David Breault Department of Pediatrics Harvard Medical School Biography Publications Institution JoVE Articles David Breault David Breault, MD, PhD is a physician-scientists and pediatric endocrinologist at Boston CHildren's Hospital and Harvard Medical School. He is the Associate Chief of the Division of Endocrinology at Boston Children's Hospital and an Associate Professor of Pediatrics at Harvard Medical School. He is a Principal Faculty member of the Harvard Stem Cell Institute and an Affiliate Faculty member of the Department of Stem Cell and Regenerative Biology at Harvard University. He obtained his MD and PhD from the University of Connecticut School of Medicine and pediatric training at Yale-New Haven Hospital. Publications Tacrolimus-binding Protein FKBP8 Directs Myosin Light Chain Kinase-dependent Barrier Regulation and is a Potential Therapeutic Target in Crohn's Disease Gut. May, 2022 | Pubmed ID: 35537812 Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells Stem Cells (Dayton, Ohio). 03, 2022 | Pubmed ID: 35511869 A Non-dividing Cell Population with High Pyruvate Dehydrogenase Kinase Activity Regulates Metabolic Heterogeneity and Tumorigenesis in the Intestine Nature Communications. 03, 2022 | Pubmed ID: 35314684 Establishment of Physiologically Relevant Oxygen Gradients in Microfluidic Organ Chips Lab on a Chip. 04, 2022 | Pubmed ID: 35274118 Emerging Enterococcus Pore-forming Toxins with MHC/HLA-I As Receptors Cell. Mar, 2022 | Pubmed ID: 35259335 Triple-Decker Sandwich Cultures of Intestinal Organoids for Long-Term Live Imaging, Uniform Perturbation, and Statistical Sampling Current Protocols. Jan, 2022 | Pubmed ID: 35030297 Robust Differentiation of Human Enteroendocrine Cells from Intestinal Stem Cells Nature Communications. 01, 2022 | Pubmed ID: 35017529 Yersinia Pseudotuberculosis YopE Prevents Uptake by M Cells and Instigates M Cell Extrusion in Human Ileal Enteroid-derived Monolayers Gut Microbes. Jan-Dec, 2021 | Pubmed ID: 34793276 Rapid Prototyping of Multilayer Microphysiological Systems ACS Biomaterials Science & Engineering. 07, 2021 | Pubmed ID: 34275297 Coculture of Primary Human Colon Monolayer with Human Gut Bacteria Nature Protocols. 08, 2021 | Pubmed ID: 34183870 Rosette Morphology in Zona Glomerulosa Formation and Function Molecular and Cellular Endocrinology. 06, 2021 | Pubmed ID: 33891993 Primary Human Colonic Mucosal Barrier Crosstalk with Super Oxygen-sensitive in Continuous Culture Med (New York, N.Y.). 01, 2021 | Pubmed ID: 33511375 Telomerase Expression Marks Transitional Growth-associated Skeletal Progenitor/stem Cells Stem Cells (Dayton, Ohio). 03, 2021 | Pubmed ID: 33438789 Cholinergic Activation of Primary Human Derived Intestinal Epithelium Does Not Ameliorate TNF-α Induced Injury Cellular and Molecular Bioengineering. Oct, 2020 | Pubmed ID: 33184579 Organoid Culture System for Patient-derived Lung Metastatic Osteosarcoma Medical Oncology (Northwood, London, England). Oct, 2020 | Pubmed ID: 33079257 Wnt/β-catenin Activation Cooperates with Loss of P53 to Cause Adrenocortical Carcinoma in Mice Oncogene. 07, 2020 | Pubmed ID: 32561853 Fully Synthetic Matrices for in Vitro Culture of Primary Human Intestinal Enteroids and Endometrial Organoids Biomaterials. 09, 2020 | Pubmed ID: 32502894 Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation Cell Reports. 04, 2020 | Pubmed ID: 32320669 β-Catenin and FGFR2 Regulate Postnatal Rosette-based Adrenocortical Morphogenesis Nature Communications. 04, 2020 | Pubmed ID: 32245949 Intestinal Enteroids Recapitulate the Effects of Short-chain Fatty Acids on the Intestinal Epithelium PloS One. Month, 2020 | Pubmed ID: 32240190 Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology Cellular and Molecular Gastroenterology and Hepatology. Month, 2020 | Pubmed ID: 31778828 Chemogenetic Activation of Adrenocortical Gq Signaling Causes Hyperaldosteronism and Disrupts Functional Zonation The Journal of Clinical Investigation. 01, 2020 | Pubmed ID: 31738186 Sex Differences in Adrenal Bmal1 Deletion-Induced Augmentation of Glucocorticoid Responses to Stress and ACTH in Mice Endocrinology. 10, 2019 | Pubmed ID: 31398249 Author Correction: A Complex Human Gut Microbiome Cultured in an Anaerobic Intestine-on-a-chip Nature Biomedical Engineering. Jul, 2019 | Pubmed ID: 31213704 Sulfated Glycosaminoglycans and Low-density Lipoprotein Receptor Contribute to Clostridium Difficile Toxin A Entry into Cells Nature Microbiology. 10, 2019 | Pubmed ID: 31160825 A Complex Human Gut Microbiome Cultured in an Anaerobic Intestine-on-a-chip Nature Biomedical Engineering. 07, 2019 | Pubmed ID: 31086325 Species-specific Enhancement of Enterohemorrhagic E. Coli Pathogenesis Mediated by Microbiome Metabolites Microbiome. 03, 2019 | Pubmed ID: 30890187 Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension Hypertension (Dallas, Tex. : 1979). 