Lee J. Martin Division of Neuropathology, Department of Pathology, Pathobiology Graduate Program Johns Hopkins School of Medicine Biography Publications Institution JoVE Articles Lee J. Martin has not added a biography. If you are Lee J. Martin and would like to personalize this page please email our Author Liaison for assistance. Publications The Non-human Primate Striatum Undergoes Marked Prolonged Remodeling During Postnatal Development Frontiers in Cellular Neuroscience. 2014 | Pubmed ID: 25294985 Oscillating Gradient Diffusion MRI Reveals Unique Microstructural Information in Normal and Hypoxia-ischemia Injured Mouse Brains Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Nov, 2014 | Pubmed ID: 25168861 Induced Pluripotent Stem Cells from Familial Alzheimer's Disease Patients Differentiate into Mature Neurons with Amyloidogenic Properties Stem Cells and Development. Aug, 2014 | Pubmed ID: 25027006 Skeletal Muscle DNA Damage Precedes Spinal Motor Neuron DNA Damage in a Mouse Model of Spinal Muscular Atrophy (SMA) PloS One. 2014 | Pubmed ID: 24667816 Mitochondrial Permeability Transition Pore Regulates Parkinson's Disease Development in Mutant α-synuclein Transgenic Mice Neurobiology of Aging. May, 2014 | Pubmed ID: 24325796 Imaging Neurodegeneration in the Mouse Hippocampus After Neonatal Hypoxia-ischemia Using Oscillating Gradient Diffusion MRI Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Sep, 2014 | Pubmed ID: 24123409 Mitochondrial DNMT3A and DNA Methylation in Skeletal Muscle and CNS of Transgenic Mouse Models of ALS Frontiers in Cellular Neuroscience. 2013 | Pubmed ID: 24399935 The Olfactory Bulb in Newborn Piglet is a Reservoir of Neural Stem and Progenitor Cells PloS One. 2013 | Pubmed ID: 24278384 Aberrant Regulation of DNA Methylation in Amyotrophic Lateral Sclerosis: a New Target of Disease Mechanisms Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Oct, 2013 | Pubmed ID: 23900692 Adenosine A2A Receptor Contributes to Ischemic Brain Damage in Newborn Piglet Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Oct, 2013 | Pubmed ID: 23860373 Early Antioxidant Treatment and Delayed Hypothermia After Hypoxia-ischemia Have No Additive Neuroprotection in Newborn Pigs Anesthesia and Analgesia. Sep, 2012 | Pubmed ID: 22745113 Programmed Necrosis: A Prominent Mechanism of Cell Death Following Neonatal Brain Injury Neurology Research International. 2012 | Pubmed ID: 22666585 Biology of Mitochondria in Neurodegenerative Diseases Progress in Molecular Biology and Translational Science. 2012 | Pubmed ID: 22482456 Attenuation of Neonatal Ischemic Brain Damage Using a 20-HETE Synthesis Inhibitor Journal of Neurochemistry. Apr, 2012 | Pubmed ID: 22251169 Nuclear Localization of Human SOD1 and Mutant SOD1-specific Disruption of Survival Motor Neuron Protein Complex in Transgenic Amyotrophic Lateral Sclerosis Mice Journal of Neuropathology and Experimental Neurology. Feb, 2012 | Pubmed ID: 22249462 Inhibitory Synaptic Regulation of Motoneurons: a New Target of Disease Mechanisms in Amyotrophic Lateral Sclerosis Molecular Neurobiology. Feb, 2012 | Pubmed ID: 22072396 Epigenetic Regulation of Motor Neuron Cell Death Through DNA Methylation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2011 | Pubmed ID: 22090490 Mitochondrial Pathobiology in ALS Journal of Bioenergetics and Biomembranes. Dec, 2011 | Pubmed ID: 22083126 Generation and Characterization of Transgenic Mice Expressing Mitochondrial Targeted Red Fluorescent Protein Selectively in Neurons: Modeling Mitochondriopathy in Excitotoxicity and Amyotrophic Lateral Sclerosis Molecular Neurodegeneration. 