In JoVE (1)
Other Publications (11)
- Reproductive Toxicology (Elmsford, N.Y.)
- Insect Molecular Biology
- Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance
- The British Journal of Radiology
- Transplantation Proceedings
- Nature Communications
- Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
- Radiographics : a Review Publication of the Radiological Society of North America, Inc
- The American Journal of Dermatopathology
- The Western Journal of Emergency Medicine
Articles by Iván D. Vélez in JoVE
Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs Sara M. Robledo1, Lina M. Carrillo1,2, Alejandro Daza1, Adriana M. Restrepo1, Diana L. Muñoz1, Jairo Tobón1, Javier D. Murillo1, Anderson López1, Carolina Ríos1, Carol V. Mesa1, Yulieth A. Upegui1, Alejandro Valencia-Tobón1, Karina Mondragón-Shem1, Berardo RodrÍguez2, Iván D. Vélez1 1Program for the Study and Control of Tropical Diseases -PECET-School of Medicine, University of Antioquia, 2School of Agrarian Sciences, University of Antioquia Optimization of the experimental hamster model for cutaneous leishmaniasis by intradermal injection of Leishmania promastigotes at the dorsal skin. This approach is useful during inoculation, follow-up, characterization of lesions, application of treatments and obtaining of clinical samples. Locomotion, search for food and water, play and social activities are preserved.
Other articles by Iván D. Vélez on PubMed
Pyridines in Cigarette Smoke Inhibit Hamster Oviductal Functioning in Picomolar Doses Reproductive Toxicology (Elmsford, N.Y.). Mar-Apr, 2003 | Pubmed ID: 12642152 Past studies showed that chemicals in cigarette smoke inhibit oviductal functioning in vivo and in vitro. The purposes of this study were to identify individual toxicants in cigarette smoke solutions that inhibit various aspects of oviductal functioning and to determine their effective doses using in vitro bioassays. Solid phase extraction and gas chromatography-mass spectrometry (GC-MS) were used to identify individual chemicals in mainstream (MS) and sidestream (SS) cigarette smoke solutions. Pyridines, which were the most abundant class of compounds identified, were purchased, assayed for purity, and tested in dose-response studies on hamster oviducts. The lowest observable adverse effect level was determined for each pyridine derivative using the oocyte pick-up rate, ciliary beat frequency, and infundibular muscle contraction assays. 2-Methylpyridine, 4-methylpyridine, 2-ethylpyridine, 3-ethylpyridine, and 4-vinylpyridine were inhibitory at picomolar concentrations in all assays. This work shows picomolar doses of pyridines with single methyl or ethyl substitutions significantly inhibit oviductal functioning raising questions regarding the safety of these compounds.
A Preliminary Linkage Map of the Hard Tick, Ixodes Scapularis Insect Molecular Biology. Apr, 2003 | Pubmed ID: 12653942 A linkage map of the Ixodes scapularis genome was constructed, based upon segregation amongst 127 loci. These included 84 random amplified polymorphic DNA (RAPD) markers, 32 Sequence-Tagged RAPD (STAR) markers, 5 cDNAs, and 5 microsatellites in 232 F1 intercross progeny from a single, field-collected P1 female. A preliminary linkage map of 616 cM was generated across 14 linkage groups with one marker every 10.8 cM. Assuming a genome size of approximately 109 bp, the relationship of physical to genetic distance was found to be approximately 300 kb/cM in the I. scapularis genome.
Prevalence of Selected Viral Infections Among Blood Donors Deferred for Potential Risk to Blood Safety Transfusion. Nov, 2006 | Pubmed ID: 17076856 Health history questions identify blood donors believed to pose a higher risk of transmission of infectious diseases. This study assesses the current impact of some of these questions on blood safety as reflected by infectious disease markers.
Cardiac Hemangioma: Features on Cardiovascular Magnetic Resonance Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance. 2007 | Pubmed ID: 18066746 We present a case of cardiac capillary hemangioma in a patient who presented with a history of recurrent episodes of syncope. Cardiovascular magnetic resonance played an important role in the diagnosis of cardiac hemangioma in our patient.
Left Ventricular Ejection Fraction Using 64-slice CT Coronary Angiography and New Evaluation Software: Initial Experience The British Journal of Radiology. Jun, 2008 | Pubmed ID: 18347027 The purpose of this study was to evaluate the feasibility and reliability of software-based quantification of left ventricular function using 64-slice CT coronary angiography. Data were collected from 26 subjects who underwent a 64-slice coronary CT angiography study. Two volumetric data sets at end diastole and end systole were reconstructed from each scan by means of retrospective electrocardiogram gating. Data sets were evaluated with a prototype of now commercially available software (Syngo Circulation I; Siemens Medical Solutions, Erlangen, Germany), which automatically segments the blood volume in the left ventricle after the user defines the mitral valve plane and any point within the ventricle. After segmentation of the blood pool in end systole and end diastole, the software automatically measures end systolic and end diastolic volume and calculates stroke volume and ejection fraction (EF). Two readers processed all CT data sets twice to assess for intra- and inter-observer variation. In addition, CT EF measurements were compared with those obtained by clinical echocardiography. Intra-observer variation for the calculated EF with CT were 13.6% and 15.6% for Readers 1 and 2, respectively. No significant difference in left ventricular functional parameters on CT existed between the readers (p > 0.05). A Bland-Altman plot revealed a slight mean difference between EF measurements on CT and echocardiography, with all differences falling within two standard deviations of the mean in the setting of wide limits of agreement. In conclusion, assessment of left ventricular EF from CT coronary data using the new analysis software is rapid and easy. The software is user-friendly and provides good reproducibility for EF measurements with CT.
