Jie Zhou Department of Microbiology, Li Ka Shing Faculty of Medicine The University of Hong Kong Biography Publications Institution JoVE Articles Jie Zhou has not added a biography. If you are Jie Zhou and would like to personalize this page please email our Author Liaison for assistance. Publications A Pan-sarbecovirus Vaccine Induces Highly Potent and Durable Neutralizing Antibody Responses in Non-human Primates Against SARS-CoV-2 Omicron Variant Cell Research. Feb, 2022 | Pubmed ID: 35210607 Discovery of a Novel Megakaryopoiesis Enhancer, Ingenol, Promoting Thrombopoiesis Through PI3K-Akt Signaling Independent of Thrombopoietin Pharmacological Research. Mar, 2022 | Pubmed ID: 35077844 Attenuated Replication and Pathogenicity of SARS-CoV-2 B.1.1.529 Omicron Nature. Jan, 2022 | Pubmed ID: 35062016 SPINK6 Inhibits Human Airway Serine Proteases and Restricts Influenza Virus Activation EMBO Molecular Medicine. 01, 2022 | Pubmed ID: 34826211 A(H1N1)pdm09 Influenza Viruses Replicating in Ferret Upper or Lower Respiratory Tract Differed in Onward Transmission Potential by Air The Journal of Infectious Diseases. 01, 2022 | Pubmed ID: 34036370 Emerging SARS-CoV-2 Variants Expand Species Tropism to Murines EBioMedicine. Nov, 2021 | Pubmed ID: 34689086 Targeting Highly Pathogenic Coronavirus-induced Apoptosis Reduces Viral Pathogenesis and Disease Severity Science Advances. 06, 2021 | Pubmed ID: 34134991 Monocytic MDSC Mobilization Promotes Tumor Recurrence After Liver Transplantation Via CXCL10/TLR4/MMP14 Signaling Cell Death & Disease. 05, 2021 | Pubmed ID: 33990548 STAT2-dependent Restriction of Zika Virus by Human Macrophages but Not Dendritic Cells Emerging Microbes & Infections. Dec, 2021 | Pubmed ID: 33979266 Development of Cisplatin-loaded Hydrogels for Trans-portal Vein Chemoembolization in an Orthotopic Liver Cancer Mouse Model Drug Delivery. Dec, 2021 | Pubmed ID: 33685316 Robust SARS-CoV-2 Infection in Nasal Turbinates After Treatment with Systemic Neutralizing Antibodies Cell Host & Microbe. 04, 2021 | Pubmed ID: 33657424 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th Edition) Autophagy. Feb, 2021 | Pubmed ID: 33634751 Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus Stem Cell Reports. 03, 2021 | Pubmed ID: 33626333 Development of Three-Dimensional Human Intestinal Organoids As a Physiologically Relevant Model for Characterizing the Viral Replication Kinetics and Antiviral Susceptibility of Enteroviruses Biomedicines. Jan, 2021 | Pubmed ID: 33477611 Host and Viral Determinants for Efficient SARS-CoV-2 Infection of the Human Lung Nature Communications. 01, 2021 | Pubmed ID: 33420022 SARS-CoV-2 Induces a More Robust Innate Immune Response and Replicates Less Efficiently Than SARS-CoV in the Human Intestines: An Ex Vivo Study With Implications on Pathogenesis of COVID-19 Cellular and Molecular Gastroenterology and Hepatology. 2021 | Pubmed ID: 33010495 Natural Transmission of Bat-like Severe Acute Respiratory Syndrome Coronavirus 2 Without Proline-Arginine-Arginine-Alanine Variants in Coronavirus Disease 2019 Patients Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. 07, 2021 | Pubmed ID: 32649739 Human Coronavirus Dependency on Host Heat Shock Protein 90 Reveals an Antiviral Target Emerging Microbes & Infections. Dec, 2020 | Pubmed ID: 33179566 Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian Hamsters Cell Reports. Medicine. 