Jeung Whan Han School of Pharmacy Sungkyunkwan University Biography Publications Institution JoVE Articles Jeung Whan Han has not added a biography. If you are Jeung Whan Han and would like to personalize this page please email our Author Liaison for assistance. Publications Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2017 | Pubmed ID: 28432138 A New Manufacturing Process to Remove Thrombogenic Factors (II, VII, IX, X, and XI) from Intravenous Immunoglobulin Gamma Preparations Biologicals : Journal of the International Association of Biological Standardization. Jan, 2017 | Pubmed ID: 27876270 PKN2 and Cdo Interact to Activate AKT and Promote Myoblast Differentiation Cell Death & Disease. Oct, 2016 | Pubmed ID: 27763641 Mapping the Technological Knowledge Landscape: The Case of Epigenetics Recent Patents on Anti-cancer Drug Discovery. 2016 | Pubmed ID: 27557814 Differential Regulation of the Histone Chaperone HIRA During Muscle Cell Differentiation by a Phosphorylation Switch Experimental & Molecular Medicine. Aug, 2016 | Pubmed ID: 27515126 Epigenetic Role of Nuclear S6K1 in Early Adipogenesis BMB Reports. Aug, 2016 | Pubmed ID: 27439608 Patent Cliff and Strategic Switch: Exploring Strategic Design Possibilities in the Pharmaceutical Industry SpringerPlus. 2016 | Pubmed ID: 27347468 S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis Molecular Cell. May, 2016 | Pubmed ID: 27151441 Epigenetic Reader BRD4 Inhibition As a Therapeutic Strategy to Suppress E2F2-cell Cycle Regulation Circuit in Liver Cancer Oncotarget. May, 2016 | Pubmed ID: 27081696 JQ1, an Inhibitor of the Epigenetic Reader BRD4, Suppresses the Bidirectional MYC-AP4 Axis Via Multiple Mechanisms Oncology Reports. Feb, 2016 | Pubmed ID: 26573731 Syntaxin 4 Regulates the Surface Localization of a Promyogenic Receptor Cdo Thereby Promoting Myogenic Differentiation Skeletal Muscle. 2015 | Pubmed ID: 26347807 Identification of Small Molecules That Inhibit the Histone Chaperone Asf1 and Its Chromatin Function BMB Reports. Dec, 2015 | Pubmed ID: 26058396 Epigenetic Activation of the Foxa2 Gene is Required for Maintaining the Potential of Neural Precursor Cells to Differentiate into Dopaminergic Neurons After Expansion Stem Cells and Development. Feb, 2015 | Pubmed ID: 25233056 HP1β Suppresses Metastasis of Human Cancer Cells by Decreasing the Expression and Activation of MMP2 International Journal of Oncology. Dec, 2014 | Pubmed ID: 25201136 The Role of Tumor Suppressor Menin in IL-6 Regulation in Mouse Islet Tumor Cells Biochemical and Biophysical Research Communications. Aug, 2014 | Pubmed ID: 25088994 Reversine Induces Multipotency of Lineage-committed Cells Through Epigenetic Silencing of MiR-133a Biochemical and Biophysical Research Communications. Feb, 2014 | Pubmed ID: 24513286 DNA Microarray Profiling of Genes Differentially Regulated by Three Heterochromatin Protein 1 (HP1) Homologs in Drosophila Biochemical and Biophysical Research Communications. May, 2013 | Pubmed ID: 23611785 Dissecting the Roles of the Histone Chaperones Reveals the Evolutionary Conserved Mechanism of Transcription-coupled Deposition of H3.3 Nucleic Acids Research. May, 2013 | Pubmed ID: 23563152 PRMT6 Overexpression Upregulates TSP-1 and Downregulates MMPs: Its Implication in Motility and Invasion Biochemical and Biophysical Research Communications. Mar, 2013 | Pubmed ID: 23380452 Destabilization of TNF-α MRNA by Rapamycin Biomolecules & Therapeutics. Jan, 2012 | Pubmed ID: 24116273 Protein L-isoaspartyl Methyltransferase Regulates P53 Activity Nature Communications. Jun, 2012 | Pubmed ID: 22735455 The Role of Histone Chaperones in Osteoblastic Differentiation of C2C12 Myoblasts Biochemical and Biophysical