Cleo Kontoravdi Chemical Engineering Imperial College London Biography Publications Institution JoVE Articles Cleo Kontoravdi Cleo Kontoravdi holds M.Eng. and Ph.D. degrees in Chemical Engineering from Imperial College London. After working as a R&D Scientist at Lonza Biologics she re-joined the Department of Chemical Engineering at Imperial College London, where she is now a Professor of Biological Systems Engineering. Publications Immunoglobulin G N-glycan Biomarkers for Autoimmune Diseases: Current State and a Glycoinformatics Perspective International Journal of Molecular Sciences. May, 2022 | Pubmed ID: 35563570 Quality by Design for Enabling RNA Platform Production Processes Trends in Biotechnology. Apr, 2022 | Pubmed ID: 35491266 Population Balance Modelling Captures Host Cell Protein Dynamics in CHO Cell Cultures PloS One. Month, 2022 | Pubmed ID: 35320326 Polymer Encapsulation of Bacterial Biosensors Enables Coculture with Mammalian Cells ACS Synthetic Biology. 03, 2022 | Pubmed ID: 35245022 Pandemic-response Adenoviral Vector and RNA Vaccine Manufacturing NPJ Vaccines. Mar, 2022 | Pubmed ID: 35236838 Rapid Antibody Glycoengineering in CHO Cells Via RNA Interference and CGE-LIF N-Glycomics Methods in Molecular Biology (Clifton, N.J.). Month, 2022 | Pubmed ID: 34611868 Model-Based Planning and Delivery of Mass Vaccination Campaigns Against Infectious Disease: Application to the COVID-19 Pandemic in the UK Vaccines. Dec, 2021 | Pubmed ID: 34960206 Model Identifies Genetic Predisposition of Alzheimer's Disease As Key Decider in Cell Susceptibility to Stress International Journal of Molecular Sciences. Nov, 2021 | Pubmed ID: 34769426 Cell-free Protein Synthesis Using Chinese Hamster Ovary Cells Methods in Enzymology. Month, 2021 | Pubmed ID: 34752298 Hitting the Sweet Spot with Capillary Electrophoresis: Advances in N-glycomics and Glycoproteomics Current Opinion in Biotechnology. 10, 2021 | Pubmed ID: 34438131 An Experimental Approach Probing the Conformational Transitions and Energy Landscape of Antibodies: a Glimmer of Hope for Reviving Lost Therapeutic Candidates Using Ionic Liquid Chemical Science. Jul, 2021 | Pubmed ID: 34349928 Quality by Design Modelling to Support Rapid RNA Vaccine Production Against Emerging Infectious Diseases NPJ Vaccines. Apr, 2021 | Pubmed ID: 33927197 Osmolality Effects on CHO Cell Growth, Cell Volume, Antibody Productivity and Glycosylation International Journal of Molecular Sciences. Mar, 2021 | Pubmed ID: 33804825 Correction: Kis, Z. Et Al. Resources, Production Scales and Time Required for Producing RNA Vaccines for the Global Pandemic Demand. 2021, , 3 Vaccines. Mar, 2021 | Pubmed ID: 33804590 Glycoengineering Chinese Hamster Ovary Cells: a Short History Biochemical Society Transactions. 04, 2021 | Pubmed ID: 33704400 Rapid Development and Deployment of High-volume Vaccines for Pandemic Response Journal of Advanced Manufacturing and Processing. Jul, 2020 | Pubmed ID: 33977274 Design, Development and Optimization of a Functional Mammalian Cell-Free Protein Synthesis Platform Frontiers in Bioengineering and Biotechnology. Month, 2020 | Pubmed ID: 33604330 Resources, Production Scales and Time Required for Producing RNA Vaccines for the Global Pandemic Demand Vaccines. Dec, 2020 | Pubmed ID: 33374802 The Era of Big Data: Genome-scale Modelling Meets Machine Learning Computational and Structural Biotechnology Journal. Month, 2020 | Pubmed ID: 33240470 High Resolution Biosensor to Test the Capping Level and Integrity of MRNAs Nucleic Acids Research. 