Irving C. Allen Department of Biomedical Sciences and Pathobiology Virginia-Maryland College of Veterinary Medicine Biography Publications Institution JoVE Articles Irving C. Allen has not added a biography. If you are Irving C. Allen and would like to personalize this page please email our Author Liaison for assistance. Publications Patient Derived Xenografts Expand Human Primary Pancreatic Tumor Tissue Availability for Irreversible Electroporation Testing Frontiers in Oncology. 2020 | Pubmed ID: 32528898 To Protect or Adversely Affect? The Dichotomous Role of the NLRP1 Inflammasome in Human Disease Molecular Aspects of Medicine. Apr, 2020 | Pubmed ID: 32359693 Fabrication and Characterization of PLGA Nanoparticles Encapsulating Large CRISPR-Cas9 Plasmid Journal of Nanobiotechnology. Jan, 2020 | Pubmed ID: 31959180 High-Frequency Irreversible Electroporation for Treatment of Primary Liver Cancer: A Proof-of-Principle Study in Canine Hepatocellular Carcinoma Journal of Vascular and Interventional Radiology : JVIR. 03, 2020 | Pubmed ID: 31956003 Understanding the Role of Calcium-mediated Cell Death in High-frequency Irreversible Electroporation Bioelectrochemistry (Amsterdam, Netherlands). Feb, 2020 | Pubmed ID: 31706114 NLRX1 Is a Multifaceted and Enigmatic Regulator of Immune System Function Frontiers in Immunology. 2019 | Pubmed ID: 31681307 Divergent Age-dependent Peripheral Immune Transcriptomic Profile Following Traumatic Brain Injury Scientific Reports. Jun, 2019 | Pubmed ID: 31189983 High-frequency Irreversible Electroporation is an Effective Tumor Ablation Strategy That Induces Immunologic Cell Death and Promotes Systemic Anti-tumor Immunity EBioMedicine. Jun, 2019 | Pubmed ID: 31130474 Natural, Incidental, and Engineered Nanomaterials and Their Impacts on the Earth System Science (New York, N.Y.). 03, 2019 | Pubmed ID: 30923195 Using Klebsiella Pneumoniae to Model Acute Lung Inflammation in Mice Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30798531 Systemic Listeria Monocytogenes Infection As A Model to Study T Helper Cell Immune Responses Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30798529 Nanoscale Bacteria-Enabled Autonomous Drug Delivery System (NanoBEADS) Enhances Intratumoral Transport of Nanomedicine Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Feb, 2019 | Pubmed ID: 30775227 Maternal Influence and Murine Housing Confound Impact of NLRP1 Inflammasome on Microbiome Composition Journal of Innate Immunity. 2019 | Pubmed ID: 30759441 Emerging Developments in Microbiome and Microglia Research: Implications for Neurodevelopmental Disorders Frontiers in Immunology. 2018 | Pubmed ID: 30233586 Utilizing the Lung As A Model to Study Nanoparticle-Based Drug Delivery Systems Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 30051432 Photo-triggered Release of 5-fluorouracil from a MOF Drug Delivery Vehicle Chemical Communications (Cambridge, England). Jul, 2018 | Pubmed ID: 29926872 Modulating Inflammation Through the Negative Regulation of NF-κB Signaling Journal of Leukocyte Biology. Feb, 2018 | Pubmed ID: 29389019 Noncanonical NF-κB Signaling and the Essential Kinase NIK Modulate Crucial Features Associated with Eosinophilic Esophagitis Pathogenesis Disease Models & Mechanisms. 12, 2017 | Pubmed ID: 29259025 Loss of NLRX1 Exacerbates Neural Tissue Damage and NF-κB Signaling Following Brain Injury Journal of Immunology (Baltimore, Md. : 1950). 11, 2017 | Pubmed ID: 28993512 Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4 Th Cells Journal of Immunology (Baltimore, Md. : 1950). 10, 2017 | Pubmed ID: 28848064 Effect of Salmonella Enterica Serovar Typhimurium VNP20009 and VNP20009 with Restored Chemotaxis on 4T1 Mouse Mammary Carcinoma Progression Oncotarget. May, 2017 | Pubmed ID: 28431394 NLRX1 Regulates Effector and Metabolic Functions of CD4 T Cells Journal of Immunology (Baltimore, Md. : 1950). 03, 2017 | Pubmed ID: 28159898 TIPS Pentacene Loaded PEO-PDLLA Core-shell Nanoparticles Have Similar Cellular Uptake Dynamics in M1 and M2 Macrophages and in Corresponding in Vivo Microenvironments Nanomedicine : Nanotechnology, Biology, and Medicine. 