Other Publications (1)
Articles by Cindy Youn in JoVE
Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model Anjie Zhen1, Valerie Rezek1, Cindy Youn1, Jonathan Rick1, Brianna Lam1, Nelson Chang1, Jerome Zack1, Masakazu Kamata1, Scott Kitchen1 1David Geffen School of Medicine, University of California, Los Angeles This protocol describes the methods in constructing a humanized bone-marrow/liver/thymus mouse model with stem cell-based engineered immunity against HIV infection.
Other articles by Cindy Youn on PubMed
Cocaine-mediated Impact on HIV Infection in Humanized BLT Mice Scientific Reports. 2015 | Pubmed ID: 26084721 Cocaine abuse has been shown to have broad-ranging effects on human immunity. With regards to HIV infection, in vitro studies have shown that cocaine enhances infection of stimulated lymphocytes. Moreover, cohort studies in the pre- and post-HAART era have linked stimulant abuse with increased HIV pathogenesis. The latter data, however, have been undermined by a series of confounding factors underscoring the importance of controlled in vivo models to fully assess the impact of cocaine use and abuse on HIV infection and pathogenesis. Here, we have infected humanized mice with HIV-1 following acute cocaine exposure to assess the impact on infection. Stimulant exposure resulted in increased inflammatory cytokine expression, accelerated HIV infection, while blunting effector function of cytotoxic T lymphocytes. These data demonstrate cocaine's multifactorial impact on HIV infection that extends beyond high-risk behavior.