Morten A. Karsdal

Publications

• Biochemical Markers in Osteoarthritis with Lessons Learned from Osteoporosis
  Clinical and Experimental Rheumatology. Sep-Oct, 2019  |   Pubmed ID: 31621570
• Associations Between Biomarkers of Bone and Cartilage Turnover, Gender, Pain Categories and Radiographic Severity in Knee Osteoarthritis
  Arthritis Research & Therapy. Sep, 2019  |   Pubmed ID: 31481084
• Clinical Relevance of Collagen Protein Degradation Markers C3M and C4M in the Serum of Breast Cancer Patients Treated with Neoadjuvant Therapy in the GeparQuinto Trial
  Cancers. Aug, 2019  |   Pubmed ID: 31443252
• Improvement of Non-invasive Markers of NAFLD from an Individualised, Web-based Exercise Program
  Alimentary Pharmacology & Therapeutics. Oct, 2019  |   Pubmed ID: 31342533
• Mechanisms of Vascular Permeability and Remodeling Associated with Hemarthrosis in Factor VIII-deficient Mice
  Journal of Thrombosis and Haemostasis : JTH. Jul, 2019  |   Pubmed ID: 31301687
• Biomarkers of Collagen Synthesis Predict Progression in the PROFILE Idiopathic Pulmonary Fibrosis Cohort
  Respiratory Research. Jul, 2019  |   Pubmed ID: 31299951
• Circulating Levels of PRO-C3 Reflect Liver Fibrosis and Liver Function in HIV Positive Patients Receiving Modern CART
  PloS One. 2019  |   Pubmed ID: 31295293
• A Dual Amylin and Calcitonin Receptor Agonist Inhibits Pain Behavior and Reduces Cartilage Pathology in an Osteoarthritis Rat Model
  Osteoarthritis and Cartilage. Sep, 2019  |   Pubmed ID: 31176015
• Circulating Biomarkers of Testosterone's Anabolic Effects on Fat-Free Mass
  The Journal of Clinical Endocrinology and Metabolism. May, 2019  |   Pubmed ID: 31120518
• Serum Tau Fragments As Predictors of Death or Poor Neurological Outcome After Out-of-hospital Cardiac Arrest
  Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. Sep, 2019  |   Pubmed ID: 31017476
• The Message from the Matrix-should We Listen More Closely?
  Journal of Thoracic Disease. Mar, 2019  |   Pubmed ID: 30997184
• Tissue Metabolite of Type I Collagen, C1M, and CRP Predicts Structural Progression of Rheumatoid Arthritis
  BMC Rheumatology. 2019  |   Pubmed ID: 30886991
• Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography
  Hepatology (Baltimore, Md.). Jul, 2019  |   Pubmed ID: 30859582
• Matrix Metalloprotease Generated Fragments of Type VI Collagen Have Serum Biomarker Potential in Cancer - A Proof of Concept Study
  Translational Oncology. May, 2019  |   Pubmed ID: 30856553
• A Marker of Type VI Collagen Formation (PRO-C6) is Associated with Higher Arterial Stiffness in Type 1 Diabetes
  Acta Diabetologica. 06, 2019  |   Pubmed ID: 30852680
• Biochemical and Histological Characterisation of an Experimental Rodent Model of Non-alcoholic Steatohepatitis - Effects of a Peroxisome Proliferator-activated Receptor Gamma (PPAR-γ) Agonist and a Glucagon-like Peptide-1 Analogue
  Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Mar, 2019  |   Pubmed ID: 30841472
• GPDPLQ-A Type II Collagen Neo-Epitope Biomarker of Osteoclast- and Inflammation-Derived Cartilage Degradation in Vitro
  Scientific Reports. Feb, 2019  |   Pubmed ID: 30816326
• Combining Naproxen and a Dual Amylin and Calcitonin Receptor Agonist Improves Pain and Structural Outcomes in the Collagen-induced Arthritis Rat Model
  Arthritis Research & Therapy. Feb, 2019  |   Pubmed ID: 30795801
• Enhanced Processing of Von Willebrand Factor Reflects Disease Severity and Discriminates Severe Portal Hypertension in Cirrhosis
  European Journal of Gastroenterology & Hepatology. Aug, 2019  |   Pubmed ID: 30768435
• Serological Biomarker Profiles of Rapidly Progressive Osteoarthritis in Tanezumab-treated Patients
  Osteoarthritis and Cartilage. Mar, 2019  |   Pubmed ID: 30576794
• Citrullinated Vimentin and Biglycan Protein Fingerprints As Candidate Serological Biomarkers for Disease Activity in Systemic Sclerosis: a Pilot Study
  Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. May, 2019  |   Pubmed ID: 30457356
• Effect of NGM282, an FGF19 Analogue, in Primary Sclerosing Cholangitis: A Multicenter, Randomized, Double-blind, Placebo-controlled Phase II Trial
  Journal of Hepatology. Mar, 2019  |   Pubmed ID: 30414864
• Assessment of Liver Fibrosis Progression and Regression by a Serological Collagen Turnover Profile
  American Journal of Physiology. Gastrointestinal and Liver Physiology. Jan, 2019  |   Pubmed ID: 30160980
• Tofacitinib and TPCA-1 Exert Chondroprotective Effects on Extracellular Matrix Turnover in Bovine Articular Cartilage Ex Vivo
  Biochemical Pharmacology. Jul, 2019  |   Pubmed ID: 30059674
• ADAPT: An Algorithm Incorporating PRO-C3 Accurately Identifies Patients With NAFLD and Advanced Fibrosis
  Hepatology (Baltimore, Md.). Mar, 2019  |   Pubmed ID: 30014517
