Paolo Ghia Division of Experimental Oncology IRCCS Istituto Scientifico San Raffaele and Università Vita-Salute San Raffaele Biography Publications Institution JoVE Articles Paolo Ghia has not added a biography. If you are Paolo Ghia and would like to personalize this page please email our Author Liaison for assistance. Publications TP53 Aberrations in Chronic Lymphocytic Leukemia: an Overview of the Clinical Implications of Improved Diagnostics Haematologica. Nov, 2018 | Pubmed ID: 30442727 Monoclonal B-cell Lymphocytosis: Does the Elderly Patient Need a Specialistic Approach? European Journal of Internal Medicine. Sep, 2018 | Pubmed ID: 30268574 Minimal Residual Disease Analysis in Chronic Lymphocytic Leukemia: a Way for Achieving More Personalized Treatments Leukemia. Jun, 2018 | Pubmed ID: 29700386 ERIC Recommendations for TP53 Mutation Analysis in Chronic Lymphocytic Leukemia-update on Methodological Approaches and Results Interpretation Leukemia. May, 2018 | Pubmed ID: 29467486 Highly Similar Genomic Landscapes in Monoclonal B-cell Lymphocytosis and Ultra-stable Chronic Lymphocytic Leukemia with Low Frequency of Driver Mutations Haematologica. May, 2018 | Pubmed ID: 29449433 Immunoglobulin Genes in Chronic Lymphocytic Leukemia: Key to Understanding the Disease and Improving Risk Stratification Haematologica. 06, 2017 | Pubmed ID: 28566340 Distinct Molecular Genetics of Chronic Lymphocytic Leukemia in Taiwan: Clinical and Pathogenetic Implications Haematologica. Mar, 2017 | Pubmed ID: 28255015 Ibrutinib in the Real World Patient: Many Lights and Some Shades Haematologica. 12, 2016 | Pubmed ID: 27903711 Ibrutinib Holds Promise for Patients with 17p Deletion CLL The Lancet. Oncology. 10, 2016 | Pubmed ID: 27637986 Similar Epidemiological Trends of Pre-neoplastic Precursors and Their Respective Lymphoid Malignancies in Taiwan Annals of Hematology. Oct, 2016 | Pubmed ID: 27431581 A New Life for Rituximab? The Lancet. Haematology. Mar, 2016 | Pubmed ID: 26947197 Innovation in the Prognostication of Chronic Lymphocytic Leukemia: How Far Beyond TP53 Gene Analysis Can We Go? Haematologica. Mar, 2016 | Pubmed ID: 26928246 Targeting Hedgehog in Haematological Malignancies The Lancet. Haematology. Aug, 2015 | Pubmed ID: 26688482 Toll-like Receptor Stimulation in Splenic Marginal Zone Lymphoma Can Modulate Cell Signaling, Activation and Proliferation Haematologica. Nov, 2015 | Pubmed ID: 26294727 Clinical Effect of Stereotyped B-cell Receptor Immunoglobulins in Chronic Lymphocytic Leukaemia: a Retrospective Multicentre Study The Lancet. Haematology. Nov, 2014 | Pubmed ID: 27030157 Ibrutinib: Better Combined with Other Drugs? The Lancet. Oncology. Sep, 2014 | Pubmed ID: 25150799 MDM2 Promotor Polymorphism and Disease Characteristics in Chronic Lymphocytic Leukemia: Results of an Individual Patient Data-based Meta-analysis Haematologica. Aug, 2014 | Pubmed ID: 25082786 Immunogenetic Studies of Chronic Lymphocytic Leukemia: Revelations and Speculations About Ontogeny and Clinical Evolution Cancer Research. Aug, 2014 | Pubmed ID: 25074616 Mouse Models in the Study of Chronic Lymphocytic Leukemia Pathogenesis and Therapy Blood. Aug, 2014 | Pubmed ID: 25006127 Bendamustine and Subcutaneous Alemtuzumab Combination is an