Ruther Department of Microsystems Engineering (IMTEK) University of Freiburg Biography Publications Institution JoVE Articles Ruther Patrick Ruther received the Diploma degree in physics and the Ph.D. degree in mechanical engineering in 1993 and 1996, respectively. From 1996 to 1998, he held a post-doctoral position at the Research Center Karlsruhe, Germany, where he was developing LIGA-based microoptical components. Since 1998, he has been a Senior Scientist at the Department of Microsystems Engineering (IMTEK), University of Freiburg. His focus is on the design, fabrication, and characterization of CMOScompatible MEMS devices, including microoptical functionality for biomedical applications, such as neuroscience and optogenetics. He coordinated the EU project NeuroSeeker targeting the next generationof neural probes comprising electronic and optical functionality. He is a Co-Founder of the spin-off company ATLAS Neuroengineering, Belgium. He is a member of the Cluster of Excellence BrainLinks-BrainTools at the University of Freiburg. Publications Recording Site Placement on Planar Silicon-based Probes Affects Signal Quality in Acute Neuronal Recordings Scientific Reports. 01, 2021 | Pubmed ID: 33479289 Histological Assessment of a Chronically Implanted Cylindrically-shaped, Polymer-based Neural Probe in the Monkey Journal of Neural Engineering. Jan, 2021 | Pubmed ID: 33461177 Multichannel Optogenetic Stimulation of the Auditory Pathway Using Microfabricated LED Cochlear Implants in Rodents Science Translational Medicine. 07, 2020 | Pubmed ID: 32718992 μLED-based Optical Cochlear Implants for Spectrally Selective Activation of the Auditory Nerve EMBO Molecular Medicine. 08, 2020 | Pubmed ID: 32596983 Towards the Clinical Translation of Optogenetic Skeletal Muscle Stimulation Pflugers Archiv : European Journal of Physiology. 05, 2020 | Pubmed ID: 32415463 Recording Quality of Mechanically Decoupled Floating Versus Skull-Fixed Silicon-Based Neural Probes Frontiers in Neuroscience. Month, 2019 | Pubmed ID: 31164800 Microfluidic Chip to Interface Porous Microneedles for ISF Collection Biomedical Microdevices. 03, 2019 | Pubmed ID: 30847695 Fine-scale Mapping of Cortical Laminar Activity During Sleep Slow Oscillations Using High-density Linear Silicon Probes Journal of Neuroscience Methods. 03, 2019 | Pubmed ID: 30144495 Development, Modeling, Fabrication, and Characterization of a Magnetic, Micro-Spring-Suspended System for the Safe Electrical Interconnection of Neural Implants Micromachines. Aug, 2018 | Pubmed ID: 30424357 Tapered Fibers Combined With a Multi-Electrode Array for Optogenetics in Mouse Medial Prefrontal Cortex Frontiers in Neuroscience. Month, 2018 | Pubmed ID: 30416424 High-Density μLED-Based Optical Cochlear Implant With Improved Thermomechanical Behavior Frontiers in Neuroscience. Month, 2018 | Pubmed ID: 30327585 Long-term Recording Performance and Biocompatibility of Chronically Implanted Cylindrically-shaped, Polymer-based Neural Interfaces Biomedizinische Technik. Biomedical Engineering. Jun, 2018 | Pubmed ID: 29478038 A Silicon-based Neural Probe with Densely-packed Low-impedance Titanium Nitride Microelectrodes for Ultrahigh-resolution in Vivo Recordings Biosensors & Bioelectronics. May, 2018 | Pubmed ID: 29414094 Hybrid Intracerebral Probe with Integrated Bare LED Chips for Optogenetic Studies Biomedical Microdevices. Sep, 2017 | Pubmed ID: 28560702 Extending the Cortical Grasping Network: Pre-supplementary Motor Neuron Activity During Vision and Grasping of Objects Cerebral Cortex (New York, N.Y. : 1991). 12, 2016 | Pubmed ID: 27733538 Large-scale Recording of Thalamocortical Circuits: in Vivo Electrophysiology with the Two-dimensional Electronic Depth Control Silicon Probe Journal of Neurophysiology. 11, 2016 | Pubmed ID: 27535370 New Approaches for CMOS-based Devices for Large-scale Neural Recording Current Opinion in Neurobiology. Jun, 2015 | Pubmed ID: 25463562 Oscillatory Activity in the Medial Prefrontal Cortex and Nucleus Accumbens Correlates with Impulsivity and Reward Outcome PloS One. Month, 2014 | Pubmed ID: 25333512 Investigation of a New Electrode Array Technology for a Central Auditory Prosthesis PloS One. Month, 2013 | Pubmed ID: 24312638 Compact Wireless Neural Recording System for Small Animals Using Silicon-based Probe Arrays Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. Month, 2011 | Pubmed ID: 22254797 A Wireless Multi-channel Recording System for Freely Behaving Mice and Rats PloS One. Month, 2011 | Pubmed ID: 21765934 Control and Data Acquisition Software for High-density CMOS-based Microprobe Arrays Implementing Electronic Depth Control Biomedizinische Technik. Biomedical Engineering. Jun, 2010 | Pubmed ID: 20441537 Characterization of Parylene C As an Encapsulation Material for Implanted Neural Prostheses Journal of Biomedical Materials Research. Part B, Applied Biomaterials. Apr, 2010 | Pubmed ID: 20119944 Brain-computer Interfaces: an Overview of the Hardware to Record Neural Signals from the Cortex Progress in Brain Research. Month, 2009 | Pubmed ID: 19660664 Mechanisms of Fibroblast Cell Therapy for Dystrophic Epidermolysis Bullosa: High Stability of Collagen VII Favors Long-term Skin Integrity Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2009 | Pubmed ID: 19568221 Comparative Study on the Insertion Behavior of Cerebral Microprobes Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. Month, 2007 | Pubmed ID: 18003057 Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts Laura Diaz-Maue*1,2, Janna Steinebach*1, Michael Schwaerzle8,9, Stefan Luther1,3,4,6, Patrick Ruther8,9, Claudia Richter1,5,6,7 1Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, 2Research Electronics Department, Max Planck Institute for Dynamics and Self-Organization, 3Department of Pharmacology and Toxicology, University Medical Center Goettingen, 4Institute for Nonlinear Dynamics, Georg-August-University Goettingen, 5Department of Cardiology and Pneumology, University Medical Center Goettingen, 6German Center for Cardiovascular Research, DZHK e.V., partner site Goettingen, 7Laboratory Animal Science Unit, German Primate Center Leibniz Institute for Primate Research, 8Department of Microsystems Engineering (IMTEK), University of Freiburg, 9Cluster of Excellence BrainLinks-BrainTools, University of Freiburg JoVE 62335 Medicine
Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts Laura Diaz-Maue*1,2, Janna Steinebach*1, Michael Schwaerzle8,9, Stefan Luther1,3,4,6, Patrick Ruther8,9, Claudia Richter1,5,6,7 1Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, 2Research Electronics Department, Max Planck Institute for Dynamics and Self-Organization, 3Department of Pharmacology and Toxicology, University Medical Center Goettingen, 4Institute for Nonlinear Dynamics, Georg-August-University Goettingen, 5Department of Cardiology and Pneumology, University Medical Center Goettingen, 6German Center for Cardiovascular Research, DZHK e.V., partner site Goettingen, 7Laboratory Animal Science Unit, German Primate Center Leibniz Institute for Primate Research, 8Department of Microsystems Engineering (IMTEK), University of Freiburg, 9Cluster of Excellence BrainLinks-BrainTools, University of Freiburg JoVE 62335 Medicine
