John M. Coffin Department of Molecular Biology and Microbiology Tuffts University Biography Publications Institution JoVE Articles John M. Coffin has not added a biography. If you are John M. Coffin and would like to personalize this page please email our Author Liaison for assistance. Publications Restricted Replication of Xenotropic Murine Leukemia Virus-Related Virus in Pigtailed Macaques Journal of Virology. Jan, 2012 | Pubmed ID: 22238316 Characterization, Mapping, and Distribution of the Two XMRV Parental Proviruses Journal of Virology. Jan, 2012 | Pubmed ID: 22031947 Endogenous Murine Leukemia Viruses: Relationship to XMRV and Related Sequences Detected in Human DNA Samples Advances in Virology. 2011 | Pubmed ID: 22312358 Short-course Combivir After Single-dose Nevirapine Reduces but Does Not Eliminate the Emergence of Nevirapine Resistance in Women Antiviral Therapy. Nov, 2011 | Pubmed ID: 22293443 Binding of More Than One Tva800 Molecule is Required for ASLV-A Entry Retrovirology. 2011 | Pubmed ID: 22099981 Identification, Characterization, and Comparative Genomic Distribution of the HERV-K (HML-2) Group of Human Endogenous Retroviruses Retrovirology. 2011 | Pubmed ID: 22067224 Failure to Confirm XMRV/MLVs in the Blood of Patients with Chronic Fatigue Syndrome: a Multi-laboratory Study Science (New York, N.Y.). Nov, 2011 | Pubmed ID: 21940862 Majority of CD4+ T Cells from Peripheral Blood of HIV-1-infected Individuals Contain Only One HIV DNA Molecule Proceedings of the National Academy of Sciences of the United States of America. Jul, 2011 | Pubmed ID: 21690402 Recombinant Origin of the Retrovirus XMRV Science (New York, N.Y.). Jul, 2011 | Pubmed ID: 21628392 Role of Low-frequency HIV-1 Variants in Failure of Nevirapine-containing Antiviral Therapy in Women Previously Exposed to Single-dose Nevirapine Proceedings of the National Academy of Sciences of the United States of America. May, 2011 | Pubmed ID: 21576473 Estimate of Effective Recombination Rate and Average Selection Coefficient for HIV in Chronic Infection Proceedings of the National Academy of Sciences of the United States of America. Apr, 2011 | Pubmed ID: 21436045 Clonal Sequences Recovered from Plasma from Patients with Residual HIV-1 Viremia and on Intensified Antiretroviral Therapy Are Identical to Replicating Viral RNAs Recovered from Circulating Resting CD4+ T Cells Journal of Virology. May, 2011 | Pubmed ID: 21367910 The Blood Xenotropic Murine Leukemia Virus-Related Virus Scientific Research Working Group: Mission, Progress, and Plans Transfusion. Mar, 2011 | Pubmed ID: 21366602 Genetic Diversity of Simian Immunodeficiency Virus Encoding HIV-1 Reverse Transcriptase Persists in Macaques Despite Antiretroviral Therapy Journal of Virology. Jan, 2011 | Pubmed ID: 21084490 Contamination of Human DNA Samples with Mouse DNA Can Lead to False Detection of XMRV-like Sequences Retrovirology. 2010 | Pubmed ID: 21171973 Mouse DNA Contamination in Human Tissue Tested for XMRV Retrovirology. 2010 | Pubmed ID: 21171966 HIV-1 Continues to Replicate and Evolve in Patients with Natural Control of HIV Infection Journal of Virology. Dec, 2010 | Pubmed ID: 20926564 The Effect of Raltegravir Intensification on Low-level Residual Viremia in HIV-infected Patients on Antiretroviral Therapy: a Randomized Controlled Trial PLoS Medicine. 2010 | Pubmed ID: 20711481 Patterns of Human Immunodeficiency Virus Type 1 Recombination Ex Vivo Provide Evidence for Coadaptation of Distant Sites, Resulting in Purifying Selection for Intersubtype Recombinants During Replication Journal of Virology. Aug, 2010 | Pubmed ID: 20504919 Comparison of Standard PCR/cloning to Single Genome Sequencing for Analysis of HIV-1 Populations Journal of Virological Methods. Sep, 2010 | Pubmed ID: 20451557 Tumors Induced in Mice by Direct Inoculation of Plasmid DNA Expressing Both Activated H-ras and C-myc International Journal of Biological Sciences. 