Jack Wetzels Radboud Institute for Health Sciences, Department of Nephrology Radboud University Medical Center Biography Publications Institution JoVE Articles Jack Wetzels has not added a biography. If you are Jack Wetzels and would like to personalize this page please email our Author Liaison for assistance. Publications Standardized Reporting of Monoclonal Immunoglobulin-associated Renal Diseases: Recommendations from a Mayo Clinic/Renal Pathology Society Working Group Kidney International. Aug, 2020 | Pubmed ID: 32709293 Conversion of Urine Protein-Creatinine Ratio or Urine Dipstick Protein to Urine Albumin-Creatinine Ratio for Use in Chronic Kidney Disease Screening and Prognosis: An Individual Participant-Based Meta-analysis Annals of Internal Medicine. Jul, 2020 | Pubmed ID: 32658569 Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis Journal of the American Society of Nephrology : JASN. Aug, 2020 | Pubmed ID: 32561683 Salt, but Not Protein Intake, is Associated with Accelerated Disease Progression in Autosomal Dominant Polycystic Kidney Disease Kidney International. Jun, 2020 | Pubmed ID: 32534051 Treatment-resistant Nephrotic Syndrome in Dense Deposit Disease: Complement-mediated Glomerular Capillary Wall Injury? Pediatric Nephrology (Berlin, Germany). Sep, 2020 | Pubmed ID: 32447506 Inhibition of MTOR Delayed but Could Not Prevent Experimental Collapsing Focal Segmental Glomerulosclerosis Scientific Reports. May, 2020 | Pubmed ID: 32444668 The Genetic Architecture of Membranous Nephropathy and Its Potential to Improve Non-invasive Diagnosis Nature Communications. 03, 2020 | Pubmed ID: 32231244 The Complement Component C5 is Not Responsible for the Alternative Pathway Activity in Rabbit Erythrocyte Hemolytic Assays During Eculizumab Treatment Cellular & Molecular Immunology. Jun, 2020 | Pubmed ID: 32210393 The Zinc Fingers and Homeoboxes 2 Protein ZHX2 and Its Interacting Proteins Regulate Upstream Pathways in Podocyte Diseases Kidney International. Apr, 2020 | Pubmed ID: 32059999 The Multifaceted Role of Iron in Renal Health and Disease Nature Reviews. Nephrology. 02, 2020 | Pubmed ID: 31554933 Is There Long-term Value of Pathology Scoring in Immunoglobulin A Nephropathy? A Validation Study of the Oxford Classification for IgA Nephropathy (VALIGA) Update Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Jun, 2020 | Pubmed ID: 30418652 Five Non-mitochondrial Myopathy, Encephalopathy, Lactic Acidosis and Stroke-like Episodes Phenotype Adult Patients with M.3243A>G Mutation After Kidney Transplantation: Follow-up and Review of the Literature Clinical Kidney Journal. Dec, 2019 | Pubmed ID: 31807297 The Anti-PLA2R Antibody in Membranous Nephropathy: What We Know and What Remains A decade After Its Discovery Kidney International. 12, 2019 | Pubmed ID: 31611068 Complement Inhibitors Are Not Useful in Secondary Hemolytic Uremic Syndromes Kidney International. 10, 2019 | Pubmed ID: 31543154 Unraveling Hepcidin Plasma Protein Binding: Evidence from Peritoneal Equilibration Testing Pharmaceuticals (Basel, Switzerland). Aug, 2019 | Pubmed ID: 31450766 Evaluating Glomerular Filtration Rate Slope As a Surrogate End Point for ESKD in Clinical Trials: An Individual Participant Meta-Analysis of Observational Data Journal of the American Society of Nephrology : JASN. 09, 2019 | Pubmed ID: 31292199 Performance of GFR Slope As a Surrogate End Point for Kidney Disease Progression in Clinical Trials: A Statistical Simulation Journal of the American Society of Nephrology : JASN. 09, 2019 | Pubmed ID: 31292198 Genetic Identification of Two Novel Loci Associated with Steroid-Sensitive Nephrotic Syndrome Journal of the American Society of Nephrology : JASN. 08, 2019 | Pubmed ID: 31263063 The Authors Reply Kidney International. 