Julia Hoeng PMI R&D Philip Morris Products S.A. Biography Publications Institution JoVE Articles Julia Hoeng has not added a biography. If you are Julia Hoeng and would like to personalize this page please email our Author Liaison for assistance. Publications Differentiating the Neuropharmacological Properties of Nicotinic Acetylcholine Receptor-Activating Alkaloids Frontiers in Pharmacology. 2022 | Pubmed ID: 35392565 Effects of Cigarette Smoke Exposure on a Mouse Model of Multiple Sclerosis Toxicology Reports. 2022 | Pubmed ID: 35392156 Influence of Tobacco Smoking on the Development of Halitosis Toxicology Reports. 2022 | Pubmed ID: 35284240 Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing Predictions The AAPS Journal. 02, 2022 | Pubmed ID: 35132508 Translational Modeling of Chloroquine and Hydroxychloroquine Dosimetry in Human Airways for Treating Viral Respiratory Infections Pharmaceutical Research. Jan, 2022 | Pubmed ID: 35000036 Iota-carrageenan Extracted from Red Algae is a Potent Inhibitor of SARS-CoV-2 Infection in Reconstituted Human Airway Epithelia Biochemistry and Biophysics Reports. Mar, 2022 | Pubmed ID: 34931176 Impact of Aerosols on Liver Xenobiotic Metabolism: A Comparison of Two Methods of Exposure Toxicology in Vitro : an International Journal Published in Association with BIBRA. Mar, 2022 | Pubmed ID: 34843886 Discriminating Spontaneous From Cigarette Smoke and THS 2.2 Aerosol Exposure-Related Proliferative Lung Lesions in A/J Mice by Using Gene Expression and Mutation Spectrum Data Frontiers in Toxicology. 2021 | Pubmed ID: 35295134 AI-driven Laboratory Workflows Enable Operation in the Age of Social Distancing SLAS Technology. Dec, 2021 | Pubmed ID: 35058197 A Literature Review and Framework Proposal for Halitosis Assessment in Cigarette Smokers and Alternative Nicotine-Delivery Products Users Frontiers in Oral Health. 2021 | Pubmed ID: 35048075 Assessment of in Vitro Kinetics and Biological Impact of Nebulized Trehalose on Human Bronchial Epithelium Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Nov, 2021 | Pubmed ID: 34563633 A Simple Method for Decellularizing a Cell-derived Matrix for Bone Cell Cultivation and Differentiation Journal of Materials Science. Materials in Medicine. Sep, 2021 | Pubmed ID: 34524552 Systems Toxicology Study Reveals Reduced Impact of Heated Tobacco Product Aerosol Extract Relative to Cigarette Smoke on Premature Aging and Exacerbation Effects in Aged Aortic Cells in Vitro Archives of Toxicology. 10, 2021 | Pubmed ID: 34313809 Impact of 6-Month Exposure to Aerosols From Potential Modified Risk Tobacco Products Relative to Cigarette Smoke on the Rodent Gastrointestinal Tract Frontiers in Microbiology. 2021 | Pubmed ID: 34276574 Effects of Nicotinic Acetylcholine Receptor-activating Alkaloids on Anxiety-like Behavior in Zebrafish Journal of Natural Medicines. Sep, 2021 | Pubmed ID: 34264421 Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish Frontiers in Genetics. 2021 | Pubmed ID: 34211495 Subchronic Effects of Plant Alkaloids on Anxiety-like Behavior in Zebrafish Pharmacology, Biochemistry, and Behavior. 08, 2021 | Pubmed ID: 34197843 Effects of Plant Alkaloids on Mitochondrial Bioenergetic Parameters Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Aug, 2021 | Pubmed ID: 34089800 Effects of Natural Monoamine Oxidase Inhibitors on Anxiety-Like Behavior in Zebrafish Frontiers in Pharmacology. 2021 | Pubmed ID: 34079463 Systems Biology Approach Highlights Mechanistic Differences Between Crohn's Disease and Ulcerative Colitis Scientific Reports. 06, 2021 | Pubmed ID: 34075172 Differential Effects of Alkaloids on Memory in Rodents Scientific Reports. 05, 2021 | Pubmed ID: 33972592 A 6-month Inhalation Toxicology Study in Apoe Mice Demonstrates Substantially Lower Effects of E-vapor Aerosol Compared with Cigarette Smoke in the Respiratory Tract Archives of Toxicology. 05, 2021 | Pubmed ID: 33963423 Effects of Whitening Toothpaste and Bleaching Treatment on Resin Composite Discoloration Caused by Cigarette Smoke and Electronic Vapor Aerosol American Journal of Dentistry. Apr, 2021 | Pubmed ID: 33940661 Development of an Advanced Multicellular Intestinal Model for Assessing Immunomodulatory Properties of Anti-Inflammatory Compounds Frontiers in Pharmacology. 2021 | Pubmed ID: 33935729 Impact of Whole-body Versus Nose-only Inhalation Exposure Systems on Systemic, Respiratory, and Cardiovascular Endpoints in a 2-month Cigarette Smoke Exposure Study in the ApoE Mouse Model Journal of Applied Toxicology : JAT. 10, 2021 | Pubmed ID: 33825214 Profiling of a Natural Alkaloid, Anatabine, in Rodents: Pharmacokinetics and Anti-Inflammatory Efficacy Journal of Natural Products. 