Hui-Yao Lan Li Ka Shing Institute of Health Sciences and Department of Medicine & Therapeutics The Chinese University of Hong Kong Biography Publications Institution JoVE Articles Hui-Yao Lan has not added a biography. If you are Hui-Yao Lan and would like to personalize this page please email our Author Liaison for assistance. Publications The Proto-oncogene Tyrosine Protein Kinase Src is Essential for Macrophage-myofibroblast Transition During Renal Scarring Kidney International. Jan, 2018 | Pubmed ID: 29042082 Lethal (3) Malignant Brain Tumor Like 2 (L3MBTL2) Protein Protects Against Kidney Injury by Inhibiting the DNA Damage-p53-apoptosis Pathway in Renal Tubular Cells Kidney International. Dec, 2017 | Pubmed ID: 29276099 Novel LncRNA Erbb4-IR Promotes Diabetic Kidney Injury in Db/db Mice by Targeting MiR-29b Diabetes. Dec, 2017 | Pubmed ID: 29222368 TGF-β Mediates Renal Fibrosis Via the Smad3-Erbb4-IR Long Noncoding RNA Axis Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2017 | Pubmed ID: 29102563 Deletion of Angiotensin-Converting Enzyme-2 Promotes Hypertensive Nephropathy by Targeting Smad7 for Ubiquitin Degradation Hypertension (Dallas, Tex. : 1979). Oct, 2017 | Pubmed ID: 28808068 Defective CFTR Leads to Aberrant β-catenin Activation and Kidney Fibrosis Scientific Reports. Jul, 2017 | Pubmed ID: 28701694 The Incidence, Risk Factors and In-hospital Mortality of Acute Kidney Injury in Patients After Abdominal Aortic Aneurysm Repair Surgery BMC Nephrology. May, 2017 | Pubmed ID: 28569144 Smad7 Protects Against Acute Kidney Injury by Rescuing Tubular Epithelial Cells from the G1 Cell Cycle Arrest Clinical Science (London, England : 1979). Aug, 2017 | Pubmed ID: 28566468 The Regulatory T-cell Transcription Factor Foxp3 Protects Against Crescentic Glomerulonephritis Scientific Reports. May, 2017 | Pubmed ID: 28469165 C-reactive Protein and Ageing Clinical and Experimental Pharmacology & Physiology. Dec, 2017 | Pubmed ID: 28378496 Smad3 Promotes Cancer Progression by Inhibiting E4BP4-mediated NK Cell Development Nature Communications. Mar, 2017 | Pubmed ID: 28262747 Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury Journal of the American Society of Nephrology : JASN. Jul, 2017 | Pubmed ID: 28209809 N-acetyl-seryl-aspartyl-lysyl-proline Mediates the Anti-fibrotic Properties of Captopril in Unilateral Ureteric Obstructed BALB/C Mice Nephrology (Carlton, Vic.). Jan, 2017 | Pubmed ID: 28075040 The Pattern Recognition Receptor, Mincle, is Essential for Maintaining the M1 Macrophage Phenotype in Acute Renal Inflammation Kidney International. Mar, 2017 | Pubmed ID: 28017324 Peritoneal Inflammation and Fibrosis in C-reactive Protein Transgenic Mice Undergoing Peritoneal Dialysis Solution Treatment Nephrology (Carlton, Vic.). Feb, 2017 | Pubmed ID: 26857687 Inflammatory Macrophages Can Transdifferentiate into Myofibroblasts During Renal Fibrosis Cell Death & Disease. Dec, 2016 | Pubmed ID: 27906172 Calcineurin Inhibitors Cyclosporin A and Tacrolimus Protect Against Podocyte Injury Induced by Puromycin Aminonucleoside in Rodent Models Scientific Reports. Sep, 2016 | Pubmed ID: 27580845 C-reactive Protein Promotes Acute Kidney Injury Via Smad3-dependent Inhibition of CDK2/cyclin E Kidney International. Sep, 2016 | Pubmed ID: 27470679 Validity of Leptin Receptor-deficiency (db/db) Type 2 Diabetes Mellitus Mice As a Model of Secondary Osteoporosis Scientific Reports. Jun, 2016 | Pubmed ID: 27283954 TGF-β: the Master Regulator of Fibrosis Nature Reviews. Nephrology. 