Jayesh Kumar Sevak

Maternal and Child Health

Translation Health Science and Technology Institute

Jayesh Kumar Sevak

Jayesh Kumar Sevak is a Ph.D. scholar in the Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India. He has been awarded with Indian Council of Medical Research - Senior Research Fellowship (ICMR-SRF) in 2021. His research work focuses on establishing the precise association of metabolic variations, with immune effector functions and seroconversion during HBV reactivation. Further, single cells genomics analysis will reveal significant information regarding the heterogeneity of immune and metabolically active and exhausted immune cells, which might be leading to HBsAg and HBeAg seroconversion. Overall, the aim is to unravel the mechanism of immune-metabolism mediated HBsAg and HBeAg seroconversion in HBV reactivation patients.

He received his post-graduate degree in Molecular Biology and Biotechnology from Tezpur University, Assam, India. Thereafter, he worked at National Institute of High Security Animal Diseases (NIHSAD), on identification of the molecular basis of differential host responses to rapidly evolving Avian Influenza viruses in different avian species. He then moved to Institute of Life Sciences (ILS), Orissa, India where he worked on autophagy-mediated degradation of galectin-3. During his tenure as Junior Research Fellow at Translational Health Science and Technology Institute (THSTI), Haryana, India, he was trying to figure out if vitamin D deficiency is linked to premature birth and loss in muscle mass and worked on clinical samples - maternal blood, cord blood and tissue. The strategies that were followed included culturing of mesenchymal stem cells derived from cord blood and tissue and differentiating into muscle cell followed by characterization using flow cytometry, microscopy (IF and confocal) and western blotting. Besides, the study also focused on comprehending the global protein degradation and protein synthesis in the absence of vitamin D signaling.