04, 2017 | Pubmed ID: 28040495 Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M EBioMedicine. Feb, 2017 | Pubmed ID: 27939424 The Goldilocks Conundrum: NLR Inflammasome Modulation of Gastrointestinal Inflammation During Inflammatory Bowel Disease Critical Reviews in Immunology. 2016 | Pubmed ID: 28322135 Holding the Inflammatory System in Check: TLRs and NLRs Mediators of Inflammation. 2016 | Pubmed ID: 27642239 Emerging Roles for Noncanonical NF-κB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology Inflammatory Bowel Diseases. 09, 2016 | Pubmed ID: 27508514 Caspase-11 Modulates Inflammation and Attenuates Toxoplasma Gondii Pathogenesis Mediators of Inflammation. 2016 | Pubmed ID: 27378827 NLRX1 Suppresses Tumorigenesis and Attenuates Histiocytic Sarcoma Through the Negative Regulation of NF-κB Signaling Oncotarget. Apr, 2016 | Pubmed ID: 27105514 The NLRP1 Inflammasome Attenuates Colitis and Colitis-associated Tumorigenesis Journal of Immunology (Baltimore, Md. : 1950). Apr, 2015 | Pubmed ID: 25725098 Caspase-11 Attenuates Gastrointestinal Inflammation and Experimental Colitis Pathogenesis American Journal of Physiology. Gastrointestinal and Liver Physiology. Jan, 2015 | Pubmed ID: 25414099 Emerging Significance of NLRs in Inflammatory Bowel Disease Inflammatory Bowel Diseases. Dec, 2014 | Pubmed ID: 25153506 Cyclic-di-GMP and Cyclic-di-AMP Activate the NLRP3 Inflammasome EMBO Reports. Oct, 2013 | Pubmed ID: 24008845 Induction of Allergic Airway Disease Using House Dust Mite Allergen Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23943452 Contact Hypersensitivity Models in Mice Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23943450 Bacteria-mediated Acute Lung Inflammation Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23824899 Delayed-type Hypersensitivity Models in Mice Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23824893 Primary Ear Fibroblast Derivation from Mice Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23824888 Analysis of the Murine Immune Response to Pulmonary Delivery of Precisely Fabricated Nano- and Microscale Particles PloS One. 2013 | Pubmed ID: 23593509 Characterization of NLRP12 During the in Vivo Host Immune Response to Klebsiella Pneumoniae and Mycobacterium Tuberculosis PloS One. 2013 | Pubmed ID: 23577168 Plexin-B2 and Plexin-D1 in Dendritic Cells: Expression and IL-12/IL-23p40 Production PloS One. 2012 | Pubmed ID: 22916243 The Innate Immune Sensor NLRC3 Attenuates Toll-like Receptor Signaling Via Modification of the Signaling Adaptor TRAF6 and Transcription Factor NF-κB Nature Immunology. Sep, 2012 | Pubmed ID: 22863753 NLRP12 Suppresses Colon Inflammation and Tumorigenesis Through the Negative Regulation of Noncanonical NF-κB Signaling Immunity. May, 2012 | Pubmed ID: 22503542 Analysis of NLRP3 in the Development of Allergic Airway Disease in Mice Journal of Immunology (Baltimore, Md. : 1950). Mar, 2012 | Pubmed ID: 22323538 TLR2/MyD88/NF-κB Pathway, Reactive Oxygen Species, Potassium Efflux Activates NLRP3/ASC Inflammasome During Respiratory Syncytial Virus Infection PloS One. 2012 | Pubmed ID: 22295065 Characterization of NLRP12 During the Development of Allergic Airway Disease in Mice PloS One. 2012 | Pubmed ID: 22291998 Staphylococcus Aureus α-hemolysin Mediates Virulence in a Murine Model of Severe Pneumonia Through Activation of the NLRP3 Inflammasome The Journal of Infectious Diseases. Mar, 2012 | Pubmed ID: 22279123 Allergic Inflammation Induces a Persistent Mechanistic Switch in Thromboxane-mediated Airway Constriction in the Mouse American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2012 | Pubmed ID: 21984570 A NOD to Zebrafish Models of Inflammatory Bowel Disease Pathogenesis Disease Models & Mechanisms. Nov, 2011 | Pubmed ID: 22065838 NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways Immunity. Jun, 2011 | Pubmed ID: 21703540 The NLR Adaptor ASC/PYCARD Regulates DUSP10, Mitogen-activated Protein Kinase (MAPK), and Chemokine Induction Independent of the Inflammasome The Journal of Biological Chemistry. Jun, 2011 | Pubmed ID: 21487011 The Inflammasome Component NLRP3 Impairs Antitumor Vaccine by Enhancing the Accumulation of Tumor-associated Myeloid-derived Suppressor Cells Cancer Research. Dec, 2010 | Pubmed ID: 21159638 Cutting Edge: NLRP12 Controls Dendritic and Myeloid Cell Migration to Affect Contact Hypersensitivity Journal of Immunology (Baltimore, Md. : 