Elizabeth E. Howell

Publications

• Thermodynamics and Solvent Effects on Substrate and Cofactor Binding in Escherichia Coli Chromosomal Dihydrofolate Reductase
  Biochemistry. May, 2011  |   Pubmed ID: 21462996
• A Survey of Aspartate-phenylalanine and Glutamate-phenylalanine Interactions in the Protein Data Bank: Searching for Anion-Ï€ Pairs
  Biochemistry. Apr, 2011  |   Pubmed ID: 21366334
• The Tail Wagging the Dog: Insights into Catalysis in R67 Dihydrofolate Reductase
  Biochemistry. Oct, 2010  |   Pubmed ID: 20795731
• Radical Redesign of a Tandem Array of Four R67 Dihydrofolate Reductase Genes Yields a Functional, Folded Protein Possessing 45 Substitutions
  Biochemistry. Aug, 2010  |   Pubmed ID: 20684560
• The Effect of Electrostatic Shielding on H Tunneling in R67 Dihydrofolate Reductase
  Chembiochem : a European Journal of Chemical Biology. Nov, 2009  |   Pubmed ID: 19774544
• Tuning of the H-transfer Coordinate in Primitive Versus Well-evolved Enzymes
  Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. May, 2008  |   Pubmed ID: 18444258
• A Balancing Act Between Net Uptake of Water During Dihydrofolate Binding and Net Release of Water Upon NADPH Binding in R67 Dihydrofolate Reductase
  The Journal of Biological Chemistry. Feb, 2008  |   Pubmed ID: 18086667
• R67, the Other Dihydrofolate Reductase: Rational Design of an Alternate Active Site Configuration
  Biochemistry. Jan, 2008  |   Pubmed ID: 18085798
• Crystal Structure of a Type II Dihydrofolate Reductase Catalytic Ternary Complex
  Biochemistry. Dec, 2007  |   Pubmed ID: 18052202
• A Preference for Edgewise Interactions Between Aromatic Rings and Carboxylate Anions: the Biological Relevance of Anion-quadrupole Interactions
  The Journal of Physical Chemistry. B. Jul, 2007  |   Pubmed ID: 17580852
• Neutron Diffraction Studies of Escherichia Coli Dihydrofolate Reductase Complexed with Methotrexate
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006  |   Pubmed ID: 17130456
• Effects of Temperature and Viscosity on R67 Dihydrofolate Reductase Catalysis
  Biochemistry. May, 2006  |   Pubmed ID: 16716070
• Calorimetric Studies of Ligand Binding in R67 Dihydrofolate Reductase
  Biochemistry. Sep, 2005  |   Pubmed ID: 16156655
• Preliminary Neutron Diffraction Studies of Escherichia Coli Dihydrofolate Reductase Bound to the Anticancer Drug Methotrexate
  Acta Crystallographica. Section D, Biological Crystallography. May, 2005  |   Pubmed ID: 15858267
• Searching Sequence Space: Two Different Approaches to Dihydrofolate Reductase Catalysis
  Chembiochem : a European Journal of Chemical Biology. Apr, 2005  |   Pubmed ID: 15812782
• "Catch 222," the Effects of Symmetry on Ligand Binding and Catalysis in R67 Dihydrofolate Reductase As Determined by Mutations at Tyr-69
  The Journal of Biological Chemistry. Nov, 2004  |   Pubmed ID: 15333637
• Role of Lys-32 Residues in R67 Dihydrofolate Reductase Probed by Asymmetric Mutations
  The Journal of Biological Chemistry. Nov, 2004  |   Pubmed ID: 15333636
• Defining the Binding Site of Homotetrameric R67 Dihydrofolate Reductase and Correlating Binding Enthalpy with Catalysis
  Biochemistry. Jun, 2004  |   Pubmed ID: 15182183
• NMR Studies of the Interaction of a Type II Dihydrofolate Reductase with Pyridine Nucleotides Reveal Unexpected Phosphatase and Reductase Activity
  Biochemistry. Sep, 2003  |   Pubmed ID: 14503865
• Role of Ionic Interactions in Ligand Binding and Catalysis of R67 Dihydrofolate Reductase
  Biochemistry. Sep, 2003  |   Pubmed ID: 12962480
• Breaking Symmetry: Mutations Engineered into R67 Dihydrofolate Reductase, a D2 Symmetric Homotetramer Possessing a Single Active Site Pore
  Biochemistry. Dec, 2002  |   Pubmed ID: 12501195
• Intact Protein Analysis for Site-directed Mutagenesis Overexpression Products: Plasmid-encoded R67 Dihydrofolate Reductase
  Analytical Biochemistry. Jun, 2002  |   Pubmed ID: 12018947