07, 2019 | Pubmed ID: 31229039 Predicting Kidney Failure from Longitudinal Kidney Function Trajectory: A Comparison of Models PloS One. 2019 | Pubmed ID: 31071186 The Bias Between Different Albumin Assays May Affect Clinical Decision-making Kidney International. 06, 2019 | Pubmed ID: 31053386 Lanreotide Reduces Liver Growth In Patients With Autosomal Dominant Polycystic Liver and Kidney Disease Gastroenterology. Apr, 2019 | Pubmed ID: 31022403 Placental Passage of Eculizumab and Complement Blockade in a Newborn Kidney International. 04, 2019 | Pubmed ID: 30904074 Novel ELISA for Thrombospondin Type 1 Domain-containing 7A Autoantibodies in Membranous Nephropathy Kidney International. 03, 2019 | Pubmed ID: 30784662 Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab Clinical Pharmacokinetics. 07, 2019 | Pubmed ID: 30758736 Management and Treatment of Glomerular Diseases (part 1): Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference Kidney International. 02, 2019 | Pubmed ID: 30665568 Correction To: Eculizumab in Atypical Hemolytic Uremic Syndrome: Strategies Toward Restrictive Use Pediatric Nephrology (Berlin, Germany). Apr, 2019 | Pubmed ID: 30645679 Change in Albuminuria and Subsequent Risk of End-stage Kidney Disease: an Individual Participant-level Consortium Meta-analysis of Observational Studies The Lancet. Diabetes & Endocrinology. 02, 2019 | Pubmed ID: 30635225 Eculizumab in Atypical Hemolytic Uremic Syndrome: Strategies Toward Restrictive Use Pediatric Nephrology (Berlin, Germany). 11, 2019 | Pubmed ID: 30402748 The Use of N-of-1 Trials to Individualize Treatment in Patients With Renal Magnesium Wasting American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. 02, 2019 | Pubmed ID: 30318133 Nephrotic Syndrome With Mutations in NPHS2: The Role of R229Q and Implications for Genetic Counseling American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. 03, 2019 | Pubmed ID: 30241959 Antibodies Against M-Type Phospholipase Receptor and Prediction of Outcome in Membranous Nephropathy: We Are Not There Yet American Journal of Nephrology. 2018 | Pubmed ID: 30472711 Effect of Lanreotide on Kidney Function in Patients With Autosomal Dominant Polycystic Kidney Disease: The DIPAK 1 Randomized Clinical Trial JAMA. 11, 2018 | Pubmed ID: 30422235 Urine Acidification After Ammonium Chloride American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. 12, 2018 | Pubmed ID: 30297083 The Authors Reply Kidney International. 10, 2018 | Pubmed ID: 30243321 Benefit of Eculizumab Compared to Standard of Care Still Unproven in C3 Glomerulopathy American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. 12, 2018 | Pubmed ID: 30236630 What Patients with Mild-to-Moderate Kidney Disease Know, Think, and Feel About Their Disease: An In-Depth Interview Study Journal of the American Board of Family Medicine : JABFM. Jul-Aug, 2018 | Pubmed ID: 29986983 The Calcium-Dependent Protease Calpain-1 Links TRPC6 Activity to Podocyte Injury Journal of the American Society of Nephrology : JASN. 08, 2018 | Pubmed ID: 29954830 General Practitioners' Perspectives on Management of Early-stage Chronic Kidney Disease: a Focus Group Study BMC Family Practice. 06, 2018 | Pubmed ID: 29875016 Effects of Sildenafil, Metformin, and Simvastatin on ADH-independent Urine Concentration in Healthy Volunteers Physiological Reports. 04, 2018 | Pubmed ID: 29611351 Immunological Remission in PLA2R-antibody-associated Membranous Nephropathy: Cyclophosphamide Versus Rituximab Kidney International. 04, 2018 | Pubmed ID: 29571438 Interleukin-6 is Essential for Glomerular Immunoglobulin A Deposition and the Development of Renal Pathology in Cd37-deficient mice Kidney International. 