04, 2021 | Pubmed ID: 33706515 Comparison of the Biological Impact of Aerosol of E-vapor Device with MESH® Technology and Cigarette Smoke on Human Bronchial and Alveolar Cultures Toxicology Letters. Feb, 2021 | Pubmed ID: 33220401 Inflammatory Bowel Disease-Associated Changes in the Gut: Focus on Kazan Patients Inflammatory Bowel Diseases. 02, 2021 | Pubmed ID: 32766755 Comparison of the Basic Morphology and Function of 3D Lung Epithelial Cultures Derived from Several Donors Current Research in Toxicology. Jun, 2020 | Pubmed ID: 34345837 Impact of Switching to a Heat-not-burn Tobacco Product on CYP1A2 Activity Toxicology Reports. 2020 | Pubmed ID: 33204648 Ceramide Ratios Are Affected by Cigarette Smoke but Not Heat-not-burn or E-vapor Aerosols Across Four Independent Mouse Studies Life Sciences. Dec, 2020 | Pubmed ID: 33189821 A Meta-analysis of MicroRNAs Expressed in Human Aerodigestive Epithelial Cultures and Their Role As Potential Biomarkers of Exposure Response to Nicotine-containing Products Toxicology Reports. 2020 | Pubmed ID: 33014713 Comparing the Preclinical Risk Profile of Inhalable Candidate and Potential Candidate Modified Risk Tobacco Products: A Bridging Use Case Toxicology Reports. 2020 | Pubmed ID: 32995294 Anatabine Ameliorates Intestinal Inflammation and Reduces the Production of Pro-inflammatory Factors in a Dextran Sulfate Sodium Mouse Model of Colitis Journal of Inflammation (London, England). 2020 | Pubmed ID: 32855621 Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice Toxicological Sciences : an Official Journal of the Society of Toxicology. 11, 2020 | Pubmed ID: 32780831 Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke Toxicological Sciences : an Official Journal of the Society of Toxicology. 11, 2020 | Pubmed ID: 32780830 Systems Toxicology Approach for Testing Chemical Cardiotoxicity in Larval Zebrafish Chemical Research in Toxicology. 10, 2020 | Pubmed ID: 32638588 Analysis of Chemical Deposits on Tooth Enamel Exposed to Total Particulate Matter from Cigarette Smoke and Tobacco Heating System 2.2 Aerosol by Novel GC-MS Deconvolution Procedures Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Sep, 2020 | Pubmed ID: 32585495 An Intestine-on-a-Chip Model of Plug-and-Play Modularity to Study Inflammatory Processes SLAS Technology. 12, 2020 | Pubmed ID: 32576063 Multi-omics Systems Toxicology Study of Mouse Lung Assessing the Effects of Aerosols from Two Heat-not-burn Tobacco Products and Cigarette Smoke Computational and Structural Biotechnology Journal. 2020 | Pubmed ID: 32419906 Human Multi-organ Chip Co-culture of Bronchial Lung Culture and Liver Spheroids for Substance Exposure Studies Scientific Reports. 05, 2020 | Pubmed ID: 32398725 Evaluation of Toxicity of Aerosols from Flavored E-liquids in Sprague-Dawley Rats in a 90-day OECD Inhalation Study, Complemented by Transcriptomics Analysis Archives of Toxicology. 06, 2020 | Pubmed ID: 32367274 Lipid-based Biomarkers for CVD, COPD, and Aging - A Translational Perspective Progress in Lipid Research. 04, 2020 | Pubmed ID: 32339553 Comparison of Experimentally Measured and Computational Fluid Dynamic Predicted Deposition and Deposition Uniformity of Monodisperse Solid Particles in the Vitrocell® AMES 48 Air-liquid-interface In-vitro Exposure System Toxicology in Vitro : an International Journal Published in Association with BIBRA. Sep, 2020 | Pubmed ID: 32330563 Mitochondrial Network and Biogenesis in Response to Short and Long-Term Exposure of Human BEAS-2B Cells to Aerosol Extracts from the Tobacco Heating System 2.2 Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. Mar, 2020 | Pubmed ID: 32153152 The Reduction of DSS-induced Colitis Severity in Mice Exposed to Cigarette Smoke is Linked to Immune Modulation and Microbial Shifts Scientific Reports. 03, 2020 | Pubmed ID: 32123204 Alternatives to Animal Use in Risk Assessment of Mixtures International Journal of Toxicology. Mar/Apr, 2020 | Pubmed ID: 32066298 Anthropometry-based Generation of Personalized and Population-specific Human Airway Models International Journal for Numerical Methods in Biomedical Engineering. 05, 2020 | Pubmed ID: 32053266 In Vitro High-Content Imaging-Based Phenotypic Analysis of Bronchial 3D Organotypic Air-Liquid Interface Cultures SLAS Technology. Jun, 2020 | Pubmed ID: 31971054 Assessment of Single-Photon Ionization Mass Spectrometry for Online Monitoring of Aerosol Exposure Experiments Chemical Research in Toxicology. 