Ralf Bartenschlager

Publications

• Novel Non-heteroarylpyrimidine (HAP) Capsid Assembly Modifiers Have a Different Mode of Action from HAPs in Vitro
  Antiviral Research. Jul, 2018  |   Pubmed ID: 30031759
• A Reverse Genetics System for Zika Virus Based on a Simple Molecular Cloning Strategy
  Viruses. 07, 2018  |   Pubmed ID: 30002313
• Semen Inhibits Zika Virus Infection of Cells and Tissues from the Anogenital Region
  Nature Communications. Jun, 2018  |   Pubmed ID: 29880824
• HCV Modifies EGF Signalling and Upregulates Production of CXCR2 Ligands: Role in Inflammation and Antiviral Immune Response
  Journal of Hepatology. Sep, 2018  |   Pubmed ID: 29705238
• Critical Challenges and Emerging Opportunities in Hepatitis C Virus Research in an Era of Potent Antiviral Therapy: Considerations for Scientists and Funding Agencies
  Virus Research. 03, 2018  |   Pubmed ID: 29477639
• Structural Studies of Self-Assembled Subviral Particles: Combining Cell-Free Expression with 110 kHz MAS NMR Spectroscopy
  Angewandte Chemie (International Ed. in English). Apr, 2018  |   Pubmed ID: 29457857
• Rewiring Cellular Networks by Members of the Flaviviridae Family
  Nature Reviews. Microbiology. Feb, 2018  |   Pubmed ID: 29430005
• HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of Interferon
  Gastroenterology. 05, 2018  |   Pubmed ID: 29410097
• Glycine Zipper Motifs in Hepatitis C Virus Nonstructural Protein 4B Are Required for the Establishment of Viral Replication Organelles
  Journal of Virology. 02, 2018  |   Pubmed ID: 29167346
• Hepatitis C Virus Replication Depends on Endosomal Cholesterol Homeostasis
  Journal of Virology. 01, 2018  |   Pubmed ID: 29046459
• Host-directed Therapies for Bacterial and Viral Infections
  Nature Reviews. Drug Discovery. Jan, 2018  |   Pubmed ID: 28935918
• Membrane Alterations Induced by Nonstructural Proteins of Human Norovirus
  PLoS Pathogens. Oct, 2017  |   Pubmed ID: 29077760
• Optimization of Substrate-Analogue Furin Inhibitors
  ChemMedChem. 12, 2017  |   Pubmed ID: 29059503
• Genome Packaging of Reovirus is Mediated by the Scaffolding Property of the Microtubule Network
  Cellular Microbiology. 12, 2017  |   Pubmed ID: 28672089
• Maturation of Secreted HCV Particles by Incorporation of Secreted ApoE Protects from Antibodies by Enhancing Infectivity
  Journal of Hepatology. Sep, 2017  |   Pubmed ID: 28438690
• Erratum for Roth Et Al., "Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses"
  MBio. 04, 2017  |   Pubmed ID: 28420740
• Effects of NS2B-NS3 Protease and Furin Inhibition on West Nile and Dengue Virus Replication
  Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2017  |   Pubmed ID: 28385094
• A Novel Inhibitor IDPP Interferes with Entry and Egress of HCV by Targeting Glycoprotein E1 in a Genotype-Specific Manner
  Scientific Reports. 03, 2017  |   Pubmed ID: 28333153
• Immune Protection Against Reinfection with Nonprimate Hepacivirus
  Proceedings of the National Academy of Sciences of the United States of America. 03, 2017  |   Pubmed ID: 28275093
• Ultrastructural Characterization of Zika Virus Replication Factories
  Cell Reports. Feb, 2017  |   Pubmed ID: 28249158
• Novel Nucleoside Analogues Targeting HCV Replication Through an NS5A-dependent Inhibition Mechanism
  Chemical Biology & Drug Design. Sep, 2017  |   Pubmed ID: 28245093
• Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide SiRNA Screening
  Molecular Cell. Feb, 2017  |   Pubmed ID: 28132841
• Editorial: An Expanded View of Viruses
  FEMS Microbiology Reviews. 01, 2017  |   Pubmed ID: 28087690
• Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses
  MBio. 01, 2017  |   Pubmed ID: 28074025
• Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology
  Journal of Medicinal Chemistry. Jan, 2017  |   Pubmed ID: 27966962