• Protein Biomarkers Associated with Pain Mechanisms in Osteoarthritis
  Journal of Proteomics. 01, 2019  |   Pubmed ID: 29704569
• A Novel High Sensitivity Type II Collagen Blood-Based Biomarker, PRO-C2, for Assessment of Cartilage Formation
  International Journal of Molecular Sciences. Nov, 2018  |   Pubmed ID: 30404167
• Serum Type XVI Collagen is Associated with Colorectal Cancer and Ulcerative Colitis Indicating a Pathological Role in Gastrointestinal Disorders
  Cancer Medicine. 09, 2018  |   Pubmed ID: 30030909
• High Turnover of Extracellular Matrix Reflected by Specific Protein Fragments Measured in Serum is Associated with Poor Outcomes in Two Metastatic Breast Cancer Cohorts
  International Journal of Cancer. 12, 2018  |   Pubmed ID: 29923614
• A Serological Biomarker of Versican Degradation is Associated with Mortality Following Acute Exacerbations of Idiopathic Interstitial Pneumonia
  Respiratory Research. 05, 2018  |   Pubmed ID: 29728109
• Translational Biomarkers and Ex Vivo Models of Joint Tissues As a Tool for Drug Development in Rheumatoid Arthritis
  Arthritis & Rheumatology (Hoboken, N.J.). 09, 2018  |   Pubmed ID: 29669391
• Higher Collagen VI Formation Is Associated With All-Cause Mortality in Patients With Type 2 Diabetes and Microalbuminuria
  Diabetes Care. 07, 2018  |   Pubmed ID: 29643059
• Osteoclasts Degrade Bone and Cartilage Knee Joint Compartments Through Different Resorption Processes
  Arthritis Research & Therapy. 04, 2018  |   Pubmed ID: 29636095
• Assessment of Extracellular Matrix-related Biomarkers in Patients with Lower Extremity Artery Disease
  Journal of Vascular Surgery. 10, 2018  |   Pubmed ID: 29615349
• Age-related Collagen Turnover of the Interstitial Matrix and Basement Membrane: Implications of Age- and Sex-dependent Remodeling of the Extracellular Matrix
  PloS One. 2018  |   Pubmed ID: 29596429
• Development of a Neo-Epitope Specific Assay for Serological Assessment of Type VII Collagen Turnover and Its Relevance in Fibroproliferative Disorders
  Assay and Drug Development Technologies. Feb/Mar, 2018  |   Pubmed ID: 29493258
• IL-6 Receptor Inhibition Modulates Type III Collagen and C-reactive Protein Degradation in Rheumatoid Arthritis Patients with an Inadequate Response to Anti-tumour Necrosis Factor Therapy: Analysis of Connective Tissue Turnover in the Tocilizumab RADIATE Study
  Clinical and Experimental Rheumatology. Jul-Aug, 2018  |   Pubmed ID: 29465346
• Acute Decompensation Boosts Hepatic Collagen Type III Deposition and Deteriorates Experimental and Human Cirrhosis
  Hepatology Communications. 02, 2018  |   Pubmed ID: 29404528
• Identification of Pain Categories Associated with Change in Pain in Patients Receiving Placebo: Data from Two Phase 3 Randomized Clinical Trials in Symptomatic Knee Osteoarthritis
  BMC Musculoskeletal Disorders. 01, 2018  |   Pubmed ID: 29343266
• Blockade of GM-CSF Pathway Induced Sustained Suppression of Myeloid and T Cell Activities in Rheumatoid Arthritis
  Rheumatology (Oxford, England). 01, 2018  |   Pubmed ID: 29069507
• Quantification of Altered Tissue Turnover in a Liquid Biopsy: a Proposed Precision Medicine Tool to Assess Chronic Inflammation and Desmoplasia Associated with a Pro-cancerous Niche and Response to Immuno-therapeutic Anti-tumor Modalities
  Cancer Immunology, Immunotherapy : CII. 01, 2018  |   Pubmed ID: 29022089
• Sprifermin (rhFGF18) Modulates Extracellular Matrix Turnover in Cartilage Explants Ex Vivo
  Journal of Translational Medicine. Dec, 2017  |   Pubmed ID: 29233174
• Erratum: Preventive Effects of Kudzu Root on Bone Loss and Cartilage Degradation in Ovariectomized Rats
  American Journal of Translational Research. 2017  |   Pubmed ID: 29218115
• Biomarkers of Collagen Turnover Are Related to Annual Change in FEV in Patients with Chronic Obstructive Pulmonary Disease Within the ECLIPSE Study
  BMC Pulmonary Medicine. Dec, 2017  |   Pubmed ID: 29202744
• Safety, Tolerability, and Pharmacodynamics of an Anti-interleukin-1α/β Dual Variable Domain Immunoglobulin in Patients with Osteoarthritis of the Knee: a Randomized Phase 1 Study
  Osteoarthritis and Cartilage. 12, 2017  |   Pubmed ID: 28964890
• Sprifermin (rhFGF18) Enables Proliferation of Chondrocytes Producing a Hyaline Cartilage Matrix
  Osteoarthritis and Cartilage. 11, 2017  |   Pubmed ID: 28823647
• Preventive Effects of Kudzu Root on Bone Loss and Cartilage Degradation in Ovariectomized Rats [corrected]
  American Journal of Translational Research. 2017  |   Pubmed ID: 28804568
• High Resolution Molecular and Histological Analysis of Renal Disease Progression in ZSF1 Fa/faCP Rats, a Model of Type 2 Diabetic Nephropathy
  PloS One. 2017  |   Pubmed ID: 28746409