02, 2020 | Pubmed ID: 31909610 Systems Toxicology Assessment of a Representative E-liquid Formulation Using Human Primary Bronchial Epithelial Cells Toxicology Reports. 2020 | Pubmed ID: 31886136 An Electrophysiological Characterization of Naturally Occurring Tobacco Alkaloids and Their Action on Human α4β2 and α7 Nicotinic Acetylcholine Receptors Phytochemistry. Feb, 2020 | Pubmed ID: 31865001 Structural, Functional, and Molecular Impact on the Cardiovascular System in ApoE Mice Exposed to Aerosol from Candidate Modified Risk Tobacco Products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, Compared with Cigarette Smoke Chemico-biological Interactions. Jan, 2020 | Pubmed ID: 31705857 3D Human Microvessel-on-a-chip Model for Studying Monocyte-to-endothelium Adhesion Under Flow - Application in Systems Toxicology ALTEX. 2020 | Pubmed ID: 31445503 Comparison of Monoamine Oxidase Inhibition by Cigarettes and Modified Risk Tobacco Products Toxicology Reports. 2019 | Pubmed ID: 31768332 Neurobehavioral Effects of Selected Tobacco Constituents in Rodents Following Subchronic Administration European Journal of Pharmacology. Dec, 2019 | Pubmed ID: 31738931 The Extraction of Complex Relationships and Their Conversion to Biological Expression Language (BEL) Overview of the BioCreative VI (2017) BEL Track Database : the Journal of Biological Databases and Curation. 01, 2019 | Pubmed ID: 31603193 Respirable Aerosol Exposures of Nicotine Dry Powder Formulations to , , and Pre-clinical Models Demonstrate Consistency of Pharmacokinetic Profiles Inhalation Toxicology. 05, 2019 | Pubmed ID: 31496314 Application of a Multi-layer Systems Toxicology Framework for in Vitro Assessment of the Biological Effects of Classic Tobacco E-liquid and Its Corresponding Aerosol Using an E-cigarette Device with MESH™ Technology Archives of Toxicology. 11, 2019 | Pubmed ID: 31494692 NPA: an R Package for Computing Network Perturbation Amplitudes Using Gene Expression Data and Two-layer Networks BMC Bioinformatics. Sep, 2019 | Pubmed ID: 31481014 Effects of Different Discoloration Challenges and Whitening Treatments on Dental Hard Tissues and Composite Resin Restorations Journal of Dentistry. 10, 2019 | Pubmed ID: 31430508 Antiparasitic Properties of Leaf Extracts Derived from Selected Nicotiana Species and Nicotiana Tabacum Varieties Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Oct, 2019 | Pubmed ID: 31276744 Mitochondria As a Possible Target for Nicotine Action Journal of Bioenergetics and Biomembranes. 08, 2019 | Pubmed ID: 31197632 Impact of Sample Preparation Upon Intracellular Metabolite Measurements in 3D Cell Culture Systems Metabolomics : Official Journal of the Metabolomic Society. 06, 2019 | Pubmed ID: 31190156 A Meta-Analysis of the Performance of a Blood-Based Exposure Response Gene Signature Across Clinical Studies on the Tobacco Heating System 2.2 (THS 2.2) Frontiers in Pharmacology. 2019 | Pubmed ID: 30971916 Toxicological Assessment of Tobacco Heating System 2.2: Findings from an Independent Peer Review Regulatory Toxicology and Pharmacology : RTP. Jun, 2019 | Pubmed ID: 30878573 GladiaTOX: GLobal Assessment of Dose-IndicAtor in TOXicology Bioinformatics (Oxford, England). 10, 2019 | Pubmed ID: 30873538 A Lower Impact of an Acute Exposure to Electronic Cigarette Aerosols Than to Cigarette Smoke in Human Organotypic Buccal and Small Airway Cultures Was Demonstrated Using Systems Toxicology Assessment Internal and Emergency Medicine. 09, 2019 | Pubmed ID: 30835057 Construction of a Suite of Computable Biological Network Models Focused on Mucociliary Clearance in the Respiratory Tract Frontiers in Genetics. 2019 | Pubmed ID: 30828347 Assessing the Lung Cancer Risk Reduction Potential of Candidate Modified Risk Tobacco Products Internal and Emergency Medicine. 09, 2019 | Pubmed ID: 30767158 A Six-month Systems Toxicology Inhalation/cessation Study in ApoE Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Modified Risk Tobacco Products, CHTP 1.2 and THS 2.2, Compared with Conventional Cigarettes Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Apr, 2019 | Pubmed ID: 30763686 How Complex Should an in Vitro Model Be? Evaluation of Complex 3D Alveolar Model with Transcriptomic Data and Computational Biological Network Models ALTEX. 2019 | Pubmed ID: 30753736 Corrigendum to "The Biological Effects of Long-term Exposure of Human Bronchial Epithelial Cells to Total Particulate Matter from a Candidate Modified-risk Tobacco Product" Published in Toxicology in Vitro, Volume 50, August 2018, Pages 95-108 Toxicology in Vitro : an International Journal Published in Association with BIBRA. 