Claire Rodriguez-Lafrasse Laboratoire de Biochimie et Biologie Moléculaire, Groupe Hospitalier Sud Hospices Civils de Lyon Biography Publications Institution JoVE Articles Claire Rodriguez-Lafrasse has not added a biography. If you are Claire Rodriguez-Lafrasse and would like to personalize this page please email our Author Liaison for assistance. Publications Profiling of Circulating Tumor DNA in Plasma of Non-small Cell Lung Cancer Patients, Monitoring of Epidermal Growth Factor Receptor P.T790M Mutated Allelic Fraction Using Beads, Emulsion, Amplification, and Magnetics Companion Assay and Evaluation in Future Application in Mimicking Circulating Tumor Cells Cancer Medicine. Jul, 2019 | Pubmed ID: 31112372 ROS Production and Distribution: A New Paradigm to Explain the Differential Effects of X-ray and Carbon Ion Irradiation on Cancer Stem Cell Migration and Invasion Cancers. Apr, 2019 | Pubmed ID: 30987217 Cross-platform Comparison for the Detection of RAS Mutations in CfDNA (ddPCR Biorad Detection Assay, BEAMing Assay, and NGS Strategy) Oncotarget. Apr, 2018 | Pubmed ID: 29765524 Evaluation of Pre-analytical Conditions and Comparison of the Performance of Several Digital PCR Assays for the Detection of Major Mutations in Circulating DNA from Non-small Cell Lung Cancers: the CIRCAN_0 Study Oncotarget. Oct, 2017 | Pubmed ID: 29152135 Dual "mAb" HER Family Blockade in Head and Neck Cancer Human Cell Lines Combined with Photon Therapy Scientific Reports. Sep, 2017 | Pubmed ID: 28939847 Gadolinium-based Nanoparticles As Sensitizing Agents to Carbon Ions in Head and Neck Tumor Cells Nanomedicine : Nanotechnology, Biology, and Medicine. Nov, 2017 | Pubmed ID: 28779947 Non-invasive Prediction of Recurrence in Bladder Cancer by Detecting Somatic TERT Promoter Mutations in Urine British Journal of Cancer. Aug, 2017 | Pubmed ID: 28683471 Differential Pattern of HIF-1α Expression in HNSCC Cancer Stem Cells After Carbon Ion or Photon Irradiation: One Molecular Explanation of the Oxygen Effect British Journal of Cancer. May, 2017 | Pubmed ID: 28407653 Preclinical Models in HNSCC: A Comprehensive Review Oral Oncology. Feb, 2017 | Pubmed ID: 28109468 EVESOR, a Model-based, Multiparameter, Phase I Trial to Optimize the Benefit/toxicity Ratio of Everolimus and Sorafenib Future Oncology (London, England). Apr, 2017 | Pubmed ID: 28076966 Corrigendum: Influence of Dose Rate on the Cellular Response to Low- and High-LET Radiations Frontiers in Oncology. 2016 | Pubmed ID: 28105406 Immunotherapy in Head and Neck Cancer: Harnessing Profit on a System Disruption Oral Oncology. Nov, 2016 | Pubmed ID: 27623508 Carbon Ion Irradiation Withstands Cancer Stem Cells' Migration/invasion Process in Head and Neck Squamous Cell Carcinoma (HNSCC) Oncotarget. Jul, 2016 | Pubmed ID: 27374096 MiR-422a Promotes Loco-regional Recurrence by Targeting NT5E/CD73 in Head and Neck Squamous Cell Carcinoma Oncotarget. Jul, 2016 | Pubmed ID: 27281619 Influence of Dose Rate on the Cellular Response to Low- and High-LET Radiations Frontiers in Oncology. 2016 | Pubmed ID: 27014633 Nanoparticles in Radiation Oncology: From Bench-side to Bedside Cancer Letters. Jun, 2016 | Pubmed ID: 26987625 Preferential Targeting of Cancer Stem Cells in the Radiosensitizing Effect of ABT-737 on HNSCC Oncotarget. Feb, 2016 | Pubmed ID: 26934442 Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases: Proof of Concept Before Phase I Trial Theranostics. 