2011 | Pubmed ID: 22047141 Striatal Neuroprotection from Neonatal Hypoxia-ischemia in Piglets by Antioxidant Treatment with EUK-134 or Edaravone Developmental Neuroscience. 2011 | Pubmed ID: 21701140 Motoneuron Subtypes Show Specificity in Glycine Receptor Channel Abnormalities in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis Channels (Austin, Tex.). Jul-Aug, 2011 | Pubmed ID: 21558795 Neuroprotective Effect of Acid-sensing Ion Channel Inhibitor Psalmotoxin-1 After Hypoxia-ischemia in Newborn Piglet Striatum Neurobiology of Disease. Aug, 2011 | Pubmed ID: 21558004 Neuronal Cell Death in Neonatal Hypoxia-ischemia Annals of Neurology. May, 2011 | Pubmed ID: 21520238 Glycine Receptor Channels in Spinal Motoneurons Are Abnormal in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2011 | Pubmed ID: 21414903 An Approach to Experimental Synaptic Pathology Using Green Fluorescent Protein-transgenic Mice and Gene Knockout Mice to Show Mitochondrial Permeability Transition Pore-driven Excitotoxicity in Interneurons and Motoneurons Toxicologic Pathology. Jan, 2011 | Pubmed ID: 21378209 The Mitochondrial Permeability Transition Pore Regulates Nitric Oxide-mediated Apoptosis of Neurons Induced by Target Deprivation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2011 | Pubmed ID: 21209222 Necrostatin Decreases Oxidative Damage, Inflammation, and Injury After Neonatal HI Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jan, 2011 | Pubmed ID: 20571523 Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases Pharmaceuticals (Basel, Switzerland). 2010 | Pubmed ID: 21258649 Olesoxime, a Cholesterol-like Neuroprotectant for the Potential Treatment of Amyotrophic Lateral Sclerosis IDrugs : the Investigational Drugs Journal. Aug, 2010 | Pubmed ID: 20721828 Mitochondrial Pathobiology in Parkinson's Disease and Amyotrophic Lateral Sclerosis Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20413846 Skeletal Muscle-restricted Expression of Human SOD1 Causes Motor Neuron Degeneration in Transgenic Mice Human Molecular Genetics. Jun, 2010 | Pubmed ID: 20223753 Synphilin-1 Attenuates Neuronal Degeneration in the A53T Alpha-synuclein Transgenic Mouse Model Human Molecular Genetics. Jun, 2010 | Pubmed ID: 20185556 Inducible Nitric Oxide Synthase is Present in Motor Neuron Mitochondria and Schwann Cells and Contributes to Disease Mechanisms in ALS Mice Brain Structure & Function. Mar, 2010 | Pubmed ID: 19888600 Sigma Receptor Ligand 4-phenyl-1-(4-phenylbutyl)-piperidine Modulates Neuronal Nitric Oxide Synthase/postsynaptic Density-95 Coupling Mechanisms and Protects Against Neonatal Ischemic Degeneration of Striatal Neurons Experimental Neurology. Jan, 2010 | Pubmed ID: 19883643 The Mitochondrial Permeability Transition Pore: a Molecular Target for Amyotrophic Lateral Sclerosis Therapy Biochimica Et Biophysica Acta. Jan, 2010 | Pubmed ID: 19651206 Neuropathologic Studies of the Baltimore Longitudinal Study of Aging (BLSA) Journal of Alzheimer's Disease : JAD. 2009 | Pubmed ID: 19661626 The Mitochondrial Permeability Transition Pore in Motor Neurons: Involvement in the Pathobiology of ALS Mice Experimental Neurology. Aug, 2009 | Pubmed ID: 19272377 Glycinergic Innervation of Motoneurons is Deficient in Amyotrophic Lateral Sclerosis Mice: a Quantitative Confocal Analysis The