Research Communications. Jul, 2012 | Pubmed ID: 22705305 Requirement of Protein L-isoaspartyl O-methyltransferase for Transcriptional Activation of Trefoil Factor 1 (TFF1) Gene by Estrogen Receptor Alpha Biochemical and Biophysical Research Communications. Apr, 2012 | Pubmed ID: 22382029 Histone Chaperones Cooperate to Mediate Mef2-targeted Transcriptional Regulation During Skeletal Myogenesis Biochemical and Biophysical Research Communications. Apr, 2011 | Pubmed ID: 21414300 Myogenic Transcriptional Activation of MyoD Mediated by Replication-independent Histone Deposition Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011 | Pubmed ID: 21173268 HDAC Inhibitors Downregulate MRP2 Expression in Multidrug Resistant Cancer Cells: Implication for Chemosensitization International Journal of Oncology. Mar, 2011 | Pubmed ID: 21170509 Foxa2 and Nurr1 Synergistically Yield A9 Nigral Dopamine Neurons Exhibiting Improved Differentiation, Function, and Cell Survival Stem Cells (Dayton, Ohio). Mar, 2010 | Pubmed ID: 20049900 The Tumor Suppressor, Parafibromin, Mediates Histone H3 K9 Methylation for Cyclin D1 Repression Nucleic Acids Research. Jan, 2010 | Pubmed ID: 19906718 A Novel Gamma-lactam-based Histone Deacetylase Inhibitor Potently Inhibits the Growth of Human Breast and Renal Cancer Cells Biological & Pharmaceutical Bulletin. Oct, 2009 | Pubmed ID: 19801834 Oral Administration of Curcumin Suppresses Production of Matrix Metalloproteinase (MMP)-1 and MMP-3 to Ameliorate Collagen-induced Arthritis: Inhibition of the PKCdelta/JNK/c-Jun Pathway Journal of Pharmacological Sciences. Sep, 2009 | Pubmed ID: 19763044 Depletion of Embryonic Stem Cell Signature by Histone Deacetylase Inhibitor in NCCIT Cells: Involvement of Nanog Suppression Cancer Research. Jul, 2009 | Pubmed ID: 19567677 Rapamycin Down-regulates Inducible Nitric Oxide Synthase by Inducing Proteasomal Degradation Biological & Pharmaceutical Bulletin. Jun, 2009 | Pubmed ID: 19483303 Reversine Increases the Plasticity of Lineage-committed Cells Toward Neuroectodermal Lineage The Journal of Biological Chemistry. Jan, 2009 | Pubmed ID: 19015271 Lysophosphatidic Acid Receptor 2 and Gi/Src Pathway Mediate Cell Motility Through Cyclooxygenase 2 Expression in CAOV-3 Ovarian Cancer Cells Experimental & Molecular Medicine. Dec, 2008 | Pubmed ID: 19116446 Histone Deacetylase Inhibitor KBH-A42 Inhibits Cytokine Production in RAW 264.7 Macrophage Cells and in Vivo Endotoxemia Model Experimental & Molecular Medicine. Oct, 2008 | Pubmed ID: 18985016 TIMP-2 Disrupts FGF-2-induced Downstream Signaling Pathways Microvascular Research. Nov, 2008 | Pubmed ID: 18721821 Curcumin, a Constituent of Curry, Suppresses IgE-mediated Allergic Response and Mast Cell Activation at the Level of Syk The Journal of Allergy and Clinical Immunology. May, 2008 | Pubmed ID: 18394691 Histone Deacetylase Inhibitor Apicidin-mediated Drug Resistance: Involvement of P-glycoprotein Biochemical and Biophysical Research Communications. Apr, 2008 | Pubmed ID: 18275843 Hypoxia Enhances LPA-induced HIF-1alpha and VEGF Expression: Their Inhibition by Resveratrol Cancer Letters. Dec, 2007 | Pubmed ID: 17919812 Histone Chaperones Regulate Histone Exchange During Transcription The EMBO Journal. Oct, 2007 | Pubmed ID: 17914459 Modification of Cap Group in Delta-lactam-based Histone Deacetylase (HDAC) Inhibitors Bioorganic & Medicinal Chemistry Letters. Nov, 2007 | Pubmed ID: 17904843 Reversine Stimulates Adipocyte Differentiation and Downregulates Akt and P70(s6k) Signaling Pathways in 3T3-L1 Cells Biochemical and Biophysical Research Communications. Jun, 2007 | Pubmed ID: 17490611 Suppression of the NF-kappaB Signalling Pathway by