• The Good and the Bad Collagens of Fibrosis - Their Role in Signaling and Organ Function
  Advanced Drug Delivery Reviews. 11, 2017  |   Pubmed ID: 28736303
• Unique Insight into Microenvironmental Changes in Colorectal Cancer: Assessment of Matrix Metalloprotease-mediated Molecular Changes in Human Colorectal Tumor Tissue and Corresponding Non-neoplastic Adjacent Tissue
  Oncology Letters. May, 2017  |   Pubmed ID: 28529592
• Modifiable Risk Factors Promoting Neurodegeneration is Associated with Two Novel Brain Degradation Markers Measured in Serum
  Neurochemistry International. Sep, 2017  |   Pubmed ID: 28499950
• The Dual Amylin- and Calcitonin-Receptor Agonist KBP-042 Works As Adjunct to Metformin on Fasting Hyperglycemia and HbA1c in a Rat Model of Type 2 Diabetes
  The Journal of Pharmacology and Experimental Therapeutics. 07, 2017  |   Pubmed ID: 28438778
• Serum Endotrophin, a Type VI Collagen Cleavage Product, is Associated with Increased Mortality in Chronic Kidney Disease
  PloS One. 2017  |   Pubmed ID: 28403201
• Metabolic Syndrome, Insulin Resistance, and Cognitive Dysfunction: Does Your Metabolic Profile Affect Your Brain?
  Diabetes. Jul, 2017  |   Pubmed ID: 28389469
• Biomarker of Extracellular Matrix Remodelling C1M and Proinflammatory Cytokine Interleukin 6 Are Related to Synovitis and Pain in End-stage Knee Osteoarthritis Patients
  Pain. 07, 2017  |   Pubmed ID: 28333699
• Nidogen-1 Degraded by Cathepsin S Can Be Quantified in Serum and is Associated with Non-Small Cell Lung Cancer
  Neoplasia (New York, N.Y.). 04, 2017  |   Pubmed ID: 28282545
• Weight Change and Risk of Hyperglycaemia in Elderly Women
  Aging Clinical and Experimental Research. Mar, 2017  |   Pubmed ID: 28265973
• Serum Endotrophin Identifies Optimal Responders to PPARγ Agonists in Type 2 Diabetes
  Diabetologia. Jan, 2017  |   Pubmed ID: 27631136
• Systemic Biomarkers of Collagen and Elastin Turnover Are Associated With Clinically Relevant Outcomes in COPD
  Chest. Jan, 2017  |   Pubmed ID: 27575358
• Fibrogenesis Assessed by Serological Type III Collagen Formation Identifies Patients with Progressive Liver Fibrosis and Responders to a Potential Antifibrotic Therapy
  American Journal of Physiology. Gastrointestinal and Liver Physiology. 12, 2016  |   Pubmed ID: 27765759
• High Levels of Biomarkers of Collagen Remodeling Are Associated with Increased Mortality in COPD - Results from the ECLIPSE Study
  Respiratory Research. 10, 2016  |   Pubmed ID: 27716343
• Characterization of Serological Neo-epitope Biomarkers Reflecting Collagen Remodeling in Clinically Stable Chronic Obstructive Pulmonary Disease
  Clinical Biochemistry. Oct, 2016  |   Pubmed ID: 27614218
• Metabolic Syndrome and Subsequent Risk of Type 2 Diabetes and Cardiovascular Disease in Elderly Women: Challenging the Current Definition
  Medicine. Sep, 2016  |   Pubmed ID: 27603394
• A Randomized, Double-blind, Multicenter, Placebo-controlled Study to Evaluate the Efficacy and Safety of Oral Salmon Calcitonin in the Treatment of Osteoporosis in Postmenopausal Women Taking Calcium and Vitamin D
  Bone. 10, 2016  |   Pubmed ID: 27462009
• Precision-Cut Kidney Slices As a Tool to Understand the Dynamics of Extracellular Matrix Remodeling in Renal Fibrosis
  Biomarker Insights. 2016  |   Pubmed ID: 27257368
• Intercritical Circulating Levels of Neo-epitopes Reflecting Matrixmetalloprotease-driven Degradation As Markers of Gout and Frequent Gout Attacks
  Rheumatology (Oxford, England). 09, 2016  |   Pubmed ID: 27256715
• Abdominal Wall Hernias-A Local Manifestation of Systemically Impaired Quality of the Extracellular Matrix
  Surgery. 07, 2016  |   Pubmed ID: 27085685
• Association Between Biomarkers of Tissue Inflammation and Progression of Osteoarthritis: Evidence from the Rotterdam Study Cohort
  Arthritis Research & Therapy. Apr, 2016  |   Pubmed ID: 27039382
• Early Changes in Blood-based Joint Tissue Destruction Biomarkers Are Predictive of Response to Tocilizumab in the LITHE Study
  Arthritis Research & Therapy. Jan, 2016  |   Pubmed ID: 26787505
• Turnover of Type III Collagen Reflects Disease Severity and is Associated with Progression and Microinflammation in Patients with IgA Nephropathy
  Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Mar, 2016  |   Pubmed ID: 26311218
• Collagen and Tissue Turnover As a Function of Age: Implications for Fibrosis
  Journal of Hepatology. Jan, 2016  |   Pubmed ID: 26307398
• Serum Cartilage Oligomeric Matrix Protein and Development of Radiographic and Painful Knee Osteoarthritis. A Community-based Cohort of Middle-aged Women
  Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. 2015  |   Pubmed ID: 26848781
• Collagen Type III and VI Turnover in Response to Long-Term Immobilization
  PloS One. 2015  |   Pubmed ID: 26641456
• Markers of Collagen Remodeling Detect Clinically Significant Fibrosis in Chronic Hepatitis C Patients
  PloS One. 2015  |   Pubmed ID: 26406331
• Accelerated Extracellular Matrix Turnover During Exacerbations of COPD
  Respiratory Research. Jun, 2015  |   Pubmed ID: 26062683
• KBP-042 Improves Bodyweight and Glucose Homeostasis with Indices of Increased Insulin Sensitivity Irrespective of Route of Administration
  European Journal of Pharmacology. Sep, 2015  |   Pubmed ID: 26027795
• Suppression of T Cell Activation and Collagen Accumulation by an Anti-IFNAR1 MAb, Anifrolumab, in Adult Patients with Systemic Sclerosis
  The Journal of Investigative Dermatology. Oct, 2015  |   Pubmed ID: 25993119
• Serological Assessment of Neutrophil Elastase Activity on Elastin During Lung ECM Remodeling
  BMC Pulmonary Medicine. May, 2015  |   Pubmed ID: 25935650
• Call for Standardized Definitions of Osteoarthritis and Risk Stratification for Clinical Trials and Clinical Use
  Osteoarthritis and Cartilage. Aug, 2015  |   Pubmed ID: 25865392
• Clinical Drug Development Using Dynamic Biomarkers to Enable Personalized Health Care in COPD
  Chest. Jul, 2015  |   Pubmed ID: 25856563
• Serum and Urine Markers of Collagen Degradation Reflect Renal Fibrosis in Experimental Kidney Diseases
  Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Jul, 2015  |   Pubmed ID: 25784725
• Longitudinal Change in Collagen Degradation Biomarkers in Idiopathic Pulmonary Fibrosis: an Analysis from the Prospective, Multicentre PROFILE Study
  The Lancet. Respiratory Medicine. Jun, 2015  |   Pubmed ID: 25770676
• Novel Insights into the Function and Dynamics of Extracellular Matrix in Liver Fibrosis
  American Journal of Physiology. Gastrointestinal and Liver Physiology. May, 2015  |   Pubmed ID: 25767261
• Pro-C5, a Marker of True Type V Collagen Formation and Fibrillation, Correlates with Portal Hypertension in Patients with Alcoholic Cirrhosis
  Scandinavian Journal of Gastroenterology. May, 2015  |   Pubmed ID: 25639675
• The Collagen Turnover Profile is Altered in Patients with Inguinal and Incisional Hernia
  Surgery. Feb, 2015  |   Pubmed ID: 25616945
• Biological Relevance of Citrullinations: Diagnostic, Prognostic and Therapeutic Options
  Autoimmunity. Mar, 2015  |   Pubmed ID: 25520183
• Plasma Pro-C3 (N-terminal Type III Collagen Propeptide) Predicts Fibrosis Progression in Patients with Chronic Hepatitis C
  Liver International : Official Journal of the International Association for the Study of the Liver. Feb, 2015  |   Pubmed ID: 25308921
• Association of Versican Turnover with All-cause Mortality in Patients on Haemodialysis
  PloS One. 2014  |   Pubmed ID: 25354390
• PRO-C3-levels in Patients with HIV/HCV-Co-infection Reflect Fibrosis Stage and Degree of Portal Hypertension
  PloS One. 2014  |   Pubmed ID: 25265505
• Serological Biomarkers of Joint Tissue Turnover Predict Tocilizumab Response at Baseline
  Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases. Sep, 2014  |   Pubmed ID: 25160020
• Biomarkers of Cartilage and Surrounding Joint Tissue
  Biomarkers in Medicine. 2014  |   Pubmed ID: 25123039
• Serum Biomarkers Reflecting Specific Tumor Tissue Remodeling Processes Are Valuable Diagnostic Tools for Lung Cancer
  Cancer Medicine. Oct, 2014  |   Pubmed ID: 25044252
• Alpha C-telopeptide of Type I Collagen is Associated with Subchondral Bone Turnover and Predicts Progression of Joint Space Narrowing and Osteophytes in Osteoarthritis
  Arthritis & Rheumatology (Hoboken, N.J.). Sep, 2014  |   Pubmed ID: 24909851
• Oral Salmon Calcitonin Enhances Insulin Action and Glucose Metabolism in Diet-induced Obese Streptozotocin-diabetic Rats
  European Journal of Pharmacology. Aug, 2014  |   Pubmed ID: 24858364
• A Comparison of Osteoclast-rich and Osteoclast-poor Osteopetrosis in Adult Mice Sheds Light on the Role of the Osteoclast in Coupling Bone Resorption and Bone Formation
  Calcified Tissue International. Jul, 2014  |   Pubmed ID: 24838599
• A Novel Oral Dual Amylin and Calcitonin Receptor Agonist (KBP-042) Exerts Antiobesity and Antidiabetic Effects in Rats
  American Journal of Physiology. Endocrinology and Metabolism. Jul, 2014  |   Pubmed ID: 24801386
• Mammographic Texture Resemblance Generalizes As an Independent Risk Factor for Breast Cancer
  Breast Cancer Research : BCR. Apr, 2014  |   Pubmed ID: 24713478
• The Active Form of MMP-3 is a Marker of Synovial Inflammation and Cartilage Turnover in Inflammatory Joint Diseases
  BMC Musculoskeletal Disorders. Mar, 2014  |   Pubmed ID: 24641725
• Decline in Calcitonin Receptor Expression in Osteocytes with Age
  The Journal of Endocrinology. May, 2014  |   Pubmed ID: 24516262
• Rheumatoid Arthritis: a Case for Personalized Health Care?
  Arthritis Care & Research. Sep, 2014  |   Pubmed ID: 24470057
• Effect of Tocilizumab Combined with Methotrexate on Circulating Biomarkers of Synovium, Cartilage, and Bone in the LITHE Study
  Seminars in Arthritis and Rheumatism. Feb, 2014  |   Pubmed ID: 23932312
• The Future of Blood-based Biomarkers for Alzheimer's Disease
  Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Jan, 2014  |   Pubmed ID: 23850333
• Osteoclast-derived Coupling Factors in Bone Remodeling
  Calcified Tissue International. Jan, 2014  |   Pubmed ID: 23700149
• Extracellular Matrix Specific Protein Fingerprints Measured in Serum Can Separate Pancreatic Cancer Patients from Healthy Controls
  BMC Cancer. Nov, 2013  |   Pubmed ID: 24261855
• Osteoclasts Are Not Crucial for Hematopoietic Stem Cell Maintenance in Adult Mice
  Haematologica. Dec, 2013  |   Pubmed ID: 24097632
• Association of Systemic Collagen Type IV Formation with Survival Among Patients Undergoing Hemodialysis
  PloS One. 2013  |   Pubmed ID: 23990924
• Serological Identification of Fast Progressors of Structural Damage with Rheumatoid Arthritis
  Arthritis Research & Therapy. Aug, 2013  |   Pubmed ID: 23945134
• Type VI Collagen Turnover-related Peptides-novel Serological Biomarkers of Muscle Mass and Anabolic Response to Loading in Young Men
  Journal of Cachexia, Sarcopenia and Muscle. Dec, 2013  |   Pubmed ID: 23943593
• Musculoskeletal Ageing and Primary Prevention
  Best Practice & Research. Clinical Obstetrics & Gynaecology. Oct, 2013  |   Pubmed ID: 23891483
• Acute Myocardial Infarction and Pulmonary Diseases Result in Two Different Degradation Profiles of Elastin As Quantified by Two Novel ELISAs
  PloS One. 2013  |   Pubmed ID: 23805173
• Oral Salmon Calcitonin Protects Against Impaired Fasting Glycemia, Glucose Intolerance, and Obesity Induced by High-fat Diet and Ovariectomy in Rats
  Menopause (New York, N.Y.). Jul, 2013  |   Pubmed ID: 23793169
• Quantification of "end Products" of Tissue Destruction in Inflammation May Reflect Convergence of Cytokine and Signaling Pathways -- Implications for Modern Clinical Chemistry
  Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. Aug, 2013  |   Pubmed ID: 23721060
• An Enzyme-generated Fragment of Tau Measured in Serum Shows an Inverse Correlation to Cognitive Function
  PloS One. 2013  |   Pubmed ID: 23717682
• The Neo-epitope Specific PRO-C3 ELISA Measures True Formation of Type III Collagen Associated with Liver and Muscle Parameters
  American Journal of Translational Research. 2013  |   Pubmed ID: 23634241
• Role of Hormones in Cartilage and Joint Metabolism: Understanding an Unhealthy Metabolic Phenotype in Osteoarthritis
  Menopause (New York, N.Y.). May, 2013  |   Pubmed ID: 23615651
• A MMP Derived Versican Neo-epitope is Elevated in Plasma from Patients with Atherosclerotic Heart Disease
  International Journal of Clinical and Experimental Medicine. 2013  |   Pubmed ID: 23573348
• Atherofibrosis - a Unique and Common Process of the Disease Pathogenesis of Atherosclerosis and Fibrosis - Lessons for Biomarker Development
  American Journal of Translational Research. 2013  |   Pubmed ID: 23390561
• Circulating Protein Fragments of Cartilage and Connective Tissue Degradation Are Diagnostic and Prognostic Markers of Rheumatoid Arthritis and Ankylosing Spondylitis
  PloS One. 2013  |   Pubmed ID: 23365672
• Circulating Citrullinated Vimentin Fragments Reflect Disease Burden in Ankylosing Spondylitis and Have Prognostic Capacity for Radiographic Progression
  Arthritis and Rheumatism. Apr, 2013  |   Pubmed ID: 23280360
• Protein Fingerprinting of the Extracellular Matrix Remodelling in a Rat Model of Liver Fibrosis--a Serological Evaluation
  Liver International : Official Journal of the International Association for the Study of the Liver. Mar, 2013  |   Pubmed ID: 23279004
• Bringing Cancer Serological Diagnosis to a New Level: Focusing on HER2, Protein Ectodomain Shedding and Neoepitope Technology
  Future Oncology (London, England). Jan, 2013  |   Pubmed ID: 23252562
• Extracellular Matrix Remodeling: the Common Denominator in Connective Tissue Diseases. Possibilities for Evaluation and Current Understanding of the Matrix As More Than a Passive Architecture, but a Key Player in Tissue Failure
  Assay and Drug Development Technologies. Mar, 2013  |   Pubmed ID: 23046407
• Serological Muscle Loss Biomarkers: an Overview of Current Concepts and Future Possibilities
  Journal of Cachexia, Sarcopenia and Muscle. Mar, 2013  |   Pubmed ID: 22996343
• Future Detection and Monitoring of Diabetes May Entail Analysis of Both β-cell Function and Volume: How Markers of β-cell Loss May Assist
  Journal of Translational Medicine. Oct, 2012  |   Pubmed ID: 23110768
• Serological Investigation of the Collagen Degradation Profile of Patients with Chronic Obstructive Pulmonary Disease or Idiopathic Pulmonary Fibrosis