• TALEN/CRISPR-mediated Engineering of a Promoterless Anti-viral RNAi Hairpin into an Endogenous MiRNA Locus
  Nucleic Acids Research. 01, 2017  |   Pubmed ID: 27614072
• Tuning a Cellular Lipid Kinase Activity Adapts Hepatitis C Virus to Replication in Cell Culture
  Nature Microbiology. 12, 2016  |   Pubmed ID: 27991882
• The Quest for Host Targets to Combat Dengue Virus Infections
  Current Opinion in Virology. 10, 2016  |   Pubmed ID: 27648486
• Hepatitis C Virus-From Discovery to Cure: The 2016 Lasker-DeBakey Clinical Medical Research Award
  JAMA. Sep, 2016  |   Pubmed ID: 27623041
• Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses
  Cell Host & Microbe. Sep, 2016  |   Pubmed ID: 27545046
• Broad Neutralization of Hepatitis C Virus-resistant Variants by Civacir Hepatitis C Immunoglobulin
  Hepatology (Baltimore, Md.). 11, 2016  |   Pubmed ID: 27531416
• Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly
  Viruses. 06, 2016  |   Pubmed ID: 27338443
• A Slow Maturation Process Renders Hepatitis B Virus Infectious
  Cell Host & Microbe. Jul, 2016  |   Pubmed ID: 27321908
• Investigation of NS3 Protease Resistance-Associated Variants and Phenotypes for the Prediction of Treatment Response to HCV Triple Therapy
  PloS One. 2016  |   Pubmed ID: 27281344
• Reovirus Intermediate Subviral Particles Constitute a Strategy to Infect Intestinal Epithelial Cells by Exploiting TGF-β Dependent Pro-survival Signaling
  Cellular Microbiology. Dec, 2016  |   Pubmed ID: 27279006
• Cell-free Expression, Purification, and Membrane Reconstitution for NMR Studies of the Nonstructural Protein 4B from Hepatitis C Virus
  Journal of Biomolecular NMR. Jun, 2016  |   Pubmed ID: 27233794
• Geno2pheno[HCV] - A Web-based Interpretation System to Support Hepatitis C Treatment Decisions in the Era of Direct-Acting Antiviral Agents
  PloS One. 2016  |   Pubmed ID: 27196673
• Correlative Light and Electron Microscopy Methods for the Study of Virus-cell Interactions
  FEBS Letters. 07, 2016  |   Pubmed ID: 27008928
• Hepatitis C Virus Activates a Neuregulin-Driven Circuit to Modify Surface Expression of Growth Factor Receptors of the ErbB Family
  PloS One. 2016  |   Pubmed ID: 26886748
• Coordination of Hepatitis C Virus Assembly by Distinct Regulatory Regions in Nonstructural Protein 5A
  PLoS Pathogens. Jan, 2016  |   Pubmed ID: 26727512
• Paradoxical Role of Antibodies in Dengue Virus Infections: Considerations for Prophylactic Vaccine Development
  Expert Review of Vaccines. 2016  |   Pubmed ID: 26577689
• Evidence That Hepatitis B Virus Replication in Mouse Cells is Limited by the Lack of a Host Cell Dependency Factor
  Journal of Hepatology. Mar, 2016  |   Pubmed ID: 26576481
• Apolipoprotein E Mediates Evasion From Hepatitis C Virus Neutralizing Antibodies
  Gastroenterology. Jan, 2016  |   Pubmed ID: 26404951
• Flaviviridae Replication Organelles: Oh, What a Tangled Web We Weave
  Annual Review of Virology. Nov, 2015  |   Pubmed ID: 26958917
• Viral Infection at High Magnification: 3D Electron Microscopy Methods to Analyze the Architecture of Infected Cells
  Viruses. Dec, 2015  |   Pubmed ID: 26633469
• Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus
  PLoS Pathogens. Nov, 2015  |   Pubmed ID: 26588843
• Dengue Virus Non-structural Protein 1 Modulates Infectious Particle Production Via Interaction with the Structural Proteins
  PLoS Pathogens. 2015  |   Pubmed ID: 26562291
• Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue
  Journal of Medicinal Chemistry. Dec, 2015  |   Pubmed ID: 26562070
• Phenylalanine and Phenylglycine Analogues As Arginine Mimetics in Dengue Protease Inhibitors
  Journal of Medicinal Chemistry. Oct, 2015  |   Pubmed ID: 26367391
• Functional Expression, Purification, Characterization, and Membrane Reconstitution of Non-structural Protein 2 from Hepatitis C Virus
