Magdalena M. Szewczyk Structural Genomics Consortium University of Toronto Biography Publications Institution JoVE Articles Magdalena M. Szewczyk has not added a biography. If you are Magdalena M. Szewczyk and would like to personalize this page please email our Author Liaison for assistance. Publications Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid ChemMedChem. Jun, 2021 | Pubmed ID: 34164919 Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders Journal of Medicinal Chemistry. May, 2021 | Pubmed ID: 33980013 A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6 Journal of Medicinal Chemistry. 04, 2021 | Pubmed ID: 33591753 Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2 Journal of Medicinal Chemistry. 02, 2021 | Pubmed ID: 33522809 Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3) Journal of Medicinal Chemistry. Feb, 2018 | Pubmed ID: 29244490 Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6 Journal of Medicinal Chemistry. 10, 2016 | Pubmed ID: 27584694 A Potent, Selective and Cell-active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3) Angewandte Chemie (International Ed. in English). Apr, 2015 | Pubmed ID: 25728001 Author Correction: Pharmacological Inhibition of PRMT7 Links Arginine Monomethylation to the Cellular Stress Response Nature Communications. | Pubmed ID: 32457299 Pharmacological Inhibition of PRMT7 Links Arginine Monomethylation to the Cellular Stress Response Nature Communications. | Pubmed ID: 32409666 Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor Journal of Medicinal Chemistry. | Pubmed ID: 32367723 Discovery of a Chemical Probe for PRDM9 Nature Communications. | Pubmed ID: 31848333 Therapeutic Targeting of RNA Splicing Catalysis Through Inhibition of Protein Arginine Methylation Cancer Cell. | Pubmed ID: 31408619 Fragment-based Discovery of a Chemical Probe for the PWWP1 Domain of NSD3 Nature Chemical Biology. | Pubmed ID: 31285596 Characterization of Inv(3) Cell Line OCI-AML-20 with Stroma-dependent CD34 Expression Experimental Hematology. | Pubmed ID: 30352278 LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity ACS Medicinal Chemistry Letters. | Pubmed ID: 30034588 TP-064, a Potent and Selective Small Molecule Inhibitor of PRMT4 for Multiple Myeloma Oncotarget. | Pubmed ID: 29719619 Assay Interference and Off-target Liabilities of Reported Histone Acetyltransferase Inhibitors Nature Communications. | Pubmed ID: 29142305 The EED Protein-protein Interaction Inhibitor A-395 Inactivates the PRC2 Complex Nature Chemical Biology. | Pubmed ID: 28135237 Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening Journal of Medicinal Chemistry. | Pubmed ID: 27390919 Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor Journal of Medicinal Chemistry. | Pubmed ID: 26824386 Discovery of a Dual PRMT5-PRMT7 Inhibitor ACS Medicinal Chemistry Letters. | Pubmed ID: 25893041 Quantitative Methods to Study Protein Arginine Methyltransferase 1-9 Activity in Cells Magdalena M. Szewczyk1, Victoria Vu1, Dalia Barsyte-Lovejoy1,2 1Structural Genomics Consortium, University of Toronto, 2Department of Pharmacology and Toxicology, University of Toronto JoVE 62418 Biology
Quantitative Methods to Study Protein Arginine Methyltransferase 1-9 Activity in Cells Magdalena M. Szewczyk1, Victoria Vu1, Dalia Barsyte-Lovejoy1,2 1Structural Genomics Consortium, University of Toronto, 2Department of Pharmacology and Toxicology, University of Toronto JoVE 62418 Biology
