Paul Gregorevic Department of Physiology, Centre for Muscle Research (CMR) The University of Melbourne Biography Publications Institution JoVE Articles Paul Gregorevic has not added a biography. If you are Paul Gregorevic and would like to personalize this page please email our Author Liaison for assistance. Publications Bone Morphogenetic Protein 7 Gene Delivery Improves Cardiac Structure and Function in a Murine Model of Diabetic Cardiomyopathy Frontiers in Pharmacology. 2021 | Pubmed ID: 34690762 Perturbed BMP Signaling and Denervation Promote Muscle Wasting in Cancer Cachexia Science Translational Medicine. 08, 2021 | Pubmed ID: 34349036 Tissue-specific Expression of Cas9 Has No Impact on Whole-body Metabolism in Four Transgenic Mouse Lines Molecular Metabolism. Nov, 2021 | Pubmed ID: 34246805 Yap Regulates Skeletal Muscle Fatty Acid Oxidation and Adiposity in Metabolic Disease Nature Communications. 05, 2021 | Pubmed ID: 34001905 The Regulation of Polyamine Pathway Proteins in Models of Skeletal Muscle Hypertrophy and Atrophy: a Potential Role for MTORC1 American Journal of Physiology. Cell Physiology. 06, 2021 | Pubmed ID: 33881936 Phosphorylation of ERK and Dystrophin S3059 Protects Against Inflammation-associated C2C12 Myotube Atrophy American Journal of Physiology. Cell Physiology. 06, 2021 | Pubmed ID: 33729835 Fine-tuning the Cardiac O-GlcNAcylation Regulatory Enzymes Governs the Functional and Structural Phenotype of the Diabetic Heart Cardiovascular Research. Feb, 2021 | Pubmed ID: 33576380 Dynamic Changes to the Skeletal Muscle Proteome and Ubiquitinome Induced by the E3 Ligase, ASB2β Molecular & Cellular Proteomics : MCP. Jan, 2021 | Pubmed ID: 33516941 Integrated Glycoproteomics Identifies a Role of N-Glycosylation and Galectin-1 on Myogenesis and Muscle Development Molecular & Cellular Proteomics : MCP. Dec, 2020 | Pubmed ID: 33583770 TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass Frontiers in Physiology. 2020 | Pubmed ID: 33250771 Gene Therapy Targeting Cardiac Phosphoinositide 3-kinase (p110α) Attenuates Cardiac Remodeling in Type 2 Diabetes American Journal of Physiology. Heart and Circulatory Physiology. 04, 2020 | Pubmed ID: 32142359 Intravascular Follistatin Gene Delivery Improves Glycemic Control in a Mouse Model of Type 2 Diabetes FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 04, 2020 | Pubmed ID: 32141144 Treatment of Type 2 Diabetes with the Designer Cytokine IC7Fc Nature. 10, 2019 | Pubmed ID: 31554967 Activin A-Induced Cachectic Wasting Is Attenuated by Systemic Delivery of Its Cognate Propeptide in Male Mice Endocrinology. 10, 2019 | Pubmed ID: 31322699 Generation of MicroRNA-34 Sponges and Tough Decoys for the Heart: Developments and Challenges Frontiers in Pharmacology. 2018 | Pubmed ID: 30298011 Skeletal Muscle-specific Overexpression of Heat Shock Protein 72 Improves Skeletal Muscle Insulin-stimulated Glucose Uptake but Does Not Alter Whole Body Metabolism Diabetes, Obesity & Metabolism. Apr, 2018 | Pubmed ID: 29652108 The Hippo Signaling Pathway in the Regulation of Skeletal Muscle Mass and Function Exercise and Sport Sciences Reviews. 04, 2018 | Pubmed ID: 29346163 Functional Screening in Human Cardiac Organoids Reveals a Metabolic Mechanism for Cardiomyocyte Cell Cycle Arrest Proceedings of the National Academy of Sciences of the United States of America. 10, 2017 | Pubmed ID: 28916735 Phosphoinositide 3-kinase (p110α) Gene Delivery Limits Diabetes-induced Cardiac NADPH Oxidase and Cardiomyopathy in a Mouse Model with Established Diastolic Dysfunction Clinical Science (London, England : 1979). Jun, 2017 | Pubmed ID: 28487469 Glucose-6-phosphate Dehydrogenase Contributes to the Regulation of Glucose Uptake in Skeletal Muscle Molecular Metabolism. 11, 2016 | Pubmed ID: 27818934 Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation Cell Reports. Sep, 2016 | Pubmed ID: 27626651 Smad7 Gene Delivery Prevents Muscle Wasting Associated with Cancer Cachexia in Mice Science Translational Medicine. 07, 2016 | Pubmed ID: 27440729 Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia Cancer Research. 09, 2016 | Pubmed ID: 27328730 Integrated Expression Analysis of Muscle Hypertrophy Identifies As a Negative Regulator of Muscle Mass JCI Insight. Apr, 2016 | Pubmed ID: 27182554 The TGF-β Signalling Network in Muscle Development, Adaptation and Disease Advances in Experimental Medicine and Biology. 