Malin Parmar Department of Experimental Medical Science, Wallenberg Neuroscience Center, Division of Neurobiology and Lund Stem Cell Center Lund University Biography Publications Institution JoVE Articles Malin Parmar has not added a biography. If you are Malin Parmar and would like to personalize this page please email our Author Liaison for assistance. Publications Towards Stem Cell Based Therapies for Parkinson's Disease Development (Cambridge, England). Jan, 2018 | Pubmed ID: 29311261 Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus Stem Cells International. 2017 | Pubmed ID: 29317869 Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming Cell Stem Cell. Dec, 2017 | Pubmed ID: 29174331 Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era Cell Stem Cell. Nov, 2017 | Pubmed ID: 29100010 Direct Neuronal Reprogramming for Disease Modeling Studies Using Patient-Derived Neurons: What Have We Learned? Frontiers in Neuroscience. 2017 | Pubmed ID: 29033781 IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells Stem Cell Reports. Oct, 2017 | Pubmed ID: 28943253 Human IPS Cell-derived Dopaminergic Neurons Function in a Primate Parkinson's Disease Model Nature. 08, 2017 | Pubmed ID: 28858313 Generation of High-purity Human Ventral Midbrain Dopaminergic Progenitors for in Vitro Maturation and Intracerebral Transplantation Nature Protocols. Sep, 2017 | Pubmed ID: 28858290 Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons Stem Cell Reports. Sep, 2017 | Pubmed ID: 28844658 Term Amniotic Fluid: an Unexploited Reserve of Mesenchymal Stromal Cells for Reprogramming and Potential Cell Therapy Applications Stem Cell Research & Therapy. Aug, 2017 | Pubmed ID: 28841906 REST Suppression Mediates Neural Conversion of Adult Human Fibroblasts Via MicroRNA-dependent and -independent Pathways EMBO Molecular Medicine. Aug, 2017 | Pubmed ID: 28646119 Strategies for Bringing Stem Cell-derived Dopamine Neurons to the Clinic: A European Approach (STEM-PD) Progress in Brain Research. 2017 | Pubmed ID: 28552228 Synaptic Inputs from Stroke-injured Brain to Grafted Human Stem Cell-derived Neurons Activated by Sensory Stimuli Brain : a Journal of Neurology. Mar, 2017 | Pubmed ID: 28115364 Single-Cell Analysis Reveals a Close Relationship Between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages Cell Stem Cell. Jan, 2017 | Pubmed ID: 28094018 Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of HESC-Based Therapy for Parkinson's Disease Cell Stem Cell. Jan, 2017 | Pubmed ID: 28094017 TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells Cell Reports. Jan, 2017 | Pubmed ID: 28052240 Small Molecules Increase Direct Neural Conversion of Human Fibroblasts Scientific Reports. Dec, 2016 | Pubmed ID: 27917895 Plug and Play Brain: Understanding Integration of Transplanted Neurons for Brain Repair Cell Stem Cell. 12, 2016 | Pubmed ID: 27912087 Comparability: Manufacturing, Characterization and Controls, Report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015 Regenerative Medicine. Jul, 2016 | Pubmed ID: 27404768 HESC-derived Neural Progenitors Prevent Xenograft Rejection Through Neonatal Desensitisation Experimental Neurology. Aug, 2016 | Pubmed ID: 27235932 DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor Neuron. Jun, 2016 | Pubmed ID: 27161524 Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016? Journal of Parkinson's Disease. 2016 | Pubmed ID: 27003785 In Vivo Reprogramming for Brain and Spinal Cord Repair ENeuro. Sep-Oct, 2015 | Pubmed ID: 26730402 Comprehensive Analysis of MicroRNA Expression in Regionalized Human Neural Progenitor Cells Reveals MicroRNA-10 As a Caudalizing Factor Development (Cambridge, England). Sep, 2015 | Pubmed ID: 26395143 Cell-based Therapies for Parkinson Disease—past Insights and Future Potential Nature Reviews. Neurology. Sep, 2015 | Pubmed ID: 26240036 In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons That Integrate into Local Host Circuitry Cell Reports. Jul, 2015 | Pubmed ID: 26166567 Monosynaptic Tracing Using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons Stem Cell Reports. Jun, 2015 | Pubmed ID: 26004633 Human ESC-derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson's Disease Cell Stem Cell. Nov, 2014 | Pubmed ID: 25517469 Direct Neural Conversion from Human Fibroblasts Using Self-regulating and Nonintegrating Viral Vectors Cell Reports. Dec, 2014 | Pubmed ID: 25482564 Highly Efficient Generation of Induced Neurons from Human Fibroblasts That Survive Transplantation into the Adult Rat Brain Scientific Reports. Sep, 2014 | Pubmed ID: 25208484 Isolation of Human Induced Pluripotent Stem Cell-derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation Stem Cell Reports. Mar, 2014 | Pubmed ID: 24672756 The Novel MAPT Mutation K298E: Mechanisms of Mutant Tau