Lin Cheng Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital Sichuan University Biography Publications Institution JoVE Articles Lin Cheng has not added a biography. If you are Lin Cheng and would like to personalize this page please email our Author Liaison for assistance. Publications Molecular Mechanism of Allosteric Modulation for the Cannabinoid Receptor CB1 Nature Chemical Biology. May, 2022 | Pubmed ID: 35637350 A Specific Upregulated LncRNA in Colorectal Cancer Promotes Cancer Progression JCI Insight. May, 2022 | Pubmed ID: 35617032 3D Printing Mini-Capsule Device for Islet Delivery to Treat Type 1 Diabetes ACS Applied Materials & Interfaces. May, 2022 | Pubmed ID: 35544723 Molecular Immunology Corrigendum to "Antitumor Effects Obtained by Autologous Lewis Lung Cancer Cell Vaccine Engineered to Secrete Mouse Interleukin 27 by Means of Cationic Liposome" [Mol. Immunol. 55 (3-4) (2013) 264-274] Molecular Immunology. Jan, 2022 | Pubmed ID: 34802774 Structural Insights into Sphingosine-1-phosphate Recognition and Ligand Selectivity of S1PR3-Gi Signaling Complexes Cell Research. Feb, 2022 | Pubmed ID: 34545189 Oncolytic Adenovirus Inhibits Malignant Ascites of Advanced Ovarian Cancer by Reprogramming the Ascitic Immune Microenvironment Molecular Therapy Oncolytics. Dec, 2021 | Pubmed ID: 34901391 DZNep Protects Against Retinal Ganglion Cell Death in an NMDA-induced Mouse Model of Retinal Degeneration Experimental Eye Research. 11, 2021 | Pubmed ID: 34600894 Lighting Up Cholecystokinin Nature Chemical Biology. 12, 2021 | Pubmed ID: 34556861 Structures of Signaling Complexes of Lipid Receptors S1PR1 and S1PR5 Reveal Mechanisms of Activation and Drug Recognition Cell Research. 12, 2021 | Pubmed ID: 34526663 Comparative Transcriptomic Analysis Reveals the Immunosuppressive Targets of Mesalazine in Dextran Sulfate Sodium-Induced Ulcerative Colitis Frontiers in Genetics. 2021 | Pubmed ID: 34456974 Dexamethasone Enhances the Lung Metastasis of Breast Cancer Via a PI3K-SGK1-CTGF Pathway Oncogene. 09, 2021 | Pubmed ID: 34272474 Human Placental Mesenchymal Stem Cells Ameliorate Liver Fibrosis in Mice by Upregulation of Caveolin1 in Hepatic Stellate Cells Stem Cell Research & Therapy. 05, 2021 | Pubmed ID: 34016164 Carbon Dioxide and Methane Emission of Denitrification Bioreactor Filling Waste Sawdust and Industrial Sludge for Treatment of Simulated Agricultural Surface Runoff Journal of Environmental Management. Jul, 2021 | Pubmed ID: 33823415 BATF2 Prevents Glioblastoma Multiforme Progression by Inhibiting Recruitment of Myeloid-derived Suppressor Cells Oncogene. 02, 2021 | Pubmed ID: 33452462 Corrigendum to "Anti-TNF-α Monoclonal Antibody Reverses Psoriasis Through Dual Inhibition of Inflammation and Angiogenesis" [Int. Immunopharmacol. 28(1) (2015) 731-743] International Immunopharmacology. Nov, 2020 | Pubmed ID: 33182062 Hypomethylation of GDNF Family Receptor Alpha 1 Promotes Epithelial-mesenchymal Transition and Predicts Metastasis of Colorectal Cancer PLoS Genetics. 11, 2020 | Pubmed ID: 33175846 Structure of the Human Gonadotropin-releasing Hormone Receptor GnRH1R Reveals an Unusual Ligand Binding Mode Nature Communications. 10, 2020 | Pubmed ID: 33082324 Nanomicelle Protects the Immune Activation Effects of Paclitaxel and Sensitizes Tumors to Anti-PD-1 Immunotherapy Theranostics. 2020 | Pubmed ID: 32724476 Whether the Carbon Emission from Green Roofs Can Be Effectively Mitigated by Recycling Waste Building Material As Green Roof Substrate During Five-year Operation? Environmental Science and Pollution Research International. Nov, 2020 | Pubmed ID: 32677017 TFAP2C Facilitates Somatic Cell Reprogramming by Inhibiting C-Myc-dependent Apoptosis and Promoting Mesenchymal-to-epithelial Transition Cell Death & Disease. 