06, 2018 | Pubmed ID: 29551516 CD44 is Required for the Pathogenesis of Experimental Crescentic Glomerulonephritis and Collapsing Focal Segmental Glomerulosclerosis Kidney International. 03, 2018 | Pubmed ID: 29276101 Safety and Effectiveness of Restrictive Eculizumab Treatment in Atypical Haemolytic Uremic Syndrome Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 04, 2018 | Pubmed ID: 29106598 Reference Values of Renal Tubular Function Tests Are Dependent on Age and Kidney Function Physiological Reports. Dec, 2017 | Pubmed ID: 29212860 Renal Physiology: Prostaglandins in Thiazide-induced Hyponatraemia: Do They Hold Water? Nature Reviews. Nephrology. 11, 2017 | Pubmed ID: 28944774 The Association of Combined Total Kidney and Liver Volume with Pain and Gastrointestinal Symptoms in Patients with Later Stage Autosomal Dominant Polycystic Kidney Disease American Journal of Nephrology. 2017 | Pubmed ID: 28881341 Living Donor Kidney Transplantation in Atypical Hemolytic Uremic Syndrome: A Case Series American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. Dec, 2017 | Pubmed ID: 28821363 A Novel Hypokalemic-Alkalotic Salt-Losing Tubulopathy in Patients with Mutations Journal of the American Society of Nephrology : JASN. Oct, 2017 | Pubmed ID: 28674042 Disposition and Clinical Implications of Protein-bound Uremic Toxins Clinical Science (London, England : 1979). Jul, 2017 | Pubmed ID: 28667064 Use of the Furosemide Fludrocortisone Test to Clinically Assess Distal Tubular Acidification American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. 10, 2017 | Pubmed ID: 28634085 Lithium-induced NDI: Acetazolamide Reduces Polyuria but Does Not Improve Urine Concentrating Ability American Journal of Physiology. Renal Physiology. 09, 2017 | Pubmed ID: 28615247 Urinary Excretion of α-Microglobulin Does Not Predict Graft Loss in Stable Kidney Transplant Recipients American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. 07, 2017 | Pubmed ID: 28501240 Safety of Rituximab Compared with Steroids and Cyclophosphamide for Idiopathic Membranous Nephropathy Journal of the American Society of Nephrology : JASN. Sep, 2017 | Pubmed ID: 28487395 Clinical Relevance of Differences in Glomerular Filtration Rate Estimations in Frail Older People by Creatinine- Vs. Cystatin C-Based Formulae Drugs & Aging. 06, 2017 | Pubmed ID: 28405944 Cost-effectiveness of Eculizumab Treatment After Kidney Transplantation in Patients with Atypical Haemolytic Uraemic Syndrome Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 01, 2017 | Pubmed ID: 28391343 Development and Pretesting of a Questionnaire to Assess Patient Experiences and Satisfaction with Medications (PESaM Questionnaire) The Patient. Oct, 2017 | Pubmed ID: 28357591 Adherence to Chronic Kidney Disease Guidelines in Primary Care Patients is Associated with Comorbidity Family Practice. 08, 2017 | Pubmed ID: 28207923 Web-based Consultation Between General Practitioners and Nephrologists: a Cluster Randomized Controlled Trial Family Practice. 08, 2017 | Pubmed ID: 28158576 Glomerular Disease in 2016: New Advances in the Treatment of Glomerular Disease Nature Reviews. Nephrology. 01, 2017 | Pubmed ID: 28100906 The Clinical Course of Minimal Change Nephrotic Syndrome With Onset in Adulthood or Late Adolescence: A Case Series American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. May, 2017 | Pubmed ID: 28089478 Copeptin, a Surrogate Marker for Arginine Vasopressin, is Associated with Disease Severity and Progression in IgA Nephropathy Patients Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 01, 2017 | Pubmed ID: 28057871 Lifetime Risk of Renal Replacement Therapy in Europe: a Population-based Study Using Data from the ERA-EDTA Registry Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 02, 2017 | Pubmed ID: 28031344 Hepatic Cyst Infection During Use of the Somatostatin Analog Lanreotide in Autosomal Dominant Polycystic Kidney Disease: An Interim Analysis of the Randomized Open-Label Multicenter DIPAK-1 Study Drug Safety. 