  Protein Expression and Purification. Dec, 2015  |   Pubmed ID: 26325423
• Structural and Functional Properties of the Hepatitis C Virus P7 Viroporin
  Viruses. Aug, 2015  |   Pubmed ID: 26258788
• Alleviation of Off-target Effects from Vector-encoded ShRNAs Via Codelivered RNA Decoys
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2015  |   Pubmed ID: 26170322
• NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication
  MBio. Jul, 2015  |   Pubmed ID: 26152585
• Soraphen A: A Broad-spectrum Antiviral Natural Product with Potent Anti-hepatitis C Virus Activity
  Journal of Hepatology. Oct, 2015  |   Pubmed ID: 26070407
• Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor P62
  Journal of Virology. Aug, 2015  |   Pubmed ID: 26018155
• Interferon-inducible Cholesterol-25-hydroxylase Restricts Hepatitis C Virus Replication Through Blockage of Membranous Web Formation
  Hepatology (Baltimore, Md.). Sep, 2015  |   Pubmed ID: 25999047
• A Combined Genetic-Proteomic Approach Identifies Residues Within Dengue Virus NS4B Critical for Interaction with NS3 and Viral Replication
  Journal of Virology. Jul, 2015  |   Pubmed ID: 25926641
• Control of Temporal Activation of Hepatitis C Virus-induced Interferon Response by Domain 2 of Nonstructural Protein 5A
  Journal of Hepatology. Oct, 2015  |   Pubmed ID: 25908268
• Clearance of Persistent Hepatitis C Virus Infection in Humanized Mice Using a Claudin-1-targeting Monoclonal Antibody
  Nature Biotechnology. May, 2015  |   Pubmed ID: 25798937
• Identification of HNRNPK As Regulator of Hepatitis C Virus Particle Production
  PLoS Pathogens. Jan, 2015  |   Pubmed ID: 25569684
• Going Full Circle: Validation of P-body Dispersion in Hepatitis C Virus-infected Patients
  Journal of Hepatology. Apr, 2015  |   Pubmed ID: 25559325
• Novel Dengue Virus NS2B/NS3 Protease Inhibitors
  Antimicrobial Agents and Chemotherapy. Feb, 2015  |   Pubmed ID: 25487800
• Wheat Germ Cell-free Expression: Two Detergents with a Low Critical Micelle Concentration Allow for Production of Soluble HCV Membrane Proteins
  Protein Expression and Purification. Jan, 2015  |   Pubmed ID: 25306874
• Hepatitis C Virus RNA Replication and Assembly: Living on the Fat of the Land
  Cell Host & Microbe. Nov, 2014  |   Pubmed ID: 25525790
• Apolipoprotein E Likely Contributes to a Maturation Step of Infectious Hepatitis C Virus Particles and Interacts with Viral Envelope Glycoproteins
  Journal of Virology. Nov, 2014  |   Pubmed ID: 25122793
• The Lysine Methyltransferase SMYD3 Interacts with Hepatitis C Virus NS5A and is a Negative Regulator of Viral Particle Production
  Virology. Aug, 2014  |   Pubmed ID: 25092459
• Development of a High-throughput Pyrosequencing Assay for Monitoring Temporal Evolution and Resistance Associated Variant Emergence in the Hepatitis C Virus Protease Coding-region
  Antiviral Research. Oct, 2014  |   Pubmed ID: 25057759
• Characterization of the Mode of Action of a Potent Dengue Virus Capsid Inhibitor
  Journal of Virology. Oct, 2014  |   Pubmed ID: 25056895
• Membranous Replication Factories Induced by Plus-strand RNA Viruses
  Viruses. Jul, 2014  |   Pubmed ID: 25054883
• Daclatasvir-like Inhibitors of NS5A Block Early Biogenesis of Hepatitis C Virus-induced Membranous Replication Factories, Independent of RNA Replication
  Gastroenterology. Nov, 2014  |   Pubmed ID: 25046163
• Strategies to Inhibit Entry of HBV and HDV into Hepatocytes
  Gastroenterology. Jul, 2014  |   Pubmed ID: 24768844
• Heterologous Src Homology 4 Domains Support Membrane Anchoring and Biological Activity of HIV-1 Nef
  The Journal of Biological Chemistry. May, 2014  |   Pubmed ID: 24706755
• Inhibition of HCV Replication by Cyclophilin Antagonists is Linked to Replication Fitness and Occurs by Inhibition of Membranous Web Formation