10, 2020 | Pubmed ID: 32984855 Viruses Harness YxxØ Motif to Interact with Host AP2M1 for Replication: A Vulnerable Broad-spectrum Antiviral Target Science Advances. 08, 2020 | Pubmed ID: 32923629 Comparative Tropism, Replication Kinetics, and Cell Damage Profiling of SARS-CoV-2 and SARS-CoV with Implications for Clinical Manifestations, Transmissibility, and Laboratory Studies of COVID-19: an Observational Study The Lancet. Microbe. May, 2020 | Pubmed ID: 32835326 Attenuated Interferon and Proinflammatory Response in SARS-CoV-2-Infected Human Dendritic Cells Is Associated With Viral Antagonism of STAT1 Phosphorylation The Journal of Infectious Diseases. 08, 2020 | Pubmed ID: 32563187 Infection of Bat and Human Intestinal Organoids by SARS-CoV-2 Nature Medicine. 07, 2020 | Pubmed ID: 32405028 Targeting the Inositol-Requiring Enzyme-1 Pathway Efficiently Reverts Zika Virus-Induced Neurogenesis and Spermatogenesis Marker Perturbations ACS Infectious Diseases. 07, 2020 | Pubmed ID: 32329611 Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19 Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. 09, 2020 | Pubmed ID: 32270184 Activation of C-Type Lectin Receptor and (RIG)-I-Like Receptors Contributes to Proinflammatory Response in Middle East Respiratory Syndrome Coronavirus-Infected Macrophages The Journal of Infectious Diseases. 02, 2020 | Pubmed ID: 31562757 A Novel Partial Lid for Mechanical Defeatherers Reduced Aerosol Dispersion During Processing of Avian Influenza Virus Infected Poultry PloS One. 2019 | Pubmed ID: 31067261 Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus As a Host-Targeting Antiviral Strategy International Journal of Molecular Sciences. Jan, 2019 | Pubmed ID: 30658479 SREBP-dependent Lipidomic Reprogramming As a Broad-spectrum Antiviral Target Nature Communications. 01, 2019 | Pubmed ID: 30631056 Establishment of a Lethal Aged Mouse Model of Human Respiratory Syncytial Virus Infection Antiviral Research. 01, 2019 | Pubmed ID: 30503888 Identification and Characterization of GLDC As Host Susceptibility Gene to Severe Influenza EMBO Molecular Medicine. 01, 2019 | Pubmed ID: 30498026 Dual-functional Peptide with Defective Interfering Genes Effectively Protects Mice Against Avian and Seasonal Influenza Nature Communications. 06, 2018 | Pubmed ID: 29907765 Differentiated Human Airway Organoids to Assess Infectivity of Emerging Influenza Virus Proceedings of the National Academy of Sciences of the United States of America. 06, 2018 | Pubmed ID: 29891677 Large-scale Sequence Analysis Reveals Novel Human-adaptive Markers in PB2 Segment of Seasonal Influenza A Viruses Emerging Microbes & Infections. Mar, 2018 | Pubmed ID: 29593225 Assessing the Risk of Downwind Spread of Avian Influenza Virus Via Airborne Particles from an Urban Wholesale Poultry Market Building and Environment. Jan, 2018 | Pubmed ID: 29479134 Defining the Sizes of Airborne Particles That Mediate Influenza Transmission in Ferrets Proceedings of the National Academy of Sciences of the United States of America. 03, 2018 | Pubmed ID: 29463703 Inhibitors of Influenza A Virus Polymerase ACS Infectious Diseases. 03, 2018 | Pubmed ID: 29355011 Genetic Analysis of H7N9 Highly Pathogenic Avian Influenza Virus in Guangdong, China, 2016-2017 The Journal of Infection. 01, 2018 | Pubmed ID: 28889968 Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice Frontiers in Immunology. 