02, 2017 | Pubmed ID: 27995519 Abdominal Aortic Calcification in Patients with CKD Journal of Nephrology. Feb, 2017 | Pubmed ID: 27003153 Uremic Solutes in Chronic Kidney Disease and Their Role in Progression PloS One. 2016 | Pubmed ID: 28033375 Minimal Change Disease and Idiopathic FSGS: Manifestations of the Same Disease Nature Reviews. Nephrology. Dec, 2016 | Pubmed ID: 27748392 Drug Therapy Management in Patients with Renal Impairment: How to Use Creatinine-based Formulas in Clinical Practice European Journal of Clinical Pharmacology. Dec, 2016 | Pubmed ID: 27568310 Pharmacological Treatment of Primary Membranous Nephropathy in 2016 Expert Review of Clinical Pharmacology. Nov, 2016 | Pubmed ID: 27535699 Kidney Dysfunction Increases Mortality and Incident Events After Young Stroke: The FUTURE Study Cerebrovascular Diseases (Basel, Switzerland). 2016 | Pubmed ID: 27173119 Should Aspirin Be Used for Primary Prevention of Thrombotic Events in Patients with Membranous Nephropathy? Kidney International. May, 2016 | Pubmed ID: 27083274 Quality of Chronic Kidney Disease Management in Primary Care: a Retrospective Study Scandinavian Journal of Primary Health Care. 2016 | Pubmed ID: 26853071 1,25-Vitamin D3 Deficiency Induces Albuminuria The American Journal of Pathology. Apr, 2016 | Pubmed ID: 26851346 Thiazide Responsiveness Testing in Patients With Renal Magnesium Wasting and Correlation With Genetic Analysis: A Diagnostic Test Study American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. 07, 2016 | Pubmed ID: 26830254 Renal Handling of Circulating and Renal-Synthesized Hepcidin and Its Protective Effects Against Hemoglobin-Mediated Kidney Injury Journal of the American Society of Nephrology : JASN. 09, 2016 | Pubmed ID: 26825531 Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus Journal of the American Society of Nephrology : JASN. Jul, 2016 | Pubmed ID: 26574046 Kidney Weight in Living and Postmortal Kidney Donation Transplantation. Jan, 2016 | Pubmed ID: 26469985 Hepatocyte Nuclear Factor 1β-Associated Kidney Disease: More Than Renal Cysts and Diabetes Journal of the American Society of Nephrology : JASN. Feb, 2016 | Pubmed ID: 26319241 Kidney Injury Molecule-1 and Neutrophil Gelatinase-associated Lipocalin As Prognostic Markers in Idiopathic Membranous Nephropathy Annals of Clinical Biochemistry. Jan, 2016 | Pubmed ID: 25762211 Central Arteriovenous Anastomosis and Hypertension Lancet (London, England). Nov, 2015 | Pubmed ID: 26843305 Synthetic ACTH in High Risk Patients with Idiopathic Membranous Nephropathy: A Prospective, Open Label Cohort Study PloS One. 2015 | Pubmed ID: 26562836 Prevalence of Apparent Therapy-Resistant Hypertension and Its Effect on Outcome in Patients With Chronic Kidney Disease Hypertension (Dallas, Tex. : 1979). Nov, 2015 | Pubmed ID: 26351024 Differential Expression of Specific Dermatan Sulfate Domains in Renal Pathology PloS One. 2015 | Pubmed ID: 26322947 Increased Expression of Lysosome Membrane Protein 2 in Glomeruli of Patients with Idiopathic Membranous Nephropathy Proteomics. Nov, 2015 | Pubmed ID: 26304790 Rituximab Can Induce Remission of Nephrotic Syndrome in the Absence of Peripheral B-cells Nephrology (Carlton, Vic.). Sep, 2015 | Pubmed ID: 26278122 Estimation of Total Kidney Volume in Autosomal Dominant Polycystic Kidney Disease American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. Nov, 2015 | Pubmed ID: 26235803 Proximal Tubular Efflux Transporters Involved in Renal Excretion of P-cresyl Sulfate and P-cresyl Glucuronide: Implications for Chronic Kidney Disease Pathophysiology