1950). Oct, 2010 | Pubmed ID: 20861349 Granuloma Formation and Host Defense in Chronic Mycobacterium Tuberculosis Infection Requires PYCARD/ASC but Not NLRP3 or Caspase-1 PloS One. 2010 | Pubmed ID: 20808838 The NLRP3 Inflammasome Functions As a Negative Regulator of Tumorigenesis During Colitis-associated Cancer The Journal of Experimental Medicine. May, 2010 | Pubmed ID: 20385749 Searching for an Improved Mouse Model of Allergic Airway Disease Using Dual Allergen Exposures Disease Models & Mechanisms. Nov-Dec, 2009 | Pubmed ID: 19892879 Staphylococcus Aureus Alpha-hemolysin Activates the NLRP3-inflammasome in Human and Mouse Monocytic Cells PloS One. 2009 | Pubmed ID: 19826485 NLRP3 (NALP3, Cryopyrin) Facilitates in Vivo Caspase-1 Activation, Necrosis, and HMGB1 Release Via Inflammasome-dependent and -independent Pathways Journal of Immunology (Baltimore, Md. : 1950). Aug, 2009 | Pubmed ID: 19587006 Cooperation Between Mast Cells and Neurons is Essential for Antigen-mediated Bronchoconstriction Journal of Immunology (Baltimore, Md. : 1950). Jun, 2009 | Pubmed ID: 19494266 The NLRP3 Inflammasome Mediates in Vivo Innate Immunity to Influenza A Virus Through Recognition of Viral RNA Immunity. Apr, 2009 | Pubmed ID: 19362020 Expression and Function of NPSR1/GPRA in the Lung Before and After Induction of Asthma-like Disease American Journal of Physiology. Lung Cellular and Molecular Physiology. Nov, 2006 | Pubmed ID: 16829631 Thromboxane A2 Induces Airway Constriction Through an M3 Muscarinic Acetylcholine Receptor-dependent Mechanism American Journal of Physiology. Lung Cellular and Molecular Physiology. Mar, 2006 | Pubmed ID: 16243899 Usando análise de imagem baseada em computador para melhorar a quantificação da metástase pulmonar no modelo de câncer de mama 4T1 Margaret A. Nagai-Singer1, Alissa Hendricks-Wenger1,2,3, Rebecca M. Brock1,2, Holly A. Morrison1, Juselyn D. Tupik1, Sheryl Coutermarsh-Ott1, Irving C. Allen1,2,4 1Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, 2Graduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, 3Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, 4Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Virginia Polytechnic Institute and State University JoVE 61805 Cancer Research Implementação de precisão do teste de dose mínima de eritema (MED) para avaliar a variação individual na resposta inflamatória humana John A. Richey1, Holly Sullivan-Toole2, Marlene Strege1, Corinne Carlton1, Dylan McDaniel3, Matthew Komelski4, Amy Epperley5, Hongxiao Zhu6, Irving C. Allen3,7 1Department of Psychology, Virginia Tech, 2Graduate Program in Translational Biology, Medicine and Health, Virginia Tech, 3Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, 4Department of Human Development and Family Science, Virginia Tech, 5Wellness Center, Virginia Tech, 6Department of Statistics, Virginia Tech, 7Department of Basic Science Education, Virginia Tech Carilion School of Medicine JoVE 59813 Medicine
Usando análise de imagem baseada em computador para melhorar a quantificação da metástase pulmonar no modelo de câncer de mama 4T1 Margaret A. Nagai-Singer1, Alissa Hendricks-Wenger1,2,3, Rebecca M. Brock1,2, Holly A. Morrison1, Juselyn D. Tupik1, Sheryl Coutermarsh-Ott1, Irving C. Allen1,2,4 1Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, 2Graduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, 3Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, 4Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Virginia Polytechnic Institute and State University JoVE 61805 Cancer Research
Implementação de precisão do teste de dose mínima de eritema (MED) para avaliar a variação individual na resposta inflamatória humana John A. Richey1, Holly Sullivan-Toole2, Marlene Strege1, Corinne Carlton1, Dylan McDaniel3, Matthew Komelski4, Amy Epperley5, Hongxiao Zhu6, Irving C. Allen3,7 1Department of Psychology, Virginia Tech, 2Graduate Program in Translational Biology, Medicine and Health, Virginia Tech, 3Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, 4Department of Human Development and Family Science, Virginia Tech, 5Wellness Center, Virginia Tech, 6Department of Statistics, Virginia Tech, 7Department of Basic Science Education, Virginia Tech Carilion School of Medicine JoVE 59813 Medicine
