Patrick Vanscheeuwijck

Publications

• Discriminating Spontaneous From Cigarette Smoke and THS 2.2 Aerosol Exposure-Related Proliferative Lung Lesions in A/J Mice by Using Gene Expression and Mutation Spectrum Data
  Frontiers in Toxicology. 2021  |   Pubmed ID: 35295134
• Impact of 6-Month Exposure to Aerosols From Potential Modified Risk Tobacco Products Relative to Cigarette Smoke on the Rodent Gastrointestinal Tract
  Frontiers in Microbiology. 2021  |   Pubmed ID: 34276574
• A 6-month Inhalation Toxicology Study in Apoe Mice Demonstrates Substantially Lower Effects of E-vapor Aerosol Compared with Cigarette Smoke in the Respiratory Tract
  Archives of Toxicology. 05, 2021  |   Pubmed ID: 33963423
• Impact of Whole-body Versus Nose-only Inhalation Exposure Systems on Systemic, Respiratory, and Cardiovascular Endpoints in a 2-month Cigarette Smoke Exposure Study in the ApoE Mouse Model
  Journal of Applied Toxicology : JAT. 10, 2021  |   Pubmed ID: 33825214
• Profiling of a Natural Alkaloid, Anatabine, in Rodents: Pharmacokinetics and Anti-Inflammatory Efficacy
  Journal of Natural Products. 04, 2021  |   Pubmed ID: 33706515
• Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice
  Toxicological Sciences : an Official Journal of the Society of Toxicology. 11, 2020  |   Pubmed ID: 32780831
• Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke
  Toxicological Sciences : an Official Journal of the Society of Toxicology. 11, 2020  |   Pubmed ID: 32780830
• Multi-omics Systems Toxicology Study of Mouse Lung Assessing the Effects of Aerosols from Two Heat-not-burn Tobacco Products and Cigarette Smoke
  Computational and Structural Biotechnology Journal. 2020  |   Pubmed ID: 32419906
• Evaluation of Toxicity of Aerosols from Flavored E-liquids in Sprague-Dawley Rats in a 90-day OECD Inhalation Study, Complemented by Transcriptomics Analysis
  Archives of Toxicology. 06, 2020  |   Pubmed ID: 32367274
• Development of an Integrated Assay in Human TK6 Cells to Permit Comprehensive Genotoxicity Analysis in Vitro
  Mutation Research. Genetic Toxicology and Environmental Mutagenesis. Jan, 2020  |   Pubmed ID: 32087850
• Structural, Functional, and Molecular Impact on the Cardiovascular System in ApoE Mice Exposed to Aerosol from Candidate Modified Risk Tobacco Products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, Compared with Cigarette Smoke
  Chemico-biological Interactions. Jan, 2020  |   Pubmed ID: 31705857
• Lysosomotropic-related Limitations of the BALB/c 3T3 Cell-based Neutral Red Uptake Assay and an Alternative Testing Approach for Assessing E-liquid Cytotoxicity
  Toxicology in Vitro : an International Journal Published in Association with BIBRA. Dec, 2019  |   Pubmed ID: 31518669
• Respirable Aerosol Exposures of Nicotine Dry Powder Formulations to , , and Pre-clinical Models Demonstrate Consistency of Pharmacokinetic Profiles
  Inhalation Toxicology. 05, 2019  |   Pubmed ID: 31496314
• Mode-of-action Analysis of the Effects Induced by Nicotine in the in Vitro Micronucleus Assay
  Environmental and Molecular Mutagenesis. 12, 2019  |   Pubmed ID: 31294873
• Assessing the Lung Cancer Risk Reduction Potential of Candidate Modified Risk Tobacco Products
  Internal and Emergency Medicine. 09, 2019  |   Pubmed ID: 30767158
• A Six-month Systems Toxicology Inhalation/cessation Study in ApoE Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Modified Risk Tobacco Products, CHTP 1.2 and THS 2.2, Compared with Conventional Cigarettes
  Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Apr, 2019  |   Pubmed ID: 30763686
• Biological Changes in C57BL/6 Mice Following 3 weeks of Inhalation Exposure to Cigarette Smoke or E-vapor Aerosols
  Inhalation Toxicology. Nov - Dec, 2018  |   Pubmed ID: 30849254
