Other Publications (1)
Articles by Eric Dai in JoVE
Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis Yan Li*1, Hannah Grover*1, Eric Dai2, Kevin Yang1, Zi Chen1 1Thayer School of Engineering, Dartmouth College, 2Department of Bioengineering, University of Pennsylvania Here, we present a protocol introducing a set of new ex-ovo experiments and physical modeling approaches for studying the mechanics of morphogenesis during early chick embryonic brain torsion.
Other articles by Eric Dai on PubMed
Mechano-adaptation of the Stem Cell Nucleus Nucleus (Austin, Tex.). | Pubmed ID: 29099288 Exogenous mechanical forces are transmitted through the cell and to the nucleus, initiating mechanotransductive signaling cascades with profound effects on cellular function and stem cell fate. A growing body of evidence has shown that the force sensing and force-responsive elements of the nucleus adapt to these mechanotransductive events, tuning their response to future mechanical input. The mechanisms underlying this "mechano-adaptation" are only just beginning to be elucidated, and it remains poorly understood how these components act and adapt in tandem to drive stem cell differentiation. Here, we review the evidence on how the stem cell nucleus responds and adapts to physical forces, and provide a perspective on how this mechano-adaptation may function to drive and enforce stem cell differentiation.