High Serum Level of the Soluble CD30 Identifies Chinese Kidney Transplant Recipients at High Risk of Unfavorable Outcome Transplantation Proceedings. Dec, 2008 | Pubmed ID: 19100393 We sought to investigate the relationship between serum level of sCD30 and recipient/graft survival rates, rejection types, as well as other prognostic factors among Chinese kidney transplant patients.
Deep Resequencing Reveals Excess Rare Recent Variants Consistent with Explosive Population Growth Nature Communications. 2010 | Pubmed ID: 21119644 Accurately determining the distribution of rare variants is an important goal of human genetics, but resequencing of a sample large enough for this purpose has been unfeasible until now. Here, we applied Sanger sequencing of genomic PCR amplicons to resequence the diabetes-associated genes KCNJ11 and HHEX in 13,715 people (10,422 European Americans and 3,293 African Americans) and validated amplicons potentially harbouring rare variants using 454 pyrosequencing. We observed far more variation (expected variant-site count âˆ¼578) than would have been predicted on the basis of earlier surveys, which could only capture the distribution of common variants. By comparison with earlier estimates based on common variants, our model shows a clear genetic signal of accelerating population growth, suggesting that humanity harbours a myriad of rare, deleterious variants, and that disease risk and the burden of disease in contemporary populations may be heavily influenced by the distribution of rare variants.
Polymorphisms of COMT and XPD and Risk of Esophageal Squamous Cell Carcinoma in a Population of Yili Prefecture, in Xinjiang, China Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. Feb, 2011 | Pubmed ID: 20979431 To investigate polymorphisms of COMT (Rs4680) and XPD (Rs13181) and risk of esophageal squamous cell carcinoma (ESCC) in a population from Yili Prefecture, Xinjiang, China.
Informatics in Radiology: Use of a Macro Scripting Editor to Facilitate Transfer of Dual-energy X-ray Absorptiometry Reports into an Existing Departmental Voice Recognition Dictation System Radiographics : a Review Publication of the Radiological Society of North America, Inc. Jul-Aug, 2011 | Pubmed ID: 21546554 The process of verbally reporting or manually retyping numeric data generated at dual-energy x-ray absorptiometry (DXA) involves numerous pitfalls. With use of a macro scripting editor, a customized macro was created to automate the transfer of data generated by a DXA scanner into a structured voice recognition dictation system without requiring radiologists to type in a medical record number or accession number to identify the study. A preliminary report is generated with use of software for a DXA unit and a customized template that includes numeric and qualitative assessments of osteoporosis as well as data from prior studies if available. A customized macro is then invoked by the macro scripting editor, which selectively transfers the report from the draft document into the voice recognition dictation system, thereby producing a final structured diagnostic report. All of the radiologists surveyed to evaluate this automated method reported ease of software use and greater efficiency in report production. In addition, a random audit of the 800 DXA scans that have been reported with this technique demonstrated no reports generated under an incorrect accession number and no incorrect transfer of data. Automated DXA reporting is now the preferred method of dictation at the authors' institution and represents an inexpensive, accurate, and customizable means of DXA reporting.
Perforating Granulomatous Dermatitis Reaction to Exogenous Tattoo Pigment: A Case Report and Review of the Literature The American Journal of Dermatopathology. Sep, 2011 | Pubmed ID: 21986232 The majority of cutaneous hypersensitivity reactions to exogenous tattoo pigments can be histologically classified as lichenoid or granulomatous. The etiology is still uncertain but is generally accepted to be a delayed-type hypersensitivity reaction to either the pigment itself or its carrier solution. In this report, we review the literature concerning adverse reactions to tattoos. In addition, we describe the second case of a localized granulomatous dermatitis to the red dye within a tattoo that histologically resembled granuloma annulare. This is the first reported example of a perforating granuloma annulare-like reaction.
Ileus and Small Bowel Obstruction in an Emergency Department Observation Unit: Are There Outcome Predictors? The Western Journal of Emergency Medicine. Nov, 2011 | Pubmed ID: 22224128 The purpose of our study was to describe the evaluation and outcome of patients with ileus and bowel obstruction admitted to an emergency department (ED) observation unit (OU) and to identify predictors of successful management for such patients.