Effective Treatment in Relapsed/refractory Chronic Lymphocytic Leukemia Patients Haematologica. Sep, 2014 | Pubmed ID: 24972768 Management of Chronic Lymphocytic Leukemia Haematologica. Jun, 2014 | Pubmed ID: 24881042 SIGLEC-G Deficiency Increases Susceptibility to Develop B-cell Lymphoproliferative Disorders Haematologica. Aug, 2014 | Pubmed ID: 24859880 The Frequency of TP53 Gene Defects Differs Between Chronic Lymphocytic Leukaemia Subgroups Harbouring Distinct Antigen Receptors British Journal of Haematology. Aug, 2014 | Pubmed ID: 24725250 Heterogeneous Functional Effects of Concomitant B Cell Receptor and TLR Stimulation in Chronic Lymphocytic Leukemia with Mutated Versus Unmutated Ig Genes Journal of Immunology (Baltimore, Md. : 1950). May, 2014 | Pubmed ID: 24719462 Clonal B-cell Lymphocytosis: a New Member? Blood. Feb, 2014 | Pubmed ID: 24558188 Idelalisib and Rituximab in Relapsed Chronic Lymphocytic Leukemia The New England Journal of Medicine. Mar, 2014 | Pubmed ID: 24450857 The Microenvironment in Lymphomas--dissecting the Complex Crosstalk Between Tumor Cells and 'by-stander' Cells Seminars in Cancer Biology. Feb, 2014 | Pubmed ID: 24365642 Monoclonal B-cell Lymphocytosis in Healthy Blood Donors: an Unexpectedly Common Finding Blood. Feb, 2014 | Pubmed ID: 24345750 IgG-switched CLL Has a Distinct Immunogenetic Signature from the Common MD Variant: Ontogenetic Implications Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2014 | Pubmed ID: 24240110 Monoclonal B Cell Lymphocytosis and "in Situ" Lymphoma Seminars in Cancer Biology. Feb, 2014 | Pubmed ID: 23999128 Reprogramming Cell Death: BCL2 Family Inhibition in Hematological Malignancies Immunology Letters. Sep-Oct, 2013 | Pubmed ID: 24095849 Antigen Selection in B-cell Lymphomas--tracing the Evidence Seminars in Cancer Biology. Dec, 2013 | Pubmed ID: 23932942 Loss of Function of Ribonuclease T2, an Ancient and Phylogenetically Conserved RNase, Plays a Crucial Role in Ovarian Tumorigenesis Proceedings of the National Academy of Sciences of the United States of America. May, 2013 | Pubmed ID: 23630276 Differential MicroRNA Profiles and Their Functional Implications in Different Immunogenetic Subsets of Chronic Lymphocytic Leukemia Molecular Medicine (Cambridge, Mass.). 2013 | Pubmed ID: 23615967 Immunogenetics Shows That Not All MBL Are Equal: the Larger the Clone, the More Similar to CLL Blood. May, 2013 | Pubmed ID: 23596047 MBL Versus CLL: How Important is the Distinction? Hematology/oncology Clinics of North America. Apr, 2013 | Pubmed ID: 23561472 Targeting B-cell Anergy in Chronic Lymphocytic Leukemia Blood. May, 2013 | Pubmed ID: 23460614 Targeting the LYN/HS1 Signaling Axis in Chronic Lymphocytic Leukemia Blood. Mar, 2013 | Pubmed ID: 23325840 In Vitro Sensitivity of CLL Cells to Fludarabine May Be Modulated by the Stimulation of Toll-like Receptors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2013 | Pubmed ID: 23224401 A Look into the Future: Can Minimal Residual Disease Guide Therapy and Predict Prognosis in Chronic Lymphocytic Leukemia? Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2012 | Pubmed ID: 23233566 Bone Marrow Histopathology in the Diagnostic Evaluation of Splenic Marginal-zone and Splenic Diffuse Red Pulp Small B-cell Lymphoma: a Reliable Substitute for Spleen Histopathology? The American Journal of Surgical Pathology. Nov, 2012 | Pubmed ID: 23073320 Changes in the Apoptotic Gene Expression Profile in CLL Patients Treated with Rituximab Combined with Cladribine and Cyclophosphamide-preliminary Results Leukemia Research. Sep, 2012 | Pubmed ID: 22608309 KAP1 Regulates Gene Networks Controlling Mouse B-lymphoid Cell Differentiation and Function Blood. May, 2012 | Pubmed ID: 22452978 Distinct Innate Immunity Pathways to Activation and Tolerance in Subgroups of Chronic Lymphocytic Leukemia with Distinct Immunoglobulin Receptors Molecular Medicine (Cambridge, Mass.). 2012 | Pubmed ID: 22437326 KIBRA Gene Methylation is Associated with Unfavorable Biological Prognostic Parameters in Chronic Lymphocytic Leukemia Epigenetics : Official Journal of the DNA Methylation Society. Mar, 2012 | Pubmed ID: 22430796 Monoclonal B-cell Lymphocytosis: Right Track or Red Herring? Blood. May, 2012 | Pubmed ID: 22422819 Stereotyped B-cell Receptors in One-third of Chronic Lymphocytic Leukemia: a Molecular Classification with Implications for Targeted Therapies Blood. May, 2012 | Pubmed ID: 22415752 General Population Low-count CLL-like MBL Persists over Time Without Clinical Progression, Although Carrying the Same Cytogenetic Abnormalities of CLL Blood. Dec, 2011 | Pubmed ID: 21876118 Another Piece of the Puzzle: is There a "nodal" Monoclonal B-cell Lymphocytosis? Haematologica. Aug, 2011 | Pubmed ID: 21810972 Is There a Role for Antigen Selection in Mantle Cell Lymphoma? Immunogenetic Support from a Series of 807 Cases Blood. Sep, 2011 | Pubmed ID: 21791422 Toll-like Receptor Signaling Pathway in Chronic Lymphocytic Leukemia: Distinct Gene Expression Profiles of Potential Pathogenic Significance in Specific Subsets of Patients Haematologica. Nov, 2011 | Pubmed ID: 21750087 Lack of TIR8/SIGIRR Triggers Progression of Chronic Lymphocytic Leukemia in Mouse Models Blood. Jul, 2011 | Pubmed ID: 21652674 In Vitro and in Vivo Model of a Novel Immunotherapy Approach for Chronic Lymphocytic Leukemia by Anti-CD23 Chimeric Antigen Receptor Blood. May, 2011 | Pubmed ID: 21406718 Microenvironmental Control of Malignancy Exerted by RNASET2, a Widely Conserved Extracellular RNase Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011 | Pubmed ID: 21189302 Inherited Genetic Susceptibility to Monoclonal B-cell Lymphocytosis Blood. Dec, 2010 | Pubmed ID: 20855867 Monoclonal B Cell Lymphocytosis in Hepatitis C Virus Infected Individuals Cytometry. Part B, Clinical Cytometry. 2010 | Pubmed ID: 20839339 Commentary: Comparison of Current Flow Cytometry Methods for Monoclonal B Cell Lymphocytosis Detection Cytometry. Part B, Clinical Cytometry. 2010 | Pubmed ID: 20839336 Different Biology and Clinical Outcome According to the Absolute Numbers of Clonal B-cells in Monoclonal B-cell Lymphocytosis (MBL) Cytometry. Part B, Clinical Cytometry. 