David D. Y. Chen Department of Chemistry University of British Columbia Biography Publications Institution JoVE Articles David D. Y. Chen has not added a biography. If you are David D. Y. Chen and would like to personalize this page please email our Author Liaison for assistance. Publications Quantitative Characterization of Human Oncogene Promoter G-quadruplex DNA-ligand Interactions Using a Combination of Mass Spectrometry and Capillary Electrophoresis Electrophoresis. May, 2021 | Pubmed ID: 33990994 Data-driven Development of Liquid Chromatography-mass Spectrometry Methods for Combined Sample Matrices Talanta. Mar, 2021 | Pubmed ID: 33379089 Combining Online Size Exclusion Chromatography and Electrospray Ionization Mass Spectrometry to Characterize Plant Polysaccharides Carbohydrate Polymers. Oct, 2020 | Pubmed ID: 32747250 Enantioselective Analysis in Complex Matrices Using Capillary Electrophoresis-mass Spectrometry: A Case Study of the Botanical Drug Corydalis Rhizoma Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Sep, 2020 | Pubmed ID: 32531643 Rapid Determination of Chemical Composition in the Particulate Matter of Cigarette Mainstream Smoke Talanta. Sep, 2020 | Pubmed ID: 32498828 Highly Efficient Enrichment of N-glycopeptides by Two-dimensional Hf-based Metal-organic Framework Nanosheets The Analyst. Jul, 2020 | Pubmed ID: 32441734 A Hydrophilic Two-dimensional Titanium-based Metal-organic Framework Nanosheets for Specific Enrichment of Glycopeptides Analytica Chimica Acta. Jul, 2020 | Pubmed ID: 32439055 Dynamic PH Barrage Junction Focusing of Amino Acids, Peptides, and Digested Monoclonal Antibodies in Capillary Electrophoresis-mass Spectrometry Electrophoresis. 11, 2020 | Pubmed ID: 32436592 Complementary Methods for De Novo Monoclonal Antibody Sequencing to Achieve Complete Sequence Coverage Journal of Proteome Research. 07, 2020 | Pubmed ID: 32338916 Determination of Urinary Prostaglandin E As a Potential Biomarker of Ureteral Stent Associated Inflammation Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. May, 2020 | Pubmed ID: 32315976 Characterization of Interaction Between Bcl-2 Oncogene Promoter I-Motif DNA and Flavonoids Using Electrospray Ionization Mass Spectrometry and Pressure-assisted Capillary Electrophoresis Frontal Analysis Talanta. Aug, 2020 | Pubmed ID: 32312433 Bottom-up Proteomics of Envelope Proteins Extracted from Spinach Chloroplast Via High Organic Content CE-MS Electrophoresis. 03, 2020 | Pubmed ID: 31994203 Application of Multisegment Injection on Quantification of Creatinine and Standard Addition Analysis of Urinary 5-hydroxyindoleacetic Acid Simultaneously with Creatinine Normalization Electrophoresis. 02, 2020 | Pubmed ID: 31850545 Sorbent and Solvent Co-enhanced Direct Analysis in Real Time-mass Spectrometry for High-throughput Determination of Trace Pollutants in Water Talanta. Feb, 2020 | Pubmed ID: 31816783 MALDI-imaging of Early Stage Xenopus Laevis Embryos Talanta. Nov, 2019 | Pubmed ID: 31357275 Solvent-free High-throughput Analysis of Herbicides in Environmental Water Analytica Chimica Acta. Sep, 2019 | Pubmed ID: 31128759 Evaluation of the Binding of Natural Products with Thrombin Binding Aptamer G-quadruplex Using Electrospray Ionization Mass Spectrometry and Spectroscopic Methods Talanta. Aug, 2019 | Pubmed ID: 31036205 Magnetic Nanoparticles Speed Up Mechanochemical Solid Phase Extraction with Enhanced Enrichment Capability for Organochlorines in Plants Analytica Chimica Acta. Aug, 2019 | Pubmed ID: 31027534 Quantitative Analysis of Microcystin Variants by Capillary Electrophoresis Mass Spectrometry with Dynamic PH Barrage Junction Focusing Electrophoresis. 09, 2019 | Pubmed ID: 30924152 Simultaneous Determination of Multiple Components in Cigarettes by Mechanochemical Extraction and Direct Analysis in Real Time Mass Spectrometry in Minutes Analytica Chimica Acta. May, 2019 | Pubmed ID: 30832920 Differential Hydrogen/Deuterium Exchange During Proteoform Separation Enables Characterization of Conformational Differences Between Coexisting Protein States Analytical Chemistry. 