2016 | Pubmed ID: 26909115 Targeting Head and Neck Tumoral Stem Cells: From Biological Aspects to Therapeutic Perspectives World Journal of Stem Cells. Jan, 2016 | Pubmed ID: 26839637 [Radiosensitivity And/or Radioresistance of Head and Neck Cancers: Biological Angle] Bulletin Du Cancer. Jan, 2016 | Pubmed ID: 26702507 [Cancer Stem Cells: Radiotherapeutic Features and Therapeutic Targets] Bulletin Du Cancer. Jan, 2016 | Pubmed ID: 26702506 Telomerase Inhibition Improves Tumor Response to Radiotherapy in a Murine Orthotopic Model of Human Glioblastoma Molecular Cancer. 2015 | Pubmed ID: 26183089 Multiparameter Phase I Trials: a Tool for Model-based Development of Targeted Agent Combinations--example of EVESOR Trial Future Oncology (London, England). 2015 | Pubmed ID: 25963428 Cellular and Molecular Portrait of Eleven Human Glioblastoma Cell Lines Under Photon and Carbon Ion Irradiation Cancer Letters. Apr, 2015 | Pubmed ID: 25657111 Combining Ultrasmall Gadolinium-based Nanoparticles with Photon Irradiation Overcomes Radioresistance of Head and Neck Squamous Cell Carcinoma Nanomedicine : Nanotechnology, Biology, and Medicine. Jan, 2015 | Pubmed ID: 24983891 [Radiation-induces Increased Tumor Cell Aggressiveness of Tumors of the Glioblastomas?] Bulletin Du Cancer. Sep, 2014 | Pubmed ID: 25296414 Radiation-enhanced Cell Migration/invasion Process: a Review Critical Reviews in Oncology/hematology. Nov, 2014 | Pubmed ID: 24908570 Microarray Gene Expression Profiling and Analysis of Bladder Cancer Supports the Sub Classification of the T1 Tumours in T1a and T1b Stages BJU International. Jul, 2013 | Pubmed ID: 24053469 PCA3 and PCA3-based Nomograms Improve Diagnostic Accuracy in Patients Undergoing First Prostate Biopsy International Journal of Molecular Sciences. 2013 | Pubmed ID: 23994838 Targeting Head and Neck Cancer Stem Cells to Overcome Resistance to Photon and Carbon Ion Radiation Stem Cell Reviews. Aug, 2013 | Pubmed ID: 23955575 P53-independent Early and Late Apoptosis is Mediated by Ceramide After Exposure of Tumor Cells to Photon or Carbon Ion Irradiation BMC Cancer. 2013 | Pubmed ID: 23530619 Intraperitoneal Cytokine Level in Patients with Peritoneal Surface Malignancies. A Study of the RENAPE (French Network for Rare Peritoneal Malignancies) Annals of Surgical Oncology. Aug, 2013 | Pubmed ID: 23519518 Impact of Hyperthermic Intraperitoneal Chemotherapy on Hsp27 Protein Expression in Serum of Patients with Peritoneal Carcinomatosis Cell Stress & Chaperones. Sep, 2013 | Pubmed ID: 23508575 Telomere Profiling: Toward Glioblastoma Personalized Medicine Molecular Neurobiology. Feb, 2013 | Pubmed ID: 23065374 Internalization Pathways into Cancer Cells of Gadolinium-based Radiosensitizing Nanoparticles Biomaterials. Jan, 2013 | Pubmed ID: 23046756 [Cancer Stem Cells, Cornerstone of Radioresistance and Perspectives for Radiosensitization: Glioblastoma As an Example] Bulletin Du Cancer. Dec, 2012 | Pubmed ID: 23228708 Glutathione Depletion and Carbon Ion Radiation Potentiate Clustered DNA Lesions, Cell Death and Prevent Chromosomal Changes in Cancer Cells Progeny PloS One. 2012 | Pubmed ID: 23185232 Targeting a Cornerstone of Radiation Resistance: Cancer Stem Cell Cancer Letters. Sep, 2012 | Pubmed ID: 22459349 Chronic Prostatitis Does Not Influence Urinary PCA3 Score The Prostate. Apr, 2012 | Pubmed ID: 21761426 DNA Double-strand Breaks Induced