12, 2020 | Pubmed ID: 33152073 Harnessing the Potential of Artificial Neural Networks for Predicting Protein Glycosylation Metabolic Engineering Communications. Jun, 2020 | Pubmed ID: 32489858 Low-cost and User-friendly Biosensor to Test the Integrity of MRNA Molecules Suitable for Field Applications Biosensors & Bioelectronics. Jul, 2019 | Pubmed ID: 31100599 Model-based Optimization of Antibody Galactosylation in CHO Cell Culture Biotechnology and Bioengineering. 07, 2019 | Pubmed ID: 30802295 Emerging Technologies for Low-Cost, Rapid Vaccine Manufacture Biotechnology Journal. Jan, 2019 | Pubmed ID: 30537361 Host Cell Protein Removal from Biopharmaceutical Preparations: Towards the Implementation of Quality by Design Biotechnology Advances. Jul - Aug, 2018 | Pubmed ID: 29654903 Mild Hypothermic Culture Conditions Affect Residual Host Cell Protein Composition Post-Protein A Chromatography MAbs. 04, 2018 | Pubmed ID: 29381421 Exploring Cellular Behavior Under Transient Gene Expression and Its Impact on MAb Productivity and Fc-glycosylation Biotechnology and Bioengineering. 02, 2018 | Pubmed ID: 28921534 Cascading Effect in Bioprocessing-The Impact of Mild Hypothermia on CHO Cell Behavior and Host Cell Protein Composition Biotechnology and Bioengineering. 12, 2017 | Pubmed ID: 28843000 Whole-cell Escherichia Coli Lactate Biosensor for Monitoring Mammalian Cell Cultures During Biopharmaceutical Production Biotechnology and Bioengineering. 06, 2017 | Pubmed ID: 28112405 Model-based Investigation of Intracellular Processes Determining Antibody Fc-glycosylation Under Mild Hypothermia Biotechnology and Bioengineering. 07, 2017 | Pubmed ID: 27869292 A Theoretical Estimate for Nucleotide Sugar Demand Towards Chinese Hamster Ovary Cellular Glycosylation Scientific Reports. 06, 2016 | Pubmed ID: 27345611 Modelling of Amorphous Cellulose Depolymerisation by Cellulases, Parametric Studies and Optimisation Biochemical Engineering Journal. Jan, 2016 | Pubmed ID: 26865832 Advances in the Development of Biotherapeutics BioMed Research International. Month, 2015 | Pubmed ID: 26078963 A Multi-pronged Investigation into the Effect of Glucose Starvation and Culture Duration on Fed-batch CHO Cell Culture Biotechnology and Bioengineering. Oct, 2015 | Pubmed ID: 25899530 How Does Mild Hypothermia Affect Monoclonal Antibody Glycosylation? Biotechnology and Bioengineering. Jun, 2015 | Pubmed ID: 25545631 Genetically-encoded Biosensors for Monitoring Cellular Stress in Bioprocessing Current Opinion in Biotechnology. Feb, 2015 | Pubmed ID: 25151059 A Framework for the Systematic Design of Fed-batch Strategies in Mammalian Cell Culture Biotechnology and Bioengineering. Dec, 2014 | Pubmed ID: 24975682 Towards Controlling the Glycoform: a Model Framework Linking Extracellular Metabolites to Antibody Glycosylation International Journal of Molecular Sciences. Mar, 2014 | Pubmed ID: 24637934 Analysis of Chinese Hamster Ovary Cell Metabolism Through a Combined Computational and Experimental Approach Cytotechnology. Nov, 2013 | Pubmed ID: 24292563 Comparative Analysis of Amino Acid Metabolism and Transport in CHO Variants with Different Levels of Productivity Journal of Biotechnology. Dec, 2013 | Pubmed ID: 24056080 An Optimized Method for Extraction and Quantification of Nucleotides and Nucleotide Sugars from Mammalian Cells Analytical Biochemistry. Sep, 2013 | Pubmed ID: 24036437 Systematic Methodology for the Development of Mathematical Models for Biological Processes Methods in Molecular Biology (Clifton, N.J.). Month, 2013 | Pubmed ID: 23996448 A Systems Biology Approach to Optimising Hosts for Industrial Protein Production Biotechnology Letters. Dec, 2013 | Pubmed ID: 23892981 Integration of Models and Experimentation to Optimise the Production of Potential Biotherapeutics Drug Discovery Today. Dec, 2013 | Pubmed ID: 23850703 Analysis of the Landscape of