Philip A. Marsden

Publications

• C-Myb Regulates Transcriptional Activation of MiR-143/145 in Vascular Smooth Muscle Cells
  PloS One. Month, 2018   |   Pubmed ID: 30169548
• Angiogenic Patterning by STEEL, an Endothelial-enriched Long Noncoding RNA
  Proceedings of the National Academy of Sciences of the United States of America. 03, 2018   |   Pubmed ID: 29467285
• Histone Acetyltransferase 7 (KAT7)-dependent Intragenic Histone Acetylation Regulates Endothelial Cell Gene Regulation
  The Journal of Biological Chemistry. Mar, 2018   |   Pubmed ID: 29414790
• Epigenetic Determinants of Cardiovascular Gene Expression: Vascular Endothelium
  Epigenomics. 07, 2016   |   Pubmed ID: 27381277
• A Role of Stochastic Phenotype Switching in Generating Mosaic Endothelial Cell Heterogeneity
  Nature Communications. Jan, 2016   |   Pubmed ID: 26744078
• Robust Effects of Genetic Background on Responses to Subarachnoid Hemorrhage in Mice
  Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 11, 2016   |   Pubmed ID: 26661216
• Epigenetics in the Vascular Endothelium: Looking From a Different Perspective in the Epigenomics Era
  Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2015   |   Pubmed ID: 26404488
• Posttranscriptional Adaptations of the Vascular Endothelium to Hypoxia
  Current Opinion in Hematology. May, 2015   |   Pubmed ID: 25767954
• Epigenetics of Cardiovascular Disease - A New "Beat" in Coronary Artery Disease
  Medical Epigenetics. Apr, 2014   |   Pubmed ID: 25408699
• Nitric Oxide and Hypoxia Signaling
  Vitamins and Hormones. Month, 2014   |   Pubmed ID: 25189387
• Effect of Disturbed Blood Flow on Endothelial Cell Gene Expression: a Role for Changes in RNA Processing
  Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2014   |   Pubmed ID: 25142881
• Differential HIF and NOS Responses to Acute Anemia: Defining Organ-specific Hemoglobin Thresholds for Tissue Hypoxia
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jul, 2014   |   Pubmed ID: 24760996
• Competition and Collaboration Between RNA-binding Proteins and MicroRNAs
  Wiley Interdisciplinary Reviews. RNA. Jan-Feb, 2014   |   Pubmed ID: 24124109
• Dysregulation of Angiopoietin 1 and 2 in Escherichia Coli O157:H7 Infection and the Hemolytic-uremic Syndrome
  The Journal of Infectious Diseases. Sep, 2013   |   Pubmed ID: 23801605
• Active Stabilization of Human Endothelial Nitric Oxide Synthase MRNA by HnRNP E1 Protects Against Antisense RNA and MicroRNAs
  Molecular and Cellular Biology. May, 2013   |   Pubmed ID: 23478261
• A Mechanistic Role for DNA Methylation in Endothelial Cell (EC)-enriched Gene Expression: Relationship with DNA Replication Timing
  Blood. Apr, 2013   |   Pubmed ID: 23449636
• Epigenetics and Cardiovascular Disease
  The Canadian Journal of Cardiology. Jan, 2013   |   Pubmed ID: 23261320
• Functional Importance of Dicer Protein in the Adaptive Cellular Response to Hypoxia
  The Journal of Biological Chemistry. Aug, 2012   |   Pubmed ID: 22745131
• Shiga Toxin-associated Hemolytic Uremic Syndrome: Advances in Pathogenesis and Therapeutics
  Current Opinion in Nephrology and Hypertension. Jul, 2012   |   Pubmed ID: 22660553
• Bone Marrow Cell Therapies for Endothelial Repair and Their Relevance to Kidney Disease
  Seminars in Nephrology. Mar, 2012   |   Pubmed ID: 22617771
• Gene Regulation in the Vascular Endothelium: Why Epigenetics is Important for the Kidney
  Seminars in Nephrology. Mar, 2012   |   Pubmed ID: 22617766
• Nitric Oxide Signaling in Hypoxia
  Journal of Molecular Medicine (Berlin, Germany). Mar, 2012   |   Pubmed ID: 22349396
• The CXCR4/CXCR7/SDF-1 Pathway Contributes to the Pathogenesis of Shiga Toxin-associated Hemolytic Uremic Syndrome in Humans and Mice
  The Journal of Clinical Investigation. Feb, 2012   |   Pubmed ID: 22232208
• Priming of Hypoxia-inducible Factor by Neuronal Nitric Oxide Synthase is Essential for Adaptive Responses to Severe Anemia
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011   |   Pubmed ID: 21976486
• Epigenetics in Cardiovascular Disease
  Current Opinion in Cardiology. May, 2011   |   Pubmed ID: 21415727
• Simvastatin Re-couples Dysfunctional Endothelial Nitric Oxide Synthase in Experimental Subarachnoid Hemorrhage
  PloS One. Feb, 2011   |   Pubmed ID: 21373645
• Reassessing the Risk of Hemodilutional Anemia: Some New Pieces to an Old Puzzle
  Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie. Aug, 2010   |   Pubmed ID: 20512540
• Epigenetics of the Vascular Endothelium
  Journal of Applied Physiology (Bethesda, Md. : 1985). Sep, 2010   |   Pubmed ID: 20413423