03, 2019 | Pubmed ID: 30830762 Mass Spectrometry and Affinity Capillary Electrophoresis for Characterization of Host-guest Interactions Journal of Chromatography. A. Mar, 2019 | Pubmed ID: 30686647 RawTools: Rapid and Dynamic Interrogation of Orbitrap Data Files for Mass Spectrometer System Management Journal of Proteome Research. 02, 2019 | Pubmed ID: 30462513 Optimization of Dynamic PH Barrage Junction Focusing for Weakly Alkaline or Zwitterionic Analytes in Capillary Electrophoresis Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Sep, 2018 | Pubmed ID: 30056269 Electrochemical Detection of Microcystin-LR Based on Its Deleterious Effect on DNA Talanta. Aug, 2018 | Pubmed ID: 29759219 Pressure-assisted Capillary Electrophoresis Frontal Analysis for Faster Binding Constant Determination Electrophoresis. Apr, 2018 | Pubmed ID: 29700847 Parsing and Quantification of Raw Orbitrap Mass Spectrometer Data Using RawQuant Journal of Proteome Research. 06, 2018 | Pubmed ID: 29682972 Characterization of Plant Polysaccharides from Dendrobium Officinale by Multiple Chromatographic and Mass Spectrometric Techniques Journal of Chromatography. A. Apr, 2018 | Pubmed ID: 29555359 Characterization of Athabasca Lean Oil Sands and Mixed Surficial Materials: Comparison of Capillary Electrophoresis/low-resolution Mass Spectrometry and High-resolution Mass Spectrometry Rapid Communications in Mass Spectrometry : RCM. May, 2018 | Pubmed ID: 29486520 Deducing Disulfide Patterns of Cysteine-rich Proteins Using Signature Fragments Produced by Top-down Mass Spectrometry The Analyst. Feb, 2018 | Pubmed ID: 29362732 Capillary Electrophoresis-mass Spectrometry for Targeted and Untargeted Analysis of the Sub-5 kDa Urine Metabolome of Patients with Prostate or Bladder Cancer: A Feasibility Study Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Feb, 2018 | Pubmed ID: 29334632 Nonaqueous Capillary Electrophoresis Mass Spectrometry Method for Determining Highly Hydrophobic Peptides Electrophoresis. 05, 2018 | Pubmed ID: 28990192 High Throughput Screening of Phenoxy Carboxylic Acids with Dispersive Solid Phase Extraction Followed by Direct Analysis in Real Time Mass Spectrometry Analytica Chimica Acta. Dec, 2017 | Pubmed ID: 29137704 Review of Recent Developments in Determining Volatile Organic Compounds in Exhaled Breath As Biomarkers for Lung Cancer Diagnosis Analytica Chimica Acta. Dec, 2017 | Pubmed ID: 29137702 Different in Vitro Cellular Responses to Tamoxifen Treatment in Polydimethylsiloxane-based Devices Compared to Normal Cell Culture Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Nov, 2017 | Pubmed ID: 29073477 Characterization of Dicarboxylic Naphthenic Acid Fraction Compounds Utilizing Amide Derivatization: Proof of Concept Rapid Communications in Mass Spectrometry : RCM. Dec, 2017 | Pubmed ID: 28944977 Abnormal Pinocytosis and Valence-variable Behaviors of Cerium Suggested a Cellular Mechanism for Plant Yield Reduction Induced by Environmental Cerium Environmental Pollution (Barking, Essex : 1987). Nov, 2017 | Pubmed ID: 28738302 A Preliminary Study on the Effects of Lanthanum (III) on Plant Vitronectin-like Protein and Its Toxicological Basis Ecotoxicology and Environmental Safety. Nov, 2017 | Pubmed ID: 28738206 Electroosmotic Flow Dispersion of Large Molecules in Electrokinetic Migration Analytical Chemistry. 08, 2017 | Pubmed ID: 28699728 Mobility-based Correction for Accurate Determination of Binding Constants by Capillary Electrophoresis-frontal Analysis Electrophoresis. 06, 2017 | Pubmed ID: 28247914 Quantitative Nonaqueous Capillary Electrophoresis-Mass Spectrometry Method for Determining Active Ingredients in Plant Extracts Analytical Chemistry. 02, 2017 | Pubmed ID: 28208307 Potential of Capillary Electrophoresis Mass Spectrometry for the Characterization and Monitoring of Amine-derivatized Naphthenic Acids from Oil Sands Process-affected Water Journal of Environmental Sciences (China). Nov, 2016 | Pubmed ID: 28007176 Separation of Recombinant Therapeutic Proteins Using Capillary Gel Electrophoresis and Capillary Isoelectric Focusing Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 27473487 Responses of Plant Calmodulin to Endocytosis Induced by Rare Earth Elements Chemosphere. Jul, 2016 | Pubmed ID: 27081794 Capture Efficiency of Dynamic PH Junction Focusing in Capillary Electrophoresis Electrophoresis. 05, 2016 | Pubmed ID: 26949078 Propofol Cardioprotection for On-pump Aortocoronary Bypass Surgery in Patients with Type 2 Diabetes Mellitus (PRO-TECT II): a Phase 2 Randomized-controlled Trial Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie. Apr, 2016 | Pubmed ID: 26721648 Comparison of Sample Introduction Methods for Continuous Chemical Purification in Two-dimensional Electro-fluid-dynamic Devices Analytical Chemistry. Nov, 2014 | Pubmed ID: 25303032 Simple Capillary Electrophoresis-mass Spectrometry Method for Complex Glycan Analysis Using a Flow-through Microvial Interface Analytical Chemistry. Jul, 2014 | Pubmed ID: 24873509 Applications of Capillary Electrophoresis in Characterizing Recombinant Protein Therapeutics Electrophoresis. Jan, 2014 | Pubmed ID: 24123141 Capillary Electrophoresis Mass Spectrometry for the Characterization of O-acetylated N-glycans from Fish Serum Analytical Chemistry. Oct, 2012 | Pubmed ID: 22971167 Capillary Electrophoresis-mass Spectrometry for Analysis of Complex Samples Proteomics. Oct, 2012 | Pubmed ID: 22888086 Monitoring Potential Prostate Cancer Biomarkers in Urine by Capillary Electrophoresis-tandem Mass Spectrometry Journal of Chromatography. A. Dec, 2012 | Pubmed ID: 22824219 Atmospheric Pressure Ion Lens Extends the Stable Operational Region of an Electrospray Ion Source for Capillary Electrophoresis-mass Spectrometry Electrophoresis. Apr, 2012 | Pubmed ID: 22589113 A Simple and Robust LC-MS/MS Method for Quantification of Free 3-nitrotyrosine in Human Plasma from Patients Receiving On-pump CABG Surgery Electrophoresis. Feb, 2012 | Pubmed ID: 22451063 The Cellular and Molecular Origin of Reactive Oxygen Species Generation During Myocardial Ischemia and Reperfusion Pharmacology & Therapeutics. Feb, 2012 | Pubmed ID: 22138603 Local Delivery of Antimicrobial Peptides Using Self-organized TiO2 Nanotube Arrays for Peri-implant Infections Journal of Biomedical Materials Research. Part A. Feb, 2012 | Pubmed ID: 22045618 Flow-through Microvial Facilitating Interface of Capillary Isoelectric Focusing and Electrospray Ionization Mass Spectrometry Analytical Chemistry. Nov, 2011 | Pubmed ID: 21972844 Potential of Two-dimensional Electro-fluid-dynamic Devices for Continuous Purification of Multiple Components from Complex Samples Analytical Chemistry. Nov, 2011 | Pubmed ID: 21923103 A Promising Capillary Electrophoresis-electrospray Ionization-mass Spectrometry Method for Carbohydrate Analysis Electrophoresis. Aug, 2011 | Pubmed ID: 21792989 Mass Transport in a Micro Flow-through Vial of a Junction-at-the-tip Capillary Electrophoresis-mass Spectrometry Interface Analytical Chemistry. Jun, 2011 | Pubmed ID: 21528898 Differences in Myocardial PTEN Expression and Akt Signalling in Type 2 Diabetic and Nondiabetic Patients Undergoing Coronary Bypass Surgery Clinical Endocrinology. Jun, 2011 | Pubmed ID: 21521253 Free Fatty Acids Composition in Adipocere of the Kwäday Dän Ts'ìnchí Ancient Remains Found in a Glacier Journal of Forensic Sciences. Jul, 2010 | Pubmed ID: 20384931 Decoupling CE and ESI for a More Robust Interface with MS Electrophoresis. Apr, 2010 | Pubmed ID: 20196027 Propofol Protects Against Hydrogen Peroxide-induced Injury in Cardiac H9c2 Cells Via Akt Activation and Bcl-2 Up-regulation Biochemical and Biophysical Research Communications. Nov, 2009 | Pubmed ID: 19703415 Target-achieved Propofol Concentration During On-pump Cardiac Surgery: a Pilot Dose-finding Study Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie. Sep, 2009 | Pubmed ID: 19639375 Rationale, Design and Baseline Characteristics of the PRO-TECT II Study: PROpofol CardioproTECTion for Type II Diabetics: a Randomized, Controlled Trial of High-dose Propofol Versus Isoflurane Preconditioning in Patients Undergoing On-pump Coronary Artery Bypass Graft Surgery Contemporary Clinical Trials. Jul, 2009 | Pubmed ID: 19336262 Field Distribution in an Electrospray Ionization Source Determined by Finite Element Method Rapid Communications in Mass Spectrometry : RCM. Mar, 2009 | Pubmed ID: 19189352 Twenty Years of Interface Development for Capillary Electrophoresis-electrospray Ionization-mass Spectrometry Analytica Chimica Acta. Oct, 2008 | Pubmed ID: 18790125 Behavior of Interacting Species in Vacancy Affinity Capillary Electrophoresis Described by Mass Balance Equation Electrophoresis. Aug, 2008 | Pubmed ID: 18702059 Capillary Electrophoresis Frontal Analysis for Characterization of Alphavbeta3 Integrin Binding Interactions Analytical Chemistry. May, 2008 | Pubmed ID: 18366190 Computer Simulation of Different Modes of ACE Based on the Dynamic Complexation Model Electrophoresis. Sep, 2007 | Pubmed ID: 17854123 Systematic Optimization of Exhaustive Electrokinetic Injection Combined with Micellar Sweeping in Capillary Electrophoresis The Analyst. Feb, 2007 | Pubmed ID: 17260072 Behavior of Interacting Species in Capillary Electrophoresis Described by Mass Transfer Equation Analytical Chemistry. Mar, 2006 | Pubmed ID: 16536418 Enumeration Algorithm for Determination of Binding Constants in Capillary Electrophoresis Analytical Chemistry. Apr, 2005 | Pubmed ID: 15828775 General Approach to High-efficiency Simulation of Affinity Capillary Electrophoresis Analytical Chemistry. Feb, 2005 | Pubmed ID: 15679352 Continuous Electrophoretic Purification of Individual Analytes from Multicomponent Mixtures Analytical Chemistry. Apr, 2004 | Pubmed ID: 15080741 Determination of Shapes and Maximums of Analyte Peaks Based on Solute Mobilities in Capillary Electrophoresis Analytical Chemistry. Mar, 2004 | Pubmed ID: 15018572 A Quantitative Study of Continuous Flow-counterbalanced Capillary Electrophoresis for Sample Purification Electrophoresis. Sep, 2003 | Pubmed ID: 12973791 Optimization of Cellular Nucleotide Extraction and Sample Preparation for Nucleotide Pool Analyses Using Capillary Electrophoresis Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. May, 2003 | Pubmed ID: 12668076 Molecular Interaction in Capillary Electrophoresis Current Opinion in Biotechnology. Feb, 2003 | Pubmed ID: 12566012 Multiple Sprayer System for High-throughput Electrospray Ionization Mass Spectrometry Rapid Communications in Mass Spectrometry : RCM. 2002 | Pubmed ID: 12362391 An Atmospheric Pressure Ion Lens That Improves Nebulizer Assisted Electrospray Ion Sources Journal of the American Society for Mass Spectrometry. Aug, 2002 | Pubmed ID: 12216730 Proton and Hydroxide Ion Mobility in Capillary Electrophoresis Analytical Chemistry. Jul, 2002 | Pubmed ID: 12141650 Univalent Salts As Modifiers in Micellar Capillary Electrophoresis Electrophoresis. Jun, 2002 | Pubmed ID: 12116136 Affinity Capillary Electrophoresis Using a Low-concentration Additive with the Consideration of Relative Mobilities Analytical Chemistry. Apr, 2002 | Pubmed ID: 11985325 Accurately Describing Weak Analyte-additive Interactions by Capillary Electrophoresis Electrophoresis. Mar, 2002 | Pubmed ID: 11920872 Scambio idrogeno/deuterio basato sull'elettroforesi capillare per la caratterizzazione conformazionale di proteine con spettrometria di massa top-down Lingxiao Chaihu1,2, Xiaopeng Yao1, Xiang Xu1,2, Zhongqin Zhu1, David D. Y. Chen3, Guanbo Wang1 1School of Chemistry and Materials Science, Nanjing Normal University, 2Institute for Cell Analysis, Shenzhen Bay Laboratory, 3Department of Chemistry, University of British Columbia JoVE 62672 Chemistry
Scambio idrogeno/deuterio basato sull'elettroforesi capillare per la caratterizzazione conformazionale di proteine con spettrometria di massa top-down Lingxiao Chaihu1,2, Xiaopeng Yao1, Xiang Xu1,2, Zhongqin Zhu1, David D. Y. Chen3, Guanbo Wang1 1School of Chemistry and Materials Science, Nanjing Normal University, 2Institute for Cell Analysis, Shenzhen Bay Laboratory, 3Department of Chemistry, University of British Columbia JoVE 62672 Chemistry
