Joaquim M. S. Cabral iBB - Institute for Bioengineering and Biosciences and Department of Bioengineering, Instituto Superior Técnico Universidade de Lisboa Biography Publications Institution JoVE Articles Joaquim M. S. Cabral has not added a biography. If you are Joaquim M. S. Cabral and would like to personalize this page please email our Author Liaison for assistance. Publications Scalable Manufacturing of Human Hematopoietic Stem/Progenitor Cells Exploiting a Co-culture Platform with Mesenchymal Stromal Cells Methods in Molecular Biology (Clifton, N.J.). Jun, 2020 | Pubmed ID: 32488668 Successful Use of Human AB Serum to Support the Expansion of Adipose Tissue-Derived Mesenchymal Stem/Stromal Cell in a Microcarrier-Based Platform Frontiers in Bioengineering and Biotechnology. 2020 | Pubmed ID: 32373600 Mesenchymal Stromal Cells Induce Regulatory T Cells Via Epigenetic Conversion of Human Conventional CD4 T Cells in Vitro Stem Cells (Dayton, Ohio). Apr, 2020 | Pubmed ID: 32352186 Challenges and Solutions for Commercial Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products Bioengineering (Basel, Switzerland). Mar, 2020 | Pubmed ID: 32231012 Glycosaminoglycan Disaccharide Compositional Analysis of Cell-derived Extracellular Matrices Using Liquid Chromatography-tandem Mass Spectrometry Methods in Cell Biology. 2020 | Pubmed ID: 32222228 Loss and Rescue of Osteocalcin and Osteopontin Modulate Osteogenic and Angiogenic Features of Mesenchymal Stem/stromal Cells Journal of Cellular Physiology. Mar, 2020 | Pubmed ID: 32162324 Maturation of Human Pluripotent Stem Cell-Derived Cerebellar Neurons in the Absence of Co-culture Frontiers in Bioengineering and Biotechnology. 2020 | Pubmed ID: 32117945 Glycosaminoglycan Remodeling During Chondrogenic Differentiation of Human Bone Marrow-/synovial-derived Mesenchymal Stem/stromal Cells Under Normoxia and Hypoxia Glycoconjugate Journal. Jun, 2020 | Pubmed ID: 32086666 Modulation of the in Vitro Angiogenic Potential of Human Mesenchymal Stromal Cells from Different Tissue Sources Journal of Cellular Physiology. Feb, 2020 | Pubmed ID: 32037550 Extracellular Matrix Decorated Polycaprolactone Scaffolds for Improved Mesenchymal Stem/stromal Cell Osteogenesis Towards a Patient-tailored Bone Tissue Engineering Approach Journal of Biomedical Materials Research. Part B, Applied Biomaterials. Jul, 2020 | Pubmed ID: 31916699 Addressing the Manufacturing Challenges of Cell-Based Therapies Advances in Biochemical Engineering/biotechnology. 2020 | Pubmed ID: 31844924 Kartogenin-loaded Coaxial PGS/PCL Aligned Nanofibers for Cartilage Tissue Engineering Materials Science & Engineering. C, Materials for Biological Applications. Feb, 2020 | Pubmed ID: 31761240 Human Pluripotent Stem Cells: Applications and Challenges for Regenerative Medicine and Disease Modeling Advances in Biochemical Engineering/biotechnology. 2020 | Pubmed ID: 31740987 Extruded Bioreactor Perfusion Culture Supports the Chondrogenic Differentiation of Human Mesenchymal Stem/Stromal Cells in 3D Porous Poly(ɛ-Caprolactone) Scaffolds Biotechnology Journal. Feb, 2020 | Pubmed ID: 31560160 Strategies for the Expansion of Human Induced Pluripotent Stem Cells As Aggregates in Single-use Vertical-Wheel™ Bioreactors Journal of Biological Engineering. 2019 | Pubmed ID: 31534477 Multifactorial Modeling Reveals a Dominant Role of Wnt Signaling in Lineage Commitment of Human Pluripotent Stem Cells Bioengineering (Basel, Switzerland). Aug, 2019 | Pubmed ID: 31443254 Economics of Beta-Cell Replacement Therapy Current Diabetes Reports. 