Jens Kurreck Department of Applied Biochemistry Institute of Biotechnology, Berlin University of Technology Biography Publications Institution JoVE Articles Jens Kurreck has not added a biography. If you are Jens Kurreck and would like to personalize this page please email our Author Liaison for assistance. Publications Biological Antivirals for Treatment of Adenovirus Infections Antiviral Therapy. Apr, 2016 | Pubmed ID: 27032991 The Coxsackievirus and Adenovirus Receptor: Glycosylation and the Extracellular D2 Domain Are Not Required for Coxsackievirus B3 Infection Journal of Virology. Jun, 2016 | Pubmed ID: 27030267 Hepatitis E Virus Superinfection and Clinical Progression in Hepatitis B Patients EBioMedicine. Dec, 2015 | Pubmed ID: 26844288 Application of Modified Antisense Oligonucleotides and SiRNAs As Antiviral Drugs Future Medicinal Chemistry. 2015 | Pubmed ID: 26381598 Use of a Three-dimensional Humanized Liver Model for the Study of Viral Gene Vectors Journal of Biotechnology. Oct, 2015 | Pubmed ID: 26356676 Targeting Highly Structured RNA by Cooperative Action of SiRNAs and Helper Antisense Oligomers in Living Cells PloS One. 2015 | Pubmed ID: 26308932 Enhanced Suppression of Adenovirus Replication by Triple Combination of Anti-adenoviral SiRNAs, Soluble Adenovirus Receptor Trap SCAR-Fc and Cidofovir Antiviral Research. Aug, 2015 | Pubmed ID: 26026665 Combination of RNA Interference and Virus Receptor Trap Exerts Additive Antiviral Activity in Coxsackievirus B3-induced Myocarditis in Mice The Journal of Infectious Diseases. Feb, 2015 | Pubmed ID: 25193982 Identification and Characterization of RNA Guanine-quadruplex Binding Proteins Nucleic Acids Research. Jun, 2014 | Pubmed ID: 24771345 A Novel Artificial MicroRNA Expressing AAV Vector for Phospholamban Silencing in Cardiomyocytes Improves Ca2+ Uptake into the Sarcoplasmic Reticulum PloS One. 2014 | Pubmed ID: 24670775 A Novel Method for the Quantification of Adeno-associated Virus Vectors for RNA Interference Applications Using Quantitative Polymerase Chain Reaction and Purified Genomic Adeno-associated Virus DNA As a Standard Human Gene Therapy Methods. Dec, 2013 | Pubmed ID: 23987130 Adenovirus Vector-mediated RNA Interference for the Inhibition of Human Parvovirus B19 Replication Virus Research. Sep, 2013 | Pubmed ID: 23770153 Application of Mutated MiR-206 Target Sites Enables Skeletal Muscle-specific Silencing of Transgene Expression of Cardiotropic AAV9 Vectors Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2013 | Pubmed ID: 23439498 Pharmacological and Biological Antiviral Therapeutics for Cardiac Coxsackievirus Infections Molecules (Basel, Switzerland). Oct, 2011 | Pubmed ID: 21989310 Design of Small Interfering RNAs for Antiviral Applications Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21431692 Inhibition of Adenovirus Infections by SiRNA-mediated Silencing of Early and Late Adenoviral Gene Functions Antiviral Research. Oct, 2010 | Pubmed ID: 20708037 Rapid Construction of Adeno-associated Virus Vectors Expressing Multiple Short Hairpin RNAs with High Antiviral Activity Against Echovirus 30 Oligonucleotides. Aug, 2010 | Pubmed ID: 20649454 Proof of RNA Interference in Humans After Systemic Delivery of SiRNAs Angewandte Chemie (International Ed. in English). Aug, 2010 | Pubmed ID: 20648509 Application of Small Interfering RNAs Modified by Unlocked Nucleic Acid (UNA) to Inhibit the Heart-pathogenic Coxsackievirus B3 FEBS Letters. Feb, 2010 | Pubmed ID: 20005874 Combination of Soluble Coxsackievirus-adenovirus Receptor and Anti-coxsackievirus SiRNAs Exerts Synergistic Antiviral Activity Against Coxsackievirus B3 Antiviral Research. Sep, 2009 | Pubmed ID: 19591879 Locked Nucleic Acid Aptamers Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19377996 Long-term Cardiac-targeted RNA Interference for the Treatment of Heart Failure Restores Cardiac Function and Reduces Pathological Hypertrophy Circulation. Mar, 2009 | Pubmed ID: 19237664 Antiviral Activity of Highly Potent SiRNAs Against Echovirus 30 and Its Receptor Journal of Virological Methods. May, 2009 | Pubmed ID: 19187792 RNA Interference: from Basic Research to Therapeutic Applications Angewandte Chemie (International Ed. in English). 2009 | Pubmed ID: 19153977 ESF-EMBO Symposium: Antiviral Applications of RNA Interference Retrovirology. Sep, 2008 | Pubmed ID: 18801178 Inhibition of Picornaviruses by Means of RNA Interference Nucleic Acids Symposium Series (2004). 