Ergolide, Sesquiterpene Lactone, in HeLa Cells The Journal of Pharmacy and Pharmacology. Apr, 2007 | Pubmed ID: 17430640 Meliae Cortex Extract Exhibits Anti-allergic Activity Through the Inhibition of Syk Kinase in Mast Cells Toxicology and Applied Pharmacology. May, 2007 | Pubmed ID: 17395225 Coordinated Change of a Ratio of Methylated H3-lysine 4 or Acetylated H3 to Acetylated H4 and DNA Methylation is Associated with Tissue-specific Gene Expression in Cloned Pig Experimental & Molecular Medicine. Feb, 2007 | Pubmed ID: 17334232 Reversal of Multidrug Resistance by 4-chloro-N-(3-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide Through the Reversible Inhibition of P-glycoprotein Biochemical and Biophysical Research Communications. Mar, 2007 | Pubmed ID: 17286965 PKCepsilon is Essential for Gelsolin Expression by Histone Deacetylase Inhibitor Apicidin in Human Cervix Cancer Cells Biochemical and Biophysical Research Communications. Mar, 2007 | Pubmed ID: 17257588 Activation of Hypoxia-inducible Factor-1alpha is Necessary for Lysophosphatidic Acid-induced Vascular Endothelial Growth Factor Expression Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2006 | Pubmed ID: 17085645 Autotaxin Stimulates Urokinase-type Plasminogen Activator Expression Through Phosphoinositide 3-kinase-Akt-nuclear [corrected] Factor Kappa B Signaling Cascade in Human Melanoma Cells Melanoma Research. Oct, 2006 | Pubmed ID: 17013094 Involvement of HDAC1 and the PI3K/PKC Signaling Pathways in NF-kappaB Activation by the HDAC Inhibitor Apicidin Biochemical and Biophysical Research Communications. Sep, 2006 | Pubmed ID: 16870149 Phospholipase D2 Acts As an Essential Adaptor Protein in the Activation of Syk in Antigen-stimulated Mast Cells Blood. Aug, 2006 | Pubmed ID: 16861349 Immunoglobulin Can Be Functionally Regulated by Protein Carboxylmethylation in Fc Region Archives of Pharmacal Research. May, 2006 | Pubmed ID: 16756083 Rubiae Radix Suppresses the Activation of Mast Cells Through the Inhibition of Syk Kinase for Anti-allergic Activity The Journal of Pharmacy and Pharmacology. Apr, 2006 | Pubmed ID: 16597368 Histone Deacetylase Inhibitor Apicidin Induces Cyclin E Expression Through Sp1 Sites Biochemical and Biophysical Research Communications. Apr, 2006 | Pubmed ID: 16516150 Shp-1 Mediates the Antiproliferative Activity of Tissue Inhibitor of Metalloproteinase-2 in Human Microvascular Endothelial Cells The Journal of Biological Chemistry. Feb, 2006 | Pubmed ID: 16326706 Cooperation of H2O2-mediated ERK Activation with Smad Pathway in TGF-beta1 Induction of P21WAF1/Cip1 Cellular Signalling. Feb, 2006 | Pubmed ID: 15979845 Apoptotic Potential of Sesquiterpene Lactone Ergolide Through the Inhibition of NF-kappaB Signaling Pathway The Journal of Pharmacy and Pharmacology. Dec, 2005 | Pubmed ID: 16354403 Suppression of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in RAW 264.7 Macrophages by Sesquiterpene Lactones Journal of Toxicology and Environmental Health. Part A. Dec, 2005 | Pubmed ID: 16326428 Beta-Carboline Alkaloid Suppresses NF-kappaB Transcriptional Activity Through Inhibition of IKK Signaling Pathway Journal of Toxicology and Environmental Health. Part A. Dec, 2005 | Pubmed ID: 16326420 P85 Beta-PIX is Required for Cell Motility Through Phosphorylations of Focal Adhesion Kinase and P38 MAP Kinase Experimental Cell Research. Jul, 2005 | Pubmed ID: 15893751 Effect of a Fermented Ginseng Extract, BST204, on the Expression of Cyclooxygenase-2 in Murine Macrophages International Immunopharmacology. May, 2005 | Pubmed ID: 15778128 Development of a Liquid Chromatography/electrospray Tandem Mass Spectrometry Assay for the Quantification of Apicidin, a Novel Histone Deacetylase