2017 | Pubmed ID: 28377769 Interplay Between SIRT1 and Hepatitis B Virus X Protein in the Activation of Viral Transcription Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. Apr, 2017 | Pubmed ID: 28242208 PB2 Substitutions V598T/I Increase the Virulence of H7N9 Influenza A Virus in Mammals Virology. 01, 2017 | Pubmed ID: 27889648 Identification of a Novel Small-molecule Compound Targeting the Influenza A Virus Polymerase PB1-PB2 Interface Antiviral Research. 01, 2017 | Pubmed ID: 27840201 Amino Acid Substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal Domain Increase the Virulence of H7N7 Influenza A Virus Scientific Reports. 11, 2016 | Pubmed ID: 27886255 Peptide-Mediated Interference of PB2-eIF4G1 Interaction Inhibits Influenza A Viruses' Replication in Vitro and in Vivo ACS Infectious Diseases. 07, 2016 | Pubmed ID: 27626099 Isolation of H5N6, H7N9 and H9N2 Avian Influenza A Viruses from Air Sampled at Live Poultry Markets in China, 2014 and 2015 Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin. Sep, 2016 | Pubmed ID: 27608369 MERS Coronavirus Induces Apoptosis in Kidney and Lung by Upregulating Smad7 and FGF2 Nature Microbiology. Feb, 2016 | Pubmed ID: 27572168 Novel Residues in the PA Protein of Avian Influenza H7N7 Virus Affect Virulence in Mammalian Hosts Virology. 11, 2016 | Pubmed ID: 27525812 A Novel Small-molecule Compound Disrupts Influenza A Virus PB2 Cap-binding and Inhibits Viral Replication The Journal of Antimicrobial Chemotherapy. 09, 2016 | Pubmed ID: 27272726 Novel Mutations L228I and Y232H Cause Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Combinational Pattern AIDS Research and Human Retroviruses. 09, 2016 | Pubmed ID: 27067022 A Novel Small-molecule Inhibitor of Influenza A Virus Acts by Suppressing PA Endonuclease Activity of the Viral Polymerase Scientific Reports. Mar, 2016 | Pubmed ID: 26956222 A Novel Peptide with Potent and Broad-spectrum Antiviral Activities Against Multiple Respiratory Viruses Scientific Reports. Feb, 2016 | Pubmed ID: 26911565 Quantification of Influenza Virus RNA in Aerosols in Patient Rooms PloS One. 2016 | Pubmed ID: 26849130 Identification of a Small-molecule Inhibitor of Influenza Virus Via Disrupting the Subunits Interaction of the Viral Polymerase Antiviral Research. Jan, 2016 | Pubmed ID: 26593979 Middle East Respiratory Syndrome Coronavirus Infection: Virus-host Cell Interactions and Implications on Pathogenesis Virology Journal. Dec, 2015 | Pubmed ID: 26690369 PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs Scientific Reports. Nov, 2015 | Pubmed ID: 26612672 Transmission of H7N9 Influenza Viruses with a Polymorphism at PB2 Residue 627 in Chickens and Ferrets Journal of Virology. Oct, 2015 | Pubmed ID: 26202239 Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset The Journal of Infectious Diseases. Dec, 2015 | Pubmed ID: 26198719 Host Genes and Influenza Pathogenesis in Humans: an Emerging Paradigm Current Opinion in Virology. Oct, 2015 | Pubmed ID: 26079652 Cross-protection of Influenza A Virus Infection by a DNA Aptamer Targeting the PA Endonuclease Domain Antimicrobial Agents and Chemotherapy. Jul, 2015 | Pubmed ID: 25918143 Identification of TMPRSS2 As a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza The Journal of Infectious Diseases. Oct, 2015 | Pubmed ID: 25904605 Functional Variants Regulating LGALS1 (Galectin 1) Expression Affect Human Susceptibility to Influenza A(H7N9) Scientific Reports. Feb, 2015 | Pubmed ID: 25687228 Requirement of CRTC1 Coactivator for Hepatitis B Virus Transcription Nucleic Acids Research. Nov, 2014 | Pubmed