Edgars Liepinsh

Publications

• Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19
  International Journal of Molecular Sciences. Dec, 2021  |   Pubmed ID: 35008470
• Antibacterial Activity of Apramycin at Acidic PH Warrants Wide Therapeutic Window in the Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis
  EBioMedicine. Nov, 2021  |   Pubmed ID: 34740109
• Low Cardiac Content of Long-chain Acylcarnitines in TMLHE Knockout Mice Prevents Ischaemia-reperfusion-induced Mitochondrial and Cardiac Damage
  Free Radical Biology & Medicine. 12, 2021  |   Pubmed ID: 34728372
• Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects Against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats
  Oxidative Medicine and Cellular Longevity. 2021  |   Pubmed ID: 34367467
• Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism
  International Journal of Molecular Sciences. Jun, 2021  |   Pubmed ID: 34208786
• Energy Substrate Metabolism and Mitochondrial Oxidative Stress in Cardiac Ischemia/reperfusion Injury
  Free Radical Biology & Medicine. 03, 2021  |   Pubmed ID: 33484825
• Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin
  Clinical Pharmacology and Therapeutics. 04, 2021  |   Pubmed ID: 33150591
• Rats with Congenital Hydronephrosis Show Increased Susceptibility to Renal Ischemia-reperfusion Injury
  Physiological Reports. 11, 2020  |   Pubmed ID: 33207081
• Inhibition of CPT2 Exacerbates Cardiac Dysfunction and Inflammation in Experimental Endotoxaemia
  Journal of Cellular and Molecular Medicine. 10, 2020  |   Pubmed ID: 32896106
• Metformin Decreases Bacterial Trimethylamine Production and Trimethylamine N-oxide Levels in Db/db Mice
  Scientific Reports. 09, 2020  |   Pubmed ID: 32884086
• Low-intensity Exercise Stimulates Bioenergetics and Increases Fat Oxidation in Mitochondria of Blood Mononuclear Cells from Sedentary Adults
  Physiological Reports. 06, 2020  |   Pubmed ID: 32562386
• Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload
  Cardiovascular Drugs and Therapy. 12, 2020  |   Pubmed ID: 32424653
• Cardiac Metabolism As a Driver and Therapeutic Target of Myocardial Infarction
  Journal of Cellular and Molecular Medicine. 06, 2020  |   Pubmed ID: 32384583
• Excretion of the Polymyxin Derivative NAB739 in Murine Urine
  Antibiotics (Basel, Switzerland). Mar, 2020  |   Pubmed ID: 32230751
• Altered Mitochondrial Metabolism in the Insulin-resistant Heart
  Acta Physiologica (Oxford, England). 03, 2020  |   Pubmed ID: 31840389
• Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity
  Frontiers in Endocrinology. 2019  |   Pubmed ID: 31920980
• Mitochondrial Function in the Kidney and Heart, but Not the Brain, is Mainly Altered in an Experimental Model of Endotoxaemia
  Shock (Augusta, Ga.). 12, 2019  |   Pubmed ID: 30640252
• Letter to the Editor: "Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris"
  The Journal of Clinical Endocrinology and Metabolism. 11, 2018  |   Pubmed ID: 30124877
• Plasma Acylcarnitine Concentrations Reflect the Acylcarnitine Profile in Cardiac Tissues
  Scientific Reports. 12, 2017  |   Pubmed ID: 29235526
• Acute and Long-term Administration of Palmitoylcarnitine Induces Muscle-specific Insulin Resistance in Mice
  BioFactors (Oxford, England). Sep, 2017  |   Pubmed ID: 28759135
• S-phenylpiracetam, a Selective DAT Inhibitor, Reduces Body Weight Gain Without Influencing Locomotor Activity
  Pharmacology, Biochemistry, and Behavior. 09, 2017  |   Pubmed ID: 28743458
• Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB
  Basic & Clinical Pharmacology & Toxicology. Aug, 2017  |   Pubmed ID: 28244203
• Trimethylamine N-oxide Impairs Pyruvate and Fatty Acid Oxidation in Cardiac Mitochondria
  Toxicology Letters. Feb, 2017  |   Pubmed ID: 28049038