by Mammographic Screening Procedures in Human Mammary Epithelial Cells International Journal of Radiation Biology. Nov, 2011 | Pubmed ID: 21797809 [Value of PCA3 Urinary Test for Prostate Biopsy Decision: the Lyon-Sud University Hospital Experience] Annales De Biologie Clinique. Jan-Feb, 2011 | Pubmed ID: 21463993 Urinary PCA3 Score Predicts Prostate Cancer Multifocality The Journal of Urology. Apr, 2011 | Pubmed ID: 21334023 Transient Alteration of Cellular Redox Buffering Before Irradiation Triggers Apoptosis in Head and Neck Carcinoma Stem and Non-stem Cells PloS One. 2011 | Pubmed ID: 21283807 [Microsatellite Markers and Methylation of Promoters of Tumour Suppressor Genes in Bladder Cancer] Annales De Pathologie. Nov, 2010 | Pubmed ID: 21055568 Prevalence and Spectrum of Mutations in a Cohort of 192 Unrelated Patients with Hypertrophic Cardiomyopathy European Journal of Medical Genetics. Sep-Oct, 2010 | Pubmed ID: 20624503 Quantitative Loss of Heterozygosity Analysis for Urothelial Carcinoma Detection and Prognosis Urology. Aug, 2010 | Pubmed ID: 20206968 Heat Shock Protein 27 As a New Therapeutic Target for Radiation Sensitization of Head and Neck Squamous Cell Carcinoma Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2009 | Pubmed ID: 19436268 Different Mechanisms of Cell Death in Radiosensitive and Radioresistant P53 Mutated Head and Neck Squamous Cell Carcinoma Cell Lines Exposed to Carbon Ions and X-rays International Journal of Radiation Oncology, Biology, Physics. May, 2009 | Pubmed ID: 19362238 Contribution of Long-QT Syndrome Genetic Variants in Sudden Infant Death Syndrome Pediatric Cardiology. May, 2009 | Pubmed ID: 19322600 Biophysical Characterization of a New SCN5A Mutation S1333Y in a SIDS Infant Linked to Long QT Syndrome FEBS Letters. Mar, 2009 | Pubmed ID: 19302788 Diversity and Complexity of Ceramide Generation After Exposure of Jurkat Leukemia Cells to Irradiation International Journal of Radiation Oncology, Biology, Physics. Mar, 2009 | Pubmed ID: 19251092 Rapid, Sensitive and Inexpensive Detection of SCN5A Genetic Variations by High Resolution Melting Analysis Clinical Biochemistry. Apr, 2009 | Pubmed ID: 19026623 A New C-terminal HERG Mutation A915fs+47X Associated with Symptomatic LQT2 and Auditory-trigger Syncope Heart Rhythm : the Official Journal of the Heart Rhythm Society. Nov, 2008 | Pubmed ID: 18984536 Radiobiologic Parameters and Local Effect Model Predictions for Head-and-neck Squamous Cell Carcinomas Exposed to High Linear Energy Transfer Ions International Journal of Radiation Oncology, Biology, Physics. Jun, 2008 | Pubmed ID: 18234427 Differential Regulation of Cell Death in Head and Neck Cell Carcinoma Through Alteration of Cholesterol Levels in Lipid Rafts Microdomains Biochemical Pharmacology. Feb, 2008 | Pubmed ID: 17996216 Protective Role of Hsp27 Protein Against Gamma Radiation-induced Apoptosis and Radiosensitization Effects of Hsp27 Gene Silencing in Different Human Tumor Cells International Journal of Radiation Oncology, Biology, Physics. Feb, 2008 | Pubmed ID: 17980509 Radioresistance of Human Carcinoma Cells is Correlated to a Defect in Raft Membrane Clustering Free Radical Biology & Medicine. Sep, 2007 | Pubmed ID: 17664132 Spatiotemporal Electrocardiographic Characterization of Ventricular Depolarization and Repolarization Abnormalities in Long QT Syndrome Journal of Electrocardiology. Oct, 2007 | Pubmed ID: 17316676 Torsades De Pointes Complicating Atrioventricular Block: Evidence for a Genetic Predisposition Heart Rhythm : the Official Journal of the Heart Rhythm Society. Feb, 2007 | Pubmed ID: 17275752 Plasma BNP and NT-proBNP Assays by Automated Immunoanalyzers: Analytical and Clinical Study Annals of Clinical and Laboratory Science. 