Paul D. Robbins Department of Molecular Medicine and the Center on Aging The Scripps Research Institute Biography Publications Institution JoVE Articles Paul D. Robbins has not added a biography. If you are Paul D. Robbins and would like to personalize this page please email our Author Liaison for assistance. Publications Adenoviral Gene Transfer of a Single-chain IL-23 Induces Psoriatic Arthritis-like Symptoms in NOD Mice FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2019 | Pubmed ID: 31170010 Signal Transduction, Ageing and Disease Sub-cellular Biochemistry. 2019 | Pubmed ID: 30888655 Murine Models of Accelerated Aging and Musculoskeletal Disease Bone. Aug, 2019 | Pubmed ID: 30844492 Measuring Biological Age in Mice Using Differential Mass Spectrometry Aging. Feb, 2019 | Pubmed ID: 30745468 Methods to Quantify the NF-κB Pathway During Senescence Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30474851 Mouse Models of Accelerated Cellular Senescence Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30474850 Minimal Information for Studies of Extracellular Vesicles 2018 (MISEV2018): a Position Statement of the International Society for Extracellular Vesicles and Update of the MISEV2014 Guidelines Journal of Extracellular Vesicles. 2018 | Pubmed ID: 30637094 Fisetin is a Senotherapeutic That Extends Health and Lifespan EBioMedicine. Oct, 2018 | Pubmed ID: 30279143 Dysregulation of DAF-16/FOXO3A-mediated Stress Responses Accelerates Oxidative DNA Damage Induced Aging Redox Biology. 09, 2018 | Pubmed ID: 30031267 Senolytics Improve Physical Function and Increase Lifespan in Old Age Nature Medicine. 08, 2018 | Pubmed ID: 29988130 Nuclear Genomic Instability and Aging Annual Review of Biochemistry. 06, 2018 | Pubmed ID: 29925262 Development of Novel NEMO-binding Domain Mimetics for Inhibiting IKK/NF-κB Activation PLoS Biology. 06, 2018 | Pubmed ID: 29889904 Hsp90 Inhibitors As Senolytic Drugs to Extend Healthy Aging Cell Cycle (Georgetown, Tex.). 2018 | Pubmed ID: 29886783 Treating Age-Related Diseases with Somatic Stem Cells Advances in Experimental Medicine and Biology. 2018 | Pubmed ID: 29754173 Spontaneous DNA Damage to the Nuclear Genome Promotes Senescence, Redox Imbalance and Aging Redox Biology. 07, 2018 | Pubmed ID: 29747066 Arthritis Gene Therapy is Becoming a Reality Nature Reviews. Rheumatology. Jul, 2018 | Pubmed ID: 29743627 Senotherapeutics for Healthy Ageing Nature Reviews. Drug Discovery. May, 2018 | Pubmed ID: 29651106 Arthritis Gene Therapy Approved in Korea The Journal of the American Academy of Orthopaedic Surgeons. 01, 2018 | Pubmed ID: 29303924 Circulating Levels of Monocyte Chemoattractant Protein-1 As a Potential Measure of Biological Age in Mice and Frailty in Humans Aging Cell. 04, 2018 | Pubmed ID: 29290100 Gene Delivery to Joints by Intra-Articular Injection Human Gene Therapy. 01, 2018 | Pubmed ID: 29160173 Extracellular Vesicles and Aging Stem Cell Investigation. 2017 | Pubmed ID: 29359137 Identification of HSP90 Inhibitors As a Novel Class of Senolytics Nature Communications. 09, 2017 | Pubmed ID: 28871086 The Clinical Potential of Senolytic Drugs Journal of the American Geriatrics Society. Oct, 2017 | Pubmed ID: 28869295 Senescent Intervertebral Disc Cells Exhibit Perturbed Matrix Homeostasis Phenotype Mechanisms of Ageing and Development. 09, 2017 | Pubmed ID: 28830687 Plasma-derived Exosome Characterization Reveals a Distinct MicroRNA Signature in Long Duration Type 1 Diabetes Scientific Reports. 