Motoyuki Otsuka

Publications

• Detection of Circulating Colorectal Cancer Cells by a Custom Microfluid System Before and After Endoscopic Metallic Stent Placement
  Oncology Letters. Dec, 2019  |   Pubmed ID: 31807163
• Expression of Circular RNA CDR1‑AS in Colon Cancer Cells Increases Cell Surface PD‑L1 Protein Levels
  Oncology Reports. Oct, 2019  |   Pubmed ID: 31322270
• Inhibition of HBV Transcription From CccDNA With Nitazoxanide by Targeting the HBx-DDB1 Interaction
  Cellular and Molecular Gastroenterology and Hepatology. 2019  |   Pubmed ID: 30704981
• Pevonedistat, a Neuronal Precursor Cell-Expressed Developmentally Down-Regulated Protein 8-Activating Enzyme Inhibitor, Is a Potent Inhibitor of Hepatitis B Virus
  Hepatology (Baltimore, Md.). May, 2019  |   Pubmed ID: 30586159
• Liver Stiffness Measurements in Chronic Hepatitis C: Treatment Evaluation and Risk Assessment
  Journal of Gastroenterology and Hepatology. May, 2019  |   Pubmed ID: 30393960
• Inflammation and De-differentiation in Pancreatic Carcinogenesis
  World Journal of Clinical Cases. Dec, 2018  |   Pubmed ID: 30568942
• ISGF3 with Reduced Phosphorylation is Associated with Constitutive Expression of Interferon-induced Genes in Aging Cells
  NPJ Aging and Mechanisms of Disease. 2018  |   Pubmed ID: 30455980
• Hepatitis B Virus Pathogenesis: Fresh Insights into Hepatitis B Virus RNA
  World Journal of Gastroenterology. Jun, 2018  |   Pubmed ID: 29881235
• DHX9 Regulates Production of Hepatitis B Virus-derived Circular RNA and Viral Protein Levels
  Oncotarget. Apr, 2018  |   Pubmed ID: 29765512
• Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models of Pancreatic Cancer
  Molecular Cancer Research : MCR. 08, 2018  |   Pubmed ID: 29748382
• CPT2 Downregulation Adapts HCC to Lipid-rich Environment and Promotes Carcinogenesis Via Acylcarnitine Accumulation in Obesity
  Gut. 08, 2018  |   Pubmed ID: 29437870
• RASAL1 is a Potent Regulator of Hepatic Stellate Cell Activity and Liver Fibrosis
  Oncotarget. Sep, 2017  |   Pubmed ID: 29029395
• Biliary Epithelial Injury-induced Regenerative Response by IL-33 Promotes Cholangiocarcinogenesis from Peribiliary Glands
  Proceedings of the National Academy of Sciences of the United States of America. 05, 2017  |   Pubmed ID: 28439013
• Transcriptional Activation of the MICA Gene with an Engineered CRISPR-Cas9 System
  Biochemical and Biophysical Research Communications. 04, 2017  |   Pubmed ID: 28322797
• Repression of MicroRNA Function Mediates Inflammation-associated Colon Tumorigenesis
  Gastroenterology. 02, 2017  |   Pubmed ID: 27825961
• MicroRNAs and Liver Disease
  Journal of Human Genetics. Jan, 2017  |   Pubmed ID: 27225852
• Quantitation of Circulating Satellite RNAs in Pancreatic Cancer Patients
  JCI Insight. 06, 2016  |   Pubmed ID: 27699267
• Satellite RNAs Promote Pancreatic Oncogenic Processes Via the Dysfunction of YBX1
  Nature Communications. Sep, 2016  |   Pubmed ID: 27667193
• Mutual Antagonism Between Hepatitis B Viral MRNA and Host MicroRNA Let-7
  Scientific Reports. Mar, 2016  |   Pubmed ID: 26979389
• Development of a Screening Method to Identify Regulators of MICA Shedding
  Biochemical and Biophysical Research Communications. Oct, 2015  |   Pubmed ID: 26299929
• Circulating RNAs As New Biomarkers for Detecting Pancreatic Cancer
  World Journal of Gastroenterology. Jul, 2015  |   Pubmed ID: 26229396
• ROCK Inhibition Enhances MicroRNA Function by Promoting Deadenylation of Targeted MRNAs Via Increasing PAIP2 Expression
  Nucleic Acids Research. Sep, 2015  |   Pubmed ID: 26187994
• Novel Therapeutic Approaches for Hepatitis B Virus Covalently Closed Circular DNA
  World Journal of Gastroenterology. Jun, 2015  |   Pubmed ID: 26109795
• Decreased MiR122 in Hepatocellular Carcinoma Leads to Chemoresistance with Increased Arginine
  Oncotarget. Apr, 2015  |   Pubmed ID: 25826076
• Diagnostic and Therapeutic Application of Noncoding RNAs for Hepatocellular Carcinoma
  World Journal of Hepatology. Jan, 2015  |   Pubmed ID: 25624991
• The Flavonoid Apigenin Inhibits Hepatitis C Virus Replication by Decreasing Mature MicroRNA122 Levels
