Lawrence E. Heisler Donnelly Centre for Cellular and Biomolecular Research University of Toronto Biography Publications Institution JoVE Articles Lawrence E. Heisler has not added a biography. If you are Lawrence E. Heisler and would like to personalize this page please email our Author Liaison for assistance. Publications The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression Cell. May, 2018 | Pubmed ID: 29681457 Mitochondrial Mutations Drive Prostate Cancer Aggression Nature Communications. 09, 2017 | Pubmed ID: 28939825 Genomic Hallmarks of Localized, Non-indolent Prostate Cancer Nature. 01, 2017 | Pubmed ID: 28068672 Germline BRCA2 Mutations Drive Prostate Cancers with Distinct Evolutionary Trajectories Nature Communications. Jan, 2017 | Pubmed ID: 28067867 A Comprehensive Assessment of Somatic Mutation Detection in Cancer Using Whole-genome Sequencing Nature Communications. Dec, 2015 | Pubmed ID: 26647970 A Genome Scale Overexpression Screen to Reveal Drug Activity in Human Cells Genome Medicine. 2014 | Pubmed ID: 24944581 Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures Science (New York, N.Y.). Apr, 2014 | Pubmed ID: 24723613 CHIP-MYTH: a Novel Interactive Proteomics Method for the Assessment of Agonist-dependent Interactions of the Human β₂-adrenergic Receptor Biochemical and Biophysical Research Communications. Mar, 2014 | Pubmed ID: 24561123 Miniature Short Hairpin RNA Screens to Characterize Antiproliferative Drugs G3 (Bethesda, Md.). Aug, 2013 | Pubmed ID: 23797109 Effects of the Paf1 Complex and Histone Modifications on SnoRNA 3'-end Formation Reveal Broad and Locus-specific Regulation Molecular and Cellular Biology. Jan, 2013 | Pubmed ID: 23109428 Functional Analysis with a Barcoder Yeast Gene Overexpression System G3 (Bethesda, Md.). Oct, 2012 | Pubmed ID: 23050238 Comparative Chemogenomics to Examine the Mechanism of Action of Dna-targeted Platinum-acridine Anticancer Agents ACS Chemical Biology. Nov, 2012 | Pubmed ID: 22928710 Identification of Yeast Genes That Confer Resistance to Chitosan Oligosaccharide (COS) Using Chemogenomics BMC Genomics. Jun, 2012 | Pubmed ID: 22727066 多个手段为了同样的目的: 获得的抗逆性酵母的遗传基础。 PLoS Genetics. Nov, 2011 | Pubmed ID: 22102822 复合优先次序方法增加模式生物化学探测器发现的率。 Chemistry & Biology. Oct, 2011 | Pubmed ID: 22035796 剂量抑制基因相互作用网络增强功能接线图的单元格。 Nature Biotechnology. Jun, 2011 | Pubmed ID: 21572441 一个全面的平台高度多路复用功能哺乳动物遗传屏幕。 BMC Genomics. 2011 | Pubmed ID: 21548937 高度多路复用条形码测序: 汇集样品平行分析的一种有效方法。 Nucleic Acids Research. Jul, 2010 | Pubmed ID: 20460461 基因型到表型: 一个复杂的问题。 Science (New York, N.Y.). Apr, 2010 | Pubmed ID: 20413493 DNA 条码芯片特征尺寸的比较分析。 BMC Genomics. 2009 | Pubmed ID: 19825181 通过测序深条码的定量震撼。 Genome Research. Oct, 2009 | Pubmed ID: 19622793 Imidazo [1,2-a] 吡啶和嘧啶的化学遗传分析揭示了酵母和细胞之间的保守的目标路径。 PLoS Genetics. Nov, 2008 | Pubmed ID: 19043571 关闭目标的全基因组检测在酵母中发现的精神科药物的影响。 PLoS Genetics. 2008 | Pubmed ID: 18688276 酵母 Barcoders: Chemogenomic 采集中的应用通用捐助应变携带栏代码标识符。 Nature Methods. Aug, 2008 | Pubmed ID: 18622398 作为一个普遍的外部标准,在实时荧光定量 PCR 基因组 DNA 的功能。 Nucleic Acids Research. 2006 | Pubmed ID: 16840529 从物理库中导出的 CpG 岛基因芯片探针序列是注明关于人类基因组 CpG 岛的代表。 Nucleic Acids Research. 2005 | Pubmed ID: 15911630 条形码酵母图书馆竞争力的基因屏幕 Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 Biology
条形码酵母图书馆竞争力的基因屏幕 Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 Biology