04, 2019 | Pubmed ID: 30686568 Assessment of a 72-hour Repeated Exposure to Swedish Snus Extract and Total Particulate Matter from 3R4F Cigarette Smoke on Gingival Organotypic Cultures Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Mar, 2019 | Pubmed ID: 30610935 Tobacco Heating System 2.2 Has a Limited Impact on DNA Methylation of Candidate Enhancers in Mouse Lung Compared with Cigarette Smoke Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Jan, 2019 | Pubmed ID: 30414959 Biological Changes in C57BL/6 Mice Following 3 weeks of Inhalation Exposure to Cigarette Smoke or E-vapor Aerosols Inhalation Toxicology. Nov - Dec, 2018 | Pubmed ID: 30849254 A Lung/liver-on-a-chip Platform for Acute and Chronic Toxicity Studies Lab on a Chip. 12, 2018 | Pubmed ID: 30460365 Embracing Transparency Through Data Sharing International Journal of Toxicology. Nov/Dec, 2018 | Pubmed ID: 30282506 Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification International Journal of Molecular Sciences. Sep, 2018 | Pubmed ID: 30223557 The Sbv IMPROVER Systems Toxicology Computational Challenge: Identification of Human and Species-Independent Blood Response Markers As Predictors of Smoking Exposure and Cessation Status Computational Toxicology (Amsterdam, Netherlands). Feb, 2018 | Pubmed ID: 30221212 In Vitro Systems Toxicology-based Assessment of the Potential Modified Risk Tobacco Product CHTP 1.2 for Vascular Inflammation- and Cytotoxicity-associated Mechanisms Promoting Adhesion of Monocytic Cells to Human Coronary Arterial Endothelial Cells Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Oct, 2018 | Pubmed ID: 30026091 Delivery Efficiencies of Constituents of Combustion-derived Aerosols Across the Air-liquid Interface During in Vitro Exposures Toxicology in Vitro : an International Journal Published in Association with BIBRA. Oct, 2018 | Pubmed ID: 30003980 Interrogating the Microbiome: Experimental and Computational Considerations in Support of Study Reproducibility Drug Discovery Today. 09, 2018 | Pubmed ID: 29890228 A 90-day OECD TG 413 Rat Inhalation Study with Systems Toxicology Endpoints Demonstrates Reduced Exposure Effects of the Aerosol from the Carbon Heated Tobacco Product Version 1.2 (CHTP1.2) Compared with Cigarette Smoke. I. Inhalation Exposure, Clinical Pathology and Histopathology Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Jun, 2018 | Pubmed ID: 29654848 A 90-day OECD TG 413 Rat Inhalation Study with Systems Toxicology Endpoints Demonstrates Reduced Exposure Effects of the Aerosol from the Carbon Heated Tobacco Product Version 1.2 (CHTP1.2) Compared with Cigarette Smoke. II. Systems Toxicology Assessment Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. May, 2018 | Pubmed ID: 29545142 The Biological Effects of Long-term Exposure of Human Bronchial Epithelial Cells to Total Particulate Matter from a Candidate Modified-risk Tobacco Product Toxicology in Vitro : an International Journal Published in Association with BIBRA. Aug, 2018 | Pubmed ID: 29524472 Assessment of the Impact of Aerosol from a Potential Modified Risk Tobacco Product Compared with Cigarette Smoke on Human Organotypic Oral Epithelial Cultures Under Different Exposure Regimens Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. May, 2018 | Pubmed ID: 29505817 Comparative Biological Impacts of an Aerosol from Carbon-heated Tobacco and Smoke from Cigarettes on Human Respiratory Epithelial Cultures: A Systems Toxicology Assessment Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. May, 2018 | Pubmed ID: 29501877 Assessment of Mitochondrial Function Following Short- and Long-term Exposure of Human Bronchial Epithelial Cells to Total Particulate Matter from a Candidate Modified-risk Tobacco Product and Reference Cigarettes Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. May, 2018 | Pubmed ID: 29448087 Comparative Effects of a Candidate Modified-risk Tobacco Product Aerosol and Cigarette Smoke on Human Organotypic Small Airway Cultures: a Systems Toxicology Approach Toxicology Research. Nov, 2017 | Pubmed ID: 30090554 Systems Toxicology Meta-analysis of Assessment Studies: Biological Impact of a Candidate Modified-risk Tobacco Product Aerosol Compared with Cigarette Smoke on Human Organotypic Cultures of the Aerodigestive Tract Toxicology Research. Sep, 2017 | Pubmed ID: 30090531 Effects of Cigarette Smoking on Color Stability of Dental Resin Composites American Journal of Dentistry. 12, 2017 | Pubmed ID: 29251454 Supporting Evidence-based Analysis for Modified Risk Tobacco Products Through a Toxicology Data-sharing Infrastructure F1000Research. 