Jonathon Muncie

Graduate Program in Bioengineering

University of California San Francisco

Jonathon M. Muncie
PhD Candidate

Jonathon Muncie is a PhD candidate in the Graduate Program in Bioengineering at the University of California San Francisco and University of California Berkeley. He completed his undergraduate studies at the University of Michigan, graduating Summa Cum Laude with a Bachelor in Science and Engineering in Biomedical Engineering.

Jonathon is interested in the role that mechanical forces play in regulating cell differentiation and tissue development. In the lab of Dr. Valerie Weaver at UCSF, he developed a method for patterning colonies of human embryonic stem cells in defined geometries on compliant hydrogels. This method provides control over both the tissue-scale geometry of the stem cell colonies and the elasticity of the hydrogel substrate. Jonathon is using this method to study how cellular tension, regulated by colony geometry, affects cell fate in a model of early human development.

While an undergraduate at the University of Michigan, Jonathon worked in Dr. Allen Liu's laboratory to study the effects of fluid flow on clathrin-mediated endocytosis in a microfluidic system. He also engineered lipid vesicles capable of recapitulating the initial events of the blood clotting cascade, contributing to the labs long-term goal of designing a synthetic platelet.

In 2016, Jonathon was awarded the Discovery Fellowship at UCSF.

Publications

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics

1Graduate Program in Bioengineering, University of California San Francisco and University of California Berkeley, 2Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, 3Department of Mechanical Engineering, University of California Berkeley, 4Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, 5UCSF Comprehensive Cancer Center, Helen Diller Family Cancer Research Center, University of California San Francisco, 6Department of Anatomy, Department of Bioengineering and Therapeutic Sciences, and Department of Radiation Oncology, University of California San Francisco

JoVE 60334

 Bioengineering