06, 2016 | Pubmed ID: 27108839 Therapeutic Effects of Tangshen Formula on Diabetic Nephropathy in Rats PloS One. 2016 | Pubmed ID: 26807792 TGF-β/Smad3 Signalling Regulates the Transition of Bone Marrow-derived Macrophages into Myofibroblasts During Tissue Fibrosis Oncotarget. Feb, 2016 | Pubmed ID: 26684242 Macrophage Phenotype in Kidney Injury and Repair Kidney Diseases (Basel, Switzerland). Sep, 2015 | Pubmed ID: 27536674 N-Acetyl-seryl-aspartyl-lysyl-proline Alleviates Renal Fibrosis Induced by Unilateral Ureteric Obstruction in BALB/C Mice Mediators of Inflammation. 2015 | Pubmed ID: 26508815 Treatment of Renal Fibrosis by Rebalancing TGF-β/Smad Signaling with the Combination of Asiatic Acid and Naringenin Oncotarget. Nov, 2015 | Pubmed ID: 26474462 Deletion of Smad3 Improves Cardiac Allograft Rejection in Mice Oncotarget. Jul, 2015 | Pubmed ID: 26219259 Smad7 Protects Against Chronic Aristolochic Acid Nephropathy in Mice Oncotarget. May, 2015 | Pubmed ID: 25883225 Renoprotective Effect of Berberine on Type 2 Diabetic Nephropathy in Rats Clinical and Experimental Pharmacology & Physiology. Jun, 2015 | Pubmed ID: 25867602 Transient Receptor Potential Channel M2 Contributes to Neointimal Hyperplasia in Vascular Walls Biochimica Et Biophysica Acta. Jul, 2015 | Pubmed ID: 25857618 TGF-β/Smad Signaling in Renal Fibrosis Frontiers in Physiology. 2015 | Pubmed ID: 25852569 Long Noncoding RNA Arid2-IR Is a Novel Therapeutic Target for Renal Inflammation Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2015 | Pubmed ID: 25743111 Metabolomic and Lipidomic Study of the Protective Effect of Chaihuang-Yishen Formula on Rats with Diabetic Nephropathy Journal of Ethnopharmacology. May, 2015 | Pubmed ID: 25698246 MicroRNA-29b Prevents Liver Fibrosis by Attenuating Hepatic Stellate Cell Activation and Inducing Apoptosis Through Targeting PI3K/AKT Pathway Oncotarget. Mar, 2015 | Pubmed ID: 25356754 Macrophages Promote Renal Fibrosis Through Direct and Indirect Mechanisms Kidney International Supplements. Nov, 2014 | Pubmed ID: 26312148 MicroRNA-29b Inhibits Peritoneal Fibrosis in a Mouse Model of Peritoneal Dialysis Laboratory Investigation; a Journal of Technical Methods and Pathology. Sep, 2014 | Pubmed ID: 25046436 Partial Loss of Smad7 Function Impairs Bone Remodeling, Osteogenesis and Enhances Osteoclastogenesis in Mice Bone. Oct, 2014 | Pubmed ID: 24998669 Inflammatory Processes in Renal Fibrosis Nature Reviews. Nephrology. Sep, 2014 | Pubmed ID: 24981817 Opposing Roles for Smad2 and Smad3 in Peritoneal Fibrosis in Vivo and in Vitro The American Journal of Pathology. Aug, 2014 | Pubmed ID: 24925688 Latent Transforming Growth Factor-β1 Protects Against Bleomycin-induced Lung Injury in Mice American Journal of Respiratory Cell and Molecular Biology. Dec, 2014 | Pubmed ID: 24885478 Application of MicroRNAs in Diabetes Mellitus The Journal of Endocrinology. Jul, 2014 | Pubmed ID: 24781254 Chaihuang-Yishen Granule Inhibits Diabetic Kidney Disease in Rats Through Blocking TGF-β/Smad3 Signaling PloS One. 2014 | Pubmed ID: 24646636 Tissue Kallikrein Mediates Pro-inflammatory Pathways and Activation of Protease-activated Receptor-4 in Proximal Tubular Epithelial