2008 | Pubmed ID: 18776254 Design of LNA-modified SiRNAs Against the Highly Structured 5' UTR of Coxsackievirus B3 FEBS Letters. Sep, 2008 | Pubmed ID: 18691577 Cardiac-targeted RNA Interference Mediated by an AAV9 Vector Improves Cardiac Function in Coxsackievirus B3 Cardiomyopathy Journal of Molecular Medicine (Berlin, Germany). Sep, 2008 | Pubmed ID: 18548221 Inhibition of Translation in Living Eukaryotic Cells by an RNA G-quadruplex Motif RNA (New York, N.Y.). Jul, 2008 | Pubmed ID: 18515550 Investigation of TRPV1 Loss-of-function Phenotypes in Transgenic ShRNA Expressing and Knockout Mice Molecular and Cellular Neurosciences. Mar, 2008 | Pubmed ID: 18249134 Strand-specific Silencing of a Picornavirus by RNA Interference: Evidence for the Superiority of Plus-strand Specific SiRNAs Antiviral Research. Mar, 2007 | Pubmed ID: 17112603 Antinociceptive Effect of Antisense Oligonucleotides Against the Vanilloid Receptor VR1/TRPV1 Neurochemistry International. Jan, 2007 | Pubmed ID: 17045702 SiRNA Efficiency: Structure or Sequence-that is the Question Journal of Biomedicine & Biotechnology. 2006 | Pubmed ID: 17057371 RNA Interference in Pain Research Journal of Neurochemistry. Oct, 2006 | Pubmed ID: 17029593 Silencing of Vanilloid Receptor TRPV1 by RNAi Reduces Neuropathic and Visceral Pain in Vivo Biochemical and Biophysical Research Communications. Nov, 2006 | Pubmed ID: 16996476 Comparative Crystallization and Preliminary X-ray Diffraction Studies of Locked Nucleic Acid and RNA Stems of a Tenascin C-binding Aptamer Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Jul, 2006 | Pubmed ID: 16820689 RNA Interference: Perspectives and Caveats Journal of RNAi and Gene Silencing : an International Journal of RNA and Gene Targeting Research. Oct, 2005 | Pubmed ID: 19771205 Developing an Effective RNA Interference Strategy Against a Plus-strand RNA Virus: Silencing of Coxsackievirus B3 and Its Cognate Coxsackievirus-adenovirus Receptor Biological Chemistry. Sep, 2005 | Pubmed ID: 16164410 Local RNA Target Structure Influences SiRNA Efficacy: Systematic Analysis of Intentionally Designed Binding Regions Journal of Molecular Biology. May, 2005 | Pubmed ID: 15843020 Maintaining Inhibition: SiRNA Double Expression Vectors Against Coxsackieviral RNAs Journal of Molecular Biology. Feb, 2005 | Pubmed ID: 15670596 Deletion Analysis in the Catalytic Region of the 10-23 DNA Enzyme FEBS Letters. Jan, 2005 | Pubmed ID: 15642375 Antisense and RNA Interference Approaches to Target Validation in Pain Research Current Opinion in Drug Discovery & Development. Mar, 2004 | Pubmed ID: 15603251 Application of Locked Nucleic Acids to Improve Aptamer in Vivo Stability and Targeting Function Nucleic Acids Research. 2004 | Pubmed ID: 15509871 Differentiating the Functional Role of Hypoxia-inducible Factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the Use of RNA Interference: Erythropoietin is a HIF-2alpha Target Gene in Hep3B and Kelly Cells FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2004 | Pubmed ID: 15240563 Gaining Target Access for Deoxyribozymes Journal of Molecular Biology. May, 2004 | Pubmed ID: 15136038 Expediting Target Identification and Validation Through RNAi Expert Opinion on Biological Therapy. Mar, 2004 | Pubmed ID: 15006736 Cellular Uptake and Localization of a Cy3-labeled SiRNA Specific for the Serine/threonine Kinase Pim-1 Oligonucleotides. 2003 | Pubmed ID: 15000825 Nucleic Acids Chemistry and Biology Angewandte Chemie (International Ed. in English). Nov, 2003 | Pubmed ID: 14618569 RNA Cleaving '10-23' DNAzymes with Enhanced Stability and Activity Nucleic Acids Research. Oct, 2003 | Pubmed ID: 14530446 Comparison of Different Antisense Strategies in Mammalian Cells Using Locked Nucleic Acids, 2'-O-methyl RNA, Phosphorothioates and Small Interfering RNA Nucleic Acids Research. Jun, 2003 | Pubmed ID: 12799446 Antisense Technologies. Improvement Through Novel Chemical Modifications European Journal of Biochemistry. Apr, 2003 | Pubmed ID: 12694176 Sequence Requirements in the Catalytic Core of the "10-23" DNA Enzyme The Journal of Biological Chemistry. Oct, 2002 | Pubmed ID: 12192010 Design of Antisense Oligonucleotides Stabilized by Locked Nucleic Acids Nucleic Acids Research. May, 2002 | Pubmed ID: 11972327 Comparative Study of DNA Enzymes and Ribozymes Against the Same Full-length Messenger RNA of the Vanilloid Receptor Subtype I The Journal of Biological Chemistry. Mar, 2002 | Pubmed ID: 11751899 Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2 Thomas Hiller1, Viola Röhrs1, Eva-Maria Dehne2, Anke Wagner1,3, Henry Fechner1, Roland Lauster2, Jens Kurreck1 1Department of Applied Biochemistry, Institute of Biotechnology, Berlin University of Technology, 2Department of Medical Biotechnology, Institute of Biotechnology, Berlin University of Technology, 3Department of Bioprocess Engineering, Institute of Biotechnology, Berlin University of Technology JoVE 54633 Cancer Research
Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2 Thomas Hiller1, Viola Röhrs1, Eva-Maria Dehne2, Anke Wagner1,3, Henry Fechner1, Roland Lauster2, Jens Kurreck1 1Department of Applied Biochemistry, Institute of Biotechnology, Berlin University of Technology, 2Department of Medical Biotechnology, Institute of Biotechnology, Berlin University of Technology, 3Department of Bioprocess Engineering, Institute of Biotechnology, Berlin University of Technology JoVE 54633 Cancer Research