American Journal of Pathology. Feb, 2009 | Pubmed ID: 19116365 Molecular Regulation of DNA Damage-induced Apoptosis in Neurons of Cerebral Cortex Cerebral Cortex (New York, N.Y. : 1991). Jun, 2009 | Pubmed ID: 18820287 Delayed Neural Network Degeneration After Neonatal Hypoxia-ischemia Annals of Neurology. Nov, 2008 | Pubmed ID: 19067347 DNA Damage and Repair: Relevance to Mechanisms of Neurodegeneration Journal of Neuropathology and Experimental Neurology. May, 2008 | Pubmed ID: 18431258 Maladie Du Motoneurone Intervenant Dans Un Modèle De Souris Dynactin Mutant Est Caractérisé Par Des Défauts Dans Le Trafic Vésiculaire The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2008 | Pubmed ID: 18305234 Rapid NMDA Receptor Phosphorylation and Oxidative Stress Precede Striatal Neurodegeneration After Hypoxic Ischemia in Newborn Piglets and Are Attenuated with Hypothermia International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience. Feb, 2008 | Pubmed ID: 17950559 Adult Olfactory Bulb Neural Precursor Cell Grafts Provide Temporary Protection from Motor Neuron Degeneration, Improve Motor Function, and Extend Survival in Amyotrophic Lateral Sclerosis Mice Journal of Neuropathology and Experimental Neurology. Nov, 2007 | Pubmed ID: 17984682 Resistance to Alzheimer's Pathology is Associated with Nuclear Hypertrophy in Neurons Neurobiology of Aging. Oct, 2007 | Pubmed ID: 17599696 Transgenic Mice with Human Mutant Genes Causing Parkinson's Disease and Amyotrophic Lateral Sclerosis Provide Common Insight into Mechanisms of Motor Neuron Selective Vulnerability to Degeneration Reviews in the Neurosciences. 2007 | Pubmed ID: 17593875 Dopamine Receptor Modulation of Hypoxic-ischemic Neuronal Injury in Striatum of Newborn Piglets Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jul, 2007 | Pubmed ID: 17213860 Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis Mutant Superoxide Dismutase-1 Transgenic Mice: Mechanisms of Mitochondriopathy and Cell Death The Journal of Comparative Neurology. Jan, 2007 | Pubmed ID: 17099894 Mitochondriopathy in Parkinson Disease and Amyotrophic Lateral Sclerosis Journal of Neuropathology and Experimental Neurology. Dec, 2006 | Pubmed ID: 17146283 La Sclérose Latérale Amyotrophique 2-déficience Conduit à Une Dégénérescence Neuronale Dans La Sclérose Latérale Amyotrophique Grâce Trafic Des Récepteurs AMPA Altered The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2006 | Pubmed ID: 17093100 The Adult Neural Stem and Progenitor Cell Niche is Altered in Amyotrophic Lateral Sclerosis Mouse Brain The Journal of Comparative Neurology. Jul, 2006 | Pubmed ID: 16736475 Parkinson's Disease Alpha-synuclein Transgenic Mice Develop Neuronal Mitochondrial Degeneration and Cell Death The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2006 | Pubmed ID: 16399671 Transplanted Human Embryonic Germ Cell-derived Neural Stem Cells Replace Neurons and Oligodendrocytes in the Forebrain of Neonatal Mice with Excitotoxic Brain Damage Journal of Neuroscience Research. Dec, 2005 | Pubmed ID: 16247803 Apoptosis in Perinatal Hypoxic-ischemic Brain Injury: How Important is It and Should It Be Inhibited? Brain Research. Brain Research Reviews. Dec, 2005 | Pubmed ID: 16216332 Adult Motor Neuron Apoptosis is Mediated by Nitric Oxide and Fas Death Receptor Linked by DNA Damage and P53 Activation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2005 | Pubmed ID: 16000635 In Situ Immunoradiographic Method for