2010 | Pubmed ID: 20376206 Flexible Use of Nuclear Import Pathways by HIV-1 Cell Host & Microbe. Mar, 2010 | Pubmed ID: 20227665 Antiretroviral Intensification and Valproic Acid Lack Sustained Effect on Residual HIV-1 Viremia or Resting CD4+ Cell Infection PloS One. 2010 | Pubmed ID: 20186346 Multi-site Adaptation in the Presence of Infrequent Recombination Theoretical Population Biology. May, 2010 | Pubmed ID: 20149814 Low Frequency Nonnucleoside Reverse-transcriptase Inhibitor-resistant Variants Contribute to Failure of Efavirenz-containing Regimens in Treatment- Experienced Patients The Journal of Infectious Diseases. Mar, 2010 | Pubmed ID: 20102272 Endogenous Non-retroviral RNA Virus Elements in Mammalian Genomes Nature. Jan, 2010 | Pubmed ID: 20054395 Optimization of Allele-specific PCR Using Patient-specific HIV Consensus Sequences for Primer Design Journal of Virological Methods. Mar, 2010 | Pubmed ID: 19948190 RT-SHIV Subpopulation Dynamics in Infected Macaques During Anti-HIV Therapy Retrovirology. 2009 | Pubmed ID: 19889213 Virology. A New Virus for Old Diseases? Science (New York, N.Y.). Oct, 2009 | Pubmed ID: 19815721 Persistent Low-level Viremia in HIV-1 Elite Controllers and Relationship to Immunologic Parameters The Journal of Infectious Diseases. Sep, 2009 | Pubmed ID: 19656066 High Efficiency of HIV-1 Genomic RNA Packaging and Heterozygote Formation Revealed by Single Virion Analysis Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19628694 Likely Role of APOBEC3G-mediated G-to-A Mutations in HIV-1 Evolution and Drug Resistance PLoS Pathogens. Apr, 2009 | Pubmed ID: 19343218 Regimen Simplification to Atazanavir-ritonavir Alone As Maintenance Antiretroviral Therapy: Final 48-week Clinical and Virologic Outcomes The Journal of Infectious Diseases. Mar, 2009 | Pubmed ID: 19191590 Lytic Granule Loading of CD8+ T Cells is Required for HIV-infected Cell Elimination Associated with Immune Control Immunity. Dec, 2008 | Pubmed ID: 19062316 Attenuation by a Thousand Cuts The New England Journal of Medicine. Nov, 2008 | Pubmed ID: 19020330 Host-retrovirus Arms Race: Trimming the Budget Cell Host & Microbe. Sep, 2008 | Pubmed ID: 18779045 Effects of Retroviruses on Host Genome Function Annual Review of Genetics. 2008 | Pubmed ID: 18694346 HIV-1 Reverse Transcriptase Connection Subdomain Mutations Reduce Template RNA Degradation and Enhance AZT Excision Proceedings of the National Academy of Sciences of the United States of America. Aug, 2008 | Pubmed ID: 18667707 Valproic Acid Without Intensified Antiviral Therapy Has Limited Impact on Persistent HIV Infection of Resting CD4+ T Cells AIDS (London, England). Jun, 2008 | Pubmed ID: 18525258 Interactions of Murine APOBEC3 and Human APOBEC3G with Murine Leukemia Viruses Journal of Virology. Jul, 2008 | Pubmed ID: 18448535 Low-level Viremia Persists for at Least 7 Years in Patients on Suppressive Antiretroviral Therapy Proceedings of the National Academy of Sciences of the United States of America. Mar, 2008 | Pubmed ID: 18332425 Frequent Polymorphism at Drug Resistance Sites in HIV-1 Protease and Reverse Transcriptase AIDS (London, England). Feb, 2008 | Pubmed ID: 18301062 Oncogenicity of DNA in Vivo: Tumor Induction with Expression Plasmids for Activated H-ras and C-myc Biologicals : Journal of the International Association of Biological Standardization. May, 2008 | Pubmed ID: 18218323 Role of APOBEC3 in Genetic Diversity Among Endogenous Murine Leukemia Viruses PLoS Genetics. Oct, 2007 | Pubmed ID: 17967065 Upregulation of CTLA-4 by HIV-specific CD4+ T Cells Correlates with Disease Progression and Defines a Reversible Immune Dysfunction Nature Immunology. Nov, 2007 | Pubmed ID: 17906628 Suppression of Viremia and Evolution of Human Immunodeficiency Virus Type 1 Drug Resistance in a Macaque Model for Antiretroviral Therapy Journal of Virology. Nov, 2007 | Pubmed ID: 17855539 ART Suppresses Plasma HIV-1 RNA to a Stable Set Point Predicted by Pretherapy Viremia PLoS Pathogens. Apr, 2007 | Pubmed ID: 17411338 Mutations in the Connection Domain of HIV-1 Reverse Transcriptase Increase 3'-azido-3'-deoxythymidine Resistance Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007 | Pubmed ID: 17179211 Blinded, Multicenter Comparison of Methods to Detect a Drug-resistant Mutant of Human Immunodeficiency Virus Type 1 at Low Frequency Journal of Clinical Microbiology. Jul, 2006 | Pubmed ID: 16825395 Selection and Persistence of Non-nucleoside Reverse Transcriptase Inhibitor-resistant HIV-1 in Patients Starting and Stopping Non-nucleoside Therapy AIDS (London, England). Mar, 2006 | Pubmed ID: 16514300 Evolution