2010 | Pubmed ID: 20839333 CLL-like Monoclonal B-cell Lymphocytosis: Are We All Bound to Have It? Seminars in Cancer Biology. Dec, 2010 | Pubmed ID: 20816789 How the Microenvironment Shapes Chronic Lymphocytic Leukemia: the Cytoskeleton Connection Leukemia & Lymphoma. Aug, 2010 | Pubmed ID: 20687794 ZAP-70 Expression is Associated with Increased Risk of Autoimmune Cytopenias in CLL Patients American Journal of Hematology. Jul, 2010 | Pubmed ID: 20575031 HS1 Has a Central Role in the Trafficking and Homing of Leukemic B Cells Blood. Nov, 2010 | Pubmed ID: 20530793 MicroRNA and Proliferation Control in Chronic Lymphocytic Leukemia: Functional Relationship Between MiR-221/222 Cluster and P27 Blood. May, 2010 | Pubmed ID: 20203269 A Novel Rag2-/-gammac-/--xenograft Model of Human CLL Blood. Feb, 2010 | Pubmed ID: 20018917 Evidence of Serum Immunoglobulin Abnormalities Up to 9.8 Years Before Diagnosis of Chronic Lymphocytic Leukemia: a Prospective Study Blood. Dec, 2009 | Pubmed ID: 19828698 The Microenvironment in Mature B-cell Malignancies: a Target for New Treatment Strategies Blood. Oct, 2009 | Pubmed ID: 19636060 Monoclonal B Lymphocytosis in the General Population Leukemia & Lymphoma. Mar, 2009 | Pubmed ID: 19347732 Introduction to Chronic Lymphocytic Leukemia Young Investigator's Meeting Leukemia & Lymphoma. Mar, 2009 | Pubmed ID: 19347731 B-cell Clones As Early Markers for Chronic Lymphocytic Leukemia The New England Journal of Medicine. Feb, 2009 | Pubmed ID: 19213679 Expression and Function of Toll Like Receptors in Chronic Lymphocytic Leukaemia Cells British Journal of Haematology. Feb, 2009 | Pubmed ID: 19036098 The Immunoglobulin Gene Repertoire of Low-count Chronic Lymphocytic Leukemia (CLL)-like Monoclonal B Lymphocytosis is Different from CLL: Diagnostic Implications for Clinical Monitoring Blood. Jul, 2009 | Pubmed ID: 19029437 Evidence for the Significant Role of Immunoglobulin Light Chains in Antigen Recognition and Selection in Chronic Lymphocytic Leukemia Blood. Jan, 2009 | Pubmed ID: 18948572 Novel Insights in Chronic Lymphocytic Leukemia: Are We Getting Closer to Understanding the Pathogenesis of the Disease? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Sep, 2008 | Pubmed ID: 18662968 Constitutive Activation of Distinct BCR-signaling Pathways in a Subset of CLL Patients: a Molecular Signature of Anergy Blood. Jul, 2008 | Pubmed ID: 18292287 Stereotyped Patterns of Somatic Hypermutation in Subsets of Patients with Chronic Lymphocytic Leukemia: Implications for the Role of Antigen Selection in Leukemogenesis Blood. Feb, 2008 | Pubmed ID: 17959859 From Normal to Clonal B Cells: Chronic Lymphocytic Leukemia (CLL) at the Crossroad Between Neoplasia and Autoimmunity Autoimmunity Reviews. Dec, 2007 | Pubmed ID: 18035322 Age-dependent Accumulation of Monoclonal CD4+CD8+ Double Positive T Lymphocytes in the Peripheral Blood of the Elderly British Journal of Haematology. Dec, 2007 | Pubmed ID: 18021092 Overview of Monoclonal B-cell Lymphocytosis British Journal of Haematology. Dec, 2007 | Pubmed ID: 18021084 A Woman and Her Canary: a Tale of Chlamydiae and Lymphomas Journal of the National Cancer Institute. Sep, 2007 | Pubmed ID: 17848672 The Normal Counterpart to the Chronic Lymphocytic Leukemia B Cell Best Practice & Research. Clinical Haematology. Sep, 2007 | Pubmed ID: 17707828 Chronic Lymphocytic Leukemia Critical Reviews in Oncology/hematology. Dec, 2007 | Pubmed ID: 17544290 Over 20% of Patients with Chronic Lymphocytic Leukemia Carry Stereotyped Receptors: Pathogenetic Implications and Clinical Correlations