Jed Johnson

Nanofiber Solutions

Jed Johnson

Fukunishi T, Best CA, Ong CS, Groehl T, Reinhardt J, et al. Role of Bone Marrow Mononuclear Cell Seeding for Nanofiber Vascular Grafts. Tissue Eng Part A. 2018 Jan;24(1-2):135-144. PubMed PMID: 28486019; PubMed Central PMCID: PMC5770093.

Barron MR, Blanco EW, Aho JM, Chakroff J, Johnson J, et al. Full-thickness oesophageal regeneration in pig using a polyurethane mucosal cell seeded graft. J Tissue Eng Regen Med. 2018 Jan;12(1):175-185. PubMed PMID: 27966266.

Ong CS, Fukunishi T, Liu RH, Nelson K, Zhang H, et al. Bilateral Arteriovenous Shunts as a Method for Evaluating Tissue-Engineered Vascular Grafts in Large Animal Models. Tissue Eng Part C Methods. 2017 Nov;23(11):728-735. PubMed PMID: 28741438; PubMed Central PMCID: PMC6436030.

Pepper VK, Onwuka EA, Best CA, King N, Heuer E, et al. Endoscopic management of tissue-engineered tracheal graft stenosis in an ovine model. Laryngoscope. 2017 Oct;127(10):2219-2224. PubMed PMID: 28349659; NIHMSID: NIHMS959174; PubMed Central PMCID: PMC5915324.

Fukunishi T, Best CA, Sugiura T, Opfermann J, Ong CS, et al. Preclinical study of patient-specific cell-free nanofiber tissue-engineered vascular grafts using 3-dimensional printing in a sheep model. J Thorac Cardiovasc Surg. 2017 Apr;153(4):924-932. PubMed PMID: 27938900; NIHMSID: NIHMS918684; PubMed Central PMCID: PMC5715716.

Liu Y, Nelson T, Cromeens B, Rager T, Lannutti J, et al. HB-EGF embedded in PGA/PLLA scaffolds via subcritical CO2 augments the production of tissue engineered intestine. Biomaterials. 2016 Oct;103:150-159. PubMed PMID: 27380441.

Fukunishi T, Best CA, Sugiura T, Shoji T, Yi T, et al. Tissue-Engineered Small Diameter Arterial Vascular Grafts from Cell-Free Nanofiber PCL/Chitosan Scaffolds in a Sheep Model. PLoS One. 2016;11(7):e0158555. PubMed PMID: 27467821; PubMed Central PMCID: PMC4965077.

Cromeens BP, Liu Y, Stathopoulos J, Wang Y, Johnson J, et al. Production of tissue-engineered intestine from expanded enteroids. J Surg Res. 2016 Jul;204(1):164-75. PubMed PMID: 27451883; NIHMSID: NIHMS765455; PubMed Central PMCID: PMC4963823.

Horner CB, Ico G, Johnson J, Zhao Y, Nam J. Microstructure-dependent mechanical properties of electrospun core-shell scaffolds at multi-scale levels. J Mech Behav Biomed Mater. 2016 Jun;59:207-219. PubMed PMID: 26774618.

Ott LM, Zabel TA, Walker NK, Farris AL, Chakroff JT, et al. Mechanical evaluation of gradient electrospun scaffolds with 3D printed ring reinforcements for tracheal defect repair. Biomed Mater. 2016 Apr 21;11(2):025020. PubMed PMID: 27097554.

Clark ES, Best C, Onwuka E, Sugiura T, Mahler N, et al. Effect of cell seeding on neotissue formation in a tissue engineered trachea. J Pediatr Surg. 2016 Jan;51(1):49-55. PubMed PMID: 26552897; NIHMSID: NIHMS757486; PubMed Central PMCID: PMC4824302.

Khan M, Xu Y, Hua S, Johnson J, Belevych A, et al. Correction: Evaluation of Changes in Morphology and Function of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (HiPSC-CMs) Cultured on an Aligned-Nanofiber Cardiac Patch. PLoS One. 2015;10(10):e0141176. PubMed PMID: 26473481; PubMed Central PMCID: PMC4608761.

Liu Y, Rager T, Johnson J, Enmark J, Besner GE. Enriched Intestinal Stem Cell Seeding Improves the Architecture of Tissue-Engineered Intestine. Tissue Eng Part C Methods. 2015 Aug;21(8):816-24. PubMed PMID: 25603285.

Khan M, Xu Y, Hua S, Johnson J, Belevych A, et al. Evaluation of Changes in Morphology and Function of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (HiPSC-CMs) Cultured on an Aligned-Nanofiber Cardiac Patch. PLoS One. 2015;10(5):e0126338. PubMed PMID: 25993466; PubMed Central PMCID: PMC4437999.

Maldonado M, Wong LY, Echeverria C, Ico G, Low K, et al. The effects of electrospun substrate-mediated cell colony morphology on the self-renewal of human induced pluripotent stem cells. Biomaterials. 2015 May;50:10-9. PubMed PMID: 25736491.

Johnson J. Development of Novel, Bioresorbable, Small-Diameter Electrospun Vascular Grafts. Journal of tissue science & engineering. 2015 March 25; 6(151).

Johnson J. Development and Characterization of Novel Electrospun Meshes for Hernia Repair. SOJ Materials Science and Engineering. 2015; 2(2):1-9.

Boomer L, Liu Y, Mahler N, Johnson J, Zak K, et al. Scaffolding for challenging environments: materials selection for tissue engineered intestine. J Biomed Mater Res A. 2014 Nov;102(11):3795-802. PubMed PMID: 24288210.