07, 2017 | Pubmed ID: 28729721 Inhibition of NF-κB Improves the Stress Resistance and Myogenic Differentiation of MDSPCs Isolated from Naturally Aged Mice PloS One. 2017 | Pubmed ID: 28640861 Advances in Therapeutic Approaches to Extend Healthspan: a Perspective from the 2 Scripps Symposium on the Biology of Aging Aging Cell. 08, 2017 | Pubmed ID: 28585366 ADAMTS5 Deficiency Protects Mice From Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration Spine. Oct, 2017 | Pubmed ID: 28570296 Systems Biology Guided by XCMS Online Metabolomics Nature Methods. 04, 2017 | Pubmed ID: 28448069 New Agents That Target Senescent Cells: the Flavone, Fisetin, and the BCL-X Inhibitors, A1331852 and A1155463 Aging. 03, 2017 | Pubmed ID: 28273655 Cellular Senescence Mediates Fibrotic Pulmonary Disease Nature Communications. 02, 2017 | Pubmed ID: 28230051 Expansion of Myeloid-derived Suppressor Cells with Aging in the Bone Marrow of Mice Through a NF-κB-dependent Mechanism Aging Cell. 06, 2017 | Pubmed ID: 28229533 Quantitative Analysis of Cellular Senescence in Culture and In Vivo Current Protocols in Cytometry. 01, 2017 | Pubmed ID: 28055114 MTOR Signaling Plays a Critical Role in the Defects Observed in Muscle-derived Stem/progenitor Cells Isolated from a Murine Model of Accelerated Aging Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Aug, 2016 | Pubmed ID: 27572850 Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses Analytical Chemistry. Oct, 2016 | Pubmed ID: 27560777 Barriers to the Preclinical Development of Therapeutics That Target Aging Mechanisms The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 11, 2016 | Pubmed ID: 27535964 Regulation of Chronic Inflammatory and Immune Processes by Extracellular Vesicles The Journal of Clinical Investigation. Apr, 2016 | Pubmed ID: 27035808 Identification of a Novel Senolytic Agent, Navitoclax, Targeting the Bcl-2 Family of Anti-apoptotic Factors Aging Cell. 06, 2016 | Pubmed ID: 26711051 Arsenic Promotes NF-Κb-Mediated Fibroblast Dysfunction and Matrix Remodeling to Impair Muscle Stem Cell Function Stem Cells (Dayton, Ohio). Mar, 2016 | Pubmed ID: 26537186 IL-Y, a Synthetic Member of the IL-12 Cytokine Family, Suppresses the Development of Type 1 Diabetes in NOD Mice European Journal of Immunology. Nov, 2015 | Pubmed ID: 26260044 The Achilles' Heel of Senescent Cells: from Transcriptome to Senolytic Drugs Aging Cell. Aug, 2015 | Pubmed ID: 25754370 NF-κB Activation with Aging: Characterization and Therapeutic Inhibition Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25736771 Regulation of Immune Responses by Extracellular Vesicles Nature Reviews. Immunology. Mar, 2014 | Pubmed ID: 24566916 Pharmacologic IKK/NF-κB Inhibition Causes Antigen Presenting Cells to Undergo TNFα Dependent ROS-mediated Programmed Cell Death Scientific Reports. Jan, 2014 | Pubmed ID: 24406986 Lim Mineralization Protein 3 Induces the Osteogenic Differentiation of Human Amniotic Fluid Stromal Cells Through Kruppel-like Factor-4 Downregulation and Further Bone-specific Gene Expression Journal of Biomedicine & Biotechnology. 2012 | Pubmed ID: 23097599 NF κB 저해는 DNA 손상을 유도 노화와 생쥐에서 노화 지연 The Journal of Clinical Investigation. Jul, 2012 | Pubmed ID: 22706308 SA-β-갈락토시다아제 계 선별 분석법 Heike Fuhrmann-Stroissnigg*1, Fernando E. Santiago*1,2,3, Diego Grassi1, YuanYuan Ling1, Laura J. Niedernhofer1,2,3, Paul D. Robbins1,2,3 1Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 2Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 3Institute on the Biology of Aging and Metabolism, University of Minnesota JoVE 58133 Biology
SA-β-갈락토시다아제 계 선별 분석법 Heike Fuhrmann-Stroissnigg*1, Fernando E. Santiago*1,2,3, Diego Grassi1, YuanYuan Ling1, Laura J. Niedernhofer1,2,3, Paul D. Robbins1,2,3 1Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 2Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 3Institute on the Biology of Aging and Metabolism, University of Minnesota JoVE 58133 Biology