of Broad Host Range in Retroviruses Leads to Cell Death Mediated by Highly Cytopathic Variants Journal of Virology. Jan, 2006 | Pubmed ID: 16378958 Human Endogenous Retroviral Elements As Indicators of Ectopic Recombination Events in the Primate Genome Genetics. Nov, 2005 | Pubmed ID: 16157677 Depletion of Latent HIV-1 Infection in Vivo: a Proof-of-concept Study Lancet. Aug 13-19, 2005 | Pubmed ID: 16099290 Characterization of Hortulanus Endogenous Murine Leukemia Virus, an Endogenous Provirus That Encodes an Infectious Murine Leukemia Virus of a Novel Subgroup Journal of Virology. Jul, 2005 | Pubmed ID: 15956577 Symmetrical Base Preferences Surrounding HIV-1, Avian Sarcoma/leukosis Virus, and Murine Leukemia Virus Integration Sites Proceedings of the National Academy of Sciences of the United States of America. Apr, 2005 | Pubmed ID: 15802467 Mechanism for Nucleoside Analog-mediated Abrogation of HIV-1 Replication: Balance Between RNase H Activity and Nucleotide Excision Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15684061 Relationship Between Retroviral DNA-integration-site Selection and Host Cell Transcription Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15659548 Multiple, Linked Human Immunodeficiency Virus Type 1 Drug Resistance Mutations in Treatment-experienced Patients Are Missed by Standard Genotype Analysis Journal of Clinical Microbiology. Jan, 2005 | Pubmed ID: 15635002 In Vitro Characterization of a Simian Immunodeficiency Virus-human Immunodeficiency Virus (HIV) Chimera Expressing HIV Type 1 Reverse Transcriptase to Study Antiviral Resistance in Pigtail Macaques Journal of Virology. Dec, 2004 | Pubmed ID: 15564466 Evolution of Retroviruses: Fossils in Our DNA Proceedings of the American Philosophical Society. Sep, 2004 | Pubmed ID: 15551500 Single-strand Specificity of APOBEC3G Accounts for Minus-strand Deamination of the HIV Genome Nature Structural & Molecular Biology. May, 2004 | Pubmed ID: 15098018 Human Endogenous Retrovirus K Solo-LTR Formation and Insertional Polymorphisms: Implications for Human and Viral Evolution Proceedings of the National Academy of Sciences of the United States of America. Feb, 2004 | Pubmed ID: 14757818 Nonrandom HIV-1 Infection and Double Infection Via Direct and Cell-mediated Pathways Proceedings of the National Academy of Sciences of the United States of America. Jan, 2004 | Pubmed ID: 14707263 New Real-time Reverse Transcriptase-initiated PCR Assay with Single-copy Sensitivity for Human Immunodeficiency Virus Type 1 RNA in Plasma Journal of Clinical Microbiology. Oct, 2003 | Pubmed ID: 14532178 Virology. Weapons of Mutational Destruction Science (New York, N.Y.). Aug, 2003 | Pubmed ID: 12920286 Mechanisms of Avian Retroviral Host Range Extension Journal of Virology. Jun, 2003 | Pubmed ID: 12767991 The Solitary Wave of Asexual Evolution Proceedings of the National Academy of Sciences of the United States of America. Jan, 2003 | Pubmed ID: 12525686 A Novel Endogenous Retrovirus-related Element in the Human Genome Resembles a DNA Transposon: Evidence for an Evolutionary Link? Genomics. Nov, 2002 | Pubmed ID: 12408960 Proposed Alternatives for the Use of Anti-HIV Drugs: is It Appropriate? Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. Feb, 1999 | Pubmed ID: 11504471 Amplificar e Quantificação do HIV-1 RNA no indivíduos infectados pelo HIV com carga viral abaixo do limite de detecção pela Standard Ensaios Clínicos Helene Mens1, Mary Kearney1, Ann Wiegand1, Jonathan Spindler1, Frank Maldarelli1, John W. Mellors2, John M. Coffin3 1The virology Core at the HIV Drug Resistance Program, NCI-Frederick, 2Division of Infectious Diseases, University of Pittsburgh, 3Department of Molecular Biology and Microbiology, Tuffts University JoVE 2960 Immunology and Infection
Amplificar e Quantificação do HIV-1 RNA no indivíduos infectados pelo HIV com carga viral abaixo do limite de detecção pela Standard Ensaios Clínicos Helene Mens1, Mary Kearney1, Ann Wiegand1, Jonathan Spindler1, Frank Maldarelli1, John W. Mellors2, John M. Coffin3 1The virology Core at the HIV Drug Resistance Program, NCI-Frederick, 2Division of Infectious Diseases, University of Pittsburgh, 3Department of Molecular Biology and Microbiology, Tuffts University JoVE 2960 Immunology and Infection