Toxicology in Vitro : an International Journal Published in Association with BIBRA. Oct, 2015 | Pubmed ID: 26216510 Therapy: Maintenance of Steroid-free Remission in Nephrotic Syndrome Nature Reviews. Nephrology. Oct, 2015 | Pubmed ID: 26195145 Sensitive, Reliable and Easy-performed Laboratory Monitoring of Eculizumab Therapy in Atypical Hemolytic Uremic Syndrome Clinical Immunology (Orlando, Fla.). Oct, 2015 | Pubmed ID: 26111482 Serum Anti-PLA2R Antibodies Can Be Initially Absent in Idiopathic Membranous Nephropathy: Seroconversion After Prolonged Follow-up Kidney International. Jun, 2015 | Pubmed ID: 26024039 Individualizing Pharmacotherapy in Patients with Renal Impairment: the Validity of the Modification of Diet in Renal Disease Formula in Specific Patient Populations with a Glomerular Filtration Rate Below 60 Ml/min. A Systematic Review PloS One. 2015 | Pubmed ID: 25741695 Impact of Fractional Phosphate Excretion on the Relation of FGF23 with Outcome in CKD Patients Journal of Nephrology. Aug, 2015 | Pubmed ID: 25700931 Urinary Biomarkers After Donor Nephrectomy Transplant International : Official Journal of the European Society for Organ Transplantation. May, 2015 | Pubmed ID: 25581388 Permeability Factors in Idiopathic Nephrotic Syndrome: Historical Perspectives and Lessons for the Future Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Dec, 2014 | Pubmed ID: 25416821 Novel Aspects of Atypical Haemolytic Uraemic Syndrome and the Role of Eculizumab Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Sep, 2014 | Pubmed ID: 25165180 TRPC6 Single Nucleotide Polymorphisms and Progression of Idiopathic Membranous Nephropathy PloS One. 2014 | Pubmed ID: 25019165 Glucose Specifically Regulates TRPC6 Expression in the Podocyte in an AngII-dependent Manner The American Journal of Pathology. Jun, 2014 | Pubmed ID: 24731445 Phospholipase A2 Receptor Antibodies in Membranous Nephropathy: Unresolved Issues Journal of the American Society of Nephrology : JASN. Jun, 2014 | Pubmed ID: 24610931 Long-term Treatment with Tenofovir: Prevalence of Kidney Tubular Dysfunction and Its Association with Tenofovir Plasma Concentration Antiviral Therapy. 2014 | Pubmed ID: 24584104 Nurse Practitioner Care Improves Renal Outcome in Patients with CKD Journal of the American Society of Nephrology : JASN. Feb, 2014 | Pubmed ID: 24158983 Excroissance glomerulaire en tant qu’essai Ex Vivo pour analyser les voies impliquées dans l’activation des cellules épithéliales pariétales Jennifer Eymael1, Laura Miesen1, Fieke Mooren1, Jitske Jansen1,2, Jack Wetzels3, Johan van der Vlag4, Bart Smeets1 1Radboud Institute for Molecular Life Sciences, Department of Pathology, Radboud University Medical Center, 2Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Department of Paediatric Nephrology, Radboud University Medical Center, 3Radboud Institute for Health Sciences, Department of Nephrology, Radboud University Medical Center, 4Radboud Institute for Molecular Life Sciences, Department of Nephrology, Radboud University Medical Center JoVE 60324 Biology
Excroissance glomerulaire en tant qu’essai Ex Vivo pour analyser les voies impliquées dans l’activation des cellules épithéliales pariétales Jennifer Eymael1, Laura Miesen1, Fieke Mooren1, Jitske Jansen1,2, Jack Wetzels3, Johan van der Vlag4, Bart Smeets1 1Radboud Institute for Molecular Life Sciences, Department of Pathology, Radboud University Medical Center, 2Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Department of Paediatric Nephrology, Radboud University Medical Center, 3Radboud Institute for Health Sciences, Department of Nephrology, Radboud University Medical Center, 4Radboud Institute for Molecular Life Sciences, Department of Nephrology, Radboud University Medical Center JoVE 60324 Biology