Blood. Jan, 2007 | Pubmed ID: 16985177 Evaluation of ZAP-70 Expression by Flow Cytometry in Chronic Lymphocytic Leukemia: A Multicentric International Harmonization Process Cytometry. Part B, Clinical Cytometry. Jul, 2006 | Pubmed ID: 16906588 IGHV Gene Insertions and Deletions in Chronic Lymphocytic Leukemia: "CLL-biased" Deletions in a Subset of Cases with Stereotyped Receptors European Journal of Immunology. Jul, 2006 | Pubmed ID: 16783849 The Origin of B-cell Chronic Lymphocytic Leukemia Seminars in Oncology. Apr, 2006 | Pubmed ID: 16616061 Gene Expression Profiling Identifies BAX-delta As a Novel Tumor Antigen in Acute Lymphoblastic Leukemia Cancer Research. Nov, 2005 | Pubmed ID: 16267031 Diagnostic Criteria for Monoclonal B-cell Lymphocytosis British Journal of Haematology. Aug, 2005 | Pubmed ID: 16042682 HS1 Protein is Differentially Expressed in Chronic Lymphocytic Leukemia Patient Subsets with Good or Poor Prognoses The Journal of Clinical Investigation. Jun, 2005 | Pubmed ID: 15931393 Geographic Patterns and Pathogenetic Implications of IGHV Gene Usage in Chronic Lymphocytic Leukemia: the Lesson of the IGHV3-21 Gene Blood. Feb, 2005 | Pubmed ID: 15466924 Vdelta1 T Lymphocytes from B-CLL Patients Recognize ULBP3 Expressed on Leukemic B Cells and Up-regulated by Trans-retinoic Acid Cancer Research. Dec, 2004 | Pubmed ID: 15604289 The Nature and Origin of the B-chronic Lymphocytic Leukemia Cell: a Tentative Model Hematology/oncology Clinics of North America. Aug, 2004 | Pubmed ID: 15325702 Leukemia-derived Immature Dendritic Cells Differentiate into Functionally Competent Mature Dendritic Cells That Efficiently Stimulate T Cell Responses Journal of Immunology (Baltimore, Md. : 1950). Aug, 2004 | Pubmed ID: 15295005 Monoclonal CD5+ and CD5- B-lymphocyte Expansions Are Frequent in the Peripheral Blood of the Elderly Blood. Mar, 2004 | Pubmed ID: 14630808 IL-12 Regulates an Endothelial Cell-lymphocyte Network: Effect on Metalloproteinase-9 Production Journal of Immunology (Baltimore, Md. : 1950). Oct, 2003 | Pubmed ID: 14500672 The Characterization of Chemokine Production and Chemokine Receptor Expression Reveals Possible Functional Cross-talks in AML Blasts with Monocytic Differentiation Experimental Hematology. Jun, 2003 | Pubmed ID: 12829025 Expansion of Tumor-specific CD8+ T Cell Clones in Patients with Relapsed Myeloma After Donor Lymphocyte Infusion Cancer Research. May, 2003 | Pubmed ID: 12750280 The Pattern of CD38 Expression Defines a Distinct Subset of Chronic Lymphocytic Leukemia (CLL) Patients at Risk of Disease Progression Blood. Feb, 2003 | Pubmed ID: 12406914 CD100/Plexin-B1 Interactions Sustain Proliferation and Survival of Normal and Leukemic CD5+ B Lymphocytes Blood. Mar, 2003 | Pubmed ID: 12406905 Chronic Lymphocytic Leukaemia: a Model for Investigating Potential New Targets for the Therapy of Indolent Lymphomas Best Practice & Research. Clinical Haematology. Sep, 2002 | Pubmed ID: 12468406 CXCL13 (BCA-1) is Produced by Follicular Lymphoma Cells: Role in the Accumulation of Malignant B Cells British Journal of Haematology. Nov, 2002 | Pubmed ID: 12406091 Chronic B Cell Malignancies and Bone Marrow Microenvironment Seminars in Cancer Biology. Apr, 2002 | Pubmed ID: 12027587 Chronic