• Culture-modified Bone Marrow Cells Attenuate Cardiac and Renal Injury in a Chronic Kidney Disease Rat Model Via a Novel Antifibrotic Mechanism
  PloS One. Mar, 2010   |   Pubmed ID: 20209052
• Enhanced Translation of Heme Oxygenase-2 Preserves Human Endothelial Cell Viability During Hypoxia
  The Journal of Biological Chemistry. Mar, 2010   |   Pubmed ID: 20118244
• Hypoxic Repression of Endothelial Nitric-oxide Synthase Transcription is Coupled with Eviction of Promoter Histones
  The Journal of Biological Chemistry. Jan, 2010   |   Pubmed ID: 19880524
• Role of a Distal Enhancer in the Transcriptional Responsiveness of the Human CD200 Gene to Interferon-gamma and Tumor Necrosis Factor-alpha
  Molecular Immunology. Jun, 2009   |   Pubmed ID: 19386363
• Regulation of Endocytosis Via the Oxygen-sensing Pathway
  Nature Medicine. Mar, 2009   |   Pubmed ID: 19252501
• Verotoxin Biology: Molecular Events in Vascular Endothelial Injury
  Kidney International. Supplement. Feb, 2009   |   Pubmed ID: 19180125
• Dicer Cuts the Kidney
  Journal of the American Society of Nephrology : JASN. Nov, 2008   |   Pubmed ID: 18923053
• Endothelial Nitric Oxide Synthase Gene Expression During Murine Embryogenesis: Commencement of Expression in the Embryo Occurs with the Establishment of a Unidirectional Circulatory System
  Circulation Research. Jul, 2008   |   Pubmed ID: 18556578
• Relative Reduction of Endothelial Nitric-oxide Synthase Expression and Transcription in Atherosclerosis-prone Regions of the Mouse Aorta and in an in Vitro Model of Disturbed Flow
  The American Journal of Pathology. Nov, 2007   |   Pubmed ID: 17982133
• Low-molecular-weight S-nitrosothiols and Blood Vessel Injury
  The Journal of Clinical Investigation. Sep, 2007   |   Pubmed ID: 17786231
• Role of VEGF in Maintaining Renal Structure and Function Under Normotensive and Hypertensive Conditions
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2007   |   Pubmed ID: 17726104
• Hypoxia-inducible Expression of a Natural Cis-antisense Transcript Inhibits Endothelial Nitric-oxide Synthase
  The Journal of Biological Chemistry. May, 2007   |   Pubmed ID: 17403686
• VHL Promotes E2 Box-dependent E-cadherin Transcription by HIF-mediated Regulation of SIP1 and Snail
  Molecular and Cellular Biology. Jan, 2007   |   Pubmed ID: 17060462
• Increased Expression of HIF-1alpha, NNOS, and VEGF in the Cerebral Cortex of Anemic Rats
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jan, 2007   |   Pubmed ID: 16973934
• Loss of the Tumor Suppressor Vhlh Leads to Upregulation of Cxcr4 and Rapidly Progressive Glomerulonephritis in Mice
  Nature Medicine. Sep, 2006   |   Pubmed ID: 16906157
• RNA Transfection is a Versatile Tool to Investigate Endothelin-1 Posttranscriptional Regulation
  Experimental Biology and Medicine (Maywood, N.J.). Jun, 2006   |   Pubmed ID: 16740984
• C-Jun N-terminal Kinase-mediated Stabilization of Microsomal Prostaglandin E2 Synthase-1 MRNA Regulates Delayed Microsomal Prostaglandin E2 Synthase-1 Expression and Prostaglandin E2 Biosynthesis by Cardiomyocytes
  The Journal of Biological Chemistry. Jun, 2006   |   Pubmed ID: 16627484
• Tyrosine Phosphatase MEG2 Modulates Murine Development and Platelet and Lymphocyte Activation Through Secretory Vesicle Function
  The Journal of Experimental Medicine. Dec, 2005   |   Pubmed ID: 16330817
• Hypoxia Induces a Functionally Significant and Translationally Efficient Neuronal NO Synthase MRNA Variant
  The Journal of Clinical Investigation. Nov, 2005   |   Pubmed ID: 16276418
• Epigenetic Basis for the Transcriptional Hyporesponsiveness of the Human Inducible Nitric Oxide Synthase Gene in Vascular Endothelial Cells
  Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005   |   Pubmed ID: 16148131
• Extensive Variation in the 5'-UTR of Dicer MRNAs Influences Translational Efficiency
  Biochemical and Biophysical Research Communications. Sep, 2005   |   Pubmed ID: 16095561
• Post-transcriptional Regulation of Endothelial Nitric-oxide Synthase by an Overlapping Antisense MRNA Transcript
  The Journal of Biological Chemistry. Sep, 2004   |   Pubmed ID: 15234981
• Role of the 3'-untranslated Region of Human Endothelin-1 in Vascular Endothelial Cells. Contribution to Transcript Lability and the Cellular Heat Shock Response
  The Journal of Biological Chemistry. Mar, 2004   |   Pubmed ID: 14660616
• The Fgl2/fibroleukin Prothrombinase Contributes to Immunologically Mediated Thrombosis in Experimental and Human Viral Hepatitis
  The Journal of Clinical Investigation. Jul, 2003   |   Pubmed ID: 12840059
• Germline Polymorphisms in Cardiovascular Medicine. Is That the Whole Story?
  The Canadian Journal of Cardiology. Apr, 1999   |   Pubmed ID: 10350676