• A 90-day OECD TG 413 Rat Inhalation Study with Systems Toxicology Endpoints Demonstrates Reduced Exposure Effects of the Aerosol from the Carbon Heated Tobacco Product Version 1.2 (CHTP1.2) Compared with Cigarette Smoke. I. Inhalation Exposure, Clinical Pathology and Histopathology
  Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Jun, 2018  |   Pubmed ID: 29654848
• A 90-day OECD TG 413 Rat Inhalation Study with Systems Toxicology Endpoints Demonstrates Reduced Exposure Effects of the Aerosol from the Carbon Heated Tobacco Product Version 1.2 (CHTP1.2) Compared with Cigarette Smoke. II. Systems Toxicology Assessment
  Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. May, 2018  |   Pubmed ID: 29545142
• Supporting Evidence-based Analysis for Modified Risk Tobacco Products Through a Toxicology Data-sharing Infrastructure
  F1000Research. 2017  |   Pubmed ID: 29123642
• Toxicity of the Main Electronic Cigarette Components, Propylene Glycol, Glycerin, and Nicotine, in Sprague-Dawley Rats in a 90-day OECD Inhalation Study Complemented by Molecular Endpoints
  Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Nov, 2017  |   Pubmed ID: 28882640
• Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 Rat Inhalation Study with Systems Toxicology Endpoints Demonstrates Reduced Exposure Effects of a Mentholated Version Compared with Mentholated and Non-mentholated Cigarette Smoke
  Regulatory Toxicology and Pharmacology : RTP. Nov, 2016  |   Pubmed ID: 27818348
• Evaluation of the Tobacco Heating System 2.2. Part 7: Systems Toxicological Assessment of a Mentholated Version Revealed Reduced Cellular and Molecular Exposure Effects Compared with Mentholated and Non-mentholated Cigarette Smoke
  Regulatory Toxicology and Pharmacology : RTP. Nov, 2016  |   Pubmed ID: 27818347
• Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 Rat Inhalation Study with Systems Toxicology Endpoints Demonstrates Reduced Exposure Effects Compared with Cigarette Smoke
  Regulatory Toxicology and Pharmacology : RTP. Nov, 2016  |   Pubmed ID: 27793746
• Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical Composition, Genotoxicity, Cytotoxicity, and Physical Properties of the Aerosol
  Regulatory Toxicology and Pharmacology : RTP. Nov, 2016  |   Pubmed ID: 27720919
• Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the System and the Scientific Assessment Program
  Regulatory Toxicology and Pharmacology : RTP. Nov, 2016  |   Pubmed ID: 27450400
• Comprehensive Systems Biology Analysis of a 7-month Cigarette Smoke Inhalation Study in C57BL/6 Mice
  Scientific Data. 2016  |   Pubmed ID: 26731301
• An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes
  Toxicological Sciences : an Official Journal of the Society of Toxicology. Feb, 2016  |   Pubmed ID: 26609137
• A 7-month Cigarette Smoke Inhalation Study in C57BL/6 Mice Demonstrates Reduced Lung Inflammation and Emphysema Following Smoking Cessation or Aerosol Exposure from a Prototypic Modified Risk Tobacco Product
  Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Jun, 2015  |   Pubmed ID: 25843363
• Systems Toxicology Approaches Enable Mechanistic Comparison of Spontaneous and Cigarette Smoke-related Lung Tumor Development in the A/J Mouse Model
  Interdisciplinary Toxicology. Jun, 2014  |   Pubmed ID: 26109882
• A 28-day Rat Inhalation Study with an Integrated Molecular Toxicology Endpoint Demonstrates Reduced Exposure Effects for a Prototypic Modified Risk Tobacco Product Compared with Conventional Cigarettes
  Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Jun, 2014  |   Pubmed ID: 24632068
• Cigarette Smoke Induces Molecular Responses in Respiratory Tissues of ApoE(-/-) Mice That Are Progressively Deactivated Upon Cessation
  Toxicology. Dec, 2013  |   Pubmed ID: 24096154