2017 | Pubmed ID: 29123642 Toxicity of the Main Electronic Cigarette Components, Propylene Glycol, Glycerin, and Nicotine, in Sprague-Dawley Rats in a 90-day OECD Inhalation Study Complemented by Molecular Endpoints Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Nov, 2017 | Pubmed ID: 28882640 Novel Approaches to Develop Community-built Biological Network Models for Potential Drug Discovery Expert Opinion on Drug Discovery. 08, 2017 | Pubmed ID: 28585481 Multicomponent Aerosol Particle Deposition in a Realistic Cast of the Human Upper Respiratory Tract Inhalation Toxicology. 02, 2017 | Pubmed ID: 28470142 Characterization of the Vitrocell® 24/48 Aerosol Exposure System for Its Use in Exposures to Liquid Aerosols Toxicology in Vitro : an International Journal Published in Association with BIBRA. Aug, 2017 | Pubmed ID: 28457873 Aerosol from Tobacco Heating System 2.2 Has Reduced Impact on Mouse Heart Gene Expression Compared with Cigarette Smoke Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Mar, 2017 | Pubmed ID: 28111298 Crowd-Sourced Verification of Computational Methods and Data in Systems Toxicology: A Case Study with a Heat-Not-Burn Candidate Modified Risk Tobacco Product Chemical Research in Toxicology. 04, 2017 | Pubmed ID: 28085253 Comparative Systems Toxicology Analysis of Cigarette Smoke and Aerosol from a Candidate Modified Risk Tobacco Product in Organotypic Human Gingival Epithelial Cultures: A 3-day Repeated Exposure Study Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Mar, 2017 | Pubmed ID: 28025120 A Systems Toxicology Approach for Comparative Assessment: Biological Impact of an Aerosol from a Candidate Modified-risk Tobacco Product and Cigarette Smoke on Human Organotypic Bronchial Epithelial Cultures Toxicology in Vitro : an International Journal Published in Association with BIBRA. Mar, 2017 | Pubmed ID: 27865774 A New Fluorescence-based Method for Characterizing in Vitro Aerosol Exposure Systems Toxicology in Vitro : an International Journal Published in Association with BIBRA. Feb, 2017 | Pubmed ID: 27664316 3-D Nasal Cultures: Systems Toxicological Assessment of a Candidate Modified-risk Tobacco Product ALTEX. 2017 | Pubmed ID: 27388676 Evaluation of the Tobacco Heating System 2.2 (THS2.2). Part 5: MicroRNA Expression from a 90-day Rat Inhalation Study Indicates That Exposure to THS2.2 Aerosol Causes Reduced Effects on Lung Tissue Compared with Cigarette Smoke Regulatory Toxicology and Pharmacology : RTP. Nov, 2016 | Pubmed ID: 27866933 Evaluation of the Tobacco Heating System 2.2. Part 9: Application of Systems Pharmacology to Identify Exposure Response Markers in Peripheral Blood of Smokers Switching to THS2.2 Regulatory Toxicology and Pharmacology : RTP. Nov, 2016 | Pubmed ID: 27845159 Semi-Automated Curation Allows Causal Network Model Building for the Quantification of Age-Dependent Plaque Progression in ApoE Mouse Gene Regulation and Systems Biology. 2016 | Pubmed ID: 27840576 Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 Rat Inhalation Study with Systems Toxicology Endpoints Demonstrates Reduced Exposure Effects of a Mentholated Version Compared with Mentholated and Non-mentholated Cigarette Smoke Regulatory Toxicology and Pharmacology : RTP. Nov, 2016 | Pubmed ID: 27818348 Evaluation of the Tobacco Heating System 2.2. Part 7: Systems Toxicological Assessment of a Mentholated Version Revealed Reduced Cellular and Molecular Exposure Effects Compared with Mentholated and Non-mentholated Cigarette Smoke Regulatory Toxicology and Pharmacology : RTP. Nov, 2016 | Pubmed ID: 27818347 Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 Rat Inhalation Study with Systems Toxicology Endpoints Demonstrates Reduced Exposure Effects Compared with Cigarette Smoke Regulatory Toxicology and Pharmacology : RTP. Nov, 2016 | Pubmed ID: 27793746 The BEL Information Extraction Workflow (BELIEF): Evaluation in the BioCreative V BEL and IAT Track Database : the Journal of Biological Databases and Curation. 2016 | Pubmed ID: 27694210 Alterations in Serum Polyunsaturated Fatty Acids and Eicosanoids in Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD) International Journal of Molecular Sciences. Sep, 2016 | Pubmed ID: 27657052 Training and Evaluation Corpora for the Extraction of Causal Relationships Encoded in Biological Expression Language (BEL) Database : the Journal of Biological Databases and Curation. 