Glen F. Tibbits

Publications

• Using Human Induced Pluripotent Stem Cell-derived Cardiomyocytes to Understand the Mechanisms Driving Cardiomyocyte Maturation
  Frontiers in Cardiovascular Medicine. 2022  |   Pubmed ID: 36061558
• The Effect of Mg on Ca Binding to Cardiac Troponin C in Hypertrophic Cardiomyopathy Associated TNNC1 Variants
  The FEBS Journal. Jul, 2022  |   Pubmed ID: 35838319
• RARG S427L Attenuates the DNA Repair Response to Doxorubicin in Induced Pluripotent Stem Cell-derived Cardiomyocytes
  Stem Cell Reports. 04, 2022  |   Pubmed ID: 35364012
• Investigating Inherited Arrhythmias Using HiPSC-derived Cardiomyocytes
  Methods (San Diego, Calif.). 07, 2022  |   Pubmed ID: 34197925
• Atrial-specific HiPSC-derived Cardiomyocytes in Drug Discovery and Disease Modeling
  Methods (San Diego, Calif.). 07, 2022  |   Pubmed ID: 34144175
• Mechanisms of Arrhythmogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T () Variant I79N
  Frontiers in Cell and Developmental Biology. 2021  |   Pubmed ID: 34977031
• Using HiPSC-CMs to Examine Mechanisms of Catecholaminergic Polymorphic Ventricular Tachycardia
  Current Protocols. Dec, 2021  |   Pubmed ID: 34958715
• Pediatric Catecholaminergic Polymorphic Ventricular Tachycardia: A Translational Perspective for the Clinician-Scientist
  International Journal of Molecular Sciences. Aug, 2021  |   Pubmed ID: 34502196
• Electrophysiological Characterization of the HERG R56Q LQTS Variant and Targeted Rescue by the Activator RPR260243
  The Journal of General Physiology. 10, 2021  |   Pubmed ID: 34398210
• Binding of Calcium and Magnesium to Human Cardiac Troponin C
  The Journal of Biological Chemistry. Jan-Jun, 2021  |   Pubmed ID: 33548225
• Drug Screening Platform Using Human Induced Pluripotent Stem Cell-derived Atrial Cardiomyocytes and Optical Mapping
  Stem Cells Translational Medicine. 01, 2021  |   Pubmed ID: 32927497
• Utility of Zebrafish Models of Acquired and Inherited Long QT Syndrome
  Frontiers in Physiology. 2020  |   Pubmed ID: 33519527
• Variation in RARG Increases Susceptibility to Doxorubicin-induced Cardiotoxicity in Patient Specific Induced Pluripotent Stem Cell-derived Cardiomyocytes
  Scientific Reports. 06, 2020  |   Pubmed ID: 32587261
• The HERG Channel Activator, RPR260243, Enhances Protective Current Early in the Refractory Period Reducing Arrhythmogenicity in Zebrafish Hearts
  American Journal of Physiology. Heart and Circulatory Physiology. 08, 2020  |   Pubmed ID: 32559136
• Physiological Phenotyping of the Adult Zebrafish Heart
  Marine Genomics. Feb, 2020  |   Pubmed ID: 31451352
• Investigating the Utility of Adult Zebrafish Ex Vivo Whole Hearts to Pharmacologically Screen HERG Channel Activator Compounds
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 12, 2019  |   Pubmed ID: 31664867
• Ibrutinib Displays Atrial-Specific Toxicity in Human Stem Cell-Derived Cardiomyocytes
  Stem Cell Reports. 05, 2019  |   Pubmed ID: 31031187
• In Vitro Analyses of Suspected Arrhythmogenic Thin Filament Variants As a Cause of Sudden Cardiac Death in Infants
  Proceedings of the National Academy of Sciences of the United States of America. 04, 2019  |   Pubmed ID: 30886088
• In Vivo Characterization of Doxycycline-mediated Protection of Aortic Function and Structure in a Mouse Model of Marfan Syndrome-associated Aortic Aneurysm
  Scientific Reports. 02, 2019  |   Pubmed ID: 30765726
• ROCK2 Promotes Ryanodine Receptor Phosphorylation and Arrhythmic Calcium Release in Diabetic Cardiomyocytes
  International Journal of Cardiology. Apr, 2019  |   Pubmed ID: 30728103
• Zebrafish As a Model of Mammalian Cardiac Function: Optically Mapping the Interplay of Temperature and Rate on Voltage and Calcium Dynamics
  Progress in Biophysics and Molecular Biology. 10, 2018  |   Pubmed ID: 30017908
