Jan Christian Dept. of Neurobiology and Internal Medicine, Division of Hematology and Hematologic Malignancies University of Utah Biography Publications Institution JoVE Articles Jan Christian Dr. Christian completed her PhD and postdoctoral training in the Moon lab at the University of Washington where she identified members of the Wnt gene family in Xenopus and showed that they contribute to multiple aspects of embryonic patterning. She started her independent lab at the Oregon Health Sciences University in 1993 and moved to the University of Utah in 2010. Our ongoing studies are discovering novel players in a non-canonical Toll like recptor signaling cascade that is activated by the transmembrane protein, Tril, in early embryos and that functions to concurrently inhibit nodal signaling and boost BMP signaling. We are also deciphering how human mutations in the prodomain of BMP4 and BMP6 lead to congenital defects and to iron overload, respectively. We use genetically modified mice to model these human mutations and use Xenopus as a simple vertebrate model to determine biochemically how prodomain mutations lead to a loss of ligand function. Publications Proteolytic Activation of Bmps: Analysis of Cleavage in Xenopus Oocytes and Embryos Methods in Molecular Biology (Clifton, N.J.). Month, 2019 | Pubmed ID: 30414129 Fibronectin Type III and Intracellular Domains of Toll-like Receptor 4 Interactor with Leucine-rich Repeats (Tril) Are Required for Developmental Signaling Molecular Biology of the Cell. 03, 2018 | Pubmed ID: 29298840 The TGFβ Superfamily in Lisbon: Navigating Through Development and Disease Development (Cambridge, England). 12, 2017 | Pubmed ID: 29254990 Tril Targets Smad7 for Degradation to Allow Hematopoietic Specification in Xenopus Embryos Development (Cambridge, England). 11, 2016 | Pubmed ID: 27633996 Expression Pattern of Bcar3, a Downstream Target of Gata2, and Its Binding Partner, Bcar1, During Xenopus Development Gene Expression Patterns : GEP. Jan, 2016 | Pubmed ID: 26631802 GATA2 Regulates Wnt Signaling to Promote Primitive Red Blood Cell Fate Developmental Biology. Nov, 2015 | Pubmed ID: 26365900 The Prodomain of BMP4 is Necessary and Sufficient to Generate Stable BMP4/7 Heterodimers with Enhanced Bioactivity in Vivo Proceedings of the National Academy of Sciences of the United States of America. May, 2015 | Pubmed ID: 25902523 Simultaneous Rather Than Ordered Cleavage of Two Sites Within the BMP4 Prodomain Leads to Loss of Ligand in Mice Development (Cambridge, England). Aug, 2014 | Pubmed ID: 24993941 Morphogen Gradients in Development: from Form to Function Wiley Interdisciplinary Reviews. Developmental Biology. Jan-Feb, 2012 | Pubmed ID: 23801664 ゼノプス・ラエビス胚の芽球に分泌される成長因子ßファミリー切断産物の分析 Hyung-Seok Kim1, Jan L. Christian2 1Department of Neurobiology, University of Utah, 2Departments of Neurobiology and Department of Internal Medicine, Division of Hematology and Hematologic Malignancies, University of Utah, School of Medicine JoVE 62782 Developmental Biology
ゼノプス・ラエビス胚の芽球に分泌される成長因子ßファミリー切断産物の分析 Hyung-Seok Kim1, Jan L. Christian2 1Department of Neurobiology, University of Utah, 2Departments of Neurobiology and Department of Internal Medicine, Division of Hematology and Hematologic Malignancies, University of Utah, School of Medicine JoVE 62782 Developmental Biology