06, 2020 | Pubmed ID: 32587258 Erratum: Enrichment and Characterization of Cancer Stem-like Cells in Ultra-low Concentration of Serum and Non-adhesive Culture System American Journal of Translational Research. 2020 | Pubmed ID: 32509222 Correction To: Cellular Immunotherapy Using Irradiated Lung Cancer Cell Vaccine Co-expressing GM-CSF and IL-18 Can Induce Significant Antitumor Effects BMC Cancer. 01, 2020 | Pubmed ID: 31952506 A Novel Antitumor Strategy: Simultaneously Inhibiting Angiogenesis and Complement by Targeting VEGFA/PIGF and C3b/C4b Molecular Therapy Oncolytics. Mar, 2020 | Pubmed ID: 31909182 Temporal DNA Methylation Pattern and Targeted Therapy in Colitis-associated Cancer Carcinogenesis. 04, 2020 | Pubmed ID: 31802101 SARI Suppresses Colitis-associated Cancer Development by Maintaining MCP-1-mediated Tumour-associated Macrophage Recruitment Journal of Cellular and Molecular Medicine. 01, 2020 | Pubmed ID: 31578820 SARI Attenuates Colon Inflammation by Promoting STAT1 Degradation in Intestinal Epithelial Cells Mucosal Immunology. 09, 2019 | Pubmed ID: 31182817 Temporal Expression and Functional Analysis of Long Non-coding RNAs in Colorectal Cancer Initiation Journal of Cellular and Molecular Medicine. 06, 2019 | Pubmed ID: 30920116 Targeted Demethylation of the SARI Promotor Impairs Colon Tumour Growth Cancer Letters. 04, 2019 | Pubmed ID: 30771439 Modulating the Tumor Microenvironment Via Oncolytic Viruses and CSF-1R Inhibition Synergistically Enhances Anti-PD-1 Immunotherapy Molecular Therapy : the Journal of the American Society of Gene Therapy. 01, 2019 | Pubmed ID: 30527756 Conversion of Human Adipose-derived Stem Cells into Functional and Expandable Endothelial-like Cells for Cell-based Therapies Stem Cell Research & Therapy. 12, 2018 | Pubmed ID: 30558659 Follistatin-like Protein 5 Inhibits Hepatocellular Carcinoma Progression by Inducing Caspase-dependent Apoptosis and Regulating Bcl-2 Family Proteins Journal of Cellular and Molecular Medicine. 12, 2018 | Pubmed ID: 30255547 Enrichment and Characterization of Cancer Stem-like Cells in Ultra-low Concentration of Serum and Non-adhesive Culture System American Journal of Translational Research. 2018 | Pubmed ID: 29887968 DZNep Inhibits H3K27me3 Deposition and Delays Retinal Degeneration in the Rd1 Mice Cell Death & Disease. 02, 2018 | Pubmed ID: 29472543 Ezh2 Does Not Mediate Retinal Ganglion Cell Homeostasis or Their Susceptibility to Injury PloS One. 2018 | Pubmed ID: 29408885 IL-35 Recombinant Protein Reverses Inflammatory Bowel Disease and Psoriasis Through Regulation of Inflammatory Cytokines and Immune Cells Journal of Cellular and Molecular Medicine. 02, 2018 | Pubmed ID: 29193791 Hypoxia-Inducible Factor-1α Target Genes Contribute to Retinal Neuroprotection Frontiers in Cellular Neuroscience. 2017 | Pubmed ID: 28289375 DDA1, a Novel Oncogene, Promotes Lung Cancer Progression Through Regulation of Cell Cycle Journal of Cellular and Molecular Medicine. 08, 2017 | Pubmed ID: 28211159 Postnatal Onset of Retinal Degeneration by Loss of Embryonic Ezh2 Repression of Six1 Scientific Reports. Sep, 2016 | Pubmed ID: 27677711 IL-35 Decelerates the Inflammatory Process by Regulating Inflammatory Cytokine Secretion and M1/M2 Macrophage Ratio in Psoriasis Journal of Immunology (Baltimore, Md. : 1950). 09, 2016 | Pubmed ID: 27527600 SARI Inhibits Angiogenesis and Tumour Growth of Human Colon Cancer Through Directly Targeting Ceruloplasmin Nature Communications. 