• Functional Characterization of a Novel HERG Variant in a Family with Recurrent Sudden Infant Death Syndrome: Retracting a Genetic Diagnosis
  Forensic Science International. Mar, 2018  |   Pubmed ID: 29331839
• PH Recovery from a Proton Load in Rat Cardiomyocytes: Effects of Chronic Exercise
  American Journal of Physiology. Heart and Circulatory Physiology. 02, 2018  |   Pubmed ID: 29101173
• Investigating the Genetic Causes of Sudden Unexpected Death in Children Through Targeted Next-Generation Sequencing Analysis
  Circulation. Cardiovascular Genetics. Aug, 2017  |   Pubmed ID: 28807990
• Modeling Atrial Fibrillation Using Human Embryonic Stem Cell-Derived Atrial Tissue
  Scientific Reports. 07, 2017  |   Pubmed ID: 28706272
• Changes in the Dynamics of the Cardiac Troponin C Molecule Explain the Effects of Ca-sensitizing Mutations
  The Journal of Biological Chemistry. 07, 2017  |   Pubmed ID: 28533433
• Aortic and Cardiac Structure and Function Using High-Resolution Echocardiography and Optical Coherence Tomography in a Mouse Model of Marfan Syndrome
  PloS One. 2016  |   Pubmed ID: 27824871
• The Zebrafish Heart As a Model of Mammalian Cardiac Function
  Reviews of Physiology, Biochemistry and Pharmacology. 2016  |   Pubmed ID: 27538987
• Ischemia-reperfusion Destabilizes Rhythmicity in Immature Atrioventricular Pacemakers: A Predisposing Factor for Postoperative Arrhythmias in Neonate Rabbits
  Heart Rhythm. 12, 2016  |   Pubmed ID: 27451283
• Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation And ITC
  Biophysical Journal. Jul, 2016  |   Pubmed ID: 27410732
• Functional Divergence in Teleost Cardiac Troponin Paralogs Guides Variation in the Interaction of TnI Switch Region with TnC
  Genome Biology and Evolution. Apr, 2016  |   Pubmed ID: 26979795
• Functional Assessment of Cardiac Responses of Adult Zebrafish (Danio Rerio) to Acute and Chronic Temperature Change Using High-Resolution Echocardiography
  PloS One. 2016  |   Pubmed ID: 26730947
• Construction and Use of a Zebrafish Heart Voltage and Calcium Optical Mapping System, with Integrated Electrocardiogram and Programmable Electrical Stimulation
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. May, 2015  |   Pubmed ID: 25740339
• Morphological Phenotyping of Mouse Hearts Using Optical Coherence Tomography
  Journal of Biomedical Optics. 2014  |   Pubmed ID: 25393967
• Optical Mapping of the Electrical Activity of Isolated Adult Zebrafish Hearts: Acute Effects of Temperature
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jun, 2014  |   Pubmed ID: 24671241
• Phenotype-dependent Role of the L-type Calcium Current in Embryonic Stem Cell Derived Cardiomyocytes
  American Journal of Stem Cells. 2014  |   Pubmed ID: 24660113
• Familial Hypertrophic Cardiomyopathy Related Cardiac Troponin C L29Q Mutation Alters Length-dependent Activation and Functional Effects of Phosphomimetic Troponin I*
  PloS One. 2013  |   Pubmed ID: 24260207
• Adult Teleost Heart Expresses Two Distinct Troponin C Paralogs: Cardiac TnC and a Novel and Teleost-specific SsTnC in a Chamber- and Temperature-dependent Manner
  Physiological Genomics. Sep, 2013  |   Pubmed ID: 23881286
• The Structure of Cardiac Troponin C Regulatory Domain with Bound Cd2+ Reveals a Closed Conformation and Unique Ion Coordination
  Acta Crystallographica. Section D, Biological Crystallography. May, 2013  |   Pubmed ID: 23633581
• Crystal Structure of Cardiac Troponin C Regulatory Domain in Complex with Cadmium and Deoxycholic Acid Reveals Novel Conformation
  Journal of Molecular Biology. Oct, 2011  |   Pubmed ID: 21920370
• Colocalization of Voltage-gated Na+ Channels with the Na+/Ca2+ Exchanger in Rabbit Cardiomyocytes During Development
  American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2011  |   Pubmed ID: 20971761
• Calcium Handling in Zebrafish Ventricular Myocytes