Toxicity, Brain Pathology and Tau Expression in Induced Fibroblast-derived Neurons Acta Neuropathologica. Feb, 2014 | Pubmed ID: 24292008 Human Foetal Brain Tissue As Quality Control when Developing Stem Cells Towards Cell Replacement Therapy for Neurological Diseases Neuroreport. Dec, 2013 | Pubmed ID: 24257249 Generation of Induced Neurons Via Direct Conversion in Vivo Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23530235 Efficient Expansion and Dopaminergic Differentiation of Human Fetal Ventral Midbrain Neural Stem Cells by Midbrain Morphogens Neurobiology of Disease. Jan, 2013 | Pubmed ID: 22940632 Generating Regionalized Neuronal Cells from Pluripotency, a Step-by-step Protocol Frontiers in Cellular Neuroscience. 2012 | Pubmed ID: 23316134 Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells Under Defined Conditions Cell Reports. Jun, 2012 | Pubmed ID: 22813745 Identification of Embryonic Stem Cell-derived Midbrain Dopaminergic Neurons for Engraftment The Journal of Clinical Investigation. Aug, 2012 | Pubmed ID: 22751106 Generation of Transplantable Striatal Projection Neurons from Human ESCs Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482498 Efficient Induction of Functional Neurons from Adult Human Fibroblasts Cell Cycle (Georgetown, Tex.). Oct, 2011 | Pubmed ID: 21934358 Turning Skin into Dopamine Neurons Cell Research. Oct, 2011 | Pubmed ID: 21826107 Direct Conversion of Human Fibroblasts to Dopaminergic Neurons Proceedings of the National Academy of Sciences of the United States of America. Jun, 2011 | Pubmed ID: 21646515 Neural Grafting in Parkinson's Disease Problems and Possibilities Progress in Brain Research. 2010 | Pubmed ID: 20887880 Tracking Differentiating Neural Progenitors in Pluripotent Cultures Using MicroRNA-regulated Lentiviral Vectors Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010 | Pubmed ID: 20534548 Organization of the Human Embryonic Ventral Mesencephalon Gene Expression Patterns : GEP. Dec, 2009 | Pubmed ID: 19825428 Dopamine Neuron Precursors Within the Developing Human Mesencephalon Show Radial Glial Characteristics Glia. Nov, 2009 | Pubmed ID: 19330857 Reprogramming of Neonatal SVZ Progenitors by Islet-1 and Neurogenin-2 Molecular and Cellular Neurosciences. Jul, 2008 | Pubmed ID: 18524626 Early Specification of Dopaminergic Phenotype During ES Cell Differentiation BMC Developmental Biology. Jul, 2007 | Pubmed ID: 17640353 Ngn2 and Nurr1 Act in Synergy to Induce Midbrain Dopaminergic Neurons from Expanded Neural Stem and Progenitor Cells Experimental Cell Research. Apr, 2007 | Pubmed ID: 17291494 In Vitro Characterization of a Human Neural Progenitor Cell Coexpressing SSEA4 and CD133 Journal of Neuroscience Research. Feb, 2007 | Pubmed ID: 17131412 Strengths and Limitations of the Neurosphere Culture System Molecular Neurobiology. Dec, 2006 | Pubmed ID: 17308349 Retrovirally Delivered Islet-1 Increases Recruitment of Ng2 Expressing Cells from the Postnatal SVZ into the Striatum Experimental Neurology. Oct, 2006 | Pubmed ID: 16806175 Neurogenin2 Identifies a Transplantable Dopamine Neuron Precursor in the Developing Ventral Mesencephalon Experimental Neurology. Mar, 2006 | Pubmed ID: 16438966 Striatal Neuron Differentiation from Neurosphere-expanded Progenitors Depends on Gsh2 Expression The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2004 | Pubmed ID: 15295031 Phenotypic and Molecular Identity of Cells in the Adult Subventricular Zone. in Vivo and After Expansion in Vitro Molecular and Cellular Neurosciences. Nov, 2003 | Pubmed ID: 14664822 A Transplantation Study of Expanded Human Embryonic Forebrain Precursors: Evidence for Selection of a Specific Progenitor Population Molecular and Cellular Neurosciences. Aug, 2003 | Pubmed ID: 12932435 Regional Specification of Neurosphere Cultures Derived from Subregions of the Embryonic Telencephalon Molecular and Cellular Neurosciences. Dec, 2002 | Pubmed ID: 12504597 Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts Shelby Shrigley1, Karolina Pircs1, Roger A. Barker1,2, Malin Parmar1, Janelle Drouin-Ouellet1 1Department of Experimental Medical Science, Wallenberg Neuroscience Center, Division of Neurobiology and Lund Stem Cell Center, Lund University, 2John van Geest Centre for Brain Repair & Department of Neurology, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge JoVE 56904 Neuroscience
Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts Shelby Shrigley1, Karolina Pircs1, Roger A. Barker1,2, Malin Parmar1, Janelle Drouin-Ouellet1 1Department of Experimental Medical Science, Wallenberg Neuroscience Center, Division of Neurobiology and Lund Stem Cell Center, Lund University, 2John van Geest Centre for Brain Repair & Department of Neurology, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge JoVE 56904 Neuroscience
