. Dobson1 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, 2European Research Institute for the Biology of Aging, University Medical Centre Groningen JoVE 58643 Immunology and Infection
एक व्यापक क्षेत्र के दृश्य ट्रैकिंग मंच का उपयोग कर बड़ी सी एलिगेंस आबादी का स्वचालित व्यवहार विश्लेषण Michele Perni1, Sam Casford1, Francesco A. Aprile1, Ellen A. Nollen2, Tuomas P.J. Knowles1, Michele Vendruscolo1, Christopher M. Dobson1 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, 2European Research Institute for the Biology of Aging, University Medical Centre Groningen JoVE 58643 Immunology and Infection