• Carnitine and γ-Butyrobetaine Stimulate Elimination of Meldonium Due to Competition for OCTN2-mediated Transport
  Basic & Clinical Pharmacology & Toxicology. May, 2017  |   Pubmed ID: 27983775
• Response to Comment by Sergei V. Jargin: "Meldonium (Mildronate): Primum Nоn Nocere"
  Pharmacological Research. Dec, 2016  |   Pubmed ID: 27725311
• The Unusual Pharmacokinetics of Meldonium: Implications for Doping
  Pharmacological Research. Sep, 2016  |   Pubmed ID: 27262679
• Long-chain Acylcarnitines Determine Ischaemia/reperfusion-induced Damage in Heart Mitochondria
  The Biochemical Journal. 05, 2016  |   Pubmed ID: 26936967
• Pharmacological Effects of Meldonium: Biochemical Mechanisms and Biomarkers of Cardiometabolic Activity
  Pharmacological Research. 11, 2016  |   Pubmed ID: 26850121
• Decreased Acylcarnitine Content Improves Insulin Sensitivity in Experimental Mice Models of Insulin Resistance
  Pharmacological Research. 11, 2016  |   Pubmed ID: 26621248
• The Neuroprotective Effects of R-phenibut After Focal Cerebral Ischemia
  Pharmacological Research. 11, 2016  |   Pubmed ID: 26621244
• Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella Pneumoniae
  The Journal of Biological Chemistry. Aug, 2015  |   Pubmed ID: 26187464
• Methyl-γ-butyrobetaine Decreases Levels of Acylcarnitines and Attenuates the Development of Atherosclerosis
  Vascular Pharmacology. Sep, 2015  |   Pubmed ID: 25989106
• Determination of Trimethylamine-N-oxide in Combination with L-carnitine and γ-butyrobetaine in Human Plasma by UPLC/MS/MS
  Biomedical Chromatography : BMC. Nov, 2015  |   Pubmed ID: 25873316
• Suppression of Intestinal Microbiota-dependent Production of Pro-atherogenic Trimethylamine N-oxide by Shifting L-carnitine Microbial Degradation
  Life Sciences. Nov, 2014  |   Pubmed ID: 25301199
• A Cross-sectional Survey of Urinary Iodine Status in Latvia
  Medicina (Kaunas, Lithuania). 2014  |   Pubmed ID: 25172607
• Long-chain Acylcarnitine Content Determines the Pattern of Energy Metabolism in Cardiac Mitochondria
  Molecular and Cellular Biochemistry. Oct, 2014  |   Pubmed ID: 24878991
• Selective Inhibition of OCTN2 is More Effective Than Inhibition of Gamma-butyrobetaine Dioxygenase to Decrease the Availability of L-carnitine and to Reduce Myocardial Infarct Size
  Pharmacological Research. Jul, 2014  |   Pubmed ID: 24836867
• Magnesium Nitrate Attenuates Blood Pressure Rise in SHR Rats
  Magnesium Research. Jan-Mar, 2014  |   Pubmed ID: 24827813
• Mildronate, the Inhibitor of L-carnitine Transport, Induces Brain Mitochondrial Uncoupling and Protects Against Anoxia-reoxygenation
  European Journal of Pharmacology. Jan, 2014  |   Pubmed ID: 24333219
• The Heart is Better Protected Against Myocardial Infarction in the Fed State Compared to the Fasted State
  Metabolism: Clinical and Experimental. Jan, 2014  |   Pubmed ID: 24140100
• Activated Peroxisomal Fatty Acid Metabolism Improves Cardiac Recovery in Ischemia-reperfusion
  Naunyn-Schmiedeberg's Archives of Pharmacology. Jun, 2013  |   Pubmed ID: 23525500
• Association of Reduced Glyoxalase 1 Activity and Painful Peripheral Diabetic Neuropathy in Type 1 and 2 Diabetes Mellitus Patients
  Journal of Diabetes and Its Complications. May-Jun, 2013  |   Pubmed ID: 23351995
• Troubleshooting Digital Macro Photography for Image Acquisition and the Analysis of Biological Samples
  Journal of Pharmacological and Toxicological Methods. Mar-Apr, 2013  |   Pubmed ID: 23202591
• Glyoxalase 1 and Glyoxalase 2 Activities in Blood and Neuronal Tissue Samples from Experimental Animal Models of Obesity and Type 2 Diabetes Mellitus
  The Journal of Physiological Sciences : JPS. Nov, 2012  |   Pubmed ID: 22893478
• High L-carnitine Concentrations Do Not Prevent Late Diabetic Complications in Type 1 and 2 Diabetic Patients
  Nutrition Research (New York, N.Y.). May, 2012  |   Pubmed ID: 22652370