Inhibitor, in Rat Serum: Application to a Pharmacokinetic Study Rapid Communications in Mass Spectrometry : RCM. 2005 | Pubmed ID: 15645510 Inhibitory Activity of Chrysanthemi Sibirici Herba Extract on RBL-2H3 Mast Cells and Compound 48/80-induced Anaphylaxis Journal of Ethnopharmacology. Dec, 2004 | Pubmed ID: 15507370 Hydrogen Peroxide Mediates Rac1 Activation of S6K1 Experimental Cell Research. Nov, 2004 | Pubmed ID: 15475011 Activation of RBL-2H3 Mast Cells is Dependent on Tyrosine Phosphorylation of Phospholipase D2 by Fyn and Fgr Molecular and Cellular Biology. Aug, 2004 | Pubmed ID: 15282299 In-vitro and In-vivo Anti-allergic Actions of Arecae Semen The Journal of Pharmacy and Pharmacology. Jul, 2004 | Pubmed ID: 15233873 Activation of P21-activated Kinase 1 is Required for Lysophosphatidic Acid-induced Focal Adhesion Kinase Phosphorylation and Cell Motility in Human Melanoma A2058 Cells European Journal of Biochemistry. Apr, 2004 | Pubmed ID: 15066181 Apicidin is a Histone Deacetylase Inhibitor with Anti-invasive and Anti-angiogenic Potentials Biochemical and Biophysical Research Communications. Mar, 2004 | Pubmed ID: 14985106 Hydrogen Peroxide Mediates Arsenite Activation of P70(s6k) and Extracellular Signal-regulated Kinase Experimental Cell Research. Oct, 2003 | Pubmed ID: 14516795 Expression of P21(WAF1/Cip1) Through Sp1 Sites by Histone Deacetylase Inhibitor Apicidin Requires PI 3-kinase-PKC Epsilon Signaling Pathway Oncogene. Sep, 2003 | Pubmed ID: 12955081 Purification and Characterization of Nitric Oxide Synthase from Staphylococcus Aureus FEMS Microbiology Letters. May, 2003 | Pubmed ID: 12770704 Expression of Autotaxin (NPP-2) is Closely Linked to Invasiveness of Breast Cancer Cells Clinical & Experimental Metastasis. 2002 | Pubmed ID: 12498389 Cdc42 and Rac1 Are Necessary for Autotaxin-induced Tumor Cell Motility in A2058 Melanoma Cells FEBS Letters. Dec, 2002 | Pubmed ID: 12482591 Doxorubicin Inhibits the Production of Nitric Oxide by Colorectal Cancer Cells Archives of Pharmacal Research. Oct, 2002 | Pubmed ID: 12433207 Constitutive Activation of P70S6k in Cancer Cells Archives of Pharmacal Research. Oct, 2002 | Pubmed ID: 12433206 5-Fluorouracil Inhibits Nitric Oxide Production Through the Inactivation of IkappaB Kinase in Stomach Cancer Cells Biochemical Pharmacology. Nov, 2002 | Pubmed ID: 12417257 Oligosaccharide-linked Acyl Carrier Protein, a Novel Transmethylase Inhibitor, from Porcine Liver Inhibits Cell Growth Archives of Pharmacal Research. Aug, 2002 | Pubmed ID: 12214857 Autotaxin Promotes Motility Via G Protein-coupled Phosphoinositide 3-kinase Gamma in Human Melanoma Cells FEBS Letters. Mar, 2002 | Pubmed ID: 11943209 Apicidin, a Histone Deacetylase Inhibitor, Induces Apoptosis and Fas/Fas Ligand Expression in Human Acute Promyelocytic Leukemia Cells The Journal of Biological Chemistry. Jan, 2002 | Pubmed ID: 11698395 Analysen utvikling for høy innhold kvantifisering av Sod1 Mutant Protein samlet formasjon i levende celler Honggun Lee1, Constantin Radu1, Jeung Whan Han2, Regis Grailhe3 1Automation & Logistics Management, Screening Sciences & Novel Assay Technologies, Institut Pasteur Korea, 2School of Pharmacy, Sungkyunkwan University, 3Technology Development Platform, Institut Pasteur Korea JoVE 56425 Neuroscience
Analysen utvikling for høy innhold kvantifisering av Sod1 Mutant Protein samlet formasjon i levende celler Honggun Lee1, Constantin Radu1, Jeung Whan Han2, Regis Grailhe3 1Automation & Logistics Management, Screening Sciences & Novel Assay Technologies, Institut Pasteur Korea, 2School of Pharmacy, Sungkyunkwan University, 3Technology Development Platform, Institut Pasteur Korea JoVE 56425 Neuroscience