Cells PloS One. 2014 | Pubmed ID: 24586431 MiR-29b As a Therapeutic Agent for Angiotensin II-induced Cardiac Fibrosis by Targeting TGF-β/Smad3 Signaling Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2014 | Pubmed ID: 24569834 Identification of Novel Long Noncoding RNAs Associated with TGF-β/Smad3-mediated Renal Inflammation and Fibrosis by RNA Sequencing The American Journal of Pathology. Feb, 2014 | Pubmed ID: 24262754 Dragon (repulsive Guidance Molecule RGMb) Inhibits E-cadherin Expression and Induces Apoptosis in Renal Tubular Epithelial Cells The Journal of Biological Chemistry. Nov, 2013 | Pubmed ID: 24052264 Deficiency of Smad7 Enhances Cardiac Remodeling Induced by Angiotensin II Infusion in a Mouse Model of Hypertension PloS One. 2013 | Pubmed ID: 23894614 Smad7 Inhibits Angiotensin II-induced Hypertensive Cardiac Remodelling Cardiovascular Research. Sep, 2013 | Pubmed ID: 23761400 Smads As Therapeutic Targets for Chronic Kidney Disease Kidney Research and Clinical Practice. Mar, 2012 | Pubmed ID: 26889404 TGF-β/Smad Signaling in Kidney Disease Seminars in Nephrology. May, 2012 | Pubmed ID: 22835454 Asiatic Acid Inhibits Liver Fibrosis by Blocking TGF-beta/Smad Signaling in Vivo and in Vitro PloS One. 2012 | Pubmed ID: 22363627 Transforming Growth Factor-β/Smad Signalling in Diabetic Nephropathy Clinical and Experimental Pharmacology & Physiology. Aug, 2012 | Pubmed ID: 22211842 Diverse Roles of TGF-β Receptor II in Renal Fibrosis and Inflammation in Vivo and in Vitro The Journal of Pathology. Jun, 2012 | Pubmed ID: 22190171 Disruption of Smad4 Impairs TGF-β/Smad3 and Smad7 Transcriptional Regulation During Renal Inflammation and Fibrosis in Vivo and in Vitro Kidney International. Feb, 2012 | Pubmed ID: 22048127 Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation International Journal of Biological Sciences. 2011 | Pubmed ID: 21927575 Diabetes Complications: the MicroRNA Perspective Diabetes. Jul, 2011 | Pubmed ID: 21709278 Transforming Growth Factor-β and Smads Contributions to Nephrology. 2011 | Pubmed ID: 21659760 The Protective Role of Smad7 in Diabetic Kidney Disease: Mechanism and Therapeutic Potential Diabetes. Feb, 2011 | Pubmed ID: 20980457 Angiotensin II Induces Connective Tissue Growth Factor and Collagen I Expression Via Transforming Growth Factor-beta-dependent and -independent Smad Pathways: the Role of Smad3 Hypertension (Dallas, Tex. : 1979). Oct, 2009 | Pubmed ID: 19667256 A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro Patrick Ming-Kuen Tang1,2, Philip Chiu-Tsun Tang2, Jeff Yat-Fai Chung2, Jessica Shuk Chun Hung2, Qing-Ming Wang2, Guang-Yu Lian2, Jingyi Sheng2, Xiao-Ru Huang2, Ka-Fai To1, Hui-Yao Lan2 1Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, 2Li Ka Shing Institute of Health Sciences and Department of Medicine & Therapeutics, The Chinese University of Hong Kong JoVE 56785 Immunology and Infection
A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro Patrick Ming-Kuen Tang1,2, Philip Chiu-Tsun Tang2, Jeff Yat-Fai Chung2, Jessica Shuk Chun Hung2, Qing-Ming Wang2, Guang-Yu Lian2, Jingyi Sheng2, Xiao-Ru Huang2, Ka-Fai To1, Hui-Yao Lan2 1Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, 2Li Ka Shing Institute of Health Sciences and Department of Medicine & Therapeutics, The Chinese University of Hong Kong JoVE 56785 Immunology and Infection