08, 2019 | Pubmed ID: 31375935 Transcriptomic Analysis of 3D Cardiac Differentiation of Human Induced Pluripotent Stem Cells Reveals Faster Cardiomyocyte Maturation Compared to 2D Culture Scientific Reports. 06, 2019 | Pubmed ID: 31239450 Author Correction: A Complex Human Gut Microbiome Cultured in an Anaerobic Intestine-on-a-chip Nature Biomedical Engineering. Jul, 2019 | Pubmed ID: 31213704 Cultured Cell-derived Extracellular Matrices to Enhance the Osteogenic Differentiation and Angiogenic Properties of Human Mesenchymal Stem/stromal Cells Journal of Tissue Engineering and Regenerative Medicine. 09, 2019 | Pubmed ID: 31151132 Design Principles for Pluripotent Stem Cell-Derived Organoid Engineering Stem Cells International. 2019 | Pubmed ID: 31149014 Bringing Stem Cell-Based Therapies for Type 1 Diabetes to the Clinic: Early Insights from Bioprocess Economics and Cost-Effectiveness Analysis Biotechnology Journal. Aug, 2019 | Pubmed ID: 31127682 A Complex Human Gut Microbiome Cultured in an Anaerobic Intestine-on-a-chip Nature Biomedical Engineering. 07, 2019 | Pubmed ID: 31086325 Scalable Manufacturing of Human Mesenchymal Stromal Cells in the Vertical-Wheel Bioreactor System: An Experimental and Economic Approach Biotechnology Journal. Aug, 2019 | Pubmed ID: 30945467 Co-culture Cell-derived Extracellular Matrix Loaded Electrospun Microfibrous Scaffolds for Bone Tissue Engineering Materials Science & Engineering. C, Materials for Biological Applications. Jun, 2019 | Pubmed ID: 30889723 Compositional and Structural Analysis of Glycosaminoglycans in Cell-derived Extracellular Matrices Glycoconjugate Journal. 04, 2019 | Pubmed ID: 30637588 CD7 CAR T Cells for the Therapy of Acute Myeloid Leukemia Molecular Therapy : the Journal of the American Society of Gene Therapy. 01, 2019 | Pubmed ID: 30391141 Three-Dimensional Co-culture of Human Hematopoietic Stem/Progenitor Cells and Mesenchymal Stem/Stromal Cells in a Biomimetic Hematopoietic Niche Microenvironment Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30367359 Dissolvable Microcarriers Allow Scalable Expansion And Harvesting Of Human Induced Pluripotent Stem Cells Under Xeno-Free Conditions Biotechnology Journal. Apr, 2019 | Pubmed ID: 30320457 Engineering of Human Mesenchymal Stem/Stromal Cells with Vascular Endothelial Growth Factor-Encoding Minicircles for Angiogenic Ex Vivo Gene Therapy Human Gene Therapy. 03, 2019 | Pubmed ID: 30200778 Successful Isolation and Ex Vivo Expansion of Human Mesenchymal Stem/stromal Cells Obtained from Different Synovial Tissue-derived (biopsy) Samples Journal of Cellular Physiology. 04, 2019 | Pubmed ID: 30146686 Biomimetic Matrices for Rapidly Forming Mineralized Bone Tissue Based on Stem Cell-mediated Osteogenesis Scientific Reports. 09, 2018 | Pubmed ID: 30258220 Towards Multi-Organoid Systems for Drug Screening Applications Bioengineering (Basel, Switzerland). Jun, 2018 | Pubmed ID: 29933623 A Scale out Approach Towards Neural Induction of Human Induced Pluripotent Stem Cells for Neurodevelopmental Toxicity Studies Toxicology Letters. Sep, 2018 | Pubmed ID: 29775723 Three-Dimensional Cell-Based Microarrays: Printing Pluripotent Stem Cells into 3D Microenvironments Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29633205 Biophysical Study of Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structural Maturation During Long-term Culture Biochemical and Biophysical Research Communications. 