  Gastroenterology. May, 2014  |   Pubmed ID: 24486951
• On the History of Hepatitis C Virus Cell Culture Systems
  Journal of Medicinal Chemistry. Mar, 2014  |   Pubmed ID: 24164647
• Thiazolidinone-peptide Hybrids As Dengue Virus Protease Inhibitors with Antiviral Activity in Cell Culture
  Journal of Medicinal Chemistry. Nov, 2013  |   Pubmed ID: 24083834
• Robust RNAi Enhancement Via Human Argonaute-2 Overexpression from Plasmids, Viral Vectors and Cell Lines
  Nucleic Acids Research. Nov, 2013  |   Pubmed ID: 24049077
• Replication Vesicles Are Load- and Choke-points in the Hepatitis C Virus Lifecycle
  PLoS Pathogens. 2013  |   Pubmed ID: 23990783
• Interferon-stimulated Genes and Their Role in Controlling Hepatitis C Virus
  Journal of Hepatology. Dec, 2013  |   Pubmed ID: 23933585
• Morphological and Biochemical Characterization of the Membranous Hepatitis C Virus Replication Compartment
  Journal of Virology. Oct, 2013  |   Pubmed ID: 23885072
• Evidence for Novel Hepaciviruses in Rodents
  PLoS Pathogens. 2013  |   Pubmed ID: 23818848
• The Molecular and Structural Basis of Advanced Antiviral Therapy for Hepatitis C Virus Infection
  Nature Reviews. Microbiology. Jul, 2013  |   Pubmed ID: 23748342
• Analysis of Hepatitis C Virus Resistance to Silibinin in Vitro and in Vivo Points to a Novel Mechanism Involving Nonstructural Protein 4B
  Hepatology (Baltimore, Md.). Mar, 2013  |   Pubmed ID: 23322644
• Promotion of Hepatocellular Carcinoma by Hepatitis C Virus
  Digestive Diseases (Basel, Switzerland). 2012  |   Pubmed ID: 23108300
• Dynamic Oscillation of Translation and Stress Granule Formation Mark the Cellular Response to Virus Infection
  Cell Host & Microbe. Jul, 2012  |   Pubmed ID: 22817989
• Persistence of HCV in Quiescent Hepatic Cells Under Conditions of an Interferon-induced Antiviral Response
  Gastroenterology. Aug, 2012  |   Pubmed ID: 22522091
• Mutations That Alter Use of Hepatitis C Virus Cell Entry Factors Mediate Escape from Neutralizing Antibodies
  Gastroenterology. Jul, 2012  |   Pubmed ID: 22503792
• New Targets for Antiviral Therapy of Chronic Hepatitis C
  Liver International : Official Journal of the International Association for the Study of the Liver. Feb, 2012  |   Pubmed ID: 22212566
• Normalizing for Individual Cell Population Context in the Analysis of High-content Cellular Screens
  BMC Bioinformatics. 2011  |   Pubmed ID: 22185194
• Exploitation of Cellular Pathways by Dengue Virus
  Current Opinion in Microbiology. Aug, 2011  |   Pubmed ID: 21798792
• Mouse Hepatic Cells Support Assembly of Infectious Hepatitis C Virus Particles
  Gastroenterology. Sep, 2011  |   Pubmed ID: 21699799
• Molecular Mechanism of Signal Perception and Integration by the Innate Immune Sensor Retinoic Acid-inducible Gene-I (RIG-I)
  The Journal of Biological Chemistry. Aug, 2011  |   Pubmed ID: 21659521
• Hepatitis C Virus and Host Cell Lipids: an Intimate Connection
  RNA Biology. Mar-Apr, 2011  |   Pubmed ID: 21593584
• NS4B Self-interaction Through Conserved C-terminal Elements is Required for the Establishment of Functional Hepatitis C Virus Replication Complexes
  Journal of Virology. Jul, 2011  |   Pubmed ID: 21543474
• Recruitment and Activation of a Lipid Kinase by Hepatitis C Virus NS5A is Essential for Integrity of the Membranous Replication Compartment
  Cell Host & Microbe. Jan, 2011  |   Pubmed ID: 21238945
• Assembly of Infectious Hepatitis C Virus Particles
  Trends in Microbiology. Feb, 2011  |   Pubmed ID: 21146993
• Biochemical and Morphological Properties of Hepatitis C Virus Particles and Determination of Their Lipidome
  The Journal of Biological Chemistry. Jan, 2011  |   Pubmed ID: 21056986
• New Insights into Structure and Replication of the Hepatitis C Virus and Clinical Implications
  Seminars in Liver Disease. Nov, 2010  |   Pubmed ID: 20960374