Roth AD, Elmer J, Harris DR, Huntley J, Palmer AF, et al. Hemoglobin regulates the migration of glioma cells along poly(ε-caprolactone)-aligned nanofibers. Biotechnol Prog. 2014 Sep-Oct;30(5):1214-20. PubMed PMID: 25044995.

Nelson MT, Johnson J, Lannutti J. Media-based effects on the hydrolytic degradation and crystallization of electrospun synthetic-biologic blends. J Mater Sci Mater Med. 2014 Feb;25(2):297-309. PubMed PMID: 24178985.

Han N, Bradley PA, Johnson J, Parikh KS, Hissong A, et al. Effects of hydrophobicity and mat thickness on release from hydrogel-electrospun fiber mat composites. J Biomater Sci Polym Ed. 2013;24(17):2018-30. PubMed PMID: 23905840.

Niehaus AJ, Anderson DE, Johnson JK, Lannutti JJ. Comparison of the mechanical characteristics of polymerized caprolactam and monofilament nylon loops constructed in parallel strands or as braided ropes versus cranial cruciate ligaments of cattle. Am J Vet Res. 2013 Mar;74(3):381-5. PubMed PMID: 23438112.

Han N, Johnson JK, Bradley PA, Parikh KS, Lannutti JJ, et al. Cell attachment to hydrogel-electrospun fiber mat composite materials. J Funct Biomater. 2012 Jul 27;3(3):497-513. PubMed PMID: 24955629; PubMed Central PMCID: PMC4031005.

Han N, Johnson J, Lannutti JJ, Winter JO. Hydrogel-electrospun fiber composite materials for hydrophilic protein release. J Control Release. 2012 Feb 28;158(1):165-70. PubMed PMID: 22001869.

Agudelo-Garcia PA, De Jesus JK, Williams SP, Nowicki MO, Chiocca EA, et al. Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling. Neoplasia. 2011 Sep;13(9):831-40. PubMed PMID: 21969816; PubMed Central PMCID: PMC3182275.

Nam J, Johnson J, Lannutti JJ, Agarwal S. Modulation of embryonic mesenchymal progenitor cell differentiation via control over pure mechanical modulus in electrospun nanofibers. Acta Biomater. 2011 Apr;7(4):1516-24. PubMed PMID: 21109030; NIHMSID: NIHMS254250; PubMed Central PMCID: PMC3050074.

Han N, Rao SS, Johnson J, Parikh KS, Bradley PA, et al. Hydrogel-electrospun fiber mat composite coatings for neural prostheses. Front Neuroeng. 2011;4:2. PubMed PMID: 21441993; PubMed Central PMCID: PMC3061411.

Lim YC, Johnson J, Fei Z, Wu Y, Farson DF, et al. Micropatterning and characterization of electrospun poly(ε-caprolactone)/gelatin nanofiber tissue scaffolds by femtosecond laser ablation for tissue engineering applications. Biotechnol Bioeng. 2011 Jan;108(1):116-26. PubMed PMID: 20812254.

Fischer SN, Johnson JK, Baran CP, Newland CA, Marsh CB, et al. Organ-derived coatings on electrospun nanofibers as ex vivo microenvironments. Biomaterials. 2011 Jan;32(2):538-46. PubMed PMID: 20875916; NIHMSID: NIHMS358124; PubMed Central PMCID: PMC3671867.

Veleva AN, Heath DE, Johnson JK, Nam J, Patterson C, et al. Interactions between endothelial cells and electrospun methacrylic terpolymer fibers for engineered vascular replacements. J Biomed Mater Res A. 2009 Dec 15;91(4):1131-9. PubMed PMID: 19148926; NIHMSID: NIHMS391062; PubMed Central PMCID: PMC3432312.

Johnson J, Nowicki MO, Lee CH, Chiocca EA, Viapiano MS, et al. Quantitative analysis of complex glioma cell migration on electrospun polycaprolactone using time-lapse microscopy. Tissue Eng Part C Methods. 2009 Dec;15(4):531-40. PubMed PMID: 19199562; PubMed Central PMCID: PMC3497888.

Niehaus AJ, Anderson DE, Samii VF, Weisbrode SE, Johnson JK, et al. Effects of orthopedic implants with a polycaprolactone polymer coating containing bone morphogenetic protein-2 on osseointegration in bones of sheep. Am J Vet Res. 2009 Nov;70(11):1416-25. PubMed PMID: 19878025.

Johnson J, Niehaus A, Nichols S, Lee D, Koepsel J, et al. Electrospun PCL in vitro: a microstructural basis for mechanical property changes. J Biomater Sci Polym Ed. 2009;20(4):467-81. PubMed PMID: 19228448.

Johnson J. Structuring Electrospun Polycaprolactone nanofiber tissue scaffolds by femtosecond laser ablation. Journal of laser applications. 2007 November 01; 19(4):225-231.

Johnson J. Microstructure-Property Relationships in a Tissue Engineering Scaffold. Journal of applied polymer science. 2007 June 05; 104(5):2919-2927.


Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model

1Department of Otolaryngology Head & Neck Surgery, Nationwide Children's Hospital, 2The Ohio State University College of Medicine, 3Center for Regenerative Medicine, Research Institute at Nationwide Children's Hospital, 4Center for Perinatal Research, Nationwide Children's Hospital, 5Nanofiber Solutions, Inc., 6Department of Pediatric Surgery, Nationwide Children's Hospital

JoVE 59173