05, 2018 | Pubmed ID: 29601816 Modeling Radiation Injury-induced Cell Death and Countermeasure Drug Responses in a Human Gut-on-a-Chip Cell Death & Disease. Feb, 2018 | Pubmed ID: 29445080 Regenerative Medicine Manufacturing Biotechnology Journal. Feb, 2018 | Pubmed ID: 29392889 A Fully-Closed and Automated Hollow Fiber Bioreactor for Clinical-Grade Manufacturing of Human Mesenchymal Stem/Stromal Cells Stem Cell Reviews and Reports. Feb, 2018 | Pubmed ID: 29188439 Hematopoietic Niche - Exploring Biomimetic Cues to Improve the Functionality of Hematopoietic Stem/Progenitor Cells Biotechnology Journal. Feb, 2018 | Pubmed ID: 29178199 Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent Cell Reports. Oct, 2017 | Pubmed ID: 28978471 Tridimensional Configurations of Human Mesenchymal Stem/stromal Cells to Enhance Cell Paracrine Potential Towards Wound Healing Processes Journal of Biotechnology. Nov, 2017 | Pubmed ID: 28965974 Allogeneic Cell Therapy Manufacturing: Process Development Technologies and Facility Design Options Expert Opinion on Biological Therapy. 10, 2017 | Pubmed ID: 28699788 Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System Stem Cell Reports. 06, 2017 | Pubmed ID: 28552605 Cultivation-based Strategies to Find Efficient Marine Biocatalysts Biotechnology Journal. Jul, 2017 | Pubmed ID: 28294564 Integrated Culture Platform Based on a Human Platelet Lysate Supplement for the Isolation and Scalable Manufacturing of Umbilical Cord Matrix-derived Mesenchymal Stem/stromal Cells Journal of Tissue Engineering and Regenerative Medicine. 05, 2017 | Pubmed ID: 27444977 Scaling Up a Chemically-defined Aggregate-based Suspension Culture System for Neural Commitment of Human Pluripotent Stem Cells Biotechnology Journal. Dec, 2016 | Pubmed ID: 27754603 Scalable Microcarrier-based Manufacturing of Mesenchymal Stem/stromal Cells Journal of Biotechnology. Oct, 2016 | Pubmed ID: 27527397 Microcarrier-based Platforms for in Vitro Expansion and Differentiation of Human Pluripotent Stem Cells in Bioreactor Culture Systems Journal of Biotechnology. Sep, 2016 | Pubmed ID: 27480342 Clinical-Grade Manufacturing of Therapeutic Human Mesenchymal Stem/Stromal Cells in Microcarrier-Based Culture Systems Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 27236684 Stirred Tank Bioreactor Culture Combined with Serum-/xenogeneic-free Culture Medium Enables an Efficient Expansion of Umbilical Cord-derived Mesenchymal Stem/stromal Cells Biotechnology Journal. Aug, 2016 | Pubmed ID: 27168373 Defined Essential 8™ Medium and Vitronectin Efficiently Support Scalable Xeno-Free Expansion of Human Induced Pluripotent Stem Cells in Stirred Microcarrier Culture Systems PloS One. 2016 | Pubmed ID: 26999816 Intracoronary Delivery of Human Mesenchymal/Stromal Stem Cells: Insights from Coronary Microcirculation Invasive Assessment in a Swine Model PloS One. 2015 | Pubmed ID: 26479722 Scaling Up the Ex vivo Expansion of Human Circulating CD34(+)progenitor Cells with Upregulation of Angiogenic and Anti-inflammatory Potential Cytotherapy. Dec, 2015 | Pubmed ID: 26475753 Editorial: Stem Cell Engineering Biotechnology Journal. Oct, 2015 | Pubmed ID: 26447639 A Xeno-free Microcarrier-based Stirred Culture System for the Scalable Expansion of Human Mesenchymal Stem/stromal Cells Isolated from Bone Marrow and Adipose Tissue Biotechnology Journal. Aug, 2015 | Pubmed ID: 26136376 Neural Commitment of Human Pluripotent Stem Cells Under Defined Conditions Recapitulates