ID: 25300488 Liver Grafts for Transplantation from Donors with Diabetes: an Analysis of the Scientific Registry of Transplant Recipients Database PloS One. 2014 | Pubmed ID: 24847864 Productive Replication of Middle East Respiratory Syndrome Coronavirus in Monocyte-derived Dendritic Cells Modulates Innate Immune Response Virology. Apr, 2014 | Pubmed ID: 24725946 Increased Expression of EIF5A2, Via Hypoxia or Gene Amplification, Contributes to Metastasis and Angiogenesis of Esophageal Squamous Cell Carcinoma Gastroenterology. Jun, 2014 | Pubmed ID: 24561231 Surfactant Protein B Gene Polymorphism is Associated with Severe Influenza Chest. Jun, 2014 | Pubmed ID: 24337193 Receptor Binding and Transmission Studies of H5N1 Influenza Virus in Mammals Emerging Microbes & Infections. Dec, 2013 | Pubmed ID: 26038448 Prioritizing Genes Responsible for Host Resistance to Influenza Using Network Approaches BMC Genomics. Nov, 2013 | Pubmed ID: 24261899 Investigation of Tumor Suppressing Function of CACNA2D3 in Esophageal Squamous Cell Carcinoma PloS One. 2013 | Pubmed ID: 23560067 A Functional Variation in CD55 Increases the Severity of 2009 Pandemic H1N1 Influenza A Virus Infection The Journal of Infectious Diseases. Aug, 2012 | Pubmed ID: 22693232 A Critical Role of IL-17 in Modulating the B-cell Response During H5N1 Influenza Virus Infection Cellular & Molecular Immunology. Nov, 2011 | Pubmed ID: 21946434 Krüppel-like Factor 15 Activates Hepatitis B Virus Gene Expression and Replication Hepatology (Baltimore, Md.). Jul, 2011 | Pubmed ID: 21503941 D225G Mutation in Hemagglutinin of Pandemic Influenza H1N1 (2009) Virus Enhances Virulence in Mice Experimental Biology and Medicine (Maywood, N.J.). Aug, 2010 | Pubmed ID: 20660098 Association of Candidate Susceptible Loci with Chronic Infection with Hepatitis B Virus in a Chinese Population Journal of Medical Virology. Mar, 2010 | Pubmed ID: 20087947 Functional Dissection of an IFN-alpha/beta Receptor 1 Promoter Variant That Confers Higher Risk to Chronic Hepatitis B Virus Infection Journal of Hepatology. Aug, 2009 | Pubmed ID: 19501422 A Regulatory Polymorphism in Interferon-gamma Receptor 1 Promoter is Associated with the Susceptibility to Chronic Hepatitis B Virus Infection Immunogenetics. Jun, 2009 | Pubmed ID: 19488747 Polymorphisms of Type I Interferon Receptor 1 Promoter and Their Effects on Chronic Hepatitis B Virus Infection Journal of Hepatology. Feb, 2007 | Pubmed ID: 17125879 SARS-related Virus Predating SARS Outbreak, Hong Kong Emerging Infectious Diseases. Feb, 2004 | Pubmed ID: 15030679 Het opzetten van menselijke longorganoïden en proximale differentiatie om volwassen luchtwegorganoïden te genereren Cun Li1,2, Man Chun Chiu1,2, Yifei Yu1,2, Xiaojuan Liu1,2, Ding Xiao1,2, Jingjing Huang1,2, Zhixin Wan1,2, Jie Zhou1,2,3 1Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 2Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, 3State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong JoVE 63684 Biology
Het opzetten van menselijke longorganoïden en proximale differentiatie om volwassen luchtwegorganoïden te genereren Cun Li1,2, Man Chun Chiu1,2, Yifei Yu1,2, Xiaojuan Liu1,2, Ding Xiao1,2, Jingjing Huang1,2, Zhixin Wan1,2, Jie Zhou1,2,3 1Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 2Centre for Virology, Vaccinology and Therapeutics, Hong Kong Science and Technology Park, 3State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong JoVE 63684 Biology