2006 | Pubmed ID: 16951271 Prevalence of Drug-induced Electrocardiographic Pattern of the Brugada Syndrome in a Healthy Population The American Journal of Cardiology. Jul, 2004 | Pubmed ID: 15246910 Subcellular Compartmentalization of Ceramide Metabolism: MAM (mitochondria-associated Membrane) And/or Mitochondria? The Biochemical Journal. Sep, 2004 | Pubmed ID: 15144238 Overcoming Resistance to Gamma-rays in Squamous Carcinoma Cells by Poly-drug Elevation of Ceramide Levels Oncogene. Apr, 2004 | Pubmed ID: 15048093 Increasing Endogenous Ceramide Using Inhibitors of Sphingolipid Metabolism Maximizes Ionizing Radiation-induced Mitochondrial Injury and Apoptotic Cell Killing International Journal of Cancer. Journal International Du Cancer. Oct, 2002 | Pubmed ID: 12237902 Caractérisation semi-automatique De MD-L1 et recensement des cellules tumorales circulantes de patients atteints d'immunofluorescence Jessica Garcia1,2,3, David Barthelemy1,2,3, Florence Geiguer1,2, Julie Ballandier1,2,3, Kathryn W. Li4, Jean-Phillippe Aurel4, Frédérique Le Breton5, Claire Rodriguez-Lafrasse1, Brigitte Manship3, Sébastien Couraud6,7, Léa Payen1,2,3 1Laboratoire de Biochimie et Biologie Moléculaire, Groupe Hospitalier Sud, Hospices Civils de Lyon, 2Circulating Cancer (CIRCAN) Program, Hospices Civils de Lyon Cancer Institute, 3University of Lyon, Claude Bernard University, Cancer Research Center of Lyon, 4Biolidics Limited, 5Institut de Pathologie Multisites des HCL-Site Sud, Hospices Civils de Lyon, 6Acute Respiratory Disease and Thoracic Oncology Department, Lyon Sud Hospital, Hospices Civils de Lyon Cancer Institute, 7EMR-3738 Therapeutic Targeting in Oncology, Lyon Sud Medical Faculty, Lyon 1 University JoVE 59873 Cancer Research Évaluation de l’Invasion des cellules et le processus de Migration : une comparaison de la rayure axée sur le Microscope vidéo blessure test et le test de chambre de Boyden Jean-Baptiste Guy*1,2, Sophie Espenel*1,2, Alexis Vallard1,2, Priscillia Battiston-Montagne1, Anne-Sophie Wozny1,3, Dominique Ardail1,3, Gersende Alphonse1,3, Chloé Rancoule1,2, Claire Rodriguez-Lafrasse1,3, Nicolas Magne1,2 1UMR CNRS 5822 /IN2P3, IPNL, PRISME, Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon-Sud, Université Lyon 1, 2Département de Radiothérapie, Institut de Cancérologie de la Loire - Lucien Neuwirth, 3Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud JoVE 56337 Cancer Research Isolement et caractérisation d'une tête et du cou squameux Carcinome Sous-population Ayant les cellules souches Caractéristiques Marion Gilormini1, Anne-Sophie Wozny1,2, Priscillia Battiston-Montagne1, Dominique Ardail1,2, Gersende Alphonse1,2, Claire Rodriguez-Lafrasse1,2 1UCBL1, UMR/CNRS 5822, Laboratoire de Radiobiologie Cellulaire Moléculaire, Université de Lyon, 2Hospices-Civils-de-Lyon, Centre Hospitalier Lyon-Sud Medicine Identification à base de microréseaux de HERV individuelle Loci Expression: Demande de Découverte de biomarqueurs dans le cancer de la prostate Philippe Pérot1,2, Valérie Cheynet1,2, Myriam Decaussin-Petrucci1,3,4, Guy Oriol1,2, Nathalie