Neural Development and Generates Patient-specific Neural Cells Biotechnology Journal. Oct, 2015 | Pubmed ID: 26123315 Spatial and Temporal Control of Cell Aggregation Efficiently Directs Human Pluripotent Stem Cells Towards Neural Commitment Biotechnology Journal. Oct, 2015 | Pubmed ID: 25866360 Clinical-scale Purification of Pluripotent Stem Cell Derivatives for Cell-based Therapies Biotechnology Journal. Aug, 2015 | Pubmed ID: 25851544 Developing a Co-culture System for Effective Megakaryo/thrombopoiesis from Umbilical Cord Blood Hematopoietic Stem/progenitor Cells Cytotherapy. Apr, 2015 | Pubmed ID: 25680300 Purification of Human Induced Pluripotent Stem Cell-derived Neural Precursors Using Magnetic Activated Cell Sorting Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25537837 Advanced Cell Therapies for Articular Cartilage Regeneration Trends in Biotechnology. Jan, 2015 | Pubmed ID: 25466849 Scalable Expansion of Human-induced Pluripotent Stem Cells in Xeno-free Microcarriers Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25108454 Scalable Ex Vivo Expansion of Human Mesenchymal Stem/stromal Cells in Microcarrier-based Stirred Culture Systems Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25063496 Proliferation Extent of CD34 Cells As a Key Parameter to Maximize Megakaryocytic Differentiation of Umbilical Cord Blood-derived Hematopoietic Stem/progenitor Cells in a Two-stage Culture Protocol Biotechnology Reports (Amsterdam, Netherlands). Dec, 2014 | Pubmed ID: 28626662 Differentiation of Human Umbilical Cord Matrix Mesenchymal Stem Cells into Neural-like Progenitor Cells and Maturation into an Oligodendroglial-like Lineage PloS One. 2014 | Pubmed ID: 25357129 A Xenogeneic-free Bioreactor System for the Clinical-scale Expansion of Human Mesenchymal Stem/stromal Cells Biotechnology and Bioengineering. Jun, 2014 | Pubmed ID: 24420557 Isolation and Ex Vivo Expansion of Synovial Mesenchymal Stromal Cells for Cartilage Repair Cytotherapy. Apr, 2014 | Pubmed ID: 24364906 Production and Characterization of Recombinant Cyprosin B in Saccharomyces Cerevisiae (W303-1A) Strain Journal of Bioscience and Bioengineering. Apr, 2008 | Pubmed ID: 18499044 Scalable Generation of Mature Cerebellar Organoids from Human Pluripotent Stem Cells and Characterization by Immunostaining Teresa P. Silva1,2, Tiago G. Fernandes1, Diogo E. S. Nogueira1, Carlos A. V. Rodrigues1, Evguenia P. Bekman1,2,3, Yas Hashimura4, Sunghoon Jung4, Brian Lee4, Maria Carmo-Fonseca2, Joaquim M. S. Cabral1 1iBB - Institute for Bioengineering and Biosciences and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, 2Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 3The Discoveries Centre for Regenerative and Precision Medicine, Lisbon Campus, Universidade de Lisboa, 4PBS Biotech, Inc, Camarillo, CA, USA JoVE 61143 Bioengineering
Scalable Generation of Mature Cerebellar Organoids from Human Pluripotent Stem Cells and Characterization by Immunostaining Teresa P. Silva1,2, Tiago G. Fernandes1, Diogo E. S. Nogueira1, Carlos A. V. Rodrigues1, Evguenia P. Bekman1,2,3, Yas Hashimura4, Sunghoon Jung4, Brian Lee4, Maria Carmo-Fonseca2, Joaquim M. S. Cabral1 1iBB - Institute for Bioengineering and Biosciences and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, 2Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 3The Discoveries Centre for Regenerative and Precision Medicine, Lisbon Campus, Universidade de Lisboa, 4PBS Biotech, Inc, Camarillo, CA, USA JoVE 61143 Bioengineering