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jan, 2011  |   Pubmed ID: 20926764
• Mechanistic Basis for LQT1 Caused by S3 Mutations in the KCNQ1 Subunit of IKs
  The Journal of General Physiology. May, 2010  |   Pubmed ID: 20421371
• Distribution Patterns of the Na+-Ca2+ Exchanger and Caveolin-3 in Developing Rabbit Cardiomyocytes
  Cell Calcium. Apr, 2009  |   Pubmed ID: 19250668
• Characterization of Zebrafish (Danio Rerio) NCX4: a Novel NCX with Distinct Electrophysiological Properties
  American Journal of Physiology. Cell Physiology. Jan, 2009  |   Pubmed ID: 18971388
• Gene Structure Evolution of the Na+-Ca2+ Exchanger (NCX) Family
  BMC Evolutionary Biology. Apr, 2008  |   Pubmed ID: 18447948
• Familial Hypertrophic Cardiomyopathy-related Cardiac Troponin C Mutation L29Q Affects Ca2+ Binding and Myofilament Contractility
  Physiological Genomics. Apr, 2008  |   Pubmed ID: 18285522
• Ontogeny of Ca2+-induced Ca2+ Release in Rabbit Ventricular Myocytes
  American Journal of Physiology. Cell Physiology. Feb, 2008  |   Pubmed ID: 18094144
• Hyperpolarization-activated Cyclic Nucleotide-modulated 'HCN' Channels Confer Regular and Faster Rhythmicity to Beating Mouse Embryonic Stem Cells
  The Journal of Physiology. Feb, 2008  |   Pubmed ID: 18033814
• Real-time Monitoring of Intracellular Calcium Dynamic Mobilization of a Single Cardiomyocyte in a Microfluidic Chip Pertaining to Drug Discovery
  Electrophoresis. Dec, 2007  |   Pubmed ID: 18072214
• SR Ca2+ Refilling Upon Depletion and SR Ca2+ Uptake Rates During Development in Rabbit Ventricular Myocytes
  American Journal of Physiology. Cell Physiology. Dec, 2007  |   Pubmed ID: 17928539
• Three-dimensional Distribution of Cardiac Na+-Ca2+ Exchanger and Ryanodine Receptor During Development
  Biophysical Journal. Oct, 2007  |   Pubmed ID: 17557789
• L-type Ca2+ Channel Function and Expression in Neonatal Rabbit Ventricular Myocytes
  American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2006  |   Pubmed ID: 16339821
• CDNA Cloning and Expression of the Cardiac Na+/Ca2+ Exchanger from Mozambique Tilapia (Oreochromis Mossambicus) Reveal a Teleost Membrane Transporter with Mammalian Temperature Dependence
  The Journal of Biological Chemistry. Aug, 2005  |   Pubmed ID: 15937330
• Phylogeny of Na+/Ca2+ Exchanger (NCX) Genes from Genomic Data Identifies New Gene Duplications and a New Family Member in Fish Species
  Physiological Genomics. Apr, 2005  |   Pubmed ID: 15741504
• Na+/Ca2+ Exchange Activity in Neonatal Rabbit Ventricular Myocytes
  American Journal of Physiology. Cell Physiology. Jan, 2005  |   Pubmed ID: 15317663
• Deconvolution of Confocal Images of Dihydropyridine and Ryanodine Receptors in Developing Cardiomyocytes
  Journal of Applied Physiology (Bethesda, Md. : 1985). Sep, 2004  |   Pubmed ID: 15064297
• Effect of Temperature and the F27W Mutation on the Ca2+ Activated Structural Transition of Trout Cardiac Troponin C
  Biochemistry. Jun, 2003  |   Pubmed ID: 12767223
• Sequence Mutations in Teleost Cardiac Troponin C That Are Permissive of High Ca2+ Affinity of Site II
  American Journal of Physiology. Cell Physiology. May, 2003  |   Pubmed ID: 12519747
• Temperature Dependence of Cardiac Na+/Ca2+ Exchanger
  Annals of the New York Academy of Sciences. Nov, 2002  |   Pubmed ID: 12502547
• Determinants of Cardiac Na(+)/Ca(2+) Exchanger Temperature Dependence: NH(2)-terminal Transmembrane Segments
  American Journal of Physiology. Cell Physiology. Aug, 2002  |   Pubmed ID: 12107061
• Beating the Cold: the Functional Evolution of Troponin C in Teleost Fish
  Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology. Aug, 2002  |   Pubmed ID: 12095861
• Ontogeny of Excitation-contraction Coupling in the Mammalian Heart
  Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology. Aug, 2002  |   Pubmed ID: 12095856