Laurent Jacob Neurovascular interactions Institut du Cerveau et de la Moelle épinière ICM Biography Publications Institution JoVE Articles Laurent JacobPhd Laurent Jacob is a Postdoctoral Research Fellow at the Institut du Cerveau et de la Moelle épinière ICM, in Paris.During is PhD training in Strasbourg, in the BAGNARD team, he did the preclinical demonstration of the anti-angiogenic and anti-tumoral properties of transmembrane peptides targeting the Neuropilin-1 /Plexin-A1 complex in glioblastoma. He also developed some methods for identifying personalized therapeutic strategies for patients with brain tumors.Then he moved to the Thomas' lab at the ICM, where he studied the VEGF-C/VEGFR3 signaling in adult mouse neurogenesis, focusing on the hippocampus and the olfactory bulb neurogenesis.After he discovered the spinal lymphatic drainage and its in vivo implication in neuroinflammatory diseases of the spinal cord. For this, he modified the iDISCO clarification technique and combined it with Light-Sheet Fluorescence Microscopy for 3D-imaging of the vertebral column lymphatic system in mouse. Publications Anatomy and Function of the Vertebral Column Lymphatic Network in Mice Nature Communications. 10, 2019 | Pubmed ID: 31597914 RNA Profiling of the Human and Mouse Spinal Cord Stem Cell Niches Reveals an Embryonic-like Regionalization with MSX1 Roof-Plate-Derived Cells Stem Cell Reports. 05, 2019 | Pubmed ID: 31031189 [Lymphatic System in Central Nervous System] Medecine Sciences : M/S. Jan, 2019 | Pubmed ID: 30672459 Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy Laurent Jacob*1, Jose Brito*1,2, Jean-Leon Thomas1,3 1Université Pierre et Marie Curie Paris, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière, 2Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, 3Department of Neurology, Yale University School of Medicine JoVE 61099 Immunology and Infection
Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy Laurent Jacob*1, Jose Brito*1,2, Jean-Leon Thomas1,3 1Université Pierre et Marie Curie Paris, Sorbonne Université, Institut du Cerveau et de la Moelle Epinière, 2Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, 3Department of Neurology, Yale University School of Medicine JoVE 61099 Immunology and Infection