2016 | Pubmed ID: 27554092 Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the System and the Scientific Assessment Program Regulatory Toxicology and Pharmacology : RTP. Nov, 2016 | Pubmed ID: 27450400 Community-Reviewed Biological Network Models for Toxicology and Drug Discovery Applications Gene Regulation and Systems Biology. 2016 | Pubmed ID: 27429547 The Apoe(-/-) Mouse Model: a Suitable Model to Study Cardiovascular and Respiratory Diseases in the Context of Cigarette Smoke Exposure and Harm Reduction Journal of Translational Medicine. 05, 2016 | Pubmed ID: 27207171 A Framework for in Vitro Systems Toxicology Assessment of E-liquids Toxicology Mechanisms and Methods. Apr, 2016 | Pubmed ID: 27117495 Effects of Cigarette Smoke, Cessation and Switching to a Candidate Modified Risk Tobacco Product on the Liver in Apoe(-/-) Mice - a Systems Toxicology Analysis Inhalation Toxicology. Apr, 2016 | Pubmed ID: 27027324 Comprehensive Systems Biology Analysis of a 7-month Cigarette Smoke Inhalation Study in C57BL/6 Mice Scientific Data. 2016 | Pubmed ID: 26731301 Systems Toxicology-based Assessment of the Candidate Modified Risk Tobacco Product THS2.2 for the Adhesion of Monocytic Cells to Human Coronary Arterial Endothelial Cells Toxicology. Jan, 2016 | Pubmed ID: 26655683 In Vitro Systems Toxicology Assessment of a Candidate Modified Risk Tobacco Product Shows Reduced Toxicity Compared to That of a Conventional Cigarette Chemical Research in Toxicology. Jan, 2016 | Pubmed ID: 26651182 An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes Toxicological Sciences : an Official Journal of the Society of Toxicology. Feb, 2016 | Pubmed ID: 26609137 Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe-/- Mice-An Integrative Systems Toxicology Analysis Toxicological Sciences : an Official Journal of the Society of Toxicology. Feb, 2016 | Pubmed ID: 26582801 Aerosol from a Candidate Modified Risk Tobacco Product Has Reduced Effects on Chemotaxis and Transendothelial Migration Compared to Combustion of Conventional Cigarettes Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Dec, 2015 | Pubmed ID: 26432920 Alterations in the Sputum Proteome and Transcriptome in Smokers and Early-stage COPD Subjects Journal of Proteomics. Oct, 2015 | Pubmed ID: 26306861 Toxicity of Aerosols of Nicotine and Pyruvic Acid (separate and Combined) in Sprague-Dawley Rats in a 28-day OECD 412 Inhalation Study and Assessment of Systems Toxicology Inhalation Toxicology. 2015 | Pubmed ID: 26295358 Construction of Biological Networks from Unstructured Information Based on a Semi-automated Curation Workflow Database : the Journal of Biological Databases and Curation. 2015 | Pubmed ID: 26200752 Systems Biology Reveals Cigarette Smoke-Induced Concentration-Dependent Direct and Indirect Mechanisms That Promote Monocyte-Endothelial Cell Adhesion Toxicological Sciences : an Official Journal of the Society of Toxicology. Oct, 2015 | Pubmed ID: 26141392 Systems Biology Research into Cardiovascular Disease: Contributions of Lipidomics-based Approaches to Biomarker Discovery Current Drug Discovery Technologies. 2015 | Pubmed ID: 26135855 Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts Toxicological Sciences : an Official Journal of the Society of Toxicology. Sep, 2015 | Pubmed ID: 26085348 Transcriptional Profiling and Targeted Proteomics Reveals Common Molecular Changes Associated with Cigarette Smoke-induced Lung Emphysema Development in Five Susceptible Mouse Strains Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]. Jul, 2015 | Pubmed ID: 25962837 Causal Biological Network Database: a Comprehensive Platform of Causal Biological Network Models Focused on the Pulmonary and Vascular Systems Database : the Journal of Biological Databases and Curation. 2015 | Pubmed ID: 25887162 A 7-month Cigarette Smoke Inhalation Study in C57BL/6 Mice Demonstrates Reduced Lung Inflammation and Emphysema Following Smoking Cessation or Aerosol Exposure from a Prototypic Modified Risk Tobacco Product Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Jun, 2015 | Pubmed ID: 25843363 A Prototypic Modified Risk Tobacco Product Exhibits Reduced Effects on Chemotaxis and Transendothelial Migration of Monocytes Compared with a Reference Cigarette Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Jun, 2015 | Pubmed ID: 25839901 Systems Toxicology: The Future of Risk Assessment International Journal of Toxicology. Mar, 2015 | Pubmed ID: 25804424 A Systems Biology Approach Reveals the Dose- and Time-dependent Effect of Primary Human Airway Epithelium Tissue Culture After Exposure to Cigarette Smoke in Vitro Bioinformatics and Biology Insights. 2015 | Pubmed ID: 25788831 Enhancement of COPD Biological Networks Using a Web-based Collaboration Interface F1000Research. 2015 | Pubmed ID: 25767696 Reputation-based Collaborative Network Biology Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 2015 | Pubmed ID: 25592588 Systems Toxicology Approaches Enable Mechanistic Comparison of Spontaneous and Cigarette Smoke-related Lung Tumor Development in the A/J Mouse Model Interdisciplinary Toxicology. Jun, 2014 | Pubmed ID: 26109882 The Species Translation Challenge-a Systems Biology Perspective on Human and Rat Bronchial Epithelial Cells Scientific Data. 2014 | Pubmed ID: 25977767 Characterization of the Vitrocell® 24/48 in Vitro Aerosol Exposure System Using Mainstream Cigarette Smoke Chemistry Central Journal. 2014 | Pubmed ID: 25411580 Proteomics for Systems Toxicology Computational and Structural Biotechnology Journal. Aug, 2014 | Pubmed ID: 25379146 The Response of Human Nasal and Bronchial Organotypic Tissue Cultures to Repeated Whole Cigarette Smoke Exposure International Journal of Toxicology. Nov, 2014 | Pubmed ID: 25297719 A Crowd-sourcing Approach for the Construction of Species-specific Cell Signaling Networks Bioinformatics (Oxford, England). Oct, 2014 | Pubmed ID: 25294919 Understanding the Limits of Animal Models As Predictors of Human Biology: Lessons Learned from the Sbv IMPROVER Species Translation Challenge Bioinformatics (Oxford, England). Sep, 2014 | Pubmed ID: 25236459 CSEO - the Cigarette Smoke Exposure Ontology Journal of Biomedical Semantics. 2014 | Pubmed ID: 25093069 In Vitro Systems Toxicology Approach to Investigate the Effects of Repeated Cigarette Smoke Exposure on Human Buccal and Gingival Organotypic Epithelial Tissue Cultures Toxicology Mechanisms and Methods. Oct, 2014 | Pubmed ID: 25046638 Quantification of Biological Network Perturbations for Mechanistic Insight and Diagnostics Using Two-layer Causal Models BMC Bioinformatics. 2014 | Pubmed ID: 25015298 A Vascular Biology Network Model Focused on Inflammatory Processes to Investigate Atherogenesis and Plaque Instability Journal of Translational Medicine. 2014 | Pubmed ID: 24965703 Assessment of a Novel Multi-array Normalization Method Based on Spike-in Control Probes Suitable for MicroRNA Datasets with Global Decreases in Expression BMC Research Notes. 2014 | Pubmed ID: 24886675 Mechanism of an Indirect Effect of Aqueous Cigarette Smoke Extract on the Adhesion of Monocytic Cells to Endothelial Cells in an in Vitro Assay Revealed by Transcriptomics Analysis Toxicology in Vitro : an International Journal Published in Association with BIBRA. Aug, 2014 | Pubmed ID: 24747719 A 28-day Rat Inhalation Study with an Integrated Molecular Toxicology Endpoint Demonstrates Reduced Exposure Effects for a Prototypic Modified Risk Tobacco Product Compared with Conventional Cigarettes Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Jun, 2014 | Pubmed ID: 24632068 Discovery of Emphysema Relevant Molecular Networks from an A/J Mouse Inhalation Study Using Reverse Engineering and Forward Simulation (REFS™) Gene Regulation and Systems Biology. 2014 | Pubmed ID: 24596455 Systems Toxicology: from Basic Research to Risk Assessment Chemical Research in Toxicology. Mar, 2014 | Pubmed ID: 24446777 Systems Biology Approach for Evaluating the Biological Impact of Environmental Toxicants in Vitro Chemical Research in Toxicology. Mar, 2014 | Pubmed ID: 24428674 Case Study: the Role of Mechanistic Network Models in Systems Toxicology Drug Discovery Today. Feb, 2014 | Pubmed ID: 23933191 Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues BioMed Research International. 2013 | Pubmed ID: 24224167 On Crowd-verification of Biological Networks Bioinformatics and Biology Insights. 2013 | Pubmed ID: 24151423 Cigarette Smoke Induces Molecular Responses in Respiratory Tissues of ApoE(-/-) Mice That Are Progressively Deactivated Upon Cessation Toxicology. Dec, 2013 | Pubmed ID: 24096154 Strengths and Limitations of Microarray-based Phenotype Prediction: Lessons Learned from the IMPROVER Diagnostic Signature Challenge Bioinformatics (Oxford, England). Nov, 2013 | Pubmed ID: 23966112 Quantitative Assessment of Biological Impact Using Transcriptomic Data and Mechanistic Network Models Toxicology and Applied Pharmacology. Nov, 2013 | Pubmed ID: 23933166 Systematic Verification of Upstream Regulators of a Computable Cellular Proliferation Network Model on Non-diseased Lung Cells Using a Dedicated Dataset Bioinformatics and Biology Insights. 2013 | Pubmed ID: 23926424 Confero: an Integrated Contrast Data and Gene Set Platform for Computational Analysis and Biological Interpretation of Omics Data BMC Genomics. 2013 | Pubmed ID: 23895370 Systems Approaches to Computational Modeling of the Oral Microbiome Frontiers in Physiology. 2013 | Pubmed ID: 23847548 A Modular Cell-type Focused Inflammatory Process Network Model for Non-diseased Pulmonary Tissue Bioinformatics and Biology Insights. 2013 | Pubmed ID: 23843693 Cigarette-smoke-induced Atherogenic Lipid Profiles in Plasma and Vascular Tissue of Apolipoprotein E-deficient Mice Are Attenuated by Smoking Cessation Atherosclerosis. Jul, 2013 | Pubmed ID: 23669247 Construction of a Computable Network Model for DNA Damage, Autophagy, Cell Death, and Senescence Bioinformatics and Biology Insights. 2013 | Pubmed ID: 23515068 Human Bronchial Epithelial Cells Exposed in Vitro to Cigarette Smoke at the Air-liquid Interface Resemble Bronchial Epithelium from Human Smokers American Journal of Physiology. Lung Cellular and Molecular Physiology. Apr, 2013 | Pubmed ID: 23355383 Modulation of Atherogenic Lipidome by Cigarette Smoke in Apolipoprotein E-deficient Mice Atherosclerosis. Dec, 2012 | Pubmed ID: 23102783 Assessment of Network Perturbation Amplitudes by Applying High-throughput Data to Causal Biological Networks BMC Systems Biology. 2012 | Pubmed ID: 22651900 Industrial Methodology for Process Verification in Research (IMPROVER): Toward Systems Biology Verification Bioinformatics (Oxford, England). May, 2012 | Pubmed ID: 22423044 A Network-based Approach to Quantifying the Impact of Biologically Active Substances Drug Discovery Today. May, 2012 | Pubmed ID: 22155224 A Computable Cellular Stress Network Model for Non-diseased Pulmonary and Cardiovascular Tissue BMC Systems Biology. 2011 | Pubmed ID: 22011616 Verification of Systems Biology Research in the Age of Collaborative Competition Nature Biotechnology. Sep, 2011 | Pubmed ID: 21904331 Construction of a Computable Cell Proliferation Network Focused on Non-diseased Lung Cells BMC Systems Biology. 2011 | Pubmed ID: 21722388 An ATP Gate Controls Tubulin Binding by the Tethered Head of Kinesin-1 Science (New York, N.Y.). Apr, 2007 | Pubmed ID: 17412962 Identification of New Human Cadherin Genes Using a Combination of Protein Motif Search and Gene Finding Methods Journal of Molecular Biology. Mar, 2004 | Pubmed ID: 15003449 שימוש במחולל תרסיס נימי בייצור רציף של תרסיס מבוקר למחקרים לא קליניים Didier Goedertier1, Sandra Schorderet Weber1, Francesco Lucci1, Tom Lee2, Wei Teck Tan2, Falk Radtke1, Subash Krishnan2, Patrick Vanscheeuwijck1, Arkadiusz K. Kuczaj1,3, Julia Hoeng1 1PMI R&D, Philip Morris Products S.A., 2PMI R&D, Philip Morris Research Laboratories Pte. Ltd., 3Applied Mathematics, University of Twente JoVE 61021 Engineering ניתוח הקרנת תכולה גבוהה כדי להעריך את ההשפעות טוקסיקולוגי של מזיקים מזיקים מרכיבים (HPHC) Diego Marescotti1, Ignacio Gonzalez Suarez1, Stefano Acali1, Stephanie Johne1, Alexandra Laurent1, Stefan Frentzel1, Julia Hoeng1, Manuel C. Peitsch1 1Biological System Research (BSR), Philip Morris International R&D Biology הערכת השפעה של חשיפה חוזרת ונשנית של דוגמניות תרבות רקמות Organotypic 3D הסימפונות ובאף לעשן סיגריות שלמות Diana Kuehn1, Shoaib Majeed1, Emmanuel Guedj1, Remi Dulize1, Karine Baumer1, Anita Iskandar1, Stephanie Boue1, Florian Martin1, Radina Kostadinova1, Carole Mathis1, Nikolai V. Ivanov1, Stefan Frentzel1, Julia Hoeng1, Manuel C. Peitsch1 1Biological Systems Research, Philip Morris International R&D, Philip Morris Products S.A. Bioengineering
שימוש במחולל תרסיס נימי בייצור רציף של תרסיס מבוקר למחקרים לא קליניים Didier Goedertier1, Sandra Schorderet Weber1, Francesco Lucci1, Tom Lee2, Wei Teck Tan2, Falk Radtke1, Subash Krishnan2, Patrick Vanscheeuwijck1, Arkadiusz K. Kuczaj1,3, Julia Hoeng1 1PMI R&D, Philip Morris Products S.A., 2PMI R&D, Philip Morris Research Laboratories Pte. Ltd., 3Applied Mathematics, University of Twente JoVE 61021 Engineering
ניתוח הקרנת תכולה גבוהה כדי להעריך את ההשפעות טוקסיקולוגי של מזיקים מזיקים מרכיבים (HPHC) Diego Marescotti1, Ignacio Gonzalez Suarez1, Stefano Acali1, Stephanie Johne1, Alexandra Laurent1, Stefan Frentzel1, Julia Hoeng1, Manuel C. Peitsch1 1Biological System Research (BSR), Philip Morris International R&D Biology
הערכת השפעה של חשיפה חוזרת ונשנית של דוגמניות תרבות רקמות Organotypic 3D הסימפונות ובאף לעשן סיגריות שלמות Diana Kuehn1, Shoaib Majeed1, Emmanuel Guedj1, Remi Dulize1, Karine Baumer1, Anita Iskandar1, Stephanie Boue1, Florian Martin1, Radina Kostadinova1, Carole Mathis1, Nikolai V. Ivanov1, Stefan Frentzel1, Julia Hoeng1, Manuel C. Peitsch1 1Biological Systems Research, Philip Morris International R&D, Philip Morris Products S.A. Bioengineering