• The Sensorimotor and Cognitive Deficits in Rats Following 90- and 120-min Transient Occlusion of the Middle Cerebral Artery
  Journal of Neuroscience Methods. Jul, 2012  |   Pubmed ID: 22640751
• A Short-term High-dose Administration of Sodium Pivalate Impairs Pyruvate Metabolism Without Affecting Cardiac Function
  Cardiovascular Toxicology. Dec, 2012  |   Pubmed ID: 22539084
• The Cardioprotective Effect of Mildronate is Diminished After Co-treatment with L-carnitine
  Journal of Cardiovascular Pharmacology and Therapeutics. Jun, 2012  |   Pubmed ID: 21903968
• Administration of L-carnitine and Mildronate Improves Endothelial Function and Decreases Mortality in Hypertensive Dahl Rats
  Pharmacological Reports : PR. 2011  |   Pubmed ID: 21857086
• Mildronate Treatment Alters γ-butyrobetaine and L-carnitine Concentrations in Healthy Volunteers
  The Journal of Pharmacy and Pharmacology. Sep, 2011  |   Pubmed ID: 21827492
• Mildronate Treatment Improves Functional Recovery Following Middle Cerebral Artery Occlusion in Rats
  Behavioural Brain Research. Sep, 2011  |   Pubmed ID: 21420440
• Anti-diabetic Effects of Mildronate Alone or in Combination with Metformin in Obese Zucker Rats
  European Journal of Pharmacology. May, 2011  |   Pubmed ID: 21371472
• Flow Cytometric Analysis of Glyoxalase-1 Expression in Human Leukocytes
  Cell Biochemistry and Function. Mar, 2011  |   Pubmed ID: 21370249
• Mildronate Exerts Acute Anticonvulsant and Antihypnotic Effects
  Behavioural Pharmacology. Sep, 2010  |   Pubmed ID: 20661137
• The Anti-inflammatory and Antinociceptive Effects of NF-kappaB Inhibitory Guanidine Derivative ME10092
  International Immunopharmacology. Apr, 2010  |   Pubmed ID: 20074673
• Inhibition of Carnitine Acetyltransferase by Mildronate, a Regulator of Energy Metabolism
  Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2009  |   Pubmed ID: 19912061
• Effects of Long-term Mildronate Treatment on Cardiac and Liver Functions in Rats
  Basic & Clinical Pharmacology & Toxicology. Dec, 2009  |   Pubmed ID: 19663820
• Protective Effects of Mildronate in an Experimental Model of Type 2 Diabetes in Goto-Kakizaki Rats
  British Journal of Pharmacology. Aug, 2009  |   Pubmed ID: 19594753
• Myocardial Infarct Size-limiting and Anti-arrhythmic Effects of Mildronate Orotate in the Rat Heart
  Cardiovascular Drugs and Therapy. Aug, 2009  |   Pubmed ID: 19536647
• Quantitative Analysis of Phenibut in Rat Brain Tissue Extracts by Liquid Chromatography-tandem Mass Spectrometry
  Biomedical Chromatography : BMC. Dec, 2008  |   Pubmed ID: 19034959
• Mildronate Decreases Carnitine Availability and Up-regulates Glucose Uptake and Related Gene Expression in the Mouse Heart
  Life Sciences. Oct, 2008  |   Pubmed ID: 18801379
• Effect of Inhibiting Carnitine Biosynthesis on Male Rat Sexual Performance
  Physiology & Behavior. Oct, 2008  |   Pubmed ID: 18640137
• Comparative Pharmacological Activity of Optical Isomers of Phenibut
  European Journal of Pharmacology. Mar, 2008  |   Pubmed ID: 18275958
• Mildronate, an Inhibitor of Carnitine Biosynthesis, Induces an Increase in Gamma-butyrobetaine Contents and Cardioprotection in Isolated Rat Heart Infarction
  Journal of Cardiovascular Pharmacology. Dec, 2006  |   Pubmed ID: 17204911
• Investigations on the Pharmacology of the Cardioprotective Guanidine ME10092
  Journal of Cardiovascular Pharmacology. Aug, 2004  |   Pubmed ID: 15243298
• The Methylester of Gamma-butyrobetaine, but Not Gamma-butyrobetaine Itself, Induces Muscarinic Receptor-dependent Vasodilatation
  Naunyn-Schmiedeberg's Archives of Pharmacology. May, 2004  |   Pubmed ID: 15060760
• Mildronate: Cardioprotective Action Through Carnitine-lowering Effect
  Trends in Cardiovascular Medicine. Aug, 2002  |   Pubmed ID: 12242052