06, 2016 | Pubmed ID: 27353863 Rapid and High-efficiency Generation of Mature Functional Hepatocyte-like Cells from Adipose-derived Stem Cells by a Three-step Protocol Stem Cell Research & Therapy. Oct, 2015 | Pubmed ID: 26438426 Anti-TNF-α Monoclonal Antibody Reverses Psoriasis Through Dual Inhibition of Inflammation and Angiogenesis International Immunopharmacology. Sep, 2015 | Pubmed ID: 26263167 Itraconazole Suppresses the Growth of Glioblastoma Through Induction of Autophagy: Involvement of Abnormal Cholesterol Trafficking Autophagy. Jul, 2014 | Pubmed ID: 24905460 Cellular Immunotherapy Using Irradiated Lung Cancer Cell Vaccine Co-expressing GM-CSF and IL-18 Can Induce Significant Antitumor Effects BMC Cancer. Jan, 2014 | Pubmed ID: 24475975 GPR48, a Poor Prognostic Factor, Promotes Tumor Metastasis and Activates β-catenin/TCF Signaling in Colorectal Cancer Carcinogenesis. Jun, 2013 | Pubmed ID: 23803691 Antitumor Effects Obtained by Autologous Lewis Lung Cancer Cell Vaccine Engineered to Secrete Mouse Interleukin 27 by Means of Cationic Liposome Molecular Immunology. Oct, 2013 | Pubmed ID: 23522926 Chemokine CXCL14 is Associated with Prognosis in Patients with Colorectal Carcinoma After Curative Resection Journal of Translational Medicine. Jan, 2013 | Pubmed ID: 23294544 Enhancement of Cisplatin Sensitivity in Lung Cancer Xenografts by Liposome-mediated Delivery of the Plasmid Expressing Small Hairpin RNA Targeting Survivin Journal of Biomedical Nanotechnology. Aug, 2012 | Pubmed ID: 22852473 Therapeutic Upregulation of Class A Scavenger Receptor Member 5 Inhibits Tumor Growth and Metastasis Cancer Science. Sep, 2012 | Pubmed ID: 22642751 Vector-based MiR-15a/16-1 Plasmid Inhibits Colon Cancer Growth in Vivo Cell Biology International. Aug, 2012 | Pubmed ID: 22574716 Combination of Caspy2 and IP-10 Gene Therapy Significantly Improves Therapeutic Efficacy Against Murine Malignant Neoplasm Growth and Metastasis Human Gene Therapy. Aug, 2012 | Pubmed ID: 22548488 Suppression of Epidermal Growth Factor Receptor (EGFR) Expression by Small Hairpin RNA Inhibits the Growth of Human Nonsmall Cell Lung Cancers Bearing Wild-type and Mutant EGFR Cancer Investigation. Dec, 2011 | Pubmed ID: 22085274 A Homogenous CS/NaCMC/n-HA Polyelectrolyte Complex Membrane Prepared by Gradual Electrostatic Assembling Journal of Materials Science. Materials in Medicine. Feb, 2011 | Pubmed ID: 21140198 Ectopic Osteochondral Formation of Biomimetic Porous PVA-n-HA/PA6 Bilayered Scaffold and BMSCs Construct in Rabbit Journal of Biomedical Materials Research. Part B, Applied Biomaterials. Jan, 2011 | Pubmed ID: 20967773 Antibacterial Chitosan Coating on Nano-hydroxyapatite/polyamide66 Porous Bone Scaffold for Drug Delivery Journal of Biomaterials Science. Polymer Edition. 2011 | Pubmed ID: 20566065 Characterization and Cytocompatibility of Biphasic Calcium Phosphate/polyamide 6 Scaffolds for Bone Regeneration Journal of Biomedical Materials Research. Part B, Applied Biomaterials. Nov, 2010 | Pubmed ID: 20878919 Physical and Chemical Properties of Superparamagnetic Fe-incorporated Nano Hydroxyapatite Journal of Nanoscience and Nanotechnology. Dec, 2009 | Pubmed ID: 19908688 Porous Bioactive Scaffold of Aliphatic Polyurethane and Hydroxyapatite for Tissue Regeneration Biomedical Materials (Bristol, England). Apr, 2009 | Pubmed ID: 19208942 [Preparation and Biological Safety Evaluation of Porous N-HA/PA66 Composite] Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi. Oct, 2008 | Pubmed ID: 19024460 Biocompatibility and Osteogenesis of Biomimetic Nano-hydroxyapatite/polyamide Composite Scaffolds for Bone Tissue Engineering Biomaterials. Aug, 2007 | Pubmed ID: 17481726 A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors Lin Cheng*1, Lantian Su*1, Xiaowen Tian*1, Fan Xia2, Chang Zhao1, Wei Yan1, Zhenhua Shao1 1Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, 2Department of Neurosurgery, West China Hospital, Sichuan University JoVE 64054 Biochemistry
A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors Lin Cheng*1, Lantian Su*1, Xiaowen Tian*1, Fan Xia2, Chang Zhao1, Wei Yan1, Zhenhua Shao1 1Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, 2Department of Neurosurgery, West China Hospital, Sichuan University JoVE 64054 Biochemistry