Biologically-derived Pharmaceuticals in Europe: Dominant Production Systems, Molecule Types on the Rise and Approval Trends European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Dec, 2012 | Pubmed ID: 23262060 In Situ Monitoring of Intracellular Glucose and Glutamine in CHO Cell Culture PloS One. Month, 2012 | Pubmed ID: 22509313 The Role of ER Stress-induced Apoptosis in Neurodegeneration Current Alzheimer Research. Mar, 2012 | Pubmed ID: 22299619 Genome-based Kinetic Modeling of Cytosolic Glucose Metabolism in Industrially Relevant Cell Lines: Saccharomyces Cerevisiae and Chinese Hamster Ovary Cells Bioprocess and Biosystems Engineering. Aug, 2012 | Pubmed ID: 22286123 Metabolic Network Reconstruction: Advances in in Silico Interpretation of Analytical Information Current Opinion in Biotechnology. Feb, 2012 | Pubmed ID: 22119273 Quantification of Intracellular Nucleotide Sugars and Formulation of a Mathematical Model for Prediction of Their Metabolism BMC Proceedings. Nov, 2011 | Pubmed ID: 22373482 A Dynamic Mathematical Model for Monoclonal Antibody N-linked Glycosylation and Nucleotide Sugar Donor Transport Within a Maturing Golgi Apparatus Biotechnology Progress. Nov-Dec, 2011 | Pubmed ID: 21956887 Towards the Implementation of Quality by Design to the Production of Therapeutic Monoclonal Antibodies with Desired Glycosylation Patterns Biotechnology Progress. Nov-Dec, 2010 | Pubmed ID: 20665659 Modeling Amino Acid Metabolism in Mammalian Cells-toward the Development of a Model Library Biotechnology Progress. Nov-Dec, 2007 | Pubmed ID: 17949105 Application of Global Sensitivity Analysis to Determine Goals for Design of Experiments: an Example Study on Antibody-producing Cell Cultures Biotechnology Progress. Jul-Aug, 2005 | Pubmed ID: 16080692 Glicoengenia de anticorpos rápidos em células de ovário de hamster chinês Masue Marbiah*1,2, Pavlos Kotidis*1,3, Roberto Donini1,4, Itzcóatl A. Gómez5, Ioscani Jimenez del Val5, Stuart M. Haslam4, Karen M. Polizzi1,2, Cleo Kontoravdi1 1Department of Chemical Engineering, Imperial College London, 2Imperial College Centre for Synthetic Biology, Imperial College London, 3BioPharm Process Research, GlaxoSmithKline Research and Development, 4Department of Life Science, Imperial College London, 5School of Chemical & Bioprocess Engineering, University College Dublin JoVE 63872 Bioengineering FIBS habilitado Noninvasive Metabolic Profiling Alireza Behjousiar1,2, Antony Constantinou2, Karen M. Polizzi2, Cleo Kontoravdi1 1Centre for Process Systems Engineering, Department of Chemical Engineering and Chemical Technology, Imperial College London, 2Centre for Synthetic Biology and Innovation, Division of Molecular Biosciences, Imperial College London JoVE 51200 Bioengineering
Glicoengenia de anticorpos rápidos em células de ovário de hamster chinês Masue Marbiah*1,2, Pavlos Kotidis*1,3, Roberto Donini1,4, Itzcóatl A. Gómez5, Ioscani Jimenez del Val5, Stuart M. Haslam4, Karen M. Polizzi1,2, Cleo Kontoravdi1 1Department of Chemical Engineering, Imperial College London, 2Imperial College Centre for Synthetic Biology, Imperial College London, 3BioPharm Process Research, GlaxoSmithKline Research and Development, 4Department of Life Science, Imperial College London, 5School of Chemical & Bioprocess Engineering, University College Dublin JoVE 63872 Bioengineering
FIBS habilitado Noninvasive Metabolic Profiling Alireza Behjousiar1,2, Antony Constantinou2, Karen M. Polizzi2, Cleo Kontoravdi1 1Centre for Process Systems Engineering, Department of Chemical Engineering and Chemical Technology, Imperial College London, 2Centre for Synthetic Biology and Innovation, Division of Molecular Biosciences, Imperial College London JoVE 51200 Bioengineering