Quantification of Specific Proteins in Normal and Ischemic Brain Regions Journal of Neuroscience Methods. Apr, 2005 | Pubmed ID: 15814155 Pluripotent Fates and Tissue Regenerative Potential of Adult Olfactory Bulb Neural Stem and Progenitor Cells Journal of Neurotrauma. Oct, 2004 | Pubmed ID: 15672637 Neonatal Mice Lacking Functional Fas Death Receptors Are Resistant to Hypoxic-ischemic Brain Injury Neurobiology of Disease. Oct, 2004 | Pubmed ID: 15350969 Caractérisation Histopathologique Et Comportementale D'un Modèle Original D'un Arrêt Cardiaque Et De Réanimation Cardio-respiratoire Chez La Souris Journal of Neuroscience Methods. Jun, 2004 | Pubmed ID: 15126043 La Nitration De La Striatale Na, K-ATPase Alpha3 Isoforme Se Produit Dans Le Développement Normal Du Cerveau Mais N'est Pas Augmentée Pendant Une Hypoxie-ischémie Chez Les Porcelets Nouveaux-nés Neurochemical Research. Dec, 2003 | Pubmed ID: 14649731 L'hypothermie Pendant 24 Heures Après L'infarctus Asphyxic Chez Les Porcelets Fournit Neuroprotection Striataux Qui Est Prolongées De 10 Jours Après Réchauffement Pediatric Research. Aug, 2003 | Pubmed ID: 12736390 Olfactory Bulb Core is a Rich Source of Neural Progenitor and Stem Cells in Adult Rodent and Human The Journal of Comparative Neurology. May, 2003 | Pubmed ID: 12687705 Early Events of Target Deprivation/axotomy-induced Neuronal Apoptosis in Vivo: Oxidative Stress, DNA Damage, P53 Phosphorylation and Subcellular Redistribution of Death Proteins Journal of Neurochemistry. Apr, 2003 | Pubmed ID: 12641745 DNA Damage Profiling in Motor Neurons: a Single-cell Analysis by Comet Assay Neurochemical Research. Oct, 2002 | Pubmed ID: 12462407 DNA Base-excision Repair Enzyme Apurinic/apyrimidinic Endonuclease/redox Factor-1 is Increased and Competent in the Brain and Spinal Cord of Individuals with Amyotrophic Lateral Sclerosis Neuromolecular Medicine. 2002 | Pubmed ID: 12230304 Rapid Subcellular Redistribution of Bax Precedes Caspase-3 and Endonuclease Activation During Excitotoxic Neuronal Apoptosis in Rat Brain Journal of Neurotrauma. Jul, 2002 | Pubmed ID: 12184852 Immature and Mature Cortical Neurons Engage Different Apoptotic Mechanisms Involving Caspase-3 and the Mitogen-activated Protein Kinase Pathway Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Aug, 2002 | Pubmed ID: 12172379 Expression Altérée Et La Phosphorylation Des Récepteurs N-méthyl-D-aspartate Porcinet Striatum Après Une Hypoxie-ischémie Brain Research. Molecular Brain Research. Jul, 2002 | Pubmed ID: 12117552 Long-term Culture of Mouse Cortical Neurons As a Model for Neuronal Development, Aging, and Death Journal of Neurobiology. Apr, 2002 | Pubmed ID: 11920724 Axonal Transection in Adult Rat Brain Induces Transsynaptic Apoptosis and Persistent Atrophy of Target Neurons Journal of Neurotrauma. Jan, 2002 | Pubmed ID: 11852982 Injury-induced Spinal Motor Neuron Apoptosis is Preceded by DNA Single-strand Breaks and is P53- and Bax-dependent Journal of Neurobiology. Feb, 2002 | Pubmed ID: 11810634 Détection et analyse de l'ADN dommages souris muscle squelettique Saniya Fayzullina1, Lee J. Martin1 1Division of Neuropathology, Department of Pathology, Pathobiology Graduate Program, Johns Hopkins School of Medicine Biology
Détection et analyse de l'ADN dommages souris muscle squelettique Saniya Fayzullina1, Lee J. Martin1 1Division of Neuropathology, Department of Pathology, Pathobiology Graduate Program, Johns Hopkins School of Medicine Biology