Mugnier5, Claire Rodriguez-Lafrasse1,4,6, Alain Ruffion1,4,7, François Mallet1,2 1Joint Unit Hospices de Lyon-bioMérieux, 2Medical Diagnostic Discovery Department, BioMérieux, 3Department of Pathology and Cytology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 4Medical Faculty, Lyon 1 University, 5Data and Knowledge Laboratory, BioMérieux, 6Department of Biochemistry and Molecular Biology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 7Department of Urology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon JoVE 50713 Medicine
Caractérisation semi-automatique De MD-L1 et recensement des cellules tumorales circulantes de patients atteints d'immunofluorescence Jessica Garcia1,2,3, David Barthelemy1,2,3, Florence Geiguer1,2, Julie Ballandier1,2,3, Kathryn W. Li4, Jean-Phillippe Aurel4, Frédérique Le Breton5, Claire Rodriguez-Lafrasse1, Brigitte Manship3, Sébastien Couraud6,7, Léa Payen1,2,3 1Laboratoire de Biochimie et Biologie Moléculaire, Groupe Hospitalier Sud, Hospices Civils de Lyon, 2Circulating Cancer (CIRCAN) Program, Hospices Civils de Lyon Cancer Institute, 3University of Lyon, Claude Bernard University, Cancer Research Center of Lyon, 4Biolidics Limited, 5Institut de Pathologie Multisites des HCL-Site Sud, Hospices Civils de Lyon, 6Acute Respiratory Disease and Thoracic Oncology Department, Lyon Sud Hospital, Hospices Civils de Lyon Cancer Institute, 7EMR-3738 Therapeutic Targeting in Oncology, Lyon Sud Medical Faculty, Lyon 1 University JoVE 59873 Cancer Research
Évaluation de l’Invasion des cellules et le processus de Migration : une comparaison de la rayure axée sur le Microscope vidéo blessure test et le test de chambre de Boyden Jean-Baptiste Guy*1,2, Sophie Espenel*1,2, Alexis Vallard1,2, Priscillia Battiston-Montagne1, Anne-Sophie Wozny1,3, Dominique Ardail1,3, Gersende Alphonse1,3, Chloé Rancoule1,2, Claire Rodriguez-Lafrasse1,3, Nicolas Magne1,2 1UMR CNRS 5822 /IN2P3, IPNL, PRISME, Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon-Sud, Université Lyon 1, 2Département de Radiothérapie, Institut de Cancérologie de la Loire - Lucien Neuwirth, 3Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud JoVE 56337 Cancer Research
Isolement et caractérisation d'une tête et du cou squameux Carcinome Sous-population Ayant les cellules souches Caractéristiques Marion Gilormini1, Anne-Sophie Wozny1,2, Priscillia Battiston-Montagne1, Dominique Ardail1,2, Gersende Alphonse1,2, Claire Rodriguez-Lafrasse1,2 1UCBL1, UMR/CNRS 5822, Laboratoire de Radiobiologie Cellulaire Moléculaire, Université de Lyon, 2Hospices-Civils-de-Lyon, Centre Hospitalier Lyon-Sud Medicine
Identification à base de microréseaux de HERV individuelle Loci Expression: Demande de Découverte de biomarqueurs dans le cancer de la prostate Philippe Pérot1,2, Valérie Cheynet1,2, Myriam Decaussin-Petrucci1,3,4, Guy Oriol1,2, Nathalie Mugnier5, Claire Rodriguez-Lafrasse1,4,6, Alain Ruffion1,4,7, François Mallet1,2 1Joint Unit Hospices de Lyon-bioMérieux, 2Medical Diagnostic Discovery Department, BioMérieux, 3Department of Pathology and Cytology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 4Medical Faculty, Lyon 1 University, 5Data and Knowledge Laboratory, BioMérieux, 6Department of Biochemistry and Molecular Biology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 7Department of Urology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon JoVE 50713 Medicine