2016 | Pubmed ID: 27003398 Using AAV Vectors Expressing the β2-adrenoceptor or Associated Gα Proteins to Modulate Skeletal Muscle Mass and Muscle Fibre Size Scientific Reports. Mar, 2016 | Pubmed ID: 26972746 Evaluation of Follistatin As a Therapeutic in Models of Skeletal Muscle Atrophy Associated with Denervation and Tenotomy Scientific Reports. Dec, 2015 | Pubmed ID: 26657343 Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival Cell. Sep, 2015 | Pubmed ID: 26359988 Development of Novel Activin-targeted Therapeutics Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2015 | Pubmed ID: 25399825 Functional β-adrenoceptors Are Important for Early Muscle Regeneration in Mice Through Effects on Myoblast Proliferation and Differentiation PloS One. 2014 | Pubmed ID: 25000590 The Bone Morphogenetic Protein Axis is a Positive Regulator of Skeletal Muscle Mass The Journal of Cell Biology. Oct, 2013 | Pubmed ID: 24145169 MiR-206 Represses Hypertrophy of Myogenic Cells but Not Muscle Fibers Via Inhibition of HDAC4 PloS One. 2013 | Pubmed ID: 24023888 Transduction of Skeletal Muscles with Common Reporter Genes Can Promote Muscle Fiber Degeneration and Inflammation PloS One. 2012 | Pubmed ID: 23251598 Follistatin-mediated Skeletal Muscle Hypertrophy is Regulated by Smad3 and MTOR Independently of Myostatin The Journal of Cell Biology. Jun, 2012 | Pubmed ID: 22711699 TGF-beta Regulates MiR-206 and MiR-29 to Control Myogenic Differentiation Through Regulation of HDAC4 The Journal of Biological Chemistry. Apr, 2011 | Pubmed ID: 21324893 Changes in Contractile Activation Characteristics of Rat Fast and Slow Skeletal Muscle Fibres During Regeneration The Journal of Physiology. Jul, 2004 | Pubmed ID: 15181161 The Calcineurin Signal Transduction Pathway is Essential for Successful Muscle Regeneration in Mdx Dystrophic Mice Acta Neuropathologica. Apr, 2004 | Pubmed ID: 14727129 Beta 2-agonist Administration Reverses Muscle Wasting and Improves Muscle Function in Aged Rats The Journal of Physiology. Feb, 2004 | Pubmed ID: 14617677 Beta2-adrenoceptor Agonist Fenoterol Enhances Functional Repair of Regenerating Rat Skeletal Muscle After Injury Journal of Applied Physiology (Bethesda, Md. : 1985). Apr, 2004 | Pubmed ID: 14607853 Endurance Training Adaptations Modulate the Redox-force Relationship of Rat Isolated Slow-twitch Skeletal Muscles Clinical and Experimental Pharmacology & Physiology. Jan-Feb, 2003 | Pubmed ID: 12542458 Improved Contractile Function of the Mdx Dystrophic Mouse Diaphragm Muscle After Insulin-like Growth Factor-I Administration The American Journal of Pathology. Dec, 2002 | Pubmed ID: 12466140 Beta 2-agonist Fenoterol Has Greater Effects on Contractile Function of Rat Skeletal Muscles Than Clenbuterol American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Dec, 2002 | Pubmed ID: 12388476 Hyperbaric Oxygen Increases the Contractile Function of Regenerating Rat Slow Muscles Medicine and Science in Sports and Exercise. Apr, 2002 | Pubmed ID: 11932571 Effects of Leukemia Inhibitory Factor on Rat Skeletal Muscles Are Modulated by Clenbuterol Muscle & Nerve. Feb, 2002 | Pubmed ID: 11870686 A Step-By-Step Method to Detect Neutralizing Antibodies Against AAV using a Colorimetric Cell-Based Assay Sebastian Bass-Stringer1,2, Colleen J. Thomas2,3, Clive N. May3, Paul Gregorevic4, Kate L. Weeks1,5,6, Julie R. McMullen1,2,5,6,7 1Baker Heart and Diabetes Institute, 2Department of Physiology, Anatomy and Microbiology, La Trobe University, 3Florey Institute of Neuroscience and Mental Health, University of Melbourne, 4Department of Physiology, Centre for Muscle Research (CMR), The University of Melbourne, 5Department of Diabetes, Central Clinical School, Monash University, 6Baker Department of Cardiometabolic Health, The University of Melbourne, 7Department of Physiology and Department of Medicine Alfred Hospital, Monash University JoVE 63419 Biology
A Step-By-Step Method to Detect Neutralizing Antibodies Against AAV using a Colorimetric Cell-Based Assay Sebastian Bass-Stringer1,2, Colleen J. Thomas2,3, Clive N. May3, Paul Gregorevic4, Kate L. Weeks1,5,6, Julie R. McMullen1,2,5,6,7 1Baker Heart and Diabetes Institute, 2Department of Physiology, Anatomy and Microbiology, La Trobe University, 3Florey Institute of Neuroscience and Mental Health, University of Melbourne, 4Department of Physiology, Centre for Muscle Research (CMR), The University of Melbourne, 5Department of Diabetes, Central Clinical School, Monash University, 6Baker Department of Cardiometabolic Health, The University of Melbourne, 7Department of Physiology and Department of Medicine Alfred Hospital, Monash University JoVE 63419 Biology