02, 2019 | Pubmed ID: 30580687 The Adrenal Clock Prevents Aberrant Light-Induced Alterations in Circadian Glucocorticoid Rhythms Endocrinology. 12, 2018 | Pubmed ID: 30321360 High-dimensional Immune Phenotyping and Transcriptional Analyses Reveal Robust Recovery of Viable Human Immune and Epithelial Cells from Frozen Gastrointestinal Tissue Mucosal Immunology. 11, 2018 | Pubmed ID: 30111863 Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations American Journal of Human Genetics. 07, 2018 | Pubmed ID: 29909964 Move Over Caco-2 Cells: Human-Induced Organoids Meet Gut-on-a-Chip Cellular and Molecular Gastroenterology and Hepatology. Month, 2018 | Pubmed ID: 29713662 Adrenocortical Development: Lessons from Mouse Models Annales D'endocrinologie. Jun, 2018 | Pubmed ID: 29673697 Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells Arteriosclerosis, Thrombosis, and Vascular Biology. 06, 2018 | Pubmed ID: 29599138 The Colonic Epithelium Plays an Active Role in Promoting Colitis by Shaping the Tissue Cytokine Profile PLoS Biology. 03, 2018 | Pubmed ID: 29596476 Development of a Primary Human Small Intestine-on-a-Chip Using Biopsy-derived Organoids Scientific Reports. Feb, 2018 | Pubmed ID: 29440725 PKA Signaling Drives Reticularis Differentiation and Sexually Dimorphic Adrenal Cortex Renewal JCI Insight. 01, 2018 | Pubmed ID: 29367455 JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation During Intestinal Regeneration Following Acute Inflammation Stem Cell Reports. 01, 2018 | Pubmed ID: 29276155 Bone Marrow Stem Cells Do Not Contribute to Endometrial Cell Lineages in Chimeric Mouse Models Stem Cells (Dayton, Ohio). 01, 2018 | Pubmed ID: 28913973 The Circadian Clock Gene Coordinates Intestinal Regeneration Cellular and Molecular Gastroenterology and Hepatology. Jul, 2017 | Pubmed ID: 28593182 Regulation of Zonation and Homeostasis in the Adrenal Cortex Molecular and Cellular Endocrinology. 02, 2017 | Pubmed ID: 27619404 CellMapper: Rapid and Accurate Inference of Gene Expression in Difficult-to-isolate Cell Types Genome Biology. 09, 2016 | Pubmed ID: 27687735 Frizzled Proteins Are Colonic Epithelial Receptors for C. Difficile Toxin B Nature. Oct, 2016 | Pubmed ID: 27680706 An Enduring Role for Quiescent Stem Cells Developmental Dynamics : an Official Publication of the American Association of Anatomists. 07, 2016 | Pubmed ID: 27153394 Reprogrammed Stomach Tissue As a Renewable Source of Functional β Cells for Blood Glucose Regulation Cell Stem Cell. Mar, 2016 | Pubmed ID: 26908146 The Mouse Endometrium Contains Epithelial, Endothelial and Leucocyte Populations Expressing the Stem Cell Marker Telomerase Reverse Transcriptase Molecular Human Reproduction. Apr, 2016 | Pubmed ID: 26740067 Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status Cell Reports. Dec, 2015 | Pubmed ID: 26686631 Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells Stem Cell Reports. Nov, 2015 | Pubmed ID: 26489894 Oncogenic K-Ras Promotes Proliferation in Quiescent Intestinal Stem Cells Stem Cell Research. Jul, 2015 | Pubmed ID: 26079371 Adrenocortical Zonation Results from Lineage Conversion of Differentiated Zona Glomerulosa Cells Developmental Cell. Sep, 2013 | Pubmed ID: 24035414 Optimised Protocols for the Identification of the Murine Cardiac Side Population Stem Cell Reviews. Oct, 2013 | Pubmed ID: 23619929 Tales from the Crypt: the Expanding Role of Slow Cycling Intestinal Stem Cells Cell Stem Cell. Jan, 2012 | Pubmed ID: 22226346 Characterization and Fate of Telomerase-expressing Epithelia During Kidney Repair Journal of the American Society of Nephrology : JASN. Dec, 2011 | Pubmed ID: 22021716 Mouse Telomerase Reverse Transcriptase (mTert) Expression Marks Slowly Cycling Intestinal Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011 | Pubmed ID: 21173232 Regulation of Gene Expression in the Intestinal Epithelium Progress in Molecular Biology and Translational Science. Month, 2010 | Pubmed ID: 21075346 Generation of MTert-GFP Mice As a Model to Identify and Study Tissue Progenitor Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2008 | Pubmed ID: 18650388 Small Intestinal Stem Cell Markers Journal of Anatomy. Jul, 2008 | Pubmed ID: 18638070 Härstamningsspårning av inducerbara fluorescerande märkta stamceller i den vuxna mushjärnan Gabriel S. Jensen1,2, Jake W. Willows2, David T. Breault3, Kristy L. Townsend1,2 1Graduate School of Biomedical Science and Engineering, University of Maine, 2Department of Neurosurgery, Ohio State University Wexner Medical Center, 3Boston Children’s Hospital, Harvard Medical School JoVE 63998 Neuroscience
Härstamningsspårning av inducerbara fluorescerande märkta stamceller i den vuxna mushjärnan Gabriel S. Jensen1,2, Jake W. Willows2, David T. Breault3, Kristy L. Townsend1,2 1Graduate School of Biomedical Science and Engineering, University of Maine, 2Department of Neurosurgery, Ohio State University Wexner Medical Center, 3Boston Children’s Hospital, Harvard Medical School JoVE 63998 Neuroscience
