David D. Shock Laboratory of Structural Biology NIEHS, National Institutes of Health Biography Publications Institution JoVE Articles David D. Shock has not added a biography. If you are David D. Shock and would like to personalize this page please email our Author Liaison for assistance. Publications Observing a DNA Polymerase Choose Right from Wrong Cell. Jul, 2013 | Pubmed ID: 23827680 Insights into the Conformation of Aminofluorene-deoxyguanine Adduct in a DNA Polymerase Active Site The Journal of Biological Chemistry. Aug, 2013 | Pubmed ID: 23798703 Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction Journal of the American Chemical Society. May, 2013 | Pubmed ID: 23647366 Effect of β,γ-CHF- and β,γ-CHCl-dGTP Halogen Atom Stereochemistry on the Transition State of DNA Polymerase β Biochemistry. Oct, 2012 | Pubmed ID: 23043620 Stereospecific Formation of a Ternary Complex of (S)-α,β-fluoromethylene-dATP with DNA Pol β Chembiochem : a European Journal of Chemical Biology. Mar, 2012 | Pubmed ID: 22315190 Binary Complex Crystal Structure of DNA Polymerase β Reveals Multiple Conformations of the Templating 8-oxoguanine Lesion Proceedings of the National Academy of Sciences of the United States of America. Jan, 2012 | Pubmed ID: 22178760 Metal-induced DNA Translocation Leads to DNA Polymerase Conformational Activation Nucleic Acids Research. Apr, 2012 | Pubmed ID: 22169953 Substrate Channeling in Mammalian Base Excision Repair Pathways: Passing the Baton The Journal of Biological Chemistry. Dec, 2010 | Pubmed ID: 20952393 Base Excision Repair and Design of Small Molecule Inhibitors of Human DNA Polymerase β Cellular and Molecular Life Sciences : CMLS. Nov, 2010 | Pubmed ID: 20844920 Synthesis and Biological Evaluation of Fluorinated Deoxynucleotide Analogs Based on Bis-(difluoromethylene)triphosphoric Acid Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20724659 DNA Polymerase Beta Substrate Specificity: Side Chain Modulation of the "A-rule" The Journal of Biological Chemistry. Nov, 2009 | Pubmed ID: 19759017 Alpha,beta-difluoromethylene Deoxynucleoside 5'-triphosphates: a Convenient Synthesis of Useful Probes for DNA Polymerase Beta Structure and Function Organic Letters. May, 2009 | Pubmed ID: 19351147 Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates As Noncleavable Substrates for DNA Polymerases: Isolation, Characterization, and Stability Studies of Novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT Journal of Medicinal Chemistry. Oct, 2008 | Pubmed ID: 18811136 Structures of DNA Polymerase Beta with Active-site Mismatches Suggest a Transient Abasic Site Intermediate During Misincorporation Molecular Cell. May, 2008 | Pubmed ID: 18471977 Coordination of Steps in Single-nucleotide Base Excision Repair Mediated by Apurinic/apyrimidinic Endonuclease 1 and DNA Polymerase Beta The Journal of Biological Chemistry. May, 2007 | Pubmed ID: 17355977 Structure of DNA Polymerase Beta with a Benzo[c]phenanthrene Diol Epoxide-adducted Template Exhibits Mutagenic Features Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17079493 Magnesium-induced Assembly of a Complete DNA Polymerase Catalytic Complex Structure (London, England : 1993). Apr, 2006 | Pubmed ID: 16615916 Nucleotide-induced DNA Polymerase Active Site Motions Accommodating a Mutagenic DNA Intermediate Structure (London, England : 1993). Aug, 2005 | Pubmed ID: 16084394 DNA Polymerase Lambda Mediates a Back-up Base Excision Repair Activity in Extracts of Mouse Embryonic Fibroblasts The Journal of Biological Chemistry. May, 2005 | Pubmed ID: 15749700 DNA Polymerase Beta and Flap Endonuclease 1 Enzymatic Specificities Sustain DNA Synthesis for Long Patch Base Excision Repair The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15561706 Influence of DNA Structure on DNA Polymerase Beta Active Site Function: Extension of Mutagenic DNA Intermediates The Journal of Biological Chemistry. Jul, 2004 | Pubmed ID: 15145936 Localization of the Deoxyribose Phosphate Lyase Active Site in Human DNA Polymerase Iota by Controlled Proteolysis The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12777390 Rapid Segmental and Subdomain Motions of DNA Polymerase Beta The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12458221 Efficiency of Correct Nucleotide Insertion Governs DNA Polymerase Fidelity The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12370169 Molecular Basis of CIB Binding to the Integrin Alpha IIb Cytoplasmic Domain The Journal of Biological Chemistry. Aug, 2002 | Pubmed ID: 12023286 Loss of DNA Polymerase Beta Stacking Interactions with Templating Purines, but Not Pyrimidines, Alters Catalytic Efficiency and Fidelity The Journal of Biological Chemistry. Mar, 2002 | Pubmed ID: 11756435 Steady-state, Pre-steady-state, och Single-omsättningen Kinetic Mätning för DNA-glykosylas aktivitet Akira Sassa1, William A. Beard1, David D. Shock1, Samuel H. Wilson1 1Laboratory of Structural Biology, NIEHS, National Institutes of Health JoVE 50695 Chemistry
Steady-state, Pre-steady-state, och Single-omsättningen Kinetic Mätning för DNA-glykosylas aktivitet Akira Sassa1, William A. Beard1, David D. Shock1, Samuel H. Wilson1 1Laboratory of Structural Biology, NIEHS, National Institutes of Health JoVE 50695 Chemistry