Laura J. Niedernhofer

Publications

• Adenoviral Gene Transfer of a Single-chain IL-23 Induces Psoriatic Arthritis-like Symptoms in NOD Mice
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2019  |   Pubmed ID: 31170010
• Measuring Biological Age in Mice Using Differential Mass Spectrometry
  Aging. Feb, 2019  |   Pubmed ID: 30745468
• Methods to Quantify the NF-κB Pathway During Senescence
  Methods in Molecular Biology (Clifton, N.J.). 2019  |   Pubmed ID: 30474851
• Mouse Models of Accelerated Cellular Senescence
  Methods in Molecular Biology (Clifton, N.J.). 2019  |   Pubmed ID: 30474850
• Fisetin is a Senotherapeutic That Extends Health and Lifespan
  EBioMedicine. Oct, 2018  |   Pubmed ID: 30279143
• Dysregulation of DAF-16/FOXO3A-mediated Stress Responses Accelerates Oxidative DNA Damage Induced Aging
  Redox Biology. 09, 2018  |   Pubmed ID: 30031267
• Senolytics Improve Physical Function and Increase Lifespan in Old Age
  Nature Medicine. 08, 2018  |   Pubmed ID: 29988130
• Nuclear Genomic Instability and Aging
  Annual Review of Biochemistry. 06, 2018  |   Pubmed ID: 29925262
• Neurodegeneration As the Presenting Symptom in 2 Adults with Xeroderma Pigmentosum Complementation Group F
  Neurology. Genetics. Jun, 2018  |   Pubmed ID: 29892709
• Development of Novel NEMO-binding Domain Mimetics for Inhibiting IKK/NF-κB Activation
  PLoS Biology. 06, 2018  |   Pubmed ID: 29889904
• Hsp90 Inhibitors As Senolytic Drugs to Extend Healthy Aging
  Cell Cycle (Georgetown, Tex.). 2018  |   Pubmed ID: 29886783
• ERCC1-deficient Cells and Mice Are Hypersensitive to Lipid Peroxidation
  Free Radical Biology & Medicine. 08, 2018  |   Pubmed ID: 29860127
• Spontaneous DNA Damage to the Nuclear Genome Promotes Senescence, Redox Imbalance and Aging
  Redox Biology. 07, 2018  |   Pubmed ID: 29747066
• Senotherapeutics for Healthy Ageing
  Nature Reviews. Drug Discovery. May, 2018  |   Pubmed ID: 29651106
• Oxidation Products of 5-Methylcytosine Are Decreased in Senescent Cells and Tissues of Progeroid Mice
  The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Jul, 2018  |   Pubmed ID: 29415265
• Circulating Levels of Monocyte Chemoattractant Protein-1 As a Potential Measure of Biological Age in Mice and Frailty in Humans
  Aging Cell. 04, 2018  |   Pubmed ID: 29290100
• ERCC4 Variants Identified in a Cohort of Patients with Segmental Progeroid Syndromes
  Human Mutation. 02, 2018  |   Pubmed ID: 29105242
• Identification of HSP90 Inhibitors As a Novel Class of Senolytics
  Nature Communications. 09, 2017  |   Pubmed ID: 28871086
• The Clinical Potential of Senolytic Drugs
  Journal of the American Geriatrics Society. Oct, 2017  |   Pubmed ID: 28869295
• Senescent Intervertebral Disc Cells Exhibit Perturbed Matrix Homeostasis Phenotype
  Mechanisms of Ageing and Development. 09, 2017  |   Pubmed ID: 28830687
• Inhibition of NF-κB Improves the Stress Resistance and Myogenic Differentiation of MDSPCs Isolated from Naturally Aged Mice
  PloS One. 2017  |   Pubmed ID: 28640861
• Advances in Therapeutic Approaches to Extend Healthspan: a Perspective from the 2 Scripps Symposium on the Biology of Aging
  Aging Cell. 08, 2017  |   Pubmed ID: 28585366
• ADAMTS5 Deficiency Protects Mice From Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration
  Spine. Oct, 2017  |   Pubmed ID: 28570296
• Systems Biology Guided by XCMS Online Metabolomics
  Nature Methods. 04, 2017  |   Pubmed ID: 28448069
• New Agents That Target Senescent Cells: the Flavone, Fisetin, and the BCL-X Inhibitors, A1331852 and A1155463
  Aging. 03, 2017  |   Pubmed ID: 28273655
• Expansion of Myeloid-derived Suppressor Cells with Aging in the Bone Marrow of Mice Through a NF-κB-dependent Mechanism
  Aging Cell. 06, 2017  |   Pubmed ID: 28229533
• Quantitative Analysis of Cellular Senescence in Culture and In Vivo
  Current Protocols in Cytometry. 01, 2017  |   Pubmed ID: 28055114
• Molecular Pathology Endpoints Useful for Aging Studies
  Ageing Research Reviews. May, 2017  |   Pubmed ID: 27721062
• Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage
  Chemical Research in Toxicology. 12, 2016  |   Pubmed ID: 27989142
• MTOR Signaling Plays a Critical Role in the Defects Observed in Muscle-derived Stem/progenitor Cells Isolated from a Murine Model of Accelerated Aging
  Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Aug, 2016  |   Pubmed ID: 27572850
• Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses
  Analytical Chemistry. Oct, 2016  |   Pubmed ID: 27560777
• Barriers to the Preclinical Development of Therapeutics That Target Aging Mechanisms
  The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 11, 2016  |   Pubmed ID: 27535964
• Identification of a Novel Senolytic Agent, Navitoclax, Targeting the Bcl-2 Family of Anti-apoptotic Factors
  Aging Cell. 06, 2016  |   Pubmed ID: 26711051
• In Vivo Detection and Replication Studies of α-anomeric Lesions of 2'-deoxyribonucleosides
  Nucleic Acids Research. Sep, 2015  |   Pubmed ID: 26202973
• The Achilles' Heel of Senescent Cells: from Transcriptome to Senolytic Drugs
  Aging Cell. Aug, 2015  |   Pubmed ID: 25754370
• NF-κB Activation with Aging: Characterization and Therapeutic Inhibition
  Methods in Molecular Biology (Clifton, N.J.). 2015  |   Pubmed ID: 25736771
• Comparison of Mice with Accelerated Aging Caused by Distinct Mechanisms
  Experimental Gerontology. Aug, 2015  |   Pubmed ID: 25617508
• Pharmacologic IKK/NF-κB Inhibition Causes Antigen Presenting Cells to Undergo TNFα Dependent ROS-mediated Programmed Cell Death
  Scientific Reports. Jan, 2014  |   Pubmed ID: 24406986
• Investigating the Role of DNA Damage in Tobacco Smoking-induced Spine Degeneration
  The Spine Journal : Official Journal of the North American Spine Society. Mar, 2014  |   Pubmed ID: 24211096
• DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria
  Cell Metabolism. Sep, 2013  |   Pubmed ID: 24011075
• NF κB 저해는 DNA 손상을 유도 노화와 생쥐에서 노화 지연
  The Journal of Clinical Investigation. Jul, 2012  |   Pubmed ID: 22706308