  Biomarker Insights. 2012  |   Pubmed ID: 23012495
• Molecular Serum Markers of Liver Fibrosis
  Biomarker Insights. 2012  |   Pubmed ID: 22872786
• Measurement of MMP-9 and -12 Degraded Elastin (ELM) Provides Unique Information on Lung Tissue Degradation
  BMC Pulmonary Medicine. Jul, 2012  |   Pubmed ID: 22818364
• Clinical Evaluation of a Matrix Metalloproteinase-12 Cleaved Fragment of Titin As a Cardiovascular Serological Biomarker
  Journal of Translational Medicine. Jul, 2012  |   Pubmed ID: 22768802
• A Specific Subtype of Osteoclasts Secretes Factors Inducing Nodule Formation by Osteoblasts
  Bone. Sep, 2012  |   Pubmed ID: 22722081
• Distribution, Size, and Shape of Abdominal Aortic Calcified Deposits and Their Relationship to Mortality in Postmenopausal Women
  International Journal of Biomedical Imaging. 2012  |   Pubmed ID: 22719751
• Novel Cardiac-specific Biomarkers and the Cardiovascular Continuum
  Biomarker Insights. 2012  |   Pubmed ID: 22577298
• IL-6 Receptor Inhibition Positively Modulates Bone Balance in Rheumatoid Arthritis Patients with an Inadequate Response to Anti-tumor Necrosis Factor Therapy: Biochemical Marker Analysis of Bone Metabolism in the Tocilizumab RADIATE Study (NCT00106522)
  Seminars in Arthritis and Rheumatism. Oct, 2012  |   Pubmed ID: 22397953
• Enzyme-linked Immunosorbent Serum Assay Specific for the 7S Domain of Collagen Type IV (P4NP 7S): A Marker Related to the Extracellular Matrix Remodeling During Liver Fibrogenesis
  Hepatology Research : the Official Journal of the Japan Society of Hepatology. May, 2012  |   Pubmed ID: 22221767
• Generation of Human Osteoclasts from Peripheral Blood
  Methods in Molecular Biology (Clifton, N.J.). 2012  |   Pubmed ID: 22130928
• Ankylosing Spondylitis is Characterized by an Increased Turnover of Several Different Metalloproteinase-derived Collagen Species: a Cross-sectional Study
  Rheumatology International. Nov, 2012  |   Pubmed ID: 22086471
• Tumor Necrosis Factor-α and Receptor Activator of Nuclear Factor-κB Ligand Augment Human Macrophage Foam-cell Destruction of Extracellular Matrix Through Protease-mediated Processes
  Assay and Drug Development Technologies. Feb, 2012  |   Pubmed ID: 22053710
• A Comparison of Strontium Ranelate and PTH(1-84)
  Expert Review of Endocrinology & Metabolism. Mar, 2011  |   Pubmed ID: 30290441
• Diagnosis of Osteoarthritis by Cartilage Surface Smoothness Quantified Automatically from Knee MRI
  Cartilage. Jan, 2011  |   Pubmed ID: 26069569
• Molecular Serum and Urine Marker Repertoire Supporting Clinical Research on Joint Diseases
  Best Practice & Research. Clinical Rheumatology. Dec, 2011  |   Pubmed ID: 22265266
• Abdominal Aortic Calcification Quantified by the Morphological Atherosclerotic Calcification Distribution (MACD) Index is Associated with Features of the Metabolic Syndrome
  BMC Cardiovascular Disorders. Dec, 2011  |   Pubmed ID: 22185588
• Dissociation of Bone Resorption and Bone Formation in Adult Mice with a Non-functional V-ATPase in Osteoclasts Leads to Increased Bone Strength
  PloS One. 2011  |   Pubmed ID: 22087326
• Identification of the Calcitonin Receptor in Osteoarthritic Chondrocytes
  BMC Research Notes. Oct, 2011  |   Pubmed ID: 21996094
• Assessment of Proteolytic Degradation of the Basement Membrane: a Fragment of Type IV Collagen As a Biochemical Marker for Liver Fibrosis
  Fibrogenesis & Tissue Repair. Oct, 2011  |   Pubmed ID: 21970406
• Glucocorticoids Exert Context-dependent Effects on Cells of the Joint in Vitro
  Steroids. Dec, 2011  |   Pubmed ID: 21855558
• Circulating CO3-610, a Degradation Product of Collagen III, Closely Reflects Liver Collagen and Portal Pressure in Rats with Fibrosis
  Fibrogenesis & Tissue Repair. Aug, 2011  |   Pubmed ID: 21813019
• Immunological Detection of the Type V Collagen Propeptide Fragment, PVCP-1230, in Connective Tissue Remodeling Associated with Liver Fibrosis
  Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. Aug, 2011  |   Pubmed ID: 21612338
• Development and Validation of an Enzyme-linked Immunosorbent Assay for the Quantification of a Specific MMP-9 Mediated Degradation Fragment of Type III Collagen--A Novel Biomarker of Atherosclerotic Plaque Remodeling
  Clinical Biochemistry. Jul, 2011  |   Pubmed ID: 21549691
• Biochemical Markers of Ongoing Joint Damage in Rheumatoid Arthritis--current and Future Applications, Limitations and Opportunities
  Arthritis Research & Therapy. Apr, 2011  |   Pubmed ID: 21539724
• Measurement of CO3-610, a Potential Liver Biomarker Derived from Matrix Metalloproteinase-9 Degradation of Collagen Type Iii, in a Rat Model of Reversible Carbon-tetrachloride-induced Fibrosis
  Biomarker Insights. Mar, 2011  |   Pubmed ID: 21499440
• Measurement of Matrix Metalloproteinase 9-mediated Collagen Type III Degradation Fragment As a Marker of Skin Fibrosis
  BMC Dermatology. Mar, 2011  |   Pubmed ID: 21447148
• A Microarray Analysis of Full Depth Knee Cartilage of Ovariectomized Rats
  BMC Research Notes. Mar, 2011  |   Pubmed ID: 21406075
• Efficacy and Safety of the PPARγ Partial Agonist Balaglitazone Compared with Pioglitazone and Placebo: a Phase III, Randomized, Parallel-group Study in Patients with Type 2 Diabetes on Stable Insulin Therapy
  Diabetes/metabolism Research and Reviews. May, 2011  |   Pubmed ID: 21328517
• Enzyme-linked Immunosorbent Assay (ELISAs) for Metalloproteinase Derived Type II Collagen Neoepitope, CIIM--increased Serum CIIM in Subjects with Severe Radiographic Osteoarthritis
  Clinical Biochemistry. Apr, 2011  |   Pubmed ID: 21223960
• Distribution, Size, Shape, Growth Potential and Extent of Abdominal Aortic Calcified Deposits Predict Mortality in Postmenopausal Women
  BMC Cardiovascular Disorders. Nov, 2010  |   Pubmed ID: 21067610
• Screening of Protein Kinase Inhibitors Identifies PKC Inhibitors As Inhibitors of Osteoclastic Acid Secretion and Bone Resorption
  BMC Musculoskeletal Disorders. Oct, 2010  |   Pubmed ID: 20977756
• Matrix Metalloproteinase-9-mediated Type III Collagen Degradation As a Novel Serological Biochemical Marker for Liver Fibrogenesis
  Liver International : Official Journal of the International Association for the Study of the Liver. Oct, 2010  |   Pubmed ID: 20666994
• Macrophage-mediated Proteolytic Remodeling of the Extracellular Matrix in Atherosclerosis Results in Neoepitopes: a Potential New Class of Biochemical Markers
  Assay and Drug Development Technologies. Oct, 2010  |   Pubmed ID: 20662734
• Alterations in Osteoclast Function and Phenotype Induced by Different Inhibitors of Bone Resorption--implications for Osteoclast Quality
  BMC Musculoskeletal Disorders. Jun, 2010  |   Pubmed ID: 20515459
• Human Macrophage Foam Cells Degrade Atherosclerotic Plaques Through Cathepsin K Mediated Processes
  BMC Cardiovascular Disorders. Apr, 2010  |   Pubmed ID: 20409295
• Investigation of the Direct Effects of Salmon Calcitonin on Human Osteoarthritic Chondrocytes
  BMC Musculoskeletal Disorders. Apr, 2010  |   Pubmed ID: 20367884
• Application of Biochemical Markers in Development of Drugs for Treatment of Osteoarthritis
  Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. Feb, 2010  |   Pubmed ID: 20085489
• Which Elements Are Involved in Reversible and Irreversible Cartilage Degradation in Osteoarthritis?
  Rheumatology International. Feb, 2010  |   Pubmed ID: 19816688
• Investigations of Inter- and Intraindividual Relationships Between Exposure to Oral Salmon Calcitonin and a Surrogate Marker of Pharmacodynamic Efficacy
  European Journal of Clinical Pharmacology. Jan, 2010  |   Pubmed ID: 19813008
• Biochemical Markers of Joint Tissue Turnover
  Assay and Drug Development Technologies. Feb, 2010  |   Pubmed ID: 19715454
• PLCL1 Rs7595412 Variation is Not Associated with Hip Bone Size Variation in Postmenopausal Danish Women
  BMC Medical Genetics. 2009  |   Pubmed ID: 20030815
• Suppression of MMP Activity in Bovine Cartilage Explants Cultures Has Little if Any Effect on the Release of Aggrecanase-derived Aggrecan Fragments
  BMC Research Notes. Dec, 2009  |   Pubmed ID: 20021645
• Identification of Progressors in Osteoarthritis by Combining Biochemical and MRI-based Markers
  Arthritis Research & Therapy. 2009  |   Pubmed ID: 19630944
• A Comparison of Glycemic Control, Water Retention, and Musculoskeletal Effects of Balaglitazone and Pioglitazone in Diet-induced Obese Rats
  European Journal of Pharmacology. Aug, 2009  |   Pubmed ID: 19595686
• Influence of Food Intake on the Bioavailability and Efficacy of Oral Calcitonin
  British Journal of Clinical Pharmacology. Apr, 2009  |   Pubmed ID: 19371314
• Local Communication on and Within Bone Controls Bone Remodeling
  Bone. Jun, 2009  |   Pubmed ID: 19345750
• A Pharmacokinetic and Pharmacodynamic Comparison of Synthetic and Recombinant Oral Salmon Calcitonin
  Journal of Clinical Pharmacology. Feb, 2009  |   Pubmed ID: 19179298
• Characterization of Acid Flux in Osteoclasts from Patients Harboring a G215R Mutation in ClC-7
  Biochemical and Biophysical Research Communications. Jan, 2009  |   Pubmed ID: 19070589
• Characterization of the Bone Phenotype in ClC-7-deficient Mice
  Calcified Tissue International. Dec, 2008  |   Pubmed ID: 18958510
• Ion Transporters Involved in Acidification of the Resorption Lacuna in Osteoclasts
  Calcified Tissue International. Sep, 2008  |   Pubmed ID: 18787885
• Optimizing Bioavailability of Oral Administration of Small Peptides Through Pharmacokinetic and Pharmacodynamic Parameters: the Effect of Water and Timing of Meal Intake on Oral Delivery of Salmon Calcitonin
  BMC Clinical Pharmacology. Sep, 2008  |   Pubmed ID: 18782439
• The Disease Modifying Osteoarthritis Drug (DMOAD): Is It in the Horizon?
  Pharmacological Research. Jul, 2008  |   Pubmed ID: 18590824
• Does Increased Local Bone Resorption Secondary to Breast and Prostate Cancer Result in Increased Cartilage Degradation?
  BMC Cancer. Jun, 2008  |   Pubmed ID: 18588674
• Cartilage Degradation is Fully Reversible in the Presence of Aggrecanase but Not Matrix Metalloproteinase Activity
  Arthritis Research & Therapy. 2008  |   Pubmed ID: 18513402
• Patients with Rheumatoid Arthritis Have an Altered Circulatory Aggrecan Profile
  BMC Musculoskeletal Disorders. May, 2008  |   Pubmed ID: 18507823
• Calcitonin: a Drug of the Past or for the Future? Physiologic Inhibition of Bone Resorption While Sustaining Osteoclast Numbers Improves Bone Quality
  BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 2008  |   Pubmed ID: 18481897
• Osteoclasts Secrete Non-bone Derived Signals That Induce Bone Formation
  Biochemical and Biophysical Research Communications. Feb, 2008  |   Pubmed ID: 18068671
• Evaluation of Cartilage Damage by Measuring Collagen Degradation Products in Joint Extracts in a Traumatic Model of Osteoarthritis
  Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. Feb, 2008  |   Pubmed ID: 17852072
• Calcitonin Affects Both Bone and Cartilage: a Dual Action Treatment for Osteoarthritis?
  Annals of the New York Academy of Sciences. Nov, 2007  |   Pubmed ID: 18056043
• Dissolution of the Inorganic Phase of Bone Leading to Release of Calcium Regulates Osteoclast Survival
  Biochemical and Biophysical Research Communications. Sep, 2007  |   Pubmed ID: 17631274
• Diphyllin, a Novel and Naturally Potent V-ATPase Inhibitor, Abrogates Acidification of the Osteoclastic Resorption Lacunae and Bone Resorption
  Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Oct, 2007  |   Pubmed ID: 17576165
• Are Nonresorbing Osteoclasts Sources of Bone Anabolic Activity?
  Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Apr, 2007  |   Pubmed ID: 17227224
• Effects of Ovariectomy and Estrogen Therapy on Type II Collagen Degradation and Structural Integrity of Articular Cartilage in Rats: Implications of the Time of Initiation
  Arthritis and Rheumatism. Aug, 2006  |   Pubmed ID: 16871544
• Alpha CTX As a Biomarker of Skeletal Invasion of Breast Cancer: Immunolocalization and the Load Dependency of Urinary Excretion
  Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Jul, 2006  |   Pubmed ID: 16835341
• Degradation of the Organic Phase of Bone by Osteoclasts: a Secondary Role for Lysosomal Acidification
  Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jan, 2006  |   Pubmed ID: 16355274
• Osteoclasts from Patients with Autosomal Dominant Osteopetrosis Type I Caused by a T253I Mutation in Low-density Lipoprotein Receptor-related Protein 5 Are Normal in Vitro, but Have Decreased Resorption Capacity in Vivo
  The American Journal of Pathology. Nov, 2005  |   Pubmed ID: 16251418
• Acidification of the Osteoclastic Resorption Compartment Provides Insight into the Coupling of Bone Formation to Bone Resorption
  The American Journal of Pathology. Feb, 2005  |   Pubmed ID: 15681830
• The Chloride Channel Inhibitor NS3736 [corrected] Prevents Bone Resorption in Ovariectomized Rats Without Changing Bone Formation
  Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jul, 2004  |   Pubmed ID: 15176998
• Characterization of Osteoclasts from Patients Harboring a G215R Mutation in ClC-7 Causing Autosomal Dominant Osteopetrosis Type II
  The American Journal of Pathology. May, 2004  |   Pubmed ID: 15111300
• Transforming Growth Factor-beta Controls Human Osteoclastogenesis Through the P38 MAPK and Regulation of RANK Expression
  The Journal of Biological Chemistry. Nov, 2003  |   Pubmed ID: 12933809
• Matrix Metalloproteinase-dependent Activation of Latent Transforming Growth Factor-beta Controls the Conversion of Osteoblasts into Osteocytes by Blocking Osteoblast Apoptosis
  The Journal of Biological Chemistry. Nov, 2002  |   Pubmed ID: 12226090