Lymphocytic Leukemia B Cells Are Endowed with the Capacity to Attract CD4+, CD40L+ T Cells by Producing CCL22 European Journal of Immunology. May, 2002 | Pubmed ID: 11981828 غلوبيولين مناعي تحليل تسلسل الجين في اللوكيميا اللمفاوية المزمنة: من المواد المريض إلى تفسير التسلسل Andreas Agathangelidis*1, Lesley Ann Sutton*2,3, Anastasia Hadzidimitriou1, Cristina Tresoldi4, Anton W. Langerak5, Chrysoula Belessi6, Frederic Davi7, Richard Rosenquist2,3, Kostas Stamatopoulos1,2, Paolo Ghia8 1Institute of Applied Biosciences, Centre for Research and Technology Hellas, 2Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 3Department of Molecular Medicine and Surgery, Karolinska Institutet, 4Division of Immunology, Transplantation and Infectious, IRCCS San Raffaele Scientific Institute, 5Department of Immunology, Laboratory for Medical Immunology, Erasmus University Medical Center, 6Hematology Department, Nikea General Hospital, 7Assistance publique - Hôpitaux de Paris (AP-HP), Hopital Pitié-Salpêtrière, Department of Hematology, and UPMC University Paris 06, UMRS 1138, 8Division of Experimental Oncology, IRCCS Istituto Scientifico San Raffaele and Università Vita-Salute San Raffaele JoVE 57787 Cancer Research من بقعة 2DE جل لوظيفة البروتين: الدرس المستفاد من HS1 في سرطان الدم الليمفاوي المزمن Benedetta Apollonio1,2, Maria Teresa Sabrina Bertilaccio1, Umberto Restuccia3, Pamela Ranghetti1, Federica Barbaglio1, Paolo Ghia1,4, Federico Caligaris-Cappio1,4, Cristina Scielzo1 1Division of Molecular Oncology, IRCCS, San Raffaele Scientific Institute, 2Department of Haemato-Oncology, King's College London, 3IFOM, FIRC Institute of Molecular Oncology, 4Università Vita-Salute San Raffaele JoVE 51942 Medicine
غلوبيولين مناعي تحليل تسلسل الجين في اللوكيميا اللمفاوية المزمنة: من المواد المريض إلى تفسير التسلسل Andreas Agathangelidis*1, Lesley Ann Sutton*2,3, Anastasia Hadzidimitriou1, Cristina Tresoldi4, Anton W. Langerak5, Chrysoula Belessi6, Frederic Davi7, Richard Rosenquist2,3, Kostas Stamatopoulos1,2, Paolo Ghia8 1Institute of Applied Biosciences, Centre for Research and Technology Hellas, 2Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 3Department of Molecular Medicine and Surgery, Karolinska Institutet, 4Division of Immunology, Transplantation and Infectious, IRCCS San Raffaele Scientific Institute, 5Department of Immunology, Laboratory for Medical Immunology, Erasmus University Medical Center, 6Hematology Department, Nikea General Hospital, 7Assistance publique - Hôpitaux de Paris (AP-HP), Hopital Pitié-Salpêtrière, Department of Hematology, and UPMC University Paris 06, UMRS 1138, 8Division of Experimental Oncology, IRCCS Istituto Scientifico San Raffaele and Università Vita-Salute San Raffaele JoVE 57787 Cancer Research
من بقعة 2DE جل لوظيفة البروتين: الدرس المستفاد من HS1 في سرطان الدم الليمفاوي المزمن Benedetta Apollonio1,2, Maria Teresa Sabrina Bertilaccio1, Umberto Restuccia3, Pamela Ranghetti1, Federica Barbaglio1, Paolo Ghia1,4, Federico Caligaris-Cappio1,4, Cristina Scielzo1 1Division of Molecular Oncology, IRCCS, San Raffaele Scientific Institute, 2Department of Haemato-Oncology, King's College London, 3IFOM, FIRC Institute of Molecular Oncology, 4Università Vita-Salute San Raffaele JoVE 51942 Medicine