  Virology. Aug, 2014  |   Pubmed ID: 25092460
• Specific Delivery of MicroRNA93 into HBV-replicating Hepatocytes Downregulates Protein Expression of Liver Cancer Susceptible Gene MICA
  Oncotarget. Jul, 2014  |   Pubmed ID: 25026299
• The Role of MicroRNAs in Hepatocarcinogenesis: Current Knowledge and Future Prospects
  Journal of Gastroenterology. Feb, 2014  |   Pubmed ID: 24258409
• Impact of PNPLA3 Polymorphisms on the Development of Hepatocellular Carcinoma in Patients with Chronic Hepatitis C Virus Infection
  Hepatology Research : the Official Journal of the Japan Society of Hepatology. Oct, 2014  |   Pubmed ID: 24125181
• IL28B Minor Allele is Associated with a Younger Age of Onset of Hepatocellular Carcinoma in Patients with Chronic Hepatitis C Virus Infection
  Journal of Gastroenterology. Apr, 2014  |   Pubmed ID: 23689989
• Transdifferentiation of Human Fibroblasts into Hepatocyte-like Cells by Defined Transcriptional Factors
  Hepatology International. Jul, 2013  |   Pubmed ID: 26201932
• Current Status of MiRNA-targeting Therapeutics and Preclinical Studies Against Gastroenterological Carcinoma
  Molecular and Cellular Therapies. 2013  |   Pubmed ID: 26056570
• Regulation of the Expression of the Liver Cancer Susceptibility Gene MICA by MicroRNAs
  Scientific Reports. 2013  |   Pubmed ID: 24061441
• Unique Haploinsufficient Role of the MicroRNA-processing Molecule Dicer1 in a Murine Colitis-associated Tumorigenesis Model
  PloS One. 2013  |   Pubmed ID: 24023722
• The Flavonoid Apigenin Improves Glucose Tolerance Through Inhibition of MicroRNA Maturation in MiRNA103 Transgenic Mice
  Scientific Reports. 2013  |   Pubmed ID: 23989853
• Inhibition of MicroRNA122 Decreases SREBP1 Expression by Modulating Suppressor of Cytokine Signaling 3 Expression
  Biochemical and Biophysical Research Communications. Aug, 2013  |   Pubmed ID: 23891753
• MicroRNAs and Liver Function
  Minerva Gastroenterologica E Dietologica. Jun, 2013  |   Pubmed ID: 23831909
• Histone Demethylase KDM4C Regulates Sphere Formation by Mediating the Cross Talk Between Wnt and Notch Pathways in Colonic Cancer Cells
  Carcinogenesis. Oct, 2013  |   Pubmed ID: 23698634
• A Genome-wide Association Study of HCV-induced Liver Cirrhosis in the Japanese Population Identifies Novel Susceptibility Loci at the MHC Region
  Journal of Hepatology. May, 2013  |   Pubmed ID: 23321320
• MicroRNA-140 Acts As a Liver Tumor Suppressor by Controlling NF-κB Activity by Directly Targeting DNA Methyltransferase 1 (Dnmt1) Expression
  Hepatology (Baltimore, Md.). Jan, 2013  |   Pubmed ID: 22898998
• Silencing of MicroRNA-122 Enhances Interferon-α Signaling in the Liver Through Regulating SOCS3 Promoter Methylation
  Scientific Reports. 2012  |   Pubmed ID: 22957141
• A MiRNA Machinery Component DDX20 Controls NF-κB Via MicroRNA-140 Function
  Biochemical and Biophysical Research Communications. Apr, 2012  |   Pubmed ID: 22445758
• Receptor for Activated Protein Kinase C: Requirement for Efficient MicroRNA Function and Reduced Expression in Hepatocellular Carcinoma
  PloS One. 2011  |   Pubmed ID: 21935400
• MicroRNA-22 and MicroRNA-140 Suppress NF-κB Activity by Regulating the Expression of NF-κB Coactivators
  Biochemical and Biophysical Research Communications. Aug, 2011  |   Pubmed ID: 21798241
• Altered Composition of Fatty Acids Exacerbates Hepatotumorigenesis During Activation of the Phosphatidylinositol 3-kinase Pathway
  Journal of Hepatology. Dec, 2011  |   Pubmed ID: 21703185
• MicroRNA122 is a Key Regulator of α-fetoprotein Expression and Influences the Aggressiveness of Hepatocellular Carcinoma
  Nature Communications. Jun, 2011  |   Pubmed ID: 21654638
• Direct Differentiation of Hepatic Cells from Human Induced Pluripotent Stem Cells Using a Limited Number of Cytokines
  Hepatology International. Dec, 2011  |   Pubmed ID: 21484132
• Reduced Expression of RAS Protein Activator Like-1 in Gastric Cancer
  International Journal of Cancer. Mar, 2011  |   Pubmed ID: 20473946
• Smad4-independent Regulation of P21/WAF1 by Transforming